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Cited by 163Cardiac Health and Mental HealthTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Treatment-Resistant Depression and Mortality After Acute Coronary Syndrome

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Carney, Robert M., Freedland, Kenneth E.·2009·American Journal of Psychiatry
DOI 10.1176/appi.ajp.2008.08081239PMC PMC3465939
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Abstract

Depression is a risk factor for morbidity and mortality in patients with coronary heart disease, especially following acute coronary syndrome. Evidence from recent clinical trials suggests that treatment-resistant depression may be associated with a particularly high risk of mortality or cardiac morbidity in patients following acute coronary syndrome. This article reviews this evidence and considers possible explanations for this relationship. Directions for future research are also considered, with particular emphasis on efforts to elucidate the underlying mechanisms and to develop more efficacious treatments for depression in patients with coronary heart disease.

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  • A synthesis of data from numerous intervention trials found that unsuccessful treatment of depression after hospitalization for acute coronary syndrome is linked to elevated risk of mortality and cardiac events.

    “Although there are conflicting data on the cardiovascular benefits of antidepressants in patients with CVD, a synthesis of data from numerous intervention trials found that unsuccessful treatment of depression after hospitalization for ACS is linked to elevated risk of mortality and cardiac events. 183”

    From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [183]

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Authors
Carney, R. M., & Freedland, K. E.
Affiliations
Washington University in St. Louis (US)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2009-04
Volume
166
Issue
4
Pages
410-417
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.2008.08081239
PMC
PMC3465939
OpenAlex
W2129412441
Cited by
163
References
62
Citations by year
2025: 3 · 2024: 11 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 5 · 2013: 17 · 2012: 14
FWCI
3.56
Type
journal article
Language
en
Open access
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL076808, HL-76808)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
treatment-resistant depression, acute coronary syndrome, mortality, coronary artery disease, cardiac morbidity, depression as risk factor
MeSH terms
Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Major, Major Depressive Disorder, Drug Resistance, Drug Therapy, Combination, Follow-Up Studies, Humans, Myocardial Infarction, Personality Inventory, Psychometrics, Citalopram, Comorbidity, Cognitive Behavioral Therapy, Survival Rate, Randomized Controlled Trials as Topic, Bupropion, Acute Coronary Syndrome, Secondary Prevention

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