The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder
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Animal models of depression repeatedly showed stress-induced nucleus accumbens (NAc) hypertrophy. Recently, ketamine was found to normalize this stress-induced NAc structural growth. Here, we investigated NAc structural abnormalities in major depressive disorder (MDD) in two cohorts. Cohort A included a cross-sectional sample of 34 MDD and 26 healthy control (HC) subjects, with high-resolution magnetic resonance imaging (MRI) to estimate NAc volumes. Proton MR spectroscopy (1 H MRS) was used to divide MDD subjects into two subgroups: glutamate-based depression (GBD) and non-GBD. A separate longitudinal sample (cohort B) included 16 MDD patients who underwent MRI at baseline then 24 h following intravenous infusion of ketamine (0.5 mg/kg). In cohort A, we found larger left NAc volume in MDD compared to controls (Cohen's d=1.05), but no significant enlargement in the right NAc (d=0.44). Follow-up analyses revealed significant subgrouping effects on the left (d⩾1.48) and right NAc (d⩾0.95) with larger bilateral NAc in non-GBD compared to GBD and HC. NAc volumes were not different between GBD and HC. In cohort B, ketamine treatment reduced left NAc, but increased left hippocampal, volumes in patients achieving remission. The cross-sectional data provided the first evidence of enlarged NAc in patients with MDD. These NAc abnormalities were limited to patients with non-GBD. The pilot longitudinal data revealed a pattern of normalization of left NAc and hippocampal volumes particularly in patients who achieved remission following ketamine treatment, an intriguing preliminary finding that awaits replication.
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Structural MRI evidence shows increased hippocampal volumes and decreased nucleus accumbens volumes 24 h post-infusion, correlated to treatment response.
“Structural MRI has been performed on human subjects undergoing single-infusion ketamine, and evidence has been provided showing increased hippocampal volumes and decreased nucleus accumbens volumes 24 h post-infusion, which was correlated to treatment response.212”
From Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers (2020) · cites this paper as [212]
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Fischl, B. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.021 · Cited by 9,526 · see citing works
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610 · see citing works
Within-subject template estimation for unbiased longitudinal image analysis
Reuter, M., Schmansky, N. J., Rosas, H. D., & Fischl, B. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.084 · Cited by 2,356 · see citing works
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750 · see citing works
Mechanisms of stress in the brain
McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386 · see citing works
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works
Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082 · see citing works
Kempton, M. J., Salvador, Z., Munafò, M. R., Geddes, J. R., Simmons, A., Frangou, S., & Williams, S. C. R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.60 · Cited by 886 · see citing works
Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-053013-062946 · Cited by 422 · see citing works
Self-citationWacker, J., Dillon, D. G., & Pizzagalli, D. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.058 · Cited by 405 · see citing works
Ketamine Treatment and Global Brain Connectivity in Major Depression
Abdallah, C. G., Averill, L. A., Collins, K. A., Geha, P., Schwartz, J., Averill, C., DeWilde, K. E., Wong, E., Anticevic, A., Tang, C. Y., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.186 · Cited by 300 · see citing works
Self-citationPrice, R. B., Shungu, D. C., Mao, X., Nestadt, P., Kelly, C., Collins, K. A., Murrough, J. W., Charney, D. S., & Mathew, S. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.025 · Cited by 270 · see citing works
Self-citationDefining remission by cut off score on the MADRS: selecting the optimal value
Hawley, C. J., Gale, T. M., & Sivakumaran, T. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00451-7 · Cited by 268 · see citing works
IκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works
Phillips, M. L., Chase, H. W., Sheline, Y. I., Etkin, A., Almeida, J. R. C., Deckersbach, T., & Trivedi, M. H. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010076 · Cited by 267 · see citing works
Wook Koo, J., Labonté, B., Engmann, O., Calipari, E. S., Juarez, B., Lorsch, Z., Walsh, J. J., Friedman, A. K., Yorgason, J. T., Han, M.-H., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.009 · Cited by 231 · see citing works
Belujon, P., & Grace, A. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.014 · Cited by 225 · see citing works
Kassem, M. S., Lagopoulos, J., Stait‐Gardner, T., Price, W. S., Chohan, T. W., Arnold, J. C., Hatton, S. N., & Bennett, M. R. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8365-7 · Cited by 212 · see citing works
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., Burnham, V. L., Mazei-Robison, M. S., Ferguson, D., Golden, S. A., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3591 · Cited by 210 · see citing works
KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS
Abdallah, C. G., Adams, T. G., Kelmendi, B., Esterlis, I., Sanacora, G., & Krystal, J. H. (2016) · Depression and Anxiety · doi:10.1002/da.22501 · Cited by 206 · see citing works
Self-citationGlutamate Metabolism in Major Depressive Disorder
Abdallah, C. G., Jiang, L., De Feyter, H. M., Fasula, M., Krystal, J. H., Rothman, D. L., Mason, G. F., & Sanacora, G. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010067 · Cited by 200 · see citing works
Self-citationGlutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies
Averill, L. A., Purohit, P., Averill, C. L., Boesl, M. A., Krystal, J. H., & Abdallah, C. G. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.064 · Cited by 184 · see citing works
Self-citationStress during development alters dendritic morphology in the nucleus accumbens and prefrontal cortex
Muhammad, A., Carroll, C., & Kolb, B. E. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.041 · Cited by 146 · see citing works
Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits
Tost, H., Braus, D. F., Hakimi, S., Ruf, M., Vollmert, C., Höhn, F., & Meyer‐Lindenberg, A. (2010) · Nature Neuroscience · doi:10.1038/nn.2572 · Cited by 127 · see citing works
Stress-Induced Changes in Nucleus Accumbens Glutamate Synaptic Plasticity
Campioni, M. R., Xu, M., & McGehee, D. S. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91111.2008 · Cited by 115 · see citing works
Role of the Brain's Reward Circuitry in Depression
Nestler, E. J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.07.003 · Cited by 108 · see citing works
Witkin, J. M., Monn, J. A., Schoepp, D. D., Li, X., Overshiner, C., Mitchell, S. N., Carter, G., Johnson, B., Rasmussen, K., & Rorick-Kehn, L. M. (2016) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.233627 · Cited by 105 · see citing works
Liem, F., Mérillat, S., Bezzola, L., Hirsiger, S., Philipp, M., Madhyastha, T. M., & Jäncke, L. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.12.035 · Cited by 100 · see citing works
Coplan, J. D., Gopinath, S., Abdallah, C. G., & Berry, B. R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00189 · Cited by 90 · see citing works
Self-citationEffects of Inhibitor of κB Kinase Activity in the Nucleus Accumbens on Emotional Behavior
Christoffel, D. J., Golden, S. A., Heshmati, M., Graham, A., Birnbaum, S., Neve, R. L., Hodes, G. E., & Russo, S. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.121 · Cited by 78 · see citing works
Hippocampal volume and the rapid antidepressant effect of ketamine
Abdallah, C. G., Salas, R., Jackowski, A., Baldwin, P., Sato, J. R., & Mathew, S. J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114544776 · Cited by 78 · see citing works
Self-citationLi, Y., Zhu, Z. R., Ou, B. C., Wang, Y. Q., Tan, Z. B., Deng, C. M., Gao, Y., Tang, M., So, J. H., Mu, Y., et al. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.11.016 · Cited by 72 · see citing works
Münte, T. F. (2008) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.011.2007 · Cited by 67 · see citing works
Abdallah, C. G., Jackowski, A., Sato, J. R., Mao, X., Kang, G., Cheema, R., Coplan, J. D., Mathew, S. J., & Shungu, D. C. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.025 · Cited by 67 · see citing works
Self-citationRéus, G. Z., Abelaira, H. M., dos Santos, M. A. B., Carlessi, A. S., Tomaz, D. B., Neotti, M. V., Liranço, J. L. G., Gubert, C., Barth, M., Kapczinski, F. P., et al. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.041 · Cited by 66 · see citing works
Abdallah, C. G., Coplan, J. D., Jackowski, A. P., Sato, J. R., Mao, X., Shungu, D. C., & Mathew, S. J. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.009 · Cited by 66 · see citing works
Self-citationWarren, B. L., Sial, O. K., Parise, L. F., Greenwood, M. A., Brewer, J. S., Rozofsky, J. P., Parise, E. M., & Bolaños‐Guzmán, C. A. (2014) · Developmental Neuroscience · doi:10.1159/000362875 · Cited by 59 · see citing works
The positive effect on ketamine as a priming adjuvant in antidepressant treatment
Melo, A., Kokras, N., Dalla, C., Ferreira, C., Ventura-Silva, A. P., Sousa, N., & Pêgo, J. M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.66 · Cited by 41 · see citing works
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Hashimoto, K. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12902 · Cited by 335 · see citing works
Marcantoni, W. S., Akouamba, B. S., Wassef, M., Mayrand, J., Lai, H., Richard‐Devantoy, S., & Beauchamp, S. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.007 · Cited by 246 · see citing works
Sex differences in antidepressant efficacy
LeGates, T. A., Kvarta, M. D., & Thompson, S. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0156-z · Cited by 225 · see citing works
Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.010 · Cited by 219 · see citing works
Self-citationMatveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209 · see citing works
Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin
Abdallah, C. G., Averill, L. A., Gueorguieva, R., Goktas, S., Purohit, P., Ranganathan, M., Sherif, M., Ahn, K.-H., D’Souza, D. C., Formica, R., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0644-9 · Cited by 184 · see citing works
Self-citationThe Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder
Abdallah, C. G., Averill, L. A., Akiki, T. J., Raza, M., Averill, C. L., Gomaa, H., Adikey, A., & Krystal, J. H. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021701 · Cited by 171 · see citing works
Self-citationNicosia, N., Giovenzana, M., Misztak, P., Mingardi, J., & Musazzi, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126521 · Cited by 135 · see citing works
Yao, N., Skiteva, O., Zhang, X., Svenningsson, P., & Chergui, K. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.239 · Cited by 118 · see citing works
The Nucleus Accumbens: A Common Target in the Comorbidity of Depression and Addiction
Xu, L., Nan, J., & Lan, Y. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00037 · Cited by 115 · see citing works
Abdallah, C. G., Averill, C. L., Salas, R., Averill, L. A., Baldwin, P. R., Krystal, J. H., Mathew, S. J., & Mathalon, D. H. (2017) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.04.006 · Cited by 111 · see citing works
Self-citationSynaptic Mechanisms Regulating Mood State Transitions in Depression
Parekh, P. K., Johnson, S. B., & Liston, C. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-040422 · Cited by 101 · see citing works
Air pollution exposure during pregnancy and childhood and brain morphology in preadolescents
Lubczynska, M. J., Muetzel, R. L., Marroun, H. E., Hoek, G., Kooter, I. M., Thomson, E. M., Hillegers, M. H. J., Vernooij, M. W., White, T. J. H., Tiemeier, H. W., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110446 · Cited by 100 · see citing works
Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary, M. M., Polosecki, P. I., Cecchi, G., DeAraujo, I. E., Barron, D. S., Constable, R. T., Whang, P. G., Thomas, D.-A. M., Mowafi, H. O., Small, D. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918682117 · Cited by 90 · see citing works
McIntyre, R. S., Loft, H., & Christensen, M. C. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s296451 · Cited by 87 · see citing works
Ding, Y., Chen, X., Chen, Z., Li, L., Li, X., Castellanos, F. X., Bai, T., Bo, Q., Cao, J., Chang, Z., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01995-x · Cited by 81 · see citing works
Liu, R., Wang, Y., Chen, X., Zhang, Z., Xiao, L., & Zhou, Y. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102599 · Cited by 79 · see citing works
Kang, M. J. Y., Hawken, E., & Vazquez, G. H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.860882 · Cited by 77 · see citing works
Zhou, Y., Zheng, W., Liu, W., Wang, C., Zhan, Y., Li, H., Chen, L., Li, M., & Ning, Y. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118798614 · Cited by 73 · see citing works
THERAPEUTIC MECHANISMS OF KETAMINE
Mihaljević, S., Pavlović, M., Reine, K., & Čačić, M. (2020) · Psychiatria Danubina · doi:10.24869/psyd.2020.325 · Cited by 72 · see citing works
The nucleus accumbens in reward and aversion processing: insights and implications
Xu, Y., Lin, Y., Yu, M., & Zhou, K. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1420028 · Cited by 77 · see citing works
Shin, D., Kim, H., Lee, S., Cho, Y., & Jung, W. (2024) · Journal of Medical Internet Research · doi:10.2196/54617 · Cited by 76 · see citing works
Johnston, J. N., Kadriu, B., Allen, J., Gilbert, J. R., Henter, I. D., & Zarate, C. A. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109422 · Cited by 68 · see citing works
Neurocognitive performance and repeated-dose intravenous ketamine in major depressive disorder
Zheng, W., Zhou, Y.-L., Liu, W.-J., Wang, C.-Y., Zhan, Y.-N., Li, H.-Q., Chen, L.-J., Li, M.-D., & Ning, Y.-P. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.12.005 · Cited by 64 · see citing works
GluN2A mediates ketamine-induced rapid antidepressant-like responses
Su, T., Lu, Y., Fu, C., Geng, Y., & Chen, Y. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01436-y · Cited by 63 · see citing works
Ketamine as a Treatment for Anorexia Nervosa: A Narrative Review
Keeler, J. L., Treasure, J. L., Juruena, M. F., Kan, C., & Himmerich, H. (2021) · Nutrients · doi:10.3390/nu13114158 · Cited by 56 · see citing works
Neurobiology of the rapid-acting antidepressant effects of ketamine: impact and opportunities
Shinohara, R., Aghajanian, G. K., & Abdallah, C. G. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.006 · Cited by 54 · see citing works
Self-citationSiegel, J. S., Palanca, B. J. A., Ances, B. M., Kharasch, E. D., Schweiger, J. A., Yingling, M. D., Snyder, A. Z., Nicol, G. E., Lenze, E. J., & Farber, N. B. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05762-6 · Cited by 50 · see citing works
Zhou, Y., Wu, F., Liu, W.-J., Zheng, W., Wang, C., Zhan, Y., Lan, X., & Ning, Y. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00945-9 · Cited by 49 · see citing works
Agnorelli, C., Spriggs, M. J., Godfrey, K., Sawicka, G., Bohl, B., Douglass, H. M., Fagiolini, A. M., Parastoo, H., Carhart-Harris, R. L., Nutt, D. J., et al. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106132 · Cited by 52 · see citing works
Liu, W., Zhou, Y., Zheng, W., Wang, C., Zhan, Y., Lan, X., Zhang, B., Li, H., Chen, L., & Ning, Y. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.012 · Cited by 45 · see citing works
Medeiros, G. C., Matheson, M., Demo, I., Reid, M. J., Matheson, S., Twose, C., Smith, G. S., Gould, T. D., Zarate, C. A., Barrett, F. S., et al. (2023) · The Lancet Psychiatry · doi:10.1016/s2215-0366(23)00183-9 · Cited by 49 · see citing works
Hu, Y., Zhao, C., Zhao, H., & Qiao, J. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04693-0 · Cited by 41 · see citing works
Imaging synaptic density in depression
Holmes, S. E., Abdallah, C., & Esterlis, I. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01368-4 · Cited by 39 · see citing works
Self-citationSydnor, V. J., Sylvain Bouix, A., Pasternak, O., Härtl, E., Levin-Gleba, L., Reid, B. E., Tripodis, Y., Guenette, J. P., Kaufmann, D., Makris, N., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102190 · Cited by 41 · see citing works
Guo, W., Machado‐Vieira, R., Mathew, S. J., Murrough, J. W., Charney, D. S., Grunebaum, M., Oquendo, M. A., Kadriu, B., Akula, N., Henter, I. D., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0311-7 · Cited by 38 · see citing works
Self-citationNeurobiological biomarkers of response to ketamine
Kadriu, B., Ballard, E. D., Henter, I. D., Murata, S., Gerlus, N., & Zarate, C. A. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.05.003 · Cited by 36 · see citing works
Roy, A. V., Thai, M., Klimes‐Dougan, B., Schreiner, M. W., Mueller, B. A., Albott, C. S., Lim, K. O., Fiecas, M. J. A., Tye, S. J., & Cullen, K. R. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120928203 · Cited by 36 · see citing works
Repurposing of Drugs–The Ketamine Story
Das, J. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01193 · Cited by 35 · see citing works
Ketamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression
Dai, D., Lacadie, C. M., Holmes, S. E., Cool, R., Anticevic, A., Averill, C., Abdallah, C., & Esterlis, I. (2020) · Chronic Stress · doi:10.1177/2470547020980681 · Cited by 34 · see citing works
Self-citationMisquitta, K. A., Miles, A. E., Prévot, T. D., Knoch, J., Fee, C., Newton, D. F., Ellegood, J., Lerch, J. P., Sibille, E. L., Nikolova, Y. S., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108562 · Cited by 34 · see citing works
Advances in novel molecular targets for antidepressants
Wang, Q., & Dwivedi, Y. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110041 · Cited by 32 · see citing works
Abdallah, C. G., Ahn, K.-H., Averill, L. A., Nemati, S., Averill, C. L., Fouda, S., Ranganathan, M., MORGAN, P. T., D’Souza, D. C., Mathalon, D. H., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00864-9 · Cited by 32 · see citing works
Self-citationSydnor, V. J., Lyall, A. E., Karayumak, S. C., Cheung, J. C., Felicione, J. M., Akeju, O., Shenton, M. E., Deckersbach, T., Ionescu, D. F., Pasternak, O., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01122-8 · Cited by 32 · see citing works
Lijffijt, M., Murphy, N., Iqbal, S., Green, C. E., Iqbal, T., Chang, L. C., Haile, C. N., Hirsch, L. C., Ramakrishnan, N., Fall, D. A., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01242-9 · Cited by 28 · see citing works
Self-citationRepurposing Ketamine in Depression and Related Disorders: Can This Enigmatic Drug Achieve Success?
Carboni, E., Carta, A. R., Carboni, E., & Novelli, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.657714 · Cited by 31 · see citing works
Zhou, Y., Wu, F., Wang, C., Zheng, W., Lan, X., Deng, X., & Ning, Y. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.06.068 · Cited by 28 · see citing works
Herrera-Meléndez, A. L., Stippl, A., Aust, S., Scheidegger, M., Seifritz, E., Heuser, I., Otte, C., Bajbouj, M., Grimm, S., & Gärtner, M. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.11.017 · Cited by 28 · see citing works
Neuroimaging-Derived Biomarkers of the Antidepressant Effects of Ketamine
Zavaliangos‐Petropulu, A., Al‐Sharif, N., Taraku, B., Leaver, A. M., Sahib, A. K., Espinoza, R. T., & Narr, K. L. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.11.005 · Cited by 28 · see citing works
Associations of Air Pollution on the Brain in Children: A Brain Imaging Study.
Guxens, M., Lubczynska, M. J., Pérez‐Crespo, L., Muetzel, R. L., Marroun, H. E., Basagaña, X., Hoek, G., & Tiemeier, H. W. (2022) · PubMed Central · Cited by 27 · see citing works
Wojtas, A., Bysiek, A., Wawrzczak‐Bargieła, A., Maćkowiak, M., & Gołembiowska, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010100 · Cited by 25 · see citing works
Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression?
Abdallah, C. G., & Krystal, J. H. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112628 · Cited by 23 · see citing works
Self-citationGallay, C. C., Forsyth, G., Can, A., Dutton, M., Jamieson, D., Jensen, E., Hermens, D. F., Bennett, M. R., & Lagopoulos, J. (2021) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2021.111369 · Cited by 20 · see citing works
Sex-Dependent Ketamine Addiction-Like Behavior Profile Following Exposure to Chronic Mild Stress
Wright, K. N., Hagarty, D. P., Strong, C. E., Schoepfer, K. J., & Kabbaj, M. (2019) · Chronic Stress · doi:10.1177/2470547019832613 · Cited by 20 · see citing works
Ji, M., Mao, M., Li, S., Zhang, L., Qiu, L., Li, B., Xia, J., & Yang, J. (2019) · Neuroreport · doi:10.1097/wnr.0000000000001219 · Cited by 19 · see citing works
The Downstaging Concept in Treatment-Resistant Depression: Spotlight on Ketamine
Wilkowska, A., & Cubała, W. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314605 · Cited by 19 · see citing works
Molecular and Medical Aspects of Psychedelics
Wojtas, A., & Gołembiowska, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010241 · Cited by 21 · see citing works
(2020) · Advances in Pharmacology · doi:10.1016/bs.apha.2020.04.003 · Cited by 18 · see citing works
Self-citationTranscranial magnetic stimulation and ketamine: implications for combined treatment in depression
Dębowska, W., Więdłocha, M., Dębowska, M. D., Kownacka, Z., Marcinowicz, P., & Szulc, A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1267647 · Cited by 21 · see citing works
Transient Dose-dependent Effects of Ketamine on Neural Oscillatory Activity in Wistar-Kyoto Rats
Manduca, J. D., Thériault, R.-K., Williams, O. O. F., Rasmussen, D. J., & Perreault, M. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.012 · Cited by 18 · see citing works
Ketamine and Zinc: Treatment of Anorexia Nervosa Via Dual NMDA Receptor Modulation
Mitchell, J., Hermens, D. F., Bennett, M. R., Can, A., & Lagopoulos, J. (2023) · CNS Drugs · doi:10.1007/s40263-022-00984-4 · Cited by 18 · see citing works
Calder, A. E., Hase, A., & Hasler, G. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02830-z · Cited by 17 · see citing works
Qiao, H., Yang, S., Xu, C. S., Ma, X., & An, S.-C. (2019) · Stress · doi:10.1080/10253890.2019.1673361 · Cited by 17 · see citing works
Diffusion tensor imaging brain structural clustering patterns in major depressive disorder
Xu, D., Xu, G., Zhao, Z., Sublette, M. E., Miller, J. M., & Mann, J. J. (2021) · Human Brain Mapping · doi:10.1002/hbm.25597 · Cited by 15 · see citing works
Negreira, A. M., & Abdallah, C. G. (2019) · Chronic Stress · doi:10.1177/2470547019829035 · Cited by 16 · see citing works
Self-citationTaraku, B., Loureiro, J. R., Sahib, A. K., Zavaliangos‐Petropulu, A., Al‐Sharif, N., Leaver, A. M., Wade, B., Joshi, S. H., Woods, R. P., Espinoza, R. T., et al. (2024) · Brain and Behavior · doi:10.1002/brb3.3511 · Cited by 15 · see citing works
Zhou, Y., Wang, C., Lan, X., Li, W., Chao, Z., Wu, K., McIntyre, R. S., & Ning, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.779326 · Cited by 15 · see citing works
Murray, K. D., Lin, Y., Makary, M. M., Whang, P. G., & Geha, P. (2021) · Molecular Pain · doi:10.1177/1744806921990938 · Cited by 15 · see citing works
Zhang, E., Hauson, A. O., Pollard, A. A., Meis, B., Lackey, N. S., Carson, B., Khayat, S., Fortea, L., & Raduà, J. (2023) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2023.111691 · Cited by 14 · see citing works
Carboni, E., & Carta, A. R. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2105144 · Cited by 14 · see citing works
Asch, R. H., Abdallah, C. G., Carson, R. E., & Esterlis, I. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-024-01913-3 · Cited by 13 · see citing works
Self-citationDoes mismatch negativity have utility for NMDA receptor drug development in depression?
Murphy, N., Lijffijt, M., Ramakrishnan, N., Vo-Le, B., Vo‐Le, B., Iqbal, S., Iqbal, T., O’Brien, B., Smith, M. A., Swann, A. C., et al. (2021) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-1685 · Cited by 12 · see citing works
Self-citationGuerrero-González, C., Cueto‐Ureña, C., Cantón-Habas, V., Ramı́rez-Expósito, M. J., & Martı́nez-Martos, J. M. (2024) · Physiologia · doi:10.3390/physiologia4010007 · Cited by 16 · see citing works
Kojic, M., Saelens, J., Kadriu, B., Zarate, C. A., & Kraus, C. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_313 · Cited by 12 · see citing works
Review of Herbal Medicines for the Treatment of Depression
Peng, S., Zhou, Y., Meng, L. M., & Wang, Q. (2022) · Natural Product Communications · doi:10.1177/1934578x221139082 · Cited by 11 · see citing works
Evans, J. W., Graves, M. C., Nugent, A. C., & Zarate, C. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-54370-9 · Cited by 9 · see citing works
Hippocampal subfield volumes predict treatment response to oral ketamine in people with suicidality
Dutton, M., Boyes, A., Can, A., Mohamed, A. Z., Hajishafiee, M., Shan, Z., Lagopoulos, J., & Hermens, D. F. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.11.040 · Cited by 9 · see citing works
Mavoglurant reduces cocaine use in patients with cocaine use disorder in a phase 2 clinical trial
Gomez‐Mancilla, B., Dürsteler, K. M., Vogel, M., Herdener, M., Torrens, M., Gálvez, B. P., Gual, A., Corral, R. M., Kuper, E., Mosca, D., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adi4505 · Cited by 8 · see citing works
Treatment-resistant depression and intranasal esketamine: Spanish consensus on theoretical aspects
Mora, F., Ramos‐Quiroga, J. A., Baca‐García, E., Crespo, J. M., Gutiérrez-Rojas, L., Madrazo, A., Pérez-Costillas, L., Sáiz, P. A., Tordera, V., & Vieta, E. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1623659 · Cited by 8 · see citing works
Long, Z., Li, J., & Marino, M. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.150 · Cited by 8 · see citing works
Zhuo, C., Lin, X., Tian, H., Liu, S., Bian, H., & Chen, C. (2020) · Brain and Behavior · doi:10.1002/brb3.1600 · Cited by 8 · see citing works
Hippocampal subfield volumes in treatment resistant depression and serial ketamine treatment
Zavaliangos-Petropulu, A., McClintock, S. M., Joshi, S., Taraku, B., Al-Sharif, N., Espinoza, R. T., & Narr, K. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1227879 · Cited by 7 · see citing works
Coplan, J. D., Lu, D., Sehamy, A. M. E., Tang, C. Y., Jackowski, A. P., Abdallah, C. G., Nemeroff, C. B., Owens, M. J., Mathew, S. J., & Gorman, J. M. (2018) · Chronic Stress · doi:10.1177/2470547018768450 · Cited by 7 · see citing works
Self-citationBarzilay, R., Rosen, A. F. G., Moore, T. M., Roalf, D. R., Satterthwaite, T. D., Calkins, M. E., Ruparel, K., Patrick, A., Scott, J. C., Wolf, D. H., et al. (2020) · Adversity and Resilience Science · doi:10.1007/s42844-020-00014-6 · Cited by 7 · see citing works
Li, Y., Zhang, B., Liu, Z., & Wang, R. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107500 · Cited by 7 · see citing works
Ketamina, un nuevo agente terapéutico para la depresión
Pérez‐Esparza, R., Kobayashi-Romero, L. F., Mendoza, A. M. G., Lamas-Aguilar, R., Sosa, M. V., Encarnación-Martínez, M., González-Manríquez, L. A., Eternod-Rodríguez, S. A., Maltos-Gómez, F., Vargas-Valencia, K. M., et al. (2020) · Revista de la Facultad de Medicina UNAM · doi:10.22201/fm.24484865e.2020.63.1.02 · Cited by 7 · see citing works
Hagarty, D. P., Dawoud, A., Guerrero, A. B., Phillips, K., Strong, C. E., Jennings, S. D., Crawford, M., Martinez, K., Csernecky, O., Saland, S. K., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110008 · Cited by 6 · see citing works
Ye, J., Lin, X., Jiang, D., Chen, M., Zhang, Y., Tian, H., Li, J., Zhuo, C., & Zhao, Y. (2019) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2019.1699726 · Cited by 6 · see citing works
Neurobiological Mechanisms of Ketamine: Depression, Suicide, Trauma, and Chronic Stress Pathologies
Averill, L. A., Averill, C. L., & Abdallah, C. G. (2020) · Psychiatric Annals · doi:10.3928/00485713-20200109-02 · Cited by 6 · see citing works
Self-citationPreclinical toxicological study of prolonged exposure to ketamine as an antidepressant
Zaccarelli‐Magalhães, J., Fukushima, A. R., Moreira, N. C. D. S., Manes, M., Abreu, G., Ricci, E. L., Waziry, P. A. F., & Spinosa, H. D. S. (2019) · Pharmacological Reports · doi:10.1007/s43440-019-00014-z · Cited by 6 · see citing works
Mastrodonato, A., Jin, M., Kee, N., Lanio, M., Tapia, J., Quintana, L., Zamora, A., Deng, S., Xu, X., Landry, D. W., et al. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.09.024 · Cited by 5 · see citing works
Elevated neuron specific enolase levels in post-traumatic stress disorder
Uysal, M., Ceylan, M. F., & Hesapçıoğlu, S. T. (2024) · European Journal of Pediatrics · doi:10.1007/s00431-024-05889-6 · Cited by 5 · see citing works
Li, Y., Chen, Z., Zhao, J., Yu, H., Chen, X., He, Y., Tian, Y., Wang, Y., Chen, C., Cheng, K., et al. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.862683 · Cited by 5 · see citing works
Chan, W.-L., Olbrich, S., Jiang, X., Zhang, H., Ip, C.-T., & Brunovský, M. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119477 · Cited by 5 · see citing works
Falkenberg, I., Bitsch, F., Liu, W., Matsingos, A., Noor, L., Vogelbacher, C., Yildiz, C., & Kircher, T. T. J. (2023) · Trials · doi:10.1186/s13063-023-07556-x · Cited by 4 · see citing works
Ketamine for unipolar depression: A systematic review of efficacy and safety
Peiris, T. E., Pokhrel, A., & Paudel, Y. (2025) · Australasian Psychiatry · doi:10.1177/10398562251328805 · Cited by 3 · see citing works
Teng, T., Wu, Q., Yin, B., Zhang, J., Li, X., Zhang, L., Zhou, X., & Xie, P. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01412-5 · Cited by 3 · see citing works
The role of immunometabolism in HIV-associated depression and cognitive impairment
Andalibi, M. S. S., & Ellis, R. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99744-7.00028-6 · Cited by 3 · see citing works
Updates on Preclinical and Translational Neuroscience of Mood Disorders
Mischel, N., Kritzer, M. D., Patkar, A. A., Masand, P. S., & Szabo, S. T. (2019) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001132 · Cited by 3 · see citing works
Research Progress on Neural Circuit Mechanisms of Depression
Gong, W. (2023) · BIO Web of Conferences · doi:10.1051/bioconf/20236002021 · Cited by 2 · see citing works
- Authors
- Abdallah, C. G., Jackowski, A., Salas, R., Gupta, S., Sato, J. R., Mao, X., Coplan, J. D., Shungu, D. C., & Mathew, S. J.
- Affiliations
- Yale University (US)
- Universidade Federal de São Paulo (BR)
- Michael E. DeBakey VA Medical Center (US)
- Universidade Federal do ABC (BR)
- Cornell University (US)
- SUNY Downstate Health Sciences University (US)
- Corresponding author
- Abdallah, Chadi G
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2017-03-08
- Volume
- 42
- Issue
- 8
- Pages
- 1739-1746
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5518908
- OpenAlex
- W2592351868
- Cited by
- 123
- References
- 41
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 16 · 2023: 17 · 2022: 13 · 2021: 15 · 2020: 28 · 2019: 11 · 2018: 7 · 2017: 3
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (1s10od021782-01, 5k23mh101498-05, MH-101498, UL1TR001863)
- National Center for PTSD, U.S. Department of Veterans Affairs
- National Institute of Mental Health (K23MH069656, K23MH-101498(, R01MH081870)
- National Center for Research Resources (M01RR000071)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- nucleus accumbens, major depressive disorder, ketamine, brain volume, hippocampus, depression remission, 1H NMR, animal models of depression
- MeSH terms
- Adult, Cross-Sectional Studies, Major Depressive Disorder, Female, Hippocampus, Humans, Hypertrophy, Ketamine, Functional Laterality, Longitudinal Studies, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Case-Control Studies, Glutamic Acid, Young Adult, Proton Magnetic Resonance Spectroscopy
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