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Glutamate Metabolism in Major Depressive Disorder
Open accessAbstract
Research on novel treatments for major depressive disorder focuses quite deeply on glutamate function, and this research would benefit from a brain-imaging technique that precisely quantified glutamate function. Signs of a specific form of glutamate-related dysfunction that could be targeted by novel therapies were found using novel, state-of-the-art techniques to address this issue.
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“The alteration of EPC acutely post injection may reflect a transient reduction in postsynaptic activation [9] due to blockade of postsynaptic NMDAR by ketamine and its metabolite, norketamine.”
From The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects (2018) · cites this paper as [9]
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“Carbon-13 magnetic resonance spectroscopy ( 13 C MRS) is a unique, noninvasive method to measure neurotransmitter cycling and cell-specific neuroenergetics [8][9][10].”
From The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects (2018) · cites this paper as [9]
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“Furthermore, the glutamatergic system has been reported to play important roles in regulation of synaptic plasticity and to have a significant effect on mood, cognition, and reward circuitry (Abdallah et al., 2014; Duman et al., 2016).”
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Metadata
- Authors
- Abdallah, C. G., Jiang, L., De Feyter, H. M., Fasula, M., Krystal, J. H., Rothman, D. L., Mason, G. F., & Sanacora, G.
- Affiliations
- Yale University (US)
- From the Department of Psychiatry, the Department of Diagnostic Imaging, and the Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Conn.; the Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven; and the Clinical Neuroscience Division, National Center for PTSD, West Haven, Conn.
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2014-12-01
- Volume
- 171
- Issue
- 12
- Pages
- 1320-1327
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC4472484
- OpenAlex
- W2094998611
- Cited by
- 200
- References
- 40
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 18 · 2023: 21 · 2022: 20 · 2021: 36 · 2020: 9 · 2019: 17 · 2018: 17 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 4
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k23mh101498-05)
- National Institute of Mental Health (K23MH-101498(, R01MH071676, K02MH076222)
- National Institute on Drug Abuse (R01DA021785, T32DA022975)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- glutamate metabolism, major depressive disorder, glutamate dysfunction, neuroimaging
- MeSH terms
- Adult, Aged, Carbon Isotopes, Citric Acid Cycle, Depressive Disorder, Major, Major Depressive Disorder, Female, gamma-Aminobutyric Acid, Humans, Male, Middle Aged, Mitochondria, Models, Biological, Magnetic Resonance Spectroscopy, Occipital Lobe, Protons, Glutamic Acid, Young Adult, Neuroimaging
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