Left frontotemporal hypoperfusion is associated with aggression in patients with dementia
Abstract
BACKGROUND: Aggressive behavior is common in patients with dementia. Temporolimbic and prefrontal cortical lesions can produce pathological aggression; however, involvement of these structures has not been established in aggressive patients with dementia. OBJECTIVE: To study the relation between regional brain perfusion and aggressive behavior in patients with dementia. METHODS: We compared the pattern of regional cerebral perfusion determined with technetium Tc 99m-labeled hexamethylpropelene amineoxime single photon emission computed tomography in 2 groups of 10 patients with dementia with and without aggression, that were comparable for demographic factors, severity of cognitive impairments, and other behavioral symptoms as measured by the Neuropsychiatric Inventory. RESULTS: Patients with aggression revealed significant (P<.001) hypoperfusion in the left anterior temporal cortex; additional bilateral dorsofrontal and right parietal cortex were also found to be significantly hypoperfused. CONCLUSION: These results indicated an association between aggression and decreased perfusion in the left anterior temporal cortex. Arch Neurol. 2000.
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Agitation in Alzheimer's disease is associated with hypoperfusion in left anteriotemporal, right parietal, and bilateral dorsofrontal cortex.
“The sole SPECT perfusion study (Hirono et al., 2000) linked agitation with hypoperfusion in left anteriotemporal, right parietal, and bilateral dorsofrontal cortex.”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Hirono et al., 2000
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Self-citation
- Authors
- Hirono, N., Mega, M. S., Dinov, I. D., Mishkin, F., & Cummings, J. L.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Hirono, Nobutsugu
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2000-06-01
- Volume
- 57
- Issue
- 6
- Pages
- 861
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2140956720
- Cited by
- 153
- References
- 60
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 11 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 5
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (K08AG100784, P50AG016570, P50-AG 16570)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- dementia, aggression, regional cerebral hypoperfusion, cerebral perfusion, neuropsychiatric symptoms, behavioral symptoms, frontal lobe, parietal cortex
- MeSH terms
- Aged, Aggression, Behavior, Cerebrovascular Circulation, Dementia, Female, Frontal Lobe, Humans, Male, Psychiatric Status Rating Scales, Temporal Lobe, Tomography, Emission-Computed, Single-Photon
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