Cited by 191Attention Deficit Hyperactivity DisorderAdvanced Neuroimaging Techniques and ApplicationsNeural and Behavioral Psychology Studies

Disturbed structural connectivity is related to inattention and impulsivity in adult attention deficit hyperactivity disorder

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Konrad, Andreas, Dielentheis, Thomas F., El Masri, Dschamil, Bayerl, Martin, Fehr, Christoph, Gesierich, Thomas, Vucurevic, Goran, Stoeter, Peter +1 more·2010·European Journal of Neuroscience

Abstract

Inattention and impulsivity are the most prominent clinical features of attention deficit hyperactivity disorder (ADHD) in adulthood. Structural and functional neuroimaging studies of subjects with ADHD have demonstrated abnormalities in several brain areas, including fronto-striatal and fronto-cerebellar networks. Mostly, these studies were based on volumetric measurements and have been conducted in children. We investigated white matter (WM) integrity and correlation with measures of attention and impulsivity in adult patients with ADHD adopting diffusion tensor imaging (DTI). N = 37 (21 males) never-medicated adult patients with ADHD combined subtype and N = 34 (16 males) healthy controls were investigated. ADHD diagnosis (DSM-IV) was assessed with clinical interviews and rating scales, subjects also underwent a large neuropsychological test battery including tests of attention and impulsivity. DTI was acquired, and group differences of fractional anisotropy (FA) and mean diffusivity (MD) as well as correlation analyses with measures of attentional performance and impulsivity were calculated using voxel-based analyses. In adult patients with ADHD, we found reduced FA as well as higher MD bilaterally in orbitomedial prefrontal WM and in the right anterior cingulate bundle, while elevated FA was present bilaterally in temporal WM structures. Measures of attention were correlated with DTI parameters in the right superior longitudinal fasciculus, whereas measures of impulsivity were correlated with FA in right orbitofrontal fibre tracts. This is the first DTI study demonstrating disturbed structural connectivity of the frontal-striatal circuitry in adult patients with ADHD. Moreover, a direct correlation between WM integrity and measures of attention and impulsivity is shown.

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Crossref · 10.1111/j.1460-9568.2010.07110.x

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  1. Krause, J. & Krause, K.-H. (2002) ADHD im Erwachsenenalter: ha ¨ufige psychiatrische Erkrankungen. In Voss, H. (ed), Unaufmerksam und hype- raktiv. Kirchheim, Mainz, pp. 166-182.

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Authors
Konrad, A., Dielentheis, T. F., El Masri, D., Bayerl, M., Fehr, C., Gesierich, T., Vucurevic, G., Stoeter, P., & Winterer, G.
Affiliations
  • Johannes Gutenberg University Mainz (DE)
  • University of Cologne (DE)
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2010-03
Volume
31
Issue
5
Pages
912-919
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2028768318
Cited by
191
References
56
Citations by year
2026: 1 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 18 · 2014: 18 · 2013: 27 · 2012: 19
FWCI
14.31
Type
journal article
Language
en
Open access
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
adult ADHD, inattention, impulsivity, white matter integrity, structural connectivity, fractional anisotropy, mean diffusivity, superior longitudinal fasciculus, white matter microstructure
MeSH terms
Adult, Attention Deficit Disorder with Hyperactivity, Brain, Female, Humans, Image Interpretation, Computer-Assisted, Impulsive Behavior, Male, Neural Pathways, Neuropsychological Tests, Diffusion Magnetic Resonance Imaging

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