Cited by 135Posttraumatic Stress Disorder ResearchStress Responses and CortisolChild Abuse and Trauma

Higher Levels of Basal Serial CSF Cortisol in Combat Veterans With Posttraumatic Stress Disorder

Baker, Dewleen G., Ekhator, Nosa N., Kasckow, John W., Dashevsky, Boris, Horn, Paul S., Bednarik, Ludmila, Geracioti, Thomas D.·2005·American Journal of Psychiatry

Abstract

OBJECTIVE: Results of basal peripheral cortisol measures in posttraumatic stress disorder (PTSD) have been variable. The authors' goal was to measure CSF cortisol concentrations, which more accurately reflect brain glucocorticoid exposure, in subjects with or without PTSD. METHOD: CSF was withdrawn from a subarachnoid catheter and plasma from a venous catheter, both indwelling, over a 6-hour interval to determine hourly plasma ACTH and cortisol concentrations and hourly CSF cortisol levels in eight well-characterized combat veterans with PTSD and eight matched healthy volunteers. RESULTS: Mean CSF cortisol concentrations were significantly higher in the subjects with PTSD (3.18 ng/ml, SD=0.33) than in the normal volunteers (2.33 ng/ml, SD=0.50), largely due to higher CSF cortisol concentration nadirs. No group differences were observed in either plasma ACTH or peripheral (plasma or urinary free) cortisol. CSF corticotropin-releasing hormone and CSF cortisol concentrations were positively and significantly correlated. CONCLUSIONS: Despite normal peripheral cortisol indexes in the veterans with PTSD, their CNS exposure to cortisol was greater than that of normal comparison subjects.

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Crossref · 10.1176/appi.ajp.162.5.992

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12 of 12 references verified0 citation errors · 0 not checkable

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  • Heightened levels of peripheral and central corticotropin-releasing hormone (CRH) occur in tandem with enhanced glucocorticoid sensitivity in PTSD.

    “Heightened levels of peripheral and central corticotropin-releasing hormone (CRH; Baker et al, 2005;de Kloet et al, 2008) and elevated glucocorticoid receptor (GR) expression levels in lymphocytes (Matic et al, 2013) occur in tandem with enhanced glucocorticoid sensitivity in PTSD.”

    From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Baker et al, 2005

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Authors
Baker, D. G., Ekhator, N. N., Kasckow, J. W., Dashevsky, B., Horn, P. S., Bednarik, L., & Geracioti, T. D.
Affiliations
VA San Diego Healthcare System (US)
Venue
American Journal of Psychiatry
Published
2005-05-01
Volume
162
Issue
5
Pages
992-994
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2163655547
Cited by
135
References
12
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 10 · 2014: 5 · 2013: 13 · 2012: 6
FWCI
12.34
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
post-traumatic stress disorder, basal cortisol, combat veterans, ACTH, corticotropin-releasing factor, plasma cortisol, urinary free cortisol, hypothalamic-pituitary-adrenal axis
MeSH terms
Adrenocorticotropic Hormone, Adult, Catheterization, Peripheral, Catheters, Indwelling, Circadian Rhythm, Combat Disorders, Corticotropin-Releasing Hormone, Humans, Hydrocortisone, Male, Spinal Puncture, Stress Disorders, Post-Traumatic, Subarachnoid Space, Veterans

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