Psychiatric Symptoms Vary With the Severity of Dementia in Probable Alzheimer's Disease

Lopez, Oscar L.; Becker, James T.; Sweet, Robert A.; Klunk, William; Kaufer, Daniel I.; Saxton, Judith; Habeych, Miguel; DeKosky, Steven T.

doi:10.1176/jnp.15.3.346

Cited by 286Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsHistorical and Modern Theater Studies

Psychiatric Symptoms Vary With the Severity of Dementia in Probable Alzheimer's Disease

Lopez, Oscar L., Becker, James T., Sweet, Robert A., Klunk, William, Kaufer, Daniel I., Saxton, Judith, Habeych, Miguel, DeKosky, Steven T.·2003·The Journal of Neuropsychiatry and Clinical Neurosciences

DOI 10.1176/jnp.15.3.346

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Abstract

This cross-sectional study examines relationships among the constellation of psychiatric syndromes in Alzheimer's disease (AD) as a function of dementia severity in 1155 patients with probable AD. The frequency of major depression decreased in severe stages, while agitation, aggression, and psychosis were more frequent in late stages. Major depression was associated with anhedonia, sleep disorders, depressed mood, low self-esteem, anxiety, and hopelessness in mild/moderate and severe stages. Agitation was associated with aggression and psychosis in mild/moderate stages, and psychosis was associated with aggression in moderate/severe stages. In addition, there was a constellation of psychiatric symptoms (e.g., anxiety, wandering, irritability, inappropriate behavior, uncooperativeness, emotional lability) associated with agitation, aggression, and psychosis, which varied according to the severity of the dementia, suggesting a progressive deterioration of frontal-temporal limbic structures. Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages.

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Authors: Lopez, O. L., Becker, J. T., Sweet, R. A., Klunk, W., Kaufer, D. I., Saxton, J., Habeych, M., & DeKosky, S. T.
Affiliations: Received December 11, 2001; revised May 17, 2002; accepted May 24, 2002. From the Alzheimers Disease Research Center and the Departments of Psychiatry, Neurology, and Epidemiology, University of Pittsburgh School of Medicine, Pittsburg, Pennsylvania. Address correspondence to Dr. Oscar L. Lopez, Neuropsychology Research Program, 3501 Forbes Avenue, Suite 830 Pittsburgh, PA 15213; (E-mail).
University of Pittsburgh (US)
ORCID: Becker, James T.
Sweet, Robert A.
Klunk, William
Kaufer, Daniel I.
Habeych, Miguel
DeKosky, Steven T.
Venue: The Journal of Neuropsychiatry and Clinical Neurosciences
Publisher: American Psychiatric Association Publishing
Published: 2003-08
Volume: 15
Issue: 3
Pages: 346-353
ISSN: 0895-0172 (ISSN-L)
1545-7222
DOI: 10.1176/jnp.15.3.346
OpenAlex: W2163602955
Cited by: 286
References: 45
Citations by year: 2026: 4 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 16 · 2021: 19 · 2020: 8 · 2019: 7 · 2018: 21 · 2017: 12 · 2016: 11 · 2015: 18 · 2014: 10 · 2013: 14 · 2012: 8
FWCI: 6.96
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropsychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ag003705-04)
National Institute on Aging (AG 05-133, P50AG005133, AG 03705)
National Institute of Mental Health (K02MH001077, K02-MH-01077)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords: Alzheimer's disease, dementia severity, psychiatric symptoms, major depressive disorder, agitation, aggression, psychosis, anhedonia, sleep disorders, anxiety, wandering, emotional lability, race
MeSH terms: Aggression, Alzheimer Disease, Mental Disorders, Cognition Disorders, Dementia, Depression, Female, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychomotor Agitation, Psychotic Disorders, Severity of Illness Index, Comorbidity, Chi-Square Distribution

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Psychiatric Symptoms Vary With the Severity of Dementia in Probable Alzheimer's Disease

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Integrity signals

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