Prevalence, Comorbidity, and Correlates of DSM-5 Proposed Disruptive Mood Dysregulation Disorder
Open accessAbstract
OBJECTIVE: No empirical studies on the DSM-5 proposed disruptive mood dysregulation disorder have yet been published. This study estimated prevalence, comorbidity, and correlates of this proposed disorder in the community. METHOD: Prevalence rates were estimated using data from three community studies involving 7,881 observations of 3,258 participants from 2 to 17 years old. Disruptive mood dysregulation disorder was diagnosed using structured psychiatric interviews. RESULTS: Three-month prevalence rates for meeting criteria for disruptive mood dysregulation disorder ranged from 0.8% to 3.3%, with the highest rate in preschoolers. Rates dropped slightly with the strict application of the exclusion criterion, but they were largely unaffected by the application of onset and duration criteria. Disruptive mood dysregulation co-occurred with all common psychiatric disorders. The highest levels of co-occurrence were with depressive disorders (odds ratios between 9.9 and 23.5) and oppositional defiant disorder (odds ratios between 52.9 and 103.0). Disruptive mood dysregulation occurred with another disorder 62%-92% of the time, and it occurred with both an emotional and a behavioral disorder 32%-68% of the time. Affected children displayed elevated rates of social impairments, school suspension, service use, and poverty. CONCLUSIONS: Disruptive mood dysregulation disorder is relatively uncommon after early childhood, frequently co-occurs with other psychiatric disorders, and meets common standards for psychiatric "caseness." This disorder identifies children with severe levels of both emotional and behavioral dysregulation.
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Studies in clinical and community samples have found that 70-100% of children with DMDD have symptoms that meet the diagnostic requirements for ODD.
“Studies in clinical and community samples have found that 70-100% of children with DMDD have symptoms that meet the diagnostic requirements for ODD 77,79-82 , suggesting that the irritability and behavioural symptom dimensions of ODD are not separable into different disorders 31,78 .”
From An organization‐ and category‐level comparison of diagnostic requirements for mental disorders in <scp>ICD</scp> ‐11 and <scp>DSM</scp> ‐5 (2021) · cites this paper as [81]
The Results > Comorbidity section reports very strong co-occurrence of DMDD with ODD in community samples (odds ratios 52.9–103.0), supporting the claim of substantial overlap. It does not give the claimed 70–100% of children with DMDD meeting ODD criteria, and the Discussion says these community-sample results may differ from clinical samples. No page number is available in our copy. (LLM, conf=0.84)
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Loss of Temper and Irritability: The Relationship to Tantrums in a Community and Clinical Sample
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Empirically derived patterns of psychiatric symptoms in youth: A latent profile analysis
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Preschool- and School-Age Irritability Predict Reward-Related Brain Function
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Focus on Disruptive Mood Dysregulation Disorder: A review of the literature
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Toward a Developmental Nosology for Disruptive Mood Dysregulation Disorder in Early Childhood
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A PROSPECTIVE STUDY OF SEVERE IRRITABILITY IN YOUTHS: 2- AND 4-YEAR FOLLOW-UP
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An Empirical Validation of Malicious Insider Characteristics
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Indirect Comorbidity in Childhood and Adolescence
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Treatment Options for the Cardinal Symptoms of Disruptive Mood Dysregulation Disorder.
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Oppositional and conduct disorders
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Distinguishing Bipolar Disorder From Other Psychiatric Disorders in Children
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Taking Disruptive Mood Dysregulation Disorder Out for a Test Drive
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Tonic and phasic irritability in 6‐year‐old children : differential correlates and outcomes
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Sociodemographic and Clinical Features of Disruptive Mood Dysregulation Disorder: A Chart Review
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- Authors
- Copeland, W. E., Angold, A., Costello, E. J., & Egger, H.
- Affiliations
- Duke University (US)
- Venue
- American Journal of Psychiatry
- Published
- 2013-02
- Volume
- 170
- Issue
- 2
- Pages
- 173-179
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC3573525
- OpenAlex
- W2132164699
- Cited by
- 391
- References
- 29
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 36 · 2023: 28 · 2022: 25 · 2021: 35 · 2020: 25 · 2019: 33 · 2018: 23 · 2017: 33 · 2016: 47 · 2015: 26 · 2014: 29 · 2013: 15
- FWCI
- 43.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH-63671, MH-075766, MH11301, R01MH063970, R01MH048085, MH-63970, MH080230, R01MH075766, MH-48085, K23MH080230, R01MH063671)
- National Institute on Drug Abuse (DA-016977, R01DA016977, R01DA011301, DA011301)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P2CHD065563, R24HD065563)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- disruptive mood dysregulation disorder, prevalence, comorbidities, children and adolescents, depressive disorders, oppositional defiant disorder, emotional and behavioral disorders, social dysfunction, school suspension, poverty, mental health service utilization
- MeSH terms
- Adolescent, Child, Child Welfare, Child, Preschool, Ethnicity, Family Relations, Female, Health Services, Humans, Interview, Psychological, Longitudinal Studies, Male, North Carolina, Risk Factors, Socioeconomic Factors, Comorbidity, Prevalence, Attention Deficit and Disruptive Behavior Disorders, Mood Disorders, Diagnostic and Statistical Manual of Mental Disorders
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