Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release
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The dopaminergic mechanisms that control reward-motivated behavior are the subject of intense study, but it is yet unclear how, in humans, neural activity in mesolimbic reward-circuitry and its functional neuroimaging correlates are related to dopamine release. To address this question, we obtained functional magnetic resonance imaging (fMRI) measures of reward-related neural activity and [ 11 C]raclopride positron emission tomography measures of dopamine release in the same human participants, while they performed a delayed monetary incentive task. Across the cohort, a positive correlation emerged between neural activity of the substantia nigra/ventral tegmental area (SN/VTA), the main origin of dopaminergic neurotransmission, during reward anticipation and reward-related [ 11 C]raclopride displacement as an index of dopamine release in the ventral striatum, major target of SN/VTA dopamine neurons. Neural activity in the ventral striatum/nucleus accumbens itself also correlated with ventral striatal dopamine release. Additionally, high-reward-related dopamine release was associated with increased activation of limbic structures, such as the amygdala and the hippocampus. The observed correlations of reward-related mesolimbic fMRI activation and dopamine release provide evidence that dopaminergic neurotransmission plays a quantitative role in human mesolimbic reward processing. Moreover, the combined neurochemical and hemodynamic imaging approach used here opens up new perspectives for the investigation of molecular mechanisms underlying human cognition.
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A multimodal study using [11C] raclopride and fMRI during a MID task showed a correlation between dopamine release and hemodynamic response in the substantia nigra/VTA and VS during reward anticipation.
“A multimodal study using the same radioligand and fMRI during a monetary incentive delay (MID) task could show a correlation between dopamine release, again measured using [11C] raclopride, and hemodynamic response in the substantia nigra/VTA and the VS during reward anticipation in fMRI (Schott et al., 2008).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Schott et al., 2008
The monetary incentive delay task depends at least in part on striatal dopamine function.
“Since the monetary incentive delay task has been proposed to depend - at least in part - on striatal dopamine function (Knutson and Gibbs, 2007; Schott et al., 2008), these findings suggest that low striatal dopamine signaling is associated with an increased risk of addiction.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Schott et al., 2008
Phasic dopamine release is captured as an increase in the BOLD signal in fMRI studies.
“which is captured as an increase in the functional magnetic resonance imaging (BOLD) signal (or activation) in fMRI studies.11–13”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [12]
High reward-related dopamine release is correlated with increased activation in the ventral striatum.
“Importantly, high reward-related dopamine release is correlated with increased activation in the ventral striatum, providing evidence that dopaminergic neurotransmission plays a key role in ventral striatum activation measured with fMRI (Schott et al., 2008).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Schott et al., 2008
Dopaminergic neurotransmission plays a key role in ventral striatum activation measured with fMRI.
“Importantly, high reward-related dopamine release is correlated with increased activation in the ventral striatum, providing evidence that dopaminergic neurotransmission plays a key role in ventral striatum activation measured with fMRI (Schott et al., 2008).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Schott et al., 2008
The BOLD signal does not provide direct information about neurochemistry, and it remains unclear how BOLD activation relates to striatal dopamine release.
“Moreover, the BOLD signal does not provide direct information about neurochemistry, and it remains unclear how BOLD activation relates to striatal dopamine release (Schott et al., 2008).”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Schott et al., 2008
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- Authors
- Schott, B. H., Minuzzi, L., Krebs, R. M., Elmenhorst, D., Lang, M., Winz, O. H., Seidenbecher, C. I., Coenen, H. H., Heinze, H.-J., Zilles, K., Düzel, E., & Bauer, A.
- Affiliations
- Leibniz Institute for Neurobiology (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Forschungszentrum Jülich (DE)
- University College London (GB)
- Heinrich Heine University Düsseldorf (DE)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-12-24
- Volume
- 28
- Issue
- 52
- Pages
- 14311-14319
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6671462
- OpenAlex
- W1990287391
- Cited by
- 496
- References
- 61
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 19 · 2023: 21 · 2022: 12 · 2021: 23 · 2020: 41 · 2019: 28 · 2018: 27 · 2017: 24 · 2016: 27 · 2015: 44 · 2014: 39 · 2013: 36 · 2012: 40
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft (KFG 163, TP A8, SFB 779, TP A8, SFB 779)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- mesolimbic system, reward anticipation, dopamine release, ventral striatum, substantia nigra/ventral tegmental area, nucleus accumbens, [11C]raclopride PET, monetary incentive delay task, amygdala, hippocampus, dopamine signaling, reward processing
- MeSH terms
- Adult, Basal Ganglia, Brain Mapping, Carbon Isotopes, Dopamine, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Oxygen, Reaction Time, Reward, Linear Models, Raclopride, Positron-Emission Tomography, Young Adult
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