Cited by 232Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Ventral Striatum Response During Reward and Punishment Reversal Learning in Unmedicated Major Depressive Disorder

Open access

Robinson, Oliver J., Cools, Roshan, Carlisi, Christina O., Sahakian, Barbara J., Drevets, Wayne C.·2012·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2011.11010137PMC PMC5648982

Open this paper in CoChat — free account

Abstract

OBJECTIVE: Affective biases may underlie many of the key symptoms of major depressive disorder, from anhedonia to altered cognitive performance. Understanding the cause of these biases is therefore critical in the quest for improved treatments. Depression is associated, for example, with a negative affective bias in reversal learning. However, despite the fact that reversal learning is associated with striatal response in healthy individuals and depressed individuals exhibit attenuated striatal function on multiple tasks, studies to date have not demonstrated striatal involvement in the negative bias in reversal learning in depression. In this study, the authors sought to determine whether this may be because reversal learning tasks conventionally used to study behavior examine reversals only on the basis of unexpected punishment and therefore do not adequately separate reward- and punishment-based behavior. METHOD: The authors used functional MRI to compare the hemodynamic response to a reversal learning task with mixed reward- and punishment-based reversal stages between individuals with unmedicated major depressive disorder (N=13) and healthy comparison subjects (N=14). RESULTS: Impaired reward (but not punishment) reversal accuracy was found alongside attenuated anteroventral striatal response to unexpected reward in depression. CONCLUSIONS: Attenuated neurophysiological response of the anteroventral striatum may reflect dysfunction in circuits involving afferent projections from the orbitofrontal, limbic, and/or mesostriatal dopaminergic pathways, which conceivably may, together with the ventral striatum, underlie anhedonia in depression. Learning to appreciate and enjoy positive life experiences is critical for recovery from depression. This study pinpoints a neural target for such recovery.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1176/appi.ajp.2011.11010137

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single subject brain
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319
Dissociable Roles of Ventral and Dorsal Striatum in Instrumental Conditioning
O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004) · Science · doi:10.1126/science.1094285 · Cited by 2,088
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059
By Carrot or by Stick: Cognitive Reinforcement Learning in Parkinsonism
Frank, M. J., Seeberger, L. C., & O'Reilly, R. C. (2004) · Science · doi:10.1126/science.1102941 · Cited by 1,964
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · cited 6×
“Notably, lesions in the ventral striatum, orbitofrontal cortex, pallidum, or mediodorsal nucleus of the thalamus have all been shown to cause perseverative deficits in stimulus-reward reversal tasks in rats and monkeys, such that the animals have difficulty switching away from previously rewarded but not unrewarded st…”
BackgroundResultInfluentialSelf-citation
Neurotransmitters and neuromodulators in the basal ganglia
Graybiel, A. M. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90104-i · Cited by 1,576
Neuronal Coding of Prediction Errors
Schultz, W., & Dickinson, A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.473 · Cited by 1,427
Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232
The habenula: from stress evasion to value-based decision-making
Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955

Show all 39 references

Sorted by citations

Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model
Pizzagalli, D. A. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185606 · Cited by 1,155
Neural circuits underlying the pathophysiology of mood disorders
Price, J. L., & Drevets, W. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.12.011 · Cited by 788
Self-citation
Cognitive Mechanisms of Treatment in Depression
Roiser, J. P., Elliott, R., & Sahakian, B. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.183 · Cited by 535
Self-citation
Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies
Keren, H., O’Callaghan, G., Vidal-Ribas, P., Buzzell, G. A., Brotman, M. A., Leibenluft, E., Pan, P. M., Meffert, L., Kaiser, A., Wolke, S., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17101124 · Cited by 521
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519
Treatment for Anhedonia: A Neuroscience Driven Approach: 2015 ADAA Scientific Research Symposium: Treatment for Anhedonia
Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., & Dour, H. J. (2016) · Depression and Anxiety · doi:10.1002/da.22490 · Cited by 387
Insular dysfunction within the salience network is associated with severity of symptoms and aberrant inter-network connectivity in major depressive disorder
Manoliu, A., Meng, C., Brandl, F., Doll, A., Tahmasian, M., Scherr, M., Schwerthöffer, D., Zimmer, C., Förstl, H., Bäuml, J., et al. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00930 · Cited by 382
The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies
Zhang, W.-N., Chang, S.-H., Guo, L.-Y., Zhang, K.-L., & Wang, J. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.039 · Cited by 355
Hot and cold cognition in depression
Roiser, J. P., & Sahakian, B. J. (2013) · CNS Spectrums · doi:10.1017/s1092852913000072 · Cited by 354
Self-citation
Depression is related to an absence of optimistically biased belief updating about future life events
Korn, C. W., Sharot, T., Walter, H., Heekeren, H. R., & Dolan, R. J. (2014) · Psychological Medicine · doi:10.1017/s0033291713001074 · Cited by 334
Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299
Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness
Fettes, P., Schulze, L., & Downar, J. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00025 · Cited by 299
Computational psychiatry: towards a mathematically informed understanding of mental illness
Adams, R. A., Huys, Q. J. M., & Roiser, J. P. (2015) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-310737 · Cited by 285
Distinguishing between Unipolar Depression and Bipolar Depression: Current and Future Clinical and Neuroimaging Perspectives
Almeida, J., & Phillips, M. L. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.010 · Cited by 282
Identifying Predictors, Moderators, and Mediators of Antidepressant Response in Major Depressive Disorder: Neuroimaging Approaches
Phillips, M. L., Chase, H. W., Sheline, Y. I., Etkin, A., Almeida, J. R. C., Deckersbach, T., & Trivedi, M. H. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010076 · Cited by 267
Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression
Lally, N., Nugent, A. C., Luckenbaugh, D. A., Ameli, R., Roiser, J. P., & Zarate, C. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.105 · Cited by 271
Circuit Mechanisms of Reward, Anhedonia, and Depression
Höflich, A., Michenthaler, P., Kasper, S., & Lanzenberger, R. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy081 · Cited by 253
Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression
Satterthwaite, T. D., Kable, J. W., Vandekar, L., Katchmar, N., Bassett, D. S., Baldassano, C. F., Ruparel, K., Elliott, M. A., Sheline, Y. I., Gur, R. C., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.75 · Cited by 249
Distorted Cognitive Processes in Major Depression: A Predictive Processing Perspective
Κube, T., Schwarting, R. K. W., Rozenkrantz, L., Glombiewski, J. A., & Rief, W. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.017 · Cited by 257
Neural correlates of change in major depressive disorder anhedonia following open-label ketamine
Lally, N., Nugent, A. C., Luckenbaugh, D. A., Niciu, M. J., Roiser, J. P., & Zarate, C. A. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114568041 · Cited by 224
Depression: a decision-theoretic analysis
Huys, Q. J. M., Daw, N. D., & Dayan, P. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033928 · Cited by 221
Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia
Barch, D. M., Pagliaccio, D., & Luking, K. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_376 · Cited by 218
A Transdiagnostic Review of Negative Symptom Phenomenology and Etiology
Strauss, G. P., & Cohen, A. S. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx066 · Cited by 236
PERIL AND PLEASURE: AN RDOC-INSPIRED EXAMINATION OF THREAT RESPONSES AND REWARD PROCESSING IN ANXIETY AND DEPRESSION: Neighborhood Characteristics and Mental Health
Dillon, D. G., Rosso, I. M., Pechtel, P., Killgore, W. D. S., Rauch, S. L., & Pizzagalli, D. A. (2014) · Depression and Anxiety · doi:10.1002/da.22202 · Cited by 209
Association of neural and emotional impacts of reward prediction errors with major depression
Rutledge, R. B., Moutoussis, M., Smittenaar, P., Zeidman, P., Taylor, T., Hrynkiewicz, L., Lam, J., Skandali, N., Siegel, J. Z., Ousdal, O. T., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.1713 · Cited by 209
Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression
Borsini, A., Wallis, A. S. J., Zunszain, P., Pariante, C. M., & Kempton, M. J. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00804-6 · Cited by 207
Aberrant topology of striatum’s connectivity is associated with the number of episodes in depression
Meng, C., Brandl, F., Tahmasian, M., Shao, J., Manoliu, A., Scherr, M., Schwerthöffer, D., Bäuml, J., Förstl, H., Zimmer, C., et al. (2013) · Brain · doi:10.1093/brain/awt290 · Cited by 203
The adaptive threat bias in anxiety: Amygdala–dorsomedial prefrontal cortex coupling and aversive amplification
Robinson, O. J., Charney, D. R., Overstreet, C. M., Vytal, K. E., & Grillon, C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.096 · Cited by 211
Self-citation
The basal ganglia and the cerebellum in human emotion
Pierce, J. E., & Péron, J. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa076 · Cited by 201
Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play
Savitz, J. B., Rauch, S. L., & Drevets, W. C. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.25 · Cited by 192
Self-citation
Error-related brain activity in the age of RDoC: A review of the literature
Weinberg, A., Dieterich, R., & Riesel, A. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.02.029 · Cited by 179
Altered learning under uncertainty in unmedicated mood and anxiety disorders
Aylward, J., Valton, V., Ahn, W., Bond, R. L., Dayan, P., Roiser, J. P., & Robinson, O. J. (2019) · Nature Human Behaviour · doi:10.1038/s41562-019-0628-0 · Cited by 164
Self-citation
The role of cognitive dysfunction in the symptoms and remission from depression
Gonda, X., Pompili, M., Serafini, G., Carvalho, A. F., Rihmer, Z., & Dome, P. (2015) · Annals of General Psychiatry · doi:10.1186/s12991-015-0068-9 · Cited by 173
Noninvasive brain stimulation treatments for addiction and major depression
Dunlop, K., Hanlon, C. A., & Downar, J. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12985 · Cited by 171
Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence
Wang, S., Leri, F., & Rizvi, S. J. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110289 · Cited by 171
Abnormal reward functioning across substance use disorders and major depressive disorder: Considering reward as a transdiagnostic mechanism
Baskin-sommers, A. R., & Foti, D. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.01.011 · Cited by 169
Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis
Zhang, B., Lin, P., Shi, H., Öngür, D., Auerbach, R. P., Wang, X., Yao, S., & Wang, X. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9457-6 · Cited by 152
Modeling Avoidance in Mood and Anxiety Disorders Using Reinforcement Learning
Mkrtchian, A., Aylward, J., Dayan, P., Roiser, J. P., & Robinson, O. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.017 · Cited by 151
Self-citation
Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study
Sacchet, M. D., & Gotlib, I. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-02062-y · Cited by 150
Paranoia as a deficit in non-social belief updating
Reed, E., Uddenberg, S., Suthaharan, P., Mathys, C. D., Taylor, J. R., Groman, S. M., & Corlett, P. R. (2020) · eLife · doi:10.7554/elife.56345 · Cited by 143
Alterations in amplitude of low frequency fluctuation in treatment‐naïve major depressive disorder measured with resting‐state fMRI
Liu, J., Ren, L., Womer, F. Y., Wang, J., Fan, G., Jiang, W., Blumberg, H. P., Tang, Y., Xu, K., & Wang, F. (2014) · Human Brain Mapping · doi:10.1002/hbm.22526 · Cited by 139
Positive affect treatment targets reward sensitivity: A randomized controlled trial.
Craske, M. G., Meuret, A. E., Echiverri-Cohen, A. M., Rosenfield, D., & Ritz, T. (2023) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000805 · Cited by 152
Neural mechanisms of reinforcement learning in unmedicated patients with major depressive disorder
Rothkirch, M., Tonn, J., Köhler, S., & Sterzer, P. (2017) · Brain · doi:10.1093/brain/awx025 · Cited by 124
Modelling cognitive affective biases in major depressive disorder using rodents
Hales, C. A., Stuart, S. A., Anderson, M. H., & Robinson, E. S. J. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12603 · Cited by 131
Translational studies of goal-directed action as a framework for classifying deficits across psychiatric disorders
Griffiths, K. R., Morris, R. W., & Balleine, B. W. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00101 · Cited by 118
Biomarkers for major depressive disorder
Hacımusalar, Y., & Eşel, E. (2017) · Nöro Psikiyatri Arşivi · doi:10.5152/npa.2017.19482 · Cited by 123
Mood-congruent amygdala responses to subliminally presented facial expressions in major depression: associations with anhedonia
Stuhrmann, A., Dohm, K., Kugel, H., Zwanzger, P., Redlich, R., Grotegerd, D., Rauch, A. V., Arolt, V., Heindel, W., Suslow, T., et al. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120060 · Cited by 112
Reinforcement Learning Disruptions in Individuals With Depression and Sensitivity to Symptom Change Following Cognitive Behavioral Therapy
Brown, V. M., Zhu, L., Solway, A., Wang, J. M., McCurry, K. L., King-Casas, B., & Chiu, P. H. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.1844 · Cited by 112
Effort-cost decision-making in psychosis and depression: could a similar behavioral deficit arise from disparate psychological and neural mechanisms?
Culbreth, A. J., Moran, E. K., & Barch, D. M. (2017) · Psychological Medicine · doi:10.1017/s0033291717002525 · Cited by 121
Identifying Transdiagnostic Mechanisms in Mental Health Using Computational Factor Modeling
Wise, T., Robinson, O. J., & Gillan, C. M. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.09.034 · Cited by 108
“Using functional magnetic resonance imaging, reduced neural Computational Factor Modeling signatures of reward prediction errors were also seen in both depression (42,43) and schizophrenia (42).”
Self-citation
Diagnostic and therapeutic utility of neuroimaging in depression: an overview
Arnone, D., Wise, T., Cleare, A. J., Young, A. H., & Herane-Vives, A. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s50156 · Cited by 106
Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior
Fox, M. E., Chandra, R., Menken, M. S., Larkin, E. J., Nam, H., Engeln, M., Francis, T. C., & Lobo, M. K. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0211-5 · Cited by 100
The neural correlates of regulating positive and negative emotions in medication-free major depression
Greening, S. G., Osuch, E. A., Williamson, P. C., & Mitchell, D. G. V. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst027 · Cited by 99
Abnormal Frontostriatal Activity During Unexpected Reward Receipt in Depression and Schizophrenia: Relationship to Anhedonia
Segarra, N., Metastasio, A., Ziauddeen, H., Spencer, J., Reinders, N. R., Dudas, R. B., Arrondo, G., Robbins, T. W., Clark, L., Fletcher, P. C., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.370 · Cited by 101
A model for streamlining psychotherapy in the RDoC era: the example of ‘Engage’
Alexopoulos, G. S., & Arean, P. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.150 · Cited by 95
Rethinking post-traumatic stress disorder – A predictive processing perspective
Κube, T., Berg, M., Kleim, B., & Herzog, P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.014 · Cited by 107
Neural substrates of trait impulsivity, anhedonia, and irritability: Mechanisms of heterotypic comorbidity between externalizing disorders and unipolar depression
Zisner, A. R., & Beauchaine, T. P. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000754 · Cited by 100
Stress increases aversive prediction error signal in the ventral striatum
Robinson, O. J., Overstreet, C. M., Charney, D. R., Vytal, K. E., & Grillon, C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213923110 · Cited by 97
Self-citation
The self on its axis: a framework for understanding depression
Davey, C. G., & Harrison, B. J. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01790-8 · Cited by 94
N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: Behavioral and biochemical analyses in rats
Smaga, I., Pomierny, B., Krzyżanowska, W., Pomierny-Chamioło, L., Miszkiel, J., Niedzielska, E., Ogorka, A. Z. T., & Filip, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.018 · Cited by 86
Ventromedial Prefrontal Cortex Damage Is Associated with Decreased Ventral Striatum Volume and Response to Reward
Pujara, M. S., Philippi, C. L., Motzkin, J. C., Başkaya, M. K., & Koenigs, M. R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4236-15.2016 · Cited by 87
“Engage” Therapy: Behavioral Activation and Improvement of Late-Life Major Depression
Alexopoulos, G. S., Raue, P. J., Gunning, F., Kiosses, D. N., Kanellopoulos, D., Pollari, C., Banerjee, S., & Arean, P. A. (2016) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2015.11.006 · Cited by 84
A randomized placebo-controlled PET study of ketamine´s effect on serotonin1B receptor binding in patients with SSRI-resistant depression
Tiger, M., Veldman, E. R., Ekman, C.-J., Halldin, C., Svenningsson, P., & Lundberg, J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0844-4 · Cited by 81
Anhedonia: A Concept Analysis
Ho, N., & Sommers, M. S. (2013) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2013.02.001 · Cited by 88
Differentiating the abnormalities of social and monetary reward processing associated with depressive symptoms
Zhang, D., Shen, J., Bi, R., Zhang, Y., Zhou, F., Feng, C., & Gu, R. (2020) · Psychological Medicine · doi:10.1017/s0033291720003967 · Cited by 82
Learning from negative feedback in patients with major depressive disorder is attenuated by SSRI antidepressants
Herzallah, M. M., Moustafa, A. A., Natsheh, J. Y., Abdellatif, S. M., Taha, M. B., Tayem, Y. I., Sehwail, M. A., Amleh, I., Petrides, G., Myers, C. E., et al. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00067 · Cited by 77
Cortical-Subcortical Interactions in Depression: From Animal Models to Human Psychopathology
Heller, A. S. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00020 · Cited by 79
Disturbed Anterior Prefrontal Control of the Mesolimbic Reward System and Increased Impulsivity in Bipolar Disorder
Trost, S., Diekhof, E. K., Zvonik, K., Lewandowski, M., Usher, J., Keil, M., Zilles‐Wegner, D., Falkai, P., Dechent, P., & Gruber, O. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.39 · Cited by 73
Reward and punishment reversal-learning in major depressive disorder.
Mukherjee, D., Filipowicz, A. L. S., Vo, K. D., Satterthwaite, T. D., & Kable, J. W. (2020) · Journal of Abnormal Psychology · doi:10.1037/abn0000641 · Cited by 76
Working Memory Capacity Predicts Effects of Methylphenidate on Reversal Learning
van der Schaaf, M. E., Fallon, S. J., ter Huurne, N., Buitelaar, J. K., & Cools, R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.100 · Cited by 73
Self-citation
Learning and Choice in Mood Disorders: Searching for the Computational Parameters of Anhedonia
Robinson, O. J., & Chase, H. W. (2017) · Computational Psychiatry · doi:10.1162/cpsy_a_00009 · Cited by 66
Self-citation
Impaired reward-related learning signals in remitted unmedicated patients with recurrent depression
Geugies, H., Mocking, R. J. T., Figueroa, C. A., Groot, P. F. C., Marsman, J.-B. C., Servaas, M. N., Steele, J. D., Schene, A. H., & Ruhé, H. G. (2019) · Brain · doi:10.1093/brain/awz167 · Cited by 67
Understanding psychiatric disorder by capturing ecologically relevant features of learning and decision-making
Scholl, J., & Klein-Flügge, M. C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.050 · Cited by 66
Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence
Goldstein, B. L., Kessel, E. M., Kujawa, A., Finsaas, M. C., Davila, J., Hajcak, G., & Klein, D. N. (2019) · Psychological Medicine · doi:10.1017/s0033291719001557 · Cited by 62
A multivariate neuroimaging biomarker of individual outcome to transcranial magnetic stimulation in depression
Cash, R. F. H., Cocchi, L., Anderson, R., Rogachov, A., Kucyi, A., Barnett, A. J., Zalesky, A., & Fitzgerald, P. B. (2019) · Human Brain Mapping · doi:10.1002/hbm.24725 · Cited by 63
Biased belief updating in depression
Kube, T. (2023) · Clinical Psychology Review · doi:10.1016/j.cpr.2023.102298 · Cited by 61
Momentary subjective well-being depends on learning and not reward
Blain, B., & Rutledge, R. B. (2020) · eLife · doi:10.7554/elife.57977 · Cited by 70
Antidepressants and Changes in Concentration of Endocannabinoids and N-Acylethanolamines in Rat Brain Structures
Smaga, I., Bystrowska, B., Gawliński, D., Pomierny, B., Stankowicz, P., & Filip, M. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9465-0 · Cited by 62
From laboratory to life: associating brain reward processing with real-life motivated behaviour and symptoms of depression in non-help-seeking young adults
Bakker, J. M., Goossens, L., Kumar, P., Lange, I., Michielse, S., Schruers, K. R. J., Bastiaansen, J. A., Lieverse, R., Marcelis, M. C., van Amelsvoort, T., et al. (2018) · Psychological Medicine · doi:10.1017/s0033291718003446 · Cited by 57
Conditioned fear and extinction learning performance and its association with psychiatric symptoms in active duty Marines
Acheson, D. T., Geyer, M. A., Baker, D. G., Nievergelt, C. M., Yurgil, K. A., & Risbrough, V. B. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.030 · Cited by 60
Neuroanatomy of post-stroke depression: the association between symptom clusters and lesion location
Krick, S., Koob, J. L., Latarnik, S., Volz, L. J., Fink, G. R., Grefkes, C., & Rehme, A. K. (2023) · Brain Communications · doi:10.1093/braincomms/fcad275 · Cited by 65
The rat's not for turning: Dissociating the psychological components of cognitive inflexibility
Nilsson, S. R. O., Alsiö, J., Somerville, E. M., & Clifton, P. G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.015 · Cited by 60
Familial Risk for Major Depression is Associated with Lower Striatal 5-HT4 Receptor Binding
Madsen, K. S., Torstensen, E. W., Holst, K. K., Haahr, M. E., Knorr, U., Frøkjær, V. G., Brandt-Larsen, M., Iversen, P., Fisher, P. M., & Knudsen, G. M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu034 · Cited by 61
A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey
Oikonomidis, L., Santangelo, A. M., Shiba, Y., Clarke, F. H., Robbins, T. W., & Roberts, A. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22446 · Cited by 54
Abnormal brain processing of gentle touch in anorexia nervosa
Davidovic, M., Karjalainen, L., Starck, G., Wentz, E., Björnsdotter, M., & Olausson, H. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.08.007 · Cited by 53
Mechanisms of Reward Circuit Dysfunction in Psychiatric Illness
Pujara, M. S., & Koenigs, M. R. (2013) · The Neuroscientist · doi:10.1177/1073858413499407 · Cited by 51
Comparing Engage with PST in Late-Life Major Depression: A Preliminary Report
Alexopoulos, G. S., Raue, P. J., Kiosses, D. N., Seirup, J. K., Banerjee, S., & Arean, P. A. (2015) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2014.06.008 · Cited by 51
SHAPS-C: the Snaith-Hamilton pleasure scale modified for clinician administration
Ameli, R., Luckenbaugh, D. A., Gould, N. F., Holmes, M. K., Lally, N., Ballard, E. D., & Zarate, C. A. (2014) · PeerJ · doi:10.7717/peerj.429 · Cited by 50
Desynchronization and Plasticity of Striato-frontal Connectivity in Major Depressive Disorder
Leaver, A. M., Espinoza, R. T., Joshi, S. H., Vasavada, M. M., Njau, S. N., Woods, R. P., & Narr, K. L. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv207 · Cited by 48
Multistage drug effects of ketamine in the treatment of major depression
Walter, M., Li, S., & Demenescu, L. R. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0535-3 · Cited by 49
Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms
Misaki, M., Suzuki, H., Savitz, J. B., Drevets, W. C., & Bodurka, J. (2016) · Scientific Reports · doi:10.1038/srep21227 · Cited by 47
Self-citation
The temporal dynamics of reversal learning: P3 amplitude predicts valence-specific behavioral adjustment
Donaldson, K. R., Oumeziane, B. A., Hélie, S., & Foti, D. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.03.034 · Cited by 42
Social reinforcement learning as a predictor of real-life experiences in individuals with high and low depressive symptomatology
Frey, A.-L., Frank, M. J., & McCabe, C. (2019) · Psychological Medicine · doi:10.1017/s0033291719003222 · Cited by 48
Regional amplitude abnormities in the major depressive disorder: A resting-state fMRI study and support vector machine analysis
Chen, Q., Bi, Y., Zhao, X., Lai, Y., Yan, W., Xie, L., Gao, T., Xie, S., Zeng, T., Li, J., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.03.079 · Cited by 43
The roles of valuation and reward processing in cognitive function and psychiatric disorders
Hélie, S., Shamloo, F., Novak, K. D., & Foti, D. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13327 · Cited by 47
Pretreatment Reward Sensitivity and Frontostriatal Resting-State Functional Connectivity Are Associated With Response to Bupropion After Sertraline Nonresponse
Ang, Y., Kaiser, R. H., Deckersbach, T., Almeida, J., Phillips, M. L., Chase, H. W., Webb, C. A., Parsey, R. V., D, M. F. M., McGrath, P. J., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.04.009 · Cited by 43
Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models
Boyle, C. C., Bower, J. E., Eisenberger, N. I., & Irwin, M. R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105307 · Cited by 46
Dopamine, depressive symptoms, and decision-making: the relationship between spontaneous eye blink rate and depressive symptoms predicts Iowa Gambling Task performance
Byrne, K. A., Norris, D. D., & Worthy, D. A. (2015) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-015-0377-0 · Cited by 37
Apathy in Parkinson's Disease
Pagonabarraga, J., & Kulisevsky, J. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.05.025 · Cited by 40
The Endocannabinoid/Endovanilloid System and Depression
Smaga, I., Bystrowska, B., Gawliński, D., Przegaliński, E., & Filip, M. (2014) · Current Neuropharmacology · doi:10.2174/1570159x12666140923205412 · Cited by 40

Authors: Robinson, O. J., Cools, R., Carlisi, C. O., Sahakian, B. J., & Drevets, W. C.
Affiliations: National Institutes of Health (US)
ORCID: Robinson, Oliver J.
Cools, Roshan
Carlisi, Christina O.
Sahakian, Barbara J.
Drevets, Wayne C.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2012-02
Volume: 169
Issue: 2
Pages: 152-159
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2011.11010137
PMC: PMC5648982
OpenAlex: W2052548944
Cited by: 232
References: 39
Citations by year: 2026: 4 · 2025: 8 · 2024: 6 · 2023: 17 · 2022: 8 · 2021: 19 · 2020: 20 · 2019: 14 · 2018: 10 · 2017: 21 · 2016: 16 · 2015: 27 · 2014: 29 · 2013: 22 · 2012: 8
FWCI: 10.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: Wellcome Trust
National Institutes of Health (Z99 MH999999)
National Institute of Mental Health (Z01MH002792)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: major depressive disorder, ventral striatum, affective bias, anhedonia, dopaminergic pathways, orbitofrontal cortex, untreated depression
MeSH terms: Basal Ganglia, Behavioral Symptoms, Cognition, Major Depressive Disorder, Humans, Magnetic Resonance Imaging, Psychophysiology, Punishment, Reaction Time, Reversal Learning, Reward, Task Performance and Analysis, Anhedonia, Functional Neuroimaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Ventral Striatum Response During Reward and Punishment Reversal Learning in Unmedicated Major Depressive Disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks