Cited by 253Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.

Cognitive Dysfunction and Anxious-Impulsive Personality Traits Are Endophenotypes for Drug Dependence

Open access

Ersche, Karen D., Turton, Abigail J., Chamberlain, Samuel R., Müller, Ulrich, Bullmore, Edward T., Robbins, Trevor W.·2012·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2012.11091421PMC PMC3533378

Open this paper in CoChat — free account

Abstract

OBJECTIVE: Not everyone who takes drugs becomes addicted, but the likelihood of developing drug addiction is greater in people with a family history of drug or alcohol dependence. Relatively little is known about how genetic risk mediates the development of drug dependence. By comparing the phenotypic profile of individuals with and without a family history of addiction, the authors sought to clarify the extent to which cognitive dysfunction and personality traits are shared by family members--and therefore likely to have predated drug dependence--and which aspects are specific to drug-dependent individuals. METHOD: The authors assessed cognitive function and personality traits associated with drug dependence in stimulant-dependent individuals (N=50), their biological siblings without a history of drug dependence (N=50), and unrelated healthy volunteers (N=50). RESULTS: Cognitive function was significantly impaired in the stimulant-dependent individuals across a range of domains. Deficits in executive function and response control were identified in both the stimulant-dependent individuals and in their non-drug-dependent siblings. Drug-dependent individuals and their siblings also exhibited elevated anxious-impulsive personality traits relative to healthy comparison volunteers. CONCLUSIONS: Deficits in executive function and response regulation as well as anxious-impulsive personality traits may represent endophenotypes associated with the risk of developing cocaine or amphetamine dependence. The identification of addiction endophenotypes may be useful in facilitating the rational development of therapeutic and preventive strategies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1176/appi.ajp.2012.11091421

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

FIGURE 1. Cognitive and Emotional Profiles of Participants in a Study of Endophenotypes for Drug Dependencea aPanel A shows performance profiles in four cognitive domains in healthy comparison volunteers, unaffected siblings, and drug-dependent individuals. Panel B shows characteristic profiles in affective, psychosocial, and personality domains.CC BY-NC · PubMed Central

FIGURE 2. Deficits of Motor Inhibitory Control and White Matter Organization in Drug-Dependent Individuals and Their Unaffected Siblingsa a Panel A shows stop-signal reaction time (SSRT), which was significantly prolonged in both the stimulant-dependent individuals and their nondependent siblings compared with unrelated healthy volunteers (p≤0.005 for both comparisons with the Bonferroni correction). Panel B shows the skeleton of group differences in mean fractional anisotropy (FA) is colored in blue; stimulant-dependent individuals and their first-degree relatives both had significantly reduced fractional anisotropy compared with unrelated healthy comparison volunteers. On the basis of prior literature, regions of interest were selected within the blue skeleton that included the inferior frontal gyrus and the presupplementary motor area (in orange). Panel C is a scatter plot showing that participants with greater fractional anisotropy in the right inferior frontal gyrus had better inhibitory performance (i.e., shorter stop-signal reaction time) on the stop-signal task (r=0.24, df=142, p<0.005). From Ersche et al. (56). Reprinted with permission from American Association for the Advancement of Science.CC BY-NC · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption‐II
SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,597
Statistical Methods for Psychology.
Gudgeon, A. C., & Howell, D. C. (1994) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348956 · Cited by 8,277
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: implications for substance abuse prevention
Hawkins, J. D., Catalano, R. F., & Miller, J. Y. (1992) · Psychological Bulletin · doi:10.1037/0033-2909.112.1.64 · Cited by 5,428
The Five Factor Model and impulsivity: using a structural model of personality to understand impulsivity
Whiteside, S. P., & Lynam, D. R. (2001) · Personality and Individual Differences · doi:10.1016/s0191-8869(00)00064-7 · Cited by 4,123
Comorbidity of Mental Disorders With Alcohol and Other Drug Abuse: Results From the Epidemiologic Catchment Area (ECA) Study
Regier, D. A. (1990) · JAMA · doi:10.1001/jama.1990.03450190043026 · Cited by 3,962
The Adolescent Brain
Casey, B. J., Jones, R. M., & Hare, T. A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.010 · Cited by 3,345
Cognitive and affective development in adolescence
Steinberg, L. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.12.005 · Cited by 2,978
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757
Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex
Goldstein, R. Z., & Volkow, N. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1642 · Cited by 2,667

Show all 77 references

Research works printed but not linked: 3

10.1037/0022-3514.51.3.564 · DOI
Ersche KD, Addict Disord Their Treatment
First MB, 2002, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-Patient Edition (SCID-I/NP)

Sorted by citations

Drug addiction: updating actions to habits to compulsions ten years on
Everitt, B. J., & Robbins, T. W. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033457 · Cited by 1,225
Self-citation
Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches
Snyder, H. R., Miyake, A., & Hankin, B. L. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00328 · Cited by 946
“, 2013), substance use (e.g., Nigg et al., 2006; Ersche et al., 2012), physical health (e.”
Background
From the ventral to the dorsal striatum: devolving views of their roles in drug addiction
Everitt, B. J., & Robbins, T. W. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.010 · Cited by 675
Self-citation
Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review
Zilverstand, A., Huang, A., Alia‐Klein, N., & Goldstein, R. Z. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.048 · Cited by 598
New developments in human neurocognition: clinical, genetic and brain imaging correlates of impulsivity and compulsivity
Fineberg, N. A., Chamberlain, S. R., Goudriaan, A. E., Stein, D. J., Vanderschuren, L. J. M. J., Gillan, C. M., Shekar, S., Gorwood, P. A. P. M., Voon, V., Morein-Zamir, S., et al. (2014) · CNS Spectrums · doi:10.1017/s1092852913000801 · Cited by 488
Self-citation
Neuropsychosocial profiles of current and future adolescent alcohol misusers
Whelan, R., Watts, R., Orr, C., Althoff, R. R., Artiges, É., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Carvalho, F. M., et al. (2014) · Nature · doi:10.1038/nature13402 · Cited by 454
Self-citation
Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories – indications for novel treatments of addiction
Everitt, B. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12644 · Cited by 318
Impulsive action and impulsive choice across substance and behavioral addictions: Cause or consequence?
Grant, J. E., & Chamberlain, S. R. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.04.022 · Cited by 325
Self-citation
Dissecting impulsivity and its relationships to drug addictions
Jentsch, J. D., Ashenhurst, J. R., Cervantes, M. C., Groman, S. M., James, A. S., & Pennington, Z. T. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12388 · Cited by 281
Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience
Ersche, K. D., Williams, G. B., Robbins, T. W., & Bullmore, E. T. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.017 · Cited by 205
Self-citation
Noradrenergic modulation of cognition: Therapeutic implications
Chamberlain, S. R., & Robbins, T. W. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113480988 · Cited by 211
Self-citation
Personality traits and vulnerability or resilience to substance use disorders
Belcher, A. M., Volkow, N. D., Moeller, F. G., & Ferré, S. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2014.01.010 · Cited by 173
Fronto-striatal circuits in response-inhibition: Relevance to addiction
Morein‐Zamir, S., & Robbins, T. W. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.012 · Cited by 164
Self-citation
Addictions and Personality Traits: Impulsivity and Related Constructs
Mitchell, M. R., & Potenza, M. N. (2014) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-013-0001-y · Cited by 163
Epigenetics of Stress, Addiction, and Resilience: Therapeutic Implications
Cadet, J. L. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9040-y · Cited by 169
Brain networks underlying vulnerability and resilience to drug addiction
Ersche, K. D., Meng, C., Ziauddeen, H., Štochl, J., Williams, G. B., Bullmore, E. T., & Robbins, T. W. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002509117 · Cited by 143
Self-citation
Reward, interrupted: Inhibitory control and its relevance to addictions
Jentsch, J. D., & Pennington, Z. T. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.022 · Cited by 147
‘Jumping to conclusions’ data-gathering bias in psychosis and other psychiatric disorders — Two meta-analyses of comparisons between patients and healthy individuals
So, S. H., Siu, N. Y.-F., Wong, H.-L., Chan, W., & Garety, P. A. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.05.001 · Cited by 142
Distinctive Personality Traits and Neural Correlates Associated with Stimulant Drug Use Versus Familial Risk of Stimulant Dependence
Ersche, K. D., Jones, P. S., Williams, G. B., Smith, D. G., Bullmore, E. T., & Robbins, T. W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.016 · Cited by 132
Self-citation
Response inhibition and its relation to multidimensional impulsivity
Wilbertz, T., Deserno, L., Horstmann, A., Neumann, J., Villringer, A., Heinze, H.-J., Boehler, C. N., & Schlagenhauf, F. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.09.021 · Cited by 128
Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty
Flagel, S. B., Waselus, M., Clinton, S. M., Watson, S. J., & Akil, H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.033 · Cited by 131
Neuropsychological Consequences of Chronic Drug Use: Relevance to Treatment Approaches
Cadet, J. L., & Bisagno, V. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00189 · Cited by 110
From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior
Belin, D., Daniel, M.-L., Puaud, M., Jupp, B., Sawiak, S. J., Howett, D., McKenzie, C., Caprioli, D., Besson, M., Robbins, T. W., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.140 · Cited by 109
Self-citation
Impulsivity traits and neurocognitive mechanisms conferring vulnerability to substance use disorders
Verdejo‐García, A., & Albein‐Urios, N. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108402 · Cited by 115
Meta-analyses of the functional neural alterations in subjects with Internet gaming disorder: Similarities and differences across different paradigms.
Zheng, H., Hu, Y.-B., Wang, Z.-L., Wang, M., Du, X.-X., & Dong, G. (2019) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109656 · Cited by 100
Adult hippocampal neurogenesis in the pathogenesis of addiction and dual diagnosis disorders
Chambers, R. A. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.12.005 · Cited by 110
Risk factors for recidivism in individuals receiving community sentences: a systematic review and meta-analysis
Yukhnenko, D., Blackwood, N., & Fazel, S. (2019) · CNS Spectrums · doi:10.1017/s1092852919001056 · Cited by 101
The 5-HT2A serotonin receptor in executive function: Implications for neuropsychiatric and neurodegenerative diseases
Aznar, S., & Hervig, M. E.-S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.008 · Cited by 99
Comorbidity of Personality Disorder among Substance Use Disorder Patients: A Narrative Review
Parmar, A., & Kaloiya, G. (2018) · Indian Journal of Psychological Medicine · doi:10.4103/ijpsym.ijpsym_164_18 · Cited by 93
You are the danger: Attenuated insula response in methamphetamine users during aversive interoceptive decision-making
Stewart, J. L., May, A. C., Poppa, T., Davenport, P. W., Tapert, S. F., & Paulus, M. P. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.06.003 · Cited by 86
A neurobehavioral approach to addiction: implications for the opioid epidemic and the psychology of addiction
Bechara, A., Berridge, K. C., Bickel, W. K., Morón, J. A., Williams, S. B., & Stein, J. S. (2019) · Psychological Science in the Public Interest · doi:10.1177/1529100619860513 · Cited by 82
Gambling and substance use: Comorbidity and treatment implications
Grant, J. E., & Chamberlain, S. R. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109852 · Cited by 85
Self-citation
Cue Reactivity in the Ventral Striatum Characterizes Heavy Cannabis Use, Whereas Reactivity in the Dorsal Striatum Mediates Dependent Use
Zhou, X., Zimmermann, K., Xin, F., Zhao, W., Derckx, R. T., Sassmannshausen, A., Scheele, D., Hurlemann, R., Weber, B., Kendrick, K. M., et al. (2019) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.04.006 · Cited by 77
Addictive behaviour in experimental animals: prospects for translation
Everitt, B. J., Giuliano, C., & Belin, D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0027 · Cited by 81
Behavioral endophenotypes of drug addiction: Etiological insights from neuroimaging studies
Jupp, B., & Dalley, J. W. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.041 · Cited by 78
Structural deficits in salience network regions are associated with increased impulsivity and compulsivity in alcohol dependence
Grodin, E. N., Cortes, C. R., Spagnolo, P. A., & Momenan, R. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.06.014 · Cited by 82
Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
Sampedro‐Piquero, P., de Guevara‐Miranda, D. L., Pavón, F. J., Serrano, A., Suárez, J., de Fonseca, F. R., Santín, L. J., & Castilla‐Ortega, E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.015 · Cited by 85
Neural circuitry and mechanisms of waiting impulsivity: relevance to addiction
Dalley, J. W., & Ersche, K. D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0145 · Cited by 81
Self-citation
Dopamine D3 receptor alterations in cocaine-dependent humans imaged with [11C](+)PHNO
Matuskey, D., Gallezot, J., Pittman, B. P., Williams, W. A., Wanyiri, J. W., Gaiser, E., Lee, D. E., Hannestad, J. O., Lim, K., Zheng, M.-Q., et al. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.03.013 · Cited by 76
Gambling disorder and its relationship with substance use disorders: Implications for nosological revisions and treatment
Grant, J. E., & Chamberlain, S. R. (2013) · American Journal on Addictions · doi:10.1111/ajad.12112 · Cited by 78
Self-citation
Shaping vulnerability to addiction – the contribution of behavior, neural circuits and molecular mechanisms
Egervári, G., Ciccocioppo, R., Jentsch, J. D., & Hurd, Y. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.019 · Cited by 78
Intact inhibitory control processes in abstinent drug abusers (I): A functional neuroimaging study in former cocaine addicts
Bell, R. P., Foxe, J. J., Ross, L. A., & Garavan, H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.02.018 · Cited by 71
A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials
de Sola, S., The TESDAD Study Group, de la Torre, R., Sánchez‐Benavides, G., Benejam, B., Cuenca‐Royo, A., Soriano, L. D. H., RodrÃguez, J., Catuara‐Solarz, S., Sánchez-Gutiérrez, J., et al. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00708 · Cited by 75
Changes in cocaine consumption are associated with fluctuations in self-reported impulsivity and gambling decision-making
Hulka, L. M., Vonmoos, M., Preller, K. H., Baumgartner, M. R., Seifritz, E., Gamma, A., & Quednow, B. B. (2015) · Psychological Medicine · doi:10.1017/s0033291715001063 · Cited by 70
Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel
Dickson, P. E., Miller, M. M., Calton, M. A., Bubier, J. A., Cook, M. N., Goldowitz, D., Chesler, E. J., & Mittleman, G. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4147-z · Cited by 62
Prenatal cocaine effects on brain structure in early infancy
Grewen, K., Burchinal, M., Vachet, C., Gouttard, S., Gilmore, J. H., Lin, W., Johns, J., Elam, M., & Gerig, G. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.070 · Cited by 65
Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction
Engeli, E., Zoelch, N., Hock, A., Nordt, C., Hulka, L. M., Kirschner, M., Scheidegger, M., Esposito, F., Baumgartner, M. R., Henning, A., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0828-z · Cited by 64
Perspectives on neurocognitive rehabilitation as an adjunct treatment for addictive disorders
Rezapour, T., DeVito, E. E., Sofuoglu, M., & Ekhtiari, H. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.07.022 · Cited by 65
Smaller amygdala and medial prefrontal cortex predict escalating stimulant use
Becker, B., Wagner, D. R., Koester, P., Tittgemeyer, M., Mercer‐Chalmers‐Bender, K., Hurlemann, R., Zhang, J., Gouzoulis‐Mayfrank, E., Kendrick, K. M., & Daumann, J. (2015) · Brain · doi:10.1093/brain/awv113 · Cited by 62
Prefrontal Hypoactivity Associated with Impaired Inhibition in Stimulant-Dependent Individuals but Evidence for Hyperactivation in their Unaffected Siblings
Morein‐Zamir, S., Jones, P. S., Bullmore, E. T., Robbins, T. W., & Ersche, K. D. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.90 · Cited by 63
Self-citation
Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety
Anderson, E. M., Larson, E. B., Guzman, D. D., Wissman, A. M., Neve, R. L., Nestler, E. J., & Self, D. W. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1657-17.2017 · Cited by 59
Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders
Liu, Y., van den Wildenberg, W. P. M., de Graaf, Y., Ames, S. L., Baldacchino, A., Bø, R., Cadaveira, F., Campanella, S., Christiansen, P., Claus, E. D., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.006 · Cited by 63
Volatile Solvents as Drugs of Abuse: Focus on the Cortico-Mesolimbic Circuitry
Beckley, J. T., & Woodward, J. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.206 · Cited by 60
Competing neurobehavioral decision systems theory of cocaine addiction
Bickel, W. K., Snider, S. E., Quisenberry, A. J., Stein, J. S., & Hanlon, C. A. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.07.009 · Cited by 56
Bidirectional causality between addiction and cognitive deficits
Melugin, P. R., Nolan, S. O., & Siciliano, C. A. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.11.001 · Cited by 59
The pharmacological reduction of hippocampal neurogenesis attenuates the protective effects of cannabidiol on cocaine voluntary intake
Luján, M. Á., Cantacorps, L., & Valverde, O. (2019) · Addiction Biology · doi:10.1111/adb.12778 · Cited by 54
Personality profile of binge drinking in university students is modulated by sex. A study using the Alternative Five Factor Model
Adán, A., Navarro, J. F., & Forero, D. A. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.05.015 · Cited by 53
Personality disorder and substance use disorder – An update
Köck, P., & Walter, M. (2018) · Mental Health & Prevention · doi:10.1016/j.mhp.2018.10.003 · Cited by 52
How evolutionary thinking can help us to understand ADHD
Swanepoel, A., Music, G., Launer, J., & Reiss, M. J. (2017) · BJPsych Advances · doi:10.1192/apt.bp.116.016659 · Cited by 45
Enhanced Orbitofrontal Cortex Function and Lack of Attentional Bias to Cocaine Cues in Recreational Stimulant Users
Smith, D. G., Jones, P., Bullmore, E. T., Robbins, T. W., & Ersche, K. D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.019 · Cited by 43
Self-citation
Gene variants and educational attainment in cannabis use: mediating role of DNA methylation
Gerra, M. C., Jayanthi, S., Manfredini, M., Walther, D., Schroeder, J., Phillips, K. A., Cadet, J. L., & Donnini, C. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0087-1 · Cited by 42
Endocannabinoids and striatal function
Moreira, F. A., Jupp, B., Belin, D., & Dalley, J. W. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000109 · Cited by 44
Cognitive deficit in methamphetamine users relative to childhood academic performance: link to cortical thickness
Dean, A. C., Morales, A. M., Hellemann, G., & London, E. D. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0065-1 · Cited by 40
Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety
Anderson, E. M., Sun, H., Guzman, D. D., Taniguchi, M., Cowan, C. W., Maze, I. S., Nestler, E. J., & Self, D. W. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0305-4 · Cited by 40
Biological substrates of addiction
Joffe, M. E., Grueter, C. A., & Grueter, B. A. (2014) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1273 · Cited by 42
Neural correlates of craving and impulsivity in abstinent former cocaine users: Towards biomarkers of relapse risk
Bell, R. P., Garavan, H., & Foxe, J. J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.011 · Cited by 38
Impulsivity, Emotional Dysregulation and Executive Function Deficits Could Be Associated with Alcohol and Drug Abuse in Eating Disorders
Lozano-Madrid, M., Clark Bryan, D., Granero, R., Sánchez, I., Riesco, N., Mallorquí-Bagué, N., Jiménez-Murcia, S., Treasure, J., & Fernández-Aranda, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061936 · Cited by 38
The Neural Signature of Impaired Inhibitory Control in Individuals with Heroin Use Disorder
Ceceli, A. O., King, S. G., McClain, N. E., Alia‐Klein, N., & Goldstein, R. Z. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1237-22.2022 · Cited by 36
Withdrawal from escalated cocaine self-administration impairs reversal learning by disrupting the effects of negative feedback on reward exploitation: a behavioral and computational analysis
Zhukovsky, P., Puaud, M., Jupp, B., Sala‐Bayo, J., Alsiö, J., Xia, J., Searle, L., Morris, Z. S., Sabir, A., Giuliano, C., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0381-0 · Cited by 33
Self-citation
Cognitive control dysfunction and abnormal frontal cortex activation in stimulant drug users and their biological siblings
Smith, D. G., Jones, P. S., Bullmore, E. T., Robbins, T. W., & Ersche, K. D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.32 · Cited by 36
Self-citation
Functional neural changes and altered cortical–subcortical connectivity associated with recovery from Internet gaming disorder
Dong, G., Wang, M., Zhang, J., Du, X., & Potenza, M. N. (2019) · Journal of Behavioral Addictions · doi:10.1556/2006.8.2019.75 · Cited by 35
Smaller Feedback-Related Negativity (FRN) Reflects the Risky Decision-Making Deficits of Methamphetamine Dependent Individuals
Zhong, N., Chen, T., Zhu, Y., Su, H., Ruan, X., Li, X., Tan, H., Jiang, H., Du, J., & Zhao, M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00320 · Cited by 35
Neuroscience of resilience and vulnerability for addiction medicine
Morrow, J. D., & Flagel, S. B. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.09.004 · Cited by 33
Influence of the Novelty-Seeking Endophenotype on the Rewarding Effects of Psychostimulant Drugs in Animal Models
Arenas, M. C., Aguilar, M. A., Montagud‐Romero, S., Mateos-García, A., Navarro-Francés, C. I., Miñarro, J., & Rodríguez‐Arias, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150921112841 · Cited by 33
Neuroticism and impulsivity: Their hierarchical organization in the personality characterization of drug-dependent patients from a decision tree learning perspective
Valero, S., Daigre, C., Rodríguez-Cintas, L., Barral, C., Gomà‐i‐Freixanet, M., Ferrer, M., Casas, M., & Roncero, C. (2014) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2014.03.021 · Cited by 33
Executive Cognitive Dysfunction and ADHD in Cocaine Dependence: Searching for a Common Cognitive Endophenotype for Addictive Disorders
Cunha, P. J., Gonçalves, P. D., Ometto, M., dos Santos, B., Nicastri, S., Busatto, G. F., & de Andrade, A. G. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00126 · Cited by 33
Influence of dorsolateral prefrontal cortex and ventral striatum on risk avoidance in addiction: A mediation analysis
Yamamoto, D. J., Woo, C., Wager, T. D., Regner, M. F., & Tanabe, J. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.12.026 · Cited by 37
Multiple Substance Use Disorders and Self-Reported Cognitive Function in U.S. Adults: Associations and Sex-Differences in a Nationally Representative Sample
Bourgault, Z., Rubin-Kahana, D. S., Hassan, A. N., Sanches, M., & Foll, B. L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.797578 · Cited by 34
Impact of Substance Use Disorder Pharmacotherapy on Executive Function: A Narrative Review
Butler, K., & Foll, B. L. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00098 · Cited by 31
Dissecting Impulsivity: Brain Mechanisms and Neuropsychiatric Implications
Robbins, T. W., & Dalley, J. W. (2017) · Nebraska Symposium on Motivation/The Nebraska symposium on motivation · doi:10.1007/978-3-319-51721-6_7 · Cited by 33
Self-citation
Higher impulsivity and lower grey matter volume in the bilateral prefrontal cortex in long-term abstinent individuals with severe methamphetamine use disorder
Huang, S., Dai, Y., Zhang, C., Yang, C. C., Huang, Q., Hao, W., & Shen, H. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108040 · Cited by 30
Subcortical volumes are reduced in short-term and long-term abstinent alcoholics but not those with a comorbid stimulant disorder
Fein, G., & Fein, D. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.06.018 · Cited by 30
Inflammation and infection in human cocaine addiction
Ersche, K. D., & Döffinger, R. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.12.007 · Cited by 29
Self-citation
Neurocognitive dysfunction in addiction: Testing hypotheses of diffuse versus selective phenotypic dysfunction with a classification-based approach.
Bickel, W. K., Moody, L. N., Eddy, C. R., & Franck, C. T. (2017) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000115 · Cited by 31
A Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity
Desrochers, S. S., Spring, M. G., & Nautiyal, K. M. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.791749 · Cited by 29
Alcohol-Preferring P Rats Exhibit Elevated Motor Impulsivity Concomitant with Operant Responding and Self-Administration of Alcohol
Beckwith, S. W., & Czachowski, C. L. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13044 · Cited by 29
Schizophrenia and Criminal Responsibility
Tsimploulis, G., Niveau, G., Eytan, A., Giannakopoulos, P., & Sentissi, O. (2018) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000805 · Cited by 30
Cognitive profiles in persons with opioid use disorder enrolled in methadone treatment
Sanborn, V. E., Gunstad, J., Shrestha, R., Mistler, C. B., & Copenhaver, M. M. (2020) · Applied Neuropsychology Adult · doi:10.1080/23279095.2020.1769099 · Cited by 29
The Primacy of Cognition in the Manifestations of Substance Use Disorders
Cadet, J. L., & Bisagno, V. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00189 · Cited by 29
Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users
Canavan, S. V., Forselius, E., Bessette, A. J., & MORGAN, P. T. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.02.015 · Cited by 28
Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress
Rincón‐Cortés, M. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100067 · Cited by 26
Beyond drug‐induced alteration of glutamate homeostasis, astrocytes may contribute to dopamine‐dependent intrastriatal functional shifts that underlie the development of drug addiction: A working hypothesis
Fouyssac, M., & Belin, D. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14416 · Cited by 30
The central executive network and executive function in healthy and persons with schizophrenia groups: a meta-analysis of structural and functional MRI
Pietrzykowski, M. O., Daigle, K. M., Waters, A. B., Swenson, L. P., & Gansler, D. A. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-021-00589-3 · Cited by 30
In the face of threat: neural and endocrine correlates of impaired facial emotion recognition in cocaine dependence
Ersche, K. D., Hagan, C. C., Smith, D. G., Jones, P. S., Calder, A. J., & Williams, G. B. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.58 · Cited by 29
Self-citation
Using a drug-word Stroop task to differentiate recreational from dependent drug use
Smith, D. G., & Ersche, K. D. (2014) · CNS Spectrums · doi:10.1017/s1092852914000133 · Cited by 25
Self-citation
Risk Factors for Addiction and Their Association with Model-Based Behavioral Control
Reiter, A. M. F., Deserno, L., Wilbertz, T., Heinze, H., & Schlagenhauf, F. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00026 · Cited by 29
Risk factors for substances use and misuse among young people in France: What can we learn from the Substance Use Risk Profile Scale?
Ali, A., Carré, A., Hassler, C., Spilka, S., Vanier, A., Barry, C., & Berthoz, S. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.03.027 · Cited by 30
Association of parental substance use disorder with offspring cognition: a population family‐based study
Khemiri, L., Larsson, H., Kuja‐Halkola, R., D'Onofrio, B. M., Lichtenstein, P., Jayaram‐Lindström, N., & Latvala, A. (2019) · Addiction · doi:10.1111/add.14813 · Cited by 25
The relationship between the striatal dopamine transporter and novelty seeking and cognitive flexibility in opioid dependence
Liang, C., Ho, P., Yen, C.-H., Chen, C., Kuo, S.-C., Huang, C., Yeh, Y., Ma, K., & Huang, S. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.12.001 · Cited by 24
Early life adversity potentiates expression of addiction-related traits
Hynes, T. J., Thomas, C. S., Zumbusch, A. S., Samson, A., Petriman, I., Mrdja, U., Orr, A., Cutts, E., Ruzindana, B. G., Hazari, A., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.005 · Cited by 28

Authors: Ersche, K. D., Turton, A. J., Chamberlain, S. R., Müller, U., Bullmore, E. T., & Robbins, T. W.
Affiliations: University of Cambridge (GB)
Corresponding author: Ersche, Karen D.
ORCID: Ersche, Karen D.
Chamberlain, Samuel R.
Bullmore, Edward T.
Robbins, Trevor W.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2012-09
Volume: 169
Issue: 9
Pages: 926-936
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2012.11091421
PMC: PMC3533378
OpenAlex: W2128615125
Cited by: 252
References: 77
Citations by year: 2026: 5 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 20 · 2021: 11 · 2020: 43 · 2019: 30 · 2018: 17 · 2017: 15 · 2016: 12 · 2015: 19 · 2014: 31 · 2013: 21 · 2012: 6
FWCI: 18.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc
Locations: American Journal of Psychiatry (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Funders: Eli Lilly and Company
GlaxoSmithKline
Wellcome Trust (093875)
University of Cambridge
European College of Neuropsychopharmacology
H. Lundbeck A/S
Medical Research Council
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: endophenotypes, drug addiction, stimulant use disorder, cocaine dependence, amphetamine dependence, cognitive impairment, executive function, response control, family history of addiction, biological siblings
MeSH terms: Adult, Anxiety, Cognition Disorders, Family Health, Female, Humans, Impulsive Behavior, Male, Neuropsychological Tests, Personality Assessment, Case-Control Studies, Substance-Related Disorders, Siblings, Endophenotypes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cognitive Dysfunction and Anxious-Impulsive Personality Traits Are Endophenotypes for Drug Dependence

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks