Cited by 199Dementia and Cognitive Impairment ResearchIntensive Care Unit Cognitive DisordersWorkplace Violence and Bullying

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Physical Aggression in Dementia Patients and Its Relationship to Depression

Lyketsos, Constantine G., Steele, Cynthia, Galik, Elizabeth, Rosenblatt, Adam, Steinberg, Martin, Warren, Andrew, Sheppard, Jeannie-Marie·1999·American Journal of Psychiatry

DOI 10.1176/ajp.156.1.66

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Abstract

OBJECTIVE: The goal of this study was to determine the frequency of physically aggressive behavior in community-residing patients with dementia and its relationship to depression. METHOD: A consecutive series of 541 patients with DSM-IV-defined dementia underwent comprehensive neuropsychiatric evaluation and were rated on the Cornell Scale for Depression in Dementia, the Mini-Mental State, the Psychogeriatric Dependency Rating Scale, and the General Medical Health Rating. RESULTS: Physically aggressive behavior was exhibited by 79 patients in the 2 weeks before evaluation. Aggressive behavior was closely associated with moderate to severe depression, male gender, and greater impairment in activities of daily living, even after adjustment for delusions, hallucinations, sleep disturbance, and severity of cognitive impairment. After adjustment for depression, gender, and impairment in activities of daily living, there was no association between physically aggressive behavior and the presence of either delusions or hallucinations. CONCLUSIONS: A substantial minority of patients with dementia exhibit physically aggressive behavior, and this aggression is strongly linked with the presence of depressive symptoms. It is possible that the identification and treatment of depression in dementia may be a means of preventing and managing physically aggressive behavior.

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Authors: Lyketsos, C. G., Steele, C., Galik, E., Rosenblatt, A., Steinberg, M., Warren, A., & Sheppard, J.-M.
Affiliations: Johns Hopkins University (US)
ORCID: Lyketsos, Constantine G.
Galik, Elizabeth
Rosenblatt, Adam
Steinberg, Martin
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1999-01-01
Volume: 156
Issue: 1
Pages: 66-71
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.156.1.66
OpenAlex: W2106279983
Cited by: 199
References: 37
Citations by year: 2026: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 8 · 2013: 3 · 2012: 10
FWCI: 8.79
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01mh056511-05)
National Institute of Mental Health (MH56511)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Social Sciences › Business, Management and Accounting › Organizational Behavior and Human Resource Management › Workplace Violence and Bullying
Keywords: physical aggression, dementia, depression, community-dwelling older adults, neuropsychiatric symptoms, activities of daily living, delusions, hallucinations, Cornell Scale for Depression in Dementia, gender differences
MeSH terms: Activities of Daily Living, Aged, Aggression, Cross-Sectional Studies, Delusions, Dementia, Depressive Disorder, Female, Hallucinations, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Severity of Illness Index, Sex Factors, Comorbidity

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Physical Aggression in Dementia Patients and Its Relationship to Depression

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