Disturbed structural connectivity is related to inattention and impulsivity in adult attention deficit hyperactivity disorder
Open accessAbstract
Inattention and impulsivity are the most prominent clinical features of attention deficit hyperactivity disorder (ADHD) in adulthood. Structural and functional neuroimaging studies of subjects with ADHD have demonstrated abnormalities in several brain areas, including fronto-striatal and fronto-cerebellar networks. Mostly, these studies were based on volumetric measurements and have been conducted in children. We investigated white matter (WM) integrity and correlation with measures of attention and impulsivity in adult patients with ADHD adopting diffusion tensor imaging (DTI). N = 37 (21 males) never-medicated adult patients with ADHD combined subtype and N = 34 (16 males) healthy controls were investigated. ADHD diagnosis (DSM-IV) was assessed with clinical interviews and rating scales, subjects also underwent a large neuropsychological test battery including tests of attention and impulsivity. DTI was acquired, and group differences of fractional anisotropy (FA) and mean diffusivity (MD) as well as correlation analyses with measures of attentional performance and impulsivity were calculated using voxel-based analyses. In adult patients with ADHD, we found reduced FA as well as higher MD bilaterally in orbitomedial prefrontal WM and in the right anterior cingulate bundle, while elevated FA was present bilaterally in temporal WM structures. Measures of attention were correlated with DTI parameters in the right superior longitudinal fasciculus, whereas measures of impulsivity were correlated with FA in right orbitofrontal fibre tracts. This is the first DTI study demonstrating disturbed structural connectivity of the frontal-striatal circuitry in adult patients with ADHD. Moreover, a direct correlation between WM integrity and measures of attention and impulsivity is shown.
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Adults with ADHD have increased MD in the orbito-medial prefrontal cortex, right anterior cingulate, and left fronto-occipital fasciculus.
“and increased MD in the orbito-medial prefrontal cortex, right anterior cingulate, and left fronto-occipital fasciculus [19, 22].”
From The brain anatomy of attention-deficit/hyperactivity disorder in young adults—a magnetic resonance imaging study (2017) · cites this paper as [19]
Adults with ADHD have reduced connectivity in the orbito-medial prefrontal cortex, right anterior cingulate, right anterior corona radiata, and superior as well as inferior longitudinal fasciculus.
“Some studies support that ADHD is associated with lifelong abnormal connectivity by showing that adults with ADHD have reduced connectivity in the orbito-medial prefrontal cortex, right anterior cingulate, right anterior corona radiata and the superior as well as inferior longitudinal fasciculus among other regions [18–21]”
From The brain anatomy of attention-deficit/hyperactivity disorder in young adults—a magnetic resonance imaging study (2017) · cites this paper as [19]
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- Authors
- Konrad, A., Dielentheis, T. F., El Masri, D., Bayerl, M., Fehr, C., Gesierich, T., Vucurevic, G., Stoeter, P., & Winterer, G.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- University of Cologne (DE)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 31
- Issue
- 5
- Pages
- 912-919
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2028768318
- Cited by
- 191
- References
- 56
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 18 · 2014: 18 · 2013: 27 · 2012: 19
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- adult ADHD, inattention, impulsivity, white matter integrity, structural connectivity, fractional anisotropy, mean diffusivity, superior longitudinal fasciculus, white matter microstructure
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Brain, Female, Humans, Image Interpretation, Computer-Assisted, Impulsive Behavior, Male, Neural Pathways, Neuropsychological Tests, Diffusion Magnetic Resonance Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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