Nitric oxide synthase genotype modulation of impulsivity and ventral striatal activity in adult ADHD patients and healthy comparison subjects
Open accessAbstract
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is a highly heritable disorder. The NOS1 gene encoding nitric oxide synthase is a candidate gene for ADHD and has been previously linked with impulsivity. In the present study, the authors investigated the effect of a functional variable number of tandem repeats (VNTR) polymorphism in NOS1 (NOS1 exon 1f-VNTR) on the processing of rewards, one of the cognitive deficits in ADHD. METHOD: A sample of 136 participants, consisting of 87 adult ADHD patients and 49 healthy comparison subjects, completed a reward-related impulsivity task. A total of 104 participants also underwent functional magnetic resonance imaging during a reward anticipation task. The effect of the NOS1 exon 1f-VNTR genotype on reward-related impulsivity and reward-related ventral striatal activity was examined. RESULTS: ADHD patients had higher impulsivity scores and lower ventral striatal activity than healthy comparison subjects. The association between the short allele and increased impulsivity was confirmed. However, independent of disease status, homozygous carriers of the short allele of NOS1, the ADHD risk genotype, demonstrated higher ventral striatal activity than carriers of the other NOS1 VNTR genotypes. CONCLUSIONS: The authors suggest that the NOS1 genotype influences impulsivity and its relation with ADHD is mediated through effects on this behavioral trait. Increased ventral striatal activity related to NOS1 may be compensatory for effects in other brain regions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The genetic variant that predicts increased reward-related activation in the striatum also predicts increased reward-related impulsivity.
“and suggestion that the genetic variant that predicts increased reward-related activation in the striatum also predicts increased reward-related impulsivity.22”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [22]
In adults with ADHD, most studies report reduced activation in the ventral striatum during anticipation of monetary gains compared to controls.
“In adults with ADHD most studies report reduced activation in the ventral striatum (VS) during anticipation of monetary gains compared to controls,4,21,22 with one exception.23”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [22]
The function of the reward circuitry can be modulated by functional genetic polymorphisms influencing dopamine neurotransmission in the striatum, directly (e.g. DAT1) or indirectly (e.g. NOS1).
“The function of the reward circuitry can be modulated by functional genetic polymorphisms influencing dopamine neurotransmission in the striatum, directly (e.g. the dopamine transporter gene [DAT1]) or indirectly (e.g. the nitric oxide synthase gene [NOS1]).18,22,26”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [22]
There is a positive association between trait impulsivity or reward-related impulsivity and neural activation in the striatum following reward-predicting cues in healthy adult samples.
“First, there is a positive association between trait impulsivity or reward-related impulsivity and neural activation in the striatum following reward-predicting cues19,20,22 in healthy adult samples”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [22]
Recent evidence showed that ventral striatal activation does not differ between medicated and medication-naïve adults with ADHD.
“recent evidence showed that ventral striatal activation does not differ between medicated and medication-naïve adults with ADHD.22”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [22]
Cites
Separate neural systems value immediate and delayed monetary rewards
McClure, S. M., Laibson, D. I., Loewenstein, G., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1100907 · Cited by 3,089 · see citing works
Circular analysis in systems neuroscience: the dangers of double dipping
Kriegeskorte, N., Simmons, W. K., Bellgowan, P. S. F., & Baker, C. I. (2009) · Nature Neuroscience · doi:10.1038/nn.2303 · Cited by 2,696 · see citing works
Region of interest analysis using an SPM toolbox
Brett, M. (2002) · NeuroImage · Cited by 2,273 · see citing works
FARAONE, S. V., BIEDERMAN, J., & MICK, E. (2006) · Psychological Medicine · doi:10.1017/s003329170500471x · Cited by 2,267 · see citing works
(1998) · Cited by 2,026 · see citing works
Candidate gene studies of ADHD: a meta-analytic review
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020 · see citing works
The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics
Sonuga-Barke, E. J. S. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.005 · Cited by 816 · see citing works
DELAY OR PROBABILITY DISCOUNTING IN A MODEL OF IMPULSIVE BEHAVIOR: EFFECT OF ALCOHOL
Richards, J. B., Zhang, L., Mitchell, S. H., & de Wit, H. (1999) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1999.71-121 · Cited by 792 · see citing works
Gender Differences in Dopaminergic Function in Striatum and Nucleus Accumbens
Becker, J. B. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00168-9 · Cited by 696 · see citing works
Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase
Nelson, R. J., Demas, G. E., Huang, P. L., Fishman, M. C., Dawson, V. L., Dawson, T. M., & Snyder, S. H. (1995) · Nature · doi:10.1038/378383a0 · Cited by 595 · see citing works
Hariri, A. R., Brown, S. M., Williamson, D. E., Flory, J. D., de Wit, H., & Manuck, S. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3446-06.2006 · Cited by 557 · see citing works
The impact of reinforcement contingencies on AD/HD: A review and theoretical appraisal
Luman, M., Oosterlaan, J., & Sergeant, J. A. (2005) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.11.001 · Cited by 541 · see citing works
Scheres, A., Milham, M. P., Knutson, B., & Castellanos, F. X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.042 · Cited by 499 · see citing works
Schott, B. H., Minuzzi, L., Krebs, R. M., Elmenhorst, D., Lang, M., Winz, O. H., Seidenbecher, C. I., Coenen, H. H., Heinze, H.-J., Zilles, K., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2058-08.2008 · Cited by 496 · see citing works
Burt, S. A. (2009) · Psychological Bulletin · doi:10.1037/a0015702 · Cited by 467 · see citing works
Genome-wide association studies in ADHD
Franke, B., Neale, B., & Faraone, S. (2009) · Human Genetics · doi:10.1007/s00439-009-0663-4 · Cited by 462 · see citing works
Self-citationNitric oxide: a novel link between synaptic and nonsynaptic transmission
Kiss, J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01745-8 · Cited by 340 · see citing works
Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder
Ströhle, A., Stoy, M., Wrase, J., Schwarzer, S., Schlagenhauf, F., Huss, M., Hein, J., Nedderhut, A., Neumann, B., Gregor, A., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.044 · Cited by 323 · see citing works
Toplak, M. E., Jain, U., & Tannock, R. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-8 · Cited by 303 · see citing works
Neural substrates of decision making in adults with attention deficit hyperactivity disorder
Ernst, M., Kimes, A. S., London, E. D., Matochik, J. A., Eldreth, D., Tata, S., Contoreggi, C., Leff, M., & Bolla, K. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1061 · Cited by 254 · see citing works
Reif, A., Herterich, S., Strobel, A., Ehlis, A., Saur, D., Jacob, C., Wienker, T. F., Töpner, T., Fritzen, S., Walter, U., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001779 · Cited by 210 · see citing works
Hermans, E. J., Bos, P. A., Ossewaarde, L., Ramsey, N. F., Fernández, G., & van Honk, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.019 · Cited by 208 · see citing works
Functional brain imaging of tobacco use and dependence
BRODY, A. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.04.012 · Cited by 207 · see citing works
Konrad, A., Dielentheis, T. F., El Masri, D., Bayerl, M., Fehr, C., Gesierich, T., Vucurevic, G., Stoeter, P., & Winterer, G. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07110.x · Cited by 191 · see citing works
Spencer, T. J., Biederman, J., Madras, B. K., Faraone, S. V., Dougherty, D. D., Bonab, A. A., & Fischman, A. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.036 · Cited by 185 · see citing works
Pothuizen, H. H. J., Jongen‐Rêlo, A. L., Feldon, J., & Yee, B. K. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04388.x · Cited by 183 · see citing works
Temporal reward discounting and ADHD: task and symptom specific effects
Scheres, A., Lee, A., & Sumiya, M. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-007-0813-6 · Cited by 154 · see citing works
Influence of Functional Variant of Neuronal Nitric Oxide Synthase on Impulsive Behaviors in Humans
Reif, A., Jacob, C., Rujescu, D., Herterich, S., Lang, S., Gutknecht, L., Baehne, C. G., Strobel, A., Freitag, C. M., Giegling, I., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.510 · Cited by 149 · see citing works
DURSTON, S., FOSSELLA, J. A., MULDER, M. J., CASEY, B. J., ZIERMANS, T. B., VESSAZ, M. N., & VAN ENGELAND, H. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31815a5f17 · Cited by 108 · see citing works
Altered function of ventral striatum during reward-based decision making in old age
Mell, T. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.034.2009 · Cited by 104 · see citing works
BEHAVIOURAL ASPECTS OF IMPULSIVITY IN ALCOHOLICS WITH AND WITHOUT A CLUSTER-B PERSONALITY DISORDER
Dom, G., Wilde, B. D., Hulstijn, W., van den Brink, W., & Sabbe, B. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl030 · Cited by 93 · see citing works
Are ADHD Symptoms Associated With Delay Aversion or Choice Impulsivity? A General Population Study
Paloyelis, Y., Asherson, P., & Kuntsi, J. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181ab8c97 · Cited by 82 · see citing works
Sánchez‐Mora, C., Ribasés, M., Ramos‐Quiroga, J. A., Casas, M., Bosch, R., Boreatti‐Hümmer, A., Heine, M., Jacob, C., Lesch, K., Fasmer, O. B., et al. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31008 · Cited by 66 · see citing works
Self-citationBehavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals
Wultsch, T., Chourbaji, S., Fritzen, S., Kittel, S., Grünblatt, E., Gerlach, M., Gutknecht, L., Chizat, F., Golfler, G., Schmitt, A. G., et al. (2007) · Springer eBooks · doi:10.1007/978-3-211-73574-9_10 · Cited by 52 · see citing works
Reif, A., Kiive, E., Kurrikoff, T., Paaver, M., Herterich, S., Konstabel, K., Tulviste, T., Lesch, K., & Harro, J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1915-7 · Cited by 43 · see citing works
N-cadherin mediates nitric oxide-induced neurogenesis in young and retired breeder neurospheres
Chen, J., Zacharek, A., Li, Y., Li, A., Wang, L., Katakowski, M., Roberts, C., Lü, M., & Chopp, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.064 · Cited by 42 · see citing works
Retz, W., Reif, A., Freitag, C., Retz-Junginger, P., & Rösler, M. (2010) · Journal of neural transmission · doi:10.1007/s00702-009-0352-4 · Cited by 34 · see citing works
Is NOS1 a genetic link between RLS and ADHD?
Reif, A. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.05.009 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Plichta, M. M., & Scheres, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.012 · Cited by 424 · see citing works
The genetics of attention deficit/hyperactivity disorder in adults, a review
on behalf of the International Multicentre persistent ADHD CollaboraTion (IMpACT), Franke, B., Faraone, S. V., Asherson, P., Buitelaar, J., Bau, C. H. D., Ramos-Quiroga, J. A., Mick, E., Grevet, E. H., Johansson, S., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.138 · Cited by 432 · see citing works
Self-citationGut microbiome in ADHD and its relation to neural reward anticipation
Aarts, E., Ederveen, T. H. A., Naaijen, J., Zwiers, M. P., Boekhorst, J., Timmerman, H. M., Smeekens, S. P., Netea, M. G., Buitelaar, J. K., Franke, B., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183509 · Cited by 352 · see citing works
Self-citationNoreika, V., Falter, C. M., & Rubia, K. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.09.036 · Cited by 339 · see citing works
Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders
Segal, A., Parkes, L., Aquino, K. M., Kia, S. M., Wolfers, T., Franke, B., Hoogman, M., Beckmann, C. F., Westlye, L. T., Andreassen, O. A., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01404-6 · Cited by 263 · see citing works
Self-citationBonvicini, C., Faraone, S. V., & Scassellati, C. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.74 · Cited by 240 · see citing works
Wolfers, T., Beckmann, C. F., Hoogman, M., Buitelaar, J. K., Franke, B., & Marquand, A. F. (2019) · Psychological Medicine · doi:10.1017/s0033291719000084 · Cited by 205 · see citing works
Self-citationMostert, J. C., Onnink, A. M. H., Klein, M., Dammers, J., Harneit, A., Schulten, T., van Hulzen, K. J. E., Kan, C. C., Slaats-Willemse, D., Buitelaar, J. K., et al. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.08.010 · Cited by 142 · see citing works
Self-citationMarx, I., Häcker, T., Yu, X., Cortese, S., & Sonuga-Barke, E. J. S. (2018) · Journal of Attention Disorders · doi:10.1177/1087054718772138 · Cited by 137 · see citing works
Hoogman, M., Stolte, M., Baas, M., & Kroesbergen, E. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.029 · Cited by 132 · see citing works
Self-citationResponse inhibition and its relation to multidimensional impulsivity
Wilbertz, T., Deserno, L., Horstmann, A., Neumann, J., Villringer, A., Heinze, H.-J., Boehler, C. N., & Schlagenhauf, F. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.09.021 · Cited by 128 · see citing works
Orbitofrontal reward sensitivity and impulsivity in adult attention deficit hyperactivity disorder
Wilbertz, G., Tebartz van Elst, L., Delgado, M. R., Maier, S., Feige, B., Philipsen, A., & Blechert, J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.011 · Cited by 125 · see citing works
Griffiths, K. R., Morris, R. W., & Balleine, B. W. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00101 · Cited by 118 · see citing works
Freudenberg, F., Alttoa, A., & Reif, A. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12193 · Cited by 115 · see citing works
von Rhein, D., Cools, R., Zwiers, M. P., van der Schaaf, M., Franke, B., Luman, M., Oosterlaan, J., Heslenfeld, D. J., Hoekstra, P. J., Hartman, C. A., et al. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.02.012 · Cited by 108 · see citing works
Self-citationNeurogenetics of depression: A focus on reward processing and stress sensitivity
Bogdan, R., Nikolova, Y. S., & Pizzagalli, D. A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.007 · Cited by 105 · see citing works
Klein, M., Onnink, M., van Donkelaar, M. V., Wolfers, T., Harich, B., Shi, Y., Dammers, J. T., Arias-Vásquez, A., Hoogman, M., & Franke, B. (2017) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.013 · Cited by 104 · see citing works
Self-citationStriatal sensitivity during reward processing in attention-deficit/hyperactivity disorder
Paloyelis, Y., Mehta, M. A., Faraone, S. V., Asherson, P., & Kuntsi, J. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.05.006 · Cited by 94 · see citing works
Bralten, J., Franke, B., Waldman, I., Rommelse, N., Hartman, C., Asherson, P., Banaschewski, T., Ebstein, R. P., Gill, M., Miranda, A., et al. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.08.020 · Cited by 93 · see citing works
Self-citationAbnormal striatal BOLD responses to reward anticipation and reward delivery in ADHD
Furukawa, E., Bado, P., Tripp, G., Mattos, P., Wickens, J. R., Bramati, I. E., Alsop, B., Ferreira, F. M., Lima, D., Tovar-Moll, F., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089129 · Cited by 90 · see citing works
Zisner, A. R., & Beauchaine, T. P. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000754 · Cited by 92 · see citing works
Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder
Yadav, S. K., Bhat, A. A., Hashem, S., Nisar, S., Kamal, M., Syed, N., Temanni, M.-R., Gupta, R. K., Kamran, S., Azeem, M. W., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01473-w · Cited by 99 · see citing works
Behavioral Consequences of Aberrant Alpha Lateralization in Attention-Deficit/Hyperactivity Disorder
ter Huurne, N., Onnink, A. M. H., Kan, C. C., Franke, B., Buitelaar, J. K., & Jensen, O. B. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.001 · Cited by 79 · see citing works
Self-citationDances with black widow spiders: Dysregulation of glutamate signalling enters centre stage in ADHD
Lesch, K., Merker, S., Reif, A., & Novak, M. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.07.013 · Cited by 73 · see citing works
Ma, I., van Duijvenvoorde, A. C. K., & Scheres, A. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.01.001 · Cited by 63 · see citing works
Nymberg, C., Jia, T., Lubbe, S., Ruggeri, B., Desriviéres, S., Barker, G., Büchel, C., Fauth-Buehler, M., Cattrell, A., Conrod, P., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.027 · Cited by 66 · see citing works
Nitric oxide interacts with monoamine oxidase to modulate aggression and anxiety-like behaviour
Gutiérrez, H. C., O’Leary, A., Freudenberg, F., Fedele, G., Wilkinson, R. N., Markham, E., van Eeden, F. J. M., Reif, A., & Norton, W. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.09.004 · Cited by 61 · see citing works
The dopamine transporter haplotype and reward-related striatal responses in adult ADHD
Hoogman, M., Onnink, A. M. H., Cools, R., Aarts, E., Kan, C. C., Vásquez, A. A., Buitelaar, J. K., & Franke, B. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.011 · Cited by 59 · see citing works
Self-citationTransdiagnostic neuroimaging of reward system phenotypes in ADHD and comorbid disorders
Grimm, O., van Rooij, D., Hoogman, M., Klein, M., Buitelaar, J. K., Franke, B., Reif, A., & Plichta, M. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.025 · Cited by 54 · see citing works
Self-citationCognitive flexibility depends on white matter microstructure of the basal ganglia
van Schouwenburg, M. R., Onnink, A. M. H., ter Huurne, N., Kan, C. C., Zwiers, M. P., Hoogman, M., Franke, B., Buitelaar, J. K., & Cools, R. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.11.015 · Cited by 53 · see citing works
Self-citationMostert, J. C., Hoogman, M., Onnink, A. M. H., van Rooij, D., von Rhein, D. T., van Hulzen, K. J. E., Dammers, J. T., Kan, C. C., Buitelaar, J. K., Norris, D. G., et al. (2015) · Journal of Attention Disorders · doi:10.1177/1087054715602332 · Cited by 52 · see citing works
Self-citationDisordered reward processing and functional connectivity in trichotillomania: A pilot study
White, M. P., Shirer, W. R., Molfino, M. J., Tenison, C., Damoiseaux, J. S., & Greicius, M. D. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.014 · Cited by 50 · see citing works
Differentiating neural reward responsiveness in autism versus ADHD
Kohls, G., Thönessen, H., Bartley, G. K., Grossheinrich, N., Fink, G. R., Herpertz-Dahlmann, B., & Konrad, K. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.08.003 · Cited by 50 · see citing works
Refinement by integration: aggregated effects of multimodal imaging markers on adult ADHD
Wolfers, T., Llera, A., Onnink, A. M. H., Dammers, J. T., Hoogman, M., Zwiers, M. P., Buitelaar, J. K., Franke, B., Marquand, A. F., & Beckmann, C. F. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160240 · Cited by 46 · see citing works
Self-citationReward modulation of cognitive function in adult attention-deficit/hyperactivity disorder
Aarts, E., van Holstein, M., Hoogman, M., Onnink, A. M. H., Kan, C. C., Franke, B., Buitelaar, J. K., & Cools, R. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000116 · Cited by 43 · see citing works
Self-citationPu, W., Luo, Q., Jiang, Y., Gao, Y., Ming, Q., & Yao, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-11775-z · Cited by 40 · see citing works
Association of Impulsivity and Polymorphic MicroRNA-641 Target Sites in the SNAP-25 Gene
Németh, N., Kovács-Nagy, R., Székely, A., Sasvári-Székely, M., & Rónai, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084207 · Cited by 43 · see citing works
Duan, K., Chen, J., Calhoun, V. D., Lin, D., Jiang, W., Franke, B., Buitelaar, J. K., Hoogman, M., Vásquez, A. A., Turner, J. A., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.04.035 · Cited by 40 · see citing works
Self-citationReinforcement, Dopamine and Rodent Models in Drug Development for ADHD
Tripp, G., & Wickens, J. R. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0132-y · Cited by 33 · see citing works
Gao, Y., & Heldt, S. A. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000031 · Cited by 31 · see citing works
Silvetti, M., Wiersema, J. R., Sonuga-Barke, E. J. S., & Verguts, T. (2013) · Neural Networks · doi:10.1016/j.neunet.2013.05.008 · Cited by 33 · see citing works
Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD
Kittel‐Schneider, S., Reuß, M., Meyer, A. H., Weber, H., Geßner, A., Leistner, C., Kopf, J., Schmidt, B., Hempel, S., Volkert, J., et al. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114555251 · Cited by 31 · see citing works
Recent developments in the genetics of attention‐deficit hyperactivity disorder
Grimm, O., Kittel‐Schneider, S., & Reif, A. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12673 · Cited by 31 · see citing works
van Dongen, E. V., von Rhein, D. T., O’Dwyer, L., Franke, B., Hartman, C. A., Heslenfeld, D. J., Hoekstra, P. J., Oosterlaan, J., Rommelse, N. N. J., & Buitelaar, J. K. (2015) · Molecular Autism · doi:10.1186/s13229-015-0043-y · Cited by 26 · see citing works
Self-citationKappel, V., Lorenz, R. C., Streifling, M., Renneberg, B., Lehmkuhl, U., Ströhle, A., Salbach‐Andrae, H., & Beck, A. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu135 · Cited by 28 · see citing works
Groenman, A. P., Greven, C. U., van Donkelaar, M. M. J., Schellekens, A., van Hulzen, K. J. E., Rommelse, N. N. J., Hartman, C. A., Hoekstra, P. J., Luman, M., Franke, B., et al. (2015) · Addiction Biology · doi:10.1111/adb.12230 · Cited by 27 · see citing works
Self-citationter Huurne, N., Lozano‐Soldevilla, D., Onnink, A. M. H., Kan, C., Buitelaar, J. K., & Jensen, O. B. (2017) · Psychological Medicine · doi:10.1017/s0033291717000332 · Cited by 25 · see citing works
Self-citationYu, X., Sonuga-Barke, E. J. S., & Liu, X. (2015) · Journal of Attention Disorders · doi:10.1177/1087054715570390 · Cited by 26 · see citing works
Hámori, G., File, B., Fiáth, R., Pászthy, B., Réthelyi, J., Ulbert, I., & Bunford, N. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115139 · Cited by 25 · see citing works
Imaging genetics in neurodevelopmental psychopathology
Klein, M., van Donkelaar, M. M. J., Verhoef, E., & Franke, B. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32542 · Cited by 25 · see citing works
Self-citationAnalytical strategies for large imaging genetic datasets: experiences from the IMAGEN study
Nymberg, C., Jia, T., Ruggeri, B., & Schumann, G. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12088 · Cited by 24 · see citing works
van Dijk, F. E., Mostert, J., Glennon, J. C., Onnink, A. M. H., Dammers, J. T., Vásquez, A. A., Kan, C. C., Verkes, R. J., Hoogman, M., Franke, B., et al. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.08.037 · Cited by 23 · see citing works
Self-citationMethylphenidate modifies reward cue responses in adults with ADHD: An fMRI study
Furukawa, E., da Costa, R. Q. M., Bado, P., Hoefle, S., Vigne, P., Monteiro, M., Wickens, J. R., Moll, J., Tripp, G., & Mattos, P. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107833 · Cited by 24 · see citing works
Early maternal care may counteract familial liability for psychopathology in the reward circuitry
Holz, N. E., Boecker-Schlier, R., Jennen-Steinmetz, C., Hohm, E., Buchmann, A. F., Blomeyer, D., Baumeister, S., Plichta, M. M., Esser, G., Schmidt, M. H., et al. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy087 · Cited by 22 · see citing works
Applying Imaging Genetics to ADHD: the Promises and the Challenges
Wu, Z.-M., Yang, L., & Wang, Y.-F. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8683-z · Cited by 26 · see citing works
Xu, B., Jia, T., Macare, C., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P., Flor, H., et al. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.02.009 · Cited by 20 · see citing works
Disentangling common from specific processing across tasks using task potency
Chauvin, R. J., Mennes, M., Llera, A., Buitelaar, J. K., & Beckmann, C. F. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.09.059 · Cited by 18 · see citing works
Self-citationSalatino‐Oliveira, A., Akutagava‐Martins, G. C., Bruxel, E. M., Genro, J. P., Polanczyk, G. V., Zeni, C., Kieling, C., Karam, R. G., Rovaris, D. L., Contini, V., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.01.010 · Cited by 17 · see citing works
Converging evidence for an impact of a functionalNOSgene variation on anxiety-related processes
Kuhn, M., Haaker, J., Glotzbach-Schoon, E., Schümann, D., Andreatta, M., Mechias, M.-L., Raczka, K. A., Gartmann, N., Büchel, C., Mühlberger, A., et al. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv151 · Cited by 15 · see citing works
Handling hybrid and missing data in constraint-based causal discovery to study the etiology of ADHD
Sokolova, E., von Rhein, D. T., Naaijen, J., Groot, P., Claassen, T., Buitelaar, J. K., & Heskes, T. (2016) · International Journal of Data Science and Analytics · doi:10.1007/s41060-016-0034-x · Cited by 15 · see citing works
Self-citationAssessing age-dependent multi-task functional co-activation changes using measures of task-potency
Chauvin, R. J., Mennes, M., Buitelaar, J. K., & Beckmann, C. F. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.11.011 · Cited by 13 · see citing works
Self-citationSchwarz, R., Reif, A., Scholz, C. J., Weißflog, L., Schmidt, B., Lesch, K., Jacob, C., Reichert, S., Heupel, J., Volkert, J., et al. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.948064 · Cited by 12 · see citing works
Joseph, J. E., Zhu, X., Lynam, D. R., & Kelly, T. H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.12.005 · Cited by 12 · see citing works
van Hulst, B. M., de Zeeuw, P., Lupas, K. K., Bos, D. J., Neggers, S. F. W., & Durston, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142413 · Cited by 12 · see citing works
van Ewijk, H., Bralten, J., van Duin, E. D. A., Hakobjan, M., Buitelaar, J. K., Heslenfeld, D. J., Hoekstra, P. J., Hartman, C. A., Hoogman, M., Oosterlaan, J., et al. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12742 · Cited by 12 · see citing works
Self-citationSalatino‐Oliveira, A., Wagner, F., Akutagava‐Martins, G. C., Bruxel, E. M., Genro, J. P., Zeni, C., Kieling, C., Polanczyk, G. V., Rohde, L. A., & Hutz, M. H. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0626-9 · Cited by 12 · see citing works
Multiscale Heterogeneity of White Matter Morphometry in Psychiatric Disorders
Segal, A., Smith, R. E., Chopra, S., Oldham, S., Parkes, L., Aquino, K. M., Kia, S. M., Wolfers, T., Franke, B., Hoogman, M., et al. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.03.014 · Cited by 11 · see citing works
Self-citationO'Toole, E., Doucet, M. V., Sherwin, E., & Harkin, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802456-0.00003-0 · Cited by 11 · see citing works
Paraskevopoulou, M. D., van Rooij, D., Batalla, A., Chauvin, R. J., Luijten, M., Schene, A. H., Buitelaar, J. K., & Schellekens, A. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00896-1 · Cited by 11 · see citing works
Self-citationFu, G., Chen, W., Li, H., Wang, Y., Liu, L., & Qian, Q. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13629 · Cited by 10 · see citing works
Toward a Theory of Childhood Learning Disorders, Hyperactivity, and Aggression
Mawson, A. R. (2012) · ISRN Psychiatry · doi:10.5402/2012/589792 · Cited by 10 · see citing works
Todokoro, A., Tanaka, S., Kawakubo, Y., Yahata, N., Ishii‐Takahashi, A., Nishimura, Y., Kano, Y., Ohtake, F., & Kasai, K. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12668 · Cited by 10 · see citing works
O’Leary, A., Laas, K., Vaht, M., Kiive, E., Veidebaum, T., Reif, A., & Harro, J. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.07.241 · Cited by 10 · see citing works
Dresler, T., Barth, B., Ethofer, T., Lesch, K., Ehlis, A., & Fallgatter, A. (2014) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/2051-6673-1-6 · Cited by 12 · see citing works
Bunford, N., Hámori, G., Nemoda, Z., Angyal, N., Fiáth, R., Sebők-Welker, T., Pászthy, B., Ulbert, I., & Réthelyi, J. (2023) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2023.152389 · Cited by 8 · see citing works
Lengvenytė, A., Sundaresh, A., Strumila, R., Boukouaci, W., Wu, C., Sugunasabesan, S., Guillaume, S., Sénèque, M., Leboyer, M., Olié, É., et al. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110617 · Cited by 7 · see citing works
Digging More Deeply for Genetic Effects in Psychiatric Illness
Brzustowicz, L. M., & Freedman, R. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11060928 · Cited by 7 · see citing works
Guo, X., Liu, L., Li, T., Zhao, Q., Li, H., Huang, F., Wang, Y., Qian, Q., Cao, Q., Wang, Y., et al. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13625 · Cited by 6 · see citing works
The Role of Glutamate Dysregulation in the Etiology of ADHD
Glaser, P. E. A., Batten, S. R., & Gerhardt, G. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-87480-3_16 · Cited by 4 · see citing works
Dessel, J. V., Sonuga-Barke, E. J. S., Moerkerke, M., der Oord, S. V., Morsink, S., Lemiere, J., & Danckaerts, M. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab111 · Cited by 3 · see citing works
The Genetics of Impulsivity: A Synthesis of Findings in Humans and Rodent Models
Jupp, B., & Dalley, J. W. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3777-6_3 · Cited by 3 · see citing works
Genetic factors and the brain in ADHD
Bralten, J. (2015) · Radboud Repository (Radboud University) · Cited by 3 · see citing works
Cai, W., & Mizuno, Y. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03972-0 · Cited by 3 · see citing works
Vascular Homeostasis in Suicidal Behavior: From Molecular Mechanisms to Clinical Implications
Lengvenytė, A., & Courtet, P. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.06.012 · Cited by 2 · see citing works
von Rhein, D. T., Cools, R., Mennes, M., & Buitelaar, J. K. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.05.013 · Cited by 2 · see citing works
Self-citationJiang, X.-N., Han, X., Kong, T.-T., Wu, Y., Shan, L., Yang, Z., Liu, Y.-L., & Wang, F. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148935 · Cited by 1 · see citing works
Computing Lower and Upper Bounds on the Probability of Causal Statements
Sokolova, E., Hoogman, M., Groot, P., Claassen, T., & Heskes, T. (2016) · Radboud Repository (Radboud University) · Cited by 1 · see citing works
Self-citationXu, H., Zhong, Y., Yuan, S., Wu, Y., Ma, Z., Hao, Z., Ding, H., Wu, H., Liu, G., Pang, M., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.755270 · Cited by 1 · see citing works
And the best task is …? Using Task potency to infer task specificityPreprint
Chauvin, R. J., Mennes, M., Llera, A., Buitelaar, J. K., & Beckmann, C. F. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/111187
Self-citationAufmerksamkeitsdefizit-/Hyperaktivitätsstörung im Erwachsenenalter
Sobanski, E., Alm, B., & Thome, J. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_85
Rovný, R., Marko, M., Minárik, G., & Riečanský, I. (2021) · Physiological Research · doi:10.33549/physiolres.934819
Attention-Deficit Hyperactivity Disorder: Genetic, Pharmacogenetic, and Metabolomic Insights
Younes, S. N., Al‐Jurf, R., Hammuda, S., Nasrallah, G. K., Al-Jurf, A., Ziyada, A., Abdulrouf, P. V., Qoronfleh, M. W., Samara, M. M., & Al-Dewik, N. I. E. (2022) · Nutritional neurosciences · doi:10.1007/978-981-15-9781-7_5 · Cited by 1 · see citing works
Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung im Erwachsenenalter
Sobanski, E., Alm, B., & Thome, J. (2015) · Springer eBooks · doi:10.1007/978-3-642-45028-0_85-1
Nőger, K., Rádosi, A., Pászthy, B., Réthelyi, J., Ulbert, I., & Bunford, N. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.06.054
Exploring the Integrated Gut-Brain Metabolic Model for ADHD
Taş, E., & Ülgen, K. Ö. (2025) · Biochemical Genetics · doi:10.1007/s10528-025-11234-9
Appetitive Conditioning in Psychiatric Disorders: A Systematic Review
Feusner, J. D., Beidas, Z., & Murray, S. B. (2026) · Journal of Experimental Psychopathology · doi:10.1177/20438087261456078
- Authors
- Hoogman, M., Aarts, E., Zwiers, M., Slaats-Willemse, D., Naber, M., Onnink, M., Cools, R., Kan, C., Buitelaar, J., & Franke, B.
- Affiliations
- Radboud University Nijmegen (NL)
- From the Departments of Psychiatry, Human Genetics, and Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands; Radboud University Nijmegen Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Nijmegen, the Netherlands; and the Karakter Child and Adolescent Psychiatric University Centre, Nijmegen, the Netherlands.
- Venue
- American Journal of Psychiatry
- Published
- 2011-10
- Volume
- 168
- Issue
- 10
- Pages
- 1099-1106
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1971470948
- Cited by
- 97
- References
- 38
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 13 · 2016: 10 · 2015: 14 · 2014: 10 · 2013: 9 · 2012: 7
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, nitric oxide synthase, NOS1 gene, impulsivity, ventral striatum, reward processing, reward anticipation, genetic susceptibility, adult ADHD, brain compensation
- MeSH terms
- Adult, Alleles, Attention Deficit Disorder with Hyperactivity, Basal Ganglia, Brain Mapping, Female, Genotype, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Phenotype, Tandem Repeat Sequences, Nitric Oxide Synthase Type I
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
