Cited by 319Maternal Mental Health During Pregnancy and PostpartumBirth, Development, and HealthEpigenetics and DNA Methylation

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Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal Neurobehavior

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Monk, Catherine, Feng, Tianshu, Lee, Seonjoo, Krupska, Izabela, Champagne, Frances A., Tycko, Benjamin·2016·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2015.15091171PMC PMC5026410

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Abstract

OBJECTIVE: Increased risk of psychopathology is observed in children exposed to maternal prenatal distress, and elevated maternal cortisol and epigenetic regulation of placental glucocorticoid-pathway genes are potential mechanisms. The authors examined maternal distress and salivary cortisol in relation to fetal movement and heart rate ("coupling") and DNA methylation of three glucocorticoid pathway genes-HSD11B2, NR3C1, and FKBP5-in term placentas. METHOD: Mood questionnaires and salivary cortisol were collected from 61 women between 24-27 gestational weeks, and fetal assessment was conducted at 34-37 weeks. Placental CpG methylation in the three genes was analyzed using 450K Beadchips and bisulfite sequencing; correlations between maternal and fetal variables and DNA methylation were tested; and maternal distress effects on fetal behavior via DNA methylation were investigated. RESULTS: Perceived stress (Perceived Stress Scale), but not cortisol, was associated with altered CpG methylation in placentas. In the highest tertile of the Perceived Stress Scale, the Beadchip data revealed modestly elevated methylation of HSD11B2, associated with lower fetal coupling (β=-0.51), and modestly elevated methylation of FKBP5, also with lower fetal coupling (β=-0.47). These increases in methylation were validated by bisulfite sequencing, where they occurred in a minority of clones. CONCLUSIONS: This is the first study to link the effects of pregnant women's distress on the fetus and epigenetic changes in placental genes. Since increased DNA methylation in HSD11B2 and FKBP5 are seen in a minority of bisulfite sequencing clones, these epigenetic changes, and functional consequences, may affect subpopulations of placental cells.

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Authors: Monk, C., Feng, T., Lee, S., Krupska, I., Champagne, F. A., & Tycko, B.
Affiliations: Columbia University Irving Medical Center (US)
ORCID: Monk, Catherine
Feng, Tianshu
Lee, Seonjoo
Krupska, Izabela
Champagne, Frances A.
Tycko, Benjamin
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2016-07-01
Volume: 173
Issue: 7
Pages: 705-713
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2015.15091171
PMC: PMC5026410
OpenAlex: W2304339492
Cited by: 304
References: 40
Citations by year: 2026: 17 · 2025: 22 · 2024: 32 · 2023: 19 · 2022: 28 · 2021: 39 · 2020: 61 · 2019: 21 · 2018: 32 · 2017: 23 · 2016: 10
FWCI: 28.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH092580)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: maternal distress, prenatal stress, placenta, DNA methylation, glucocorticoid pathway, 11β-hydroxysteroid dehydrogenase type 2, NR3C1, FKBP5, fetal heart rate, fetal movement, fetal neurobehavior, salivary cortisol, epigenetic regulation
MeSH terms: Tacrolimus Binding Protein 5, Adolescent, Adult, Anxiety Disorders, Arousal, Depressive Disorder, Female, Fetal Movement, Heart Rate, Fetal, Humans, Hydrocortisone, Infant, Newborn, Placenta, Pregnancy, Pregnancy Trimester, Third, Prenatal Exposure Delayed Effects, Receptors, Glucocorticoid, CpG Islands, DNA Methylation, Mood Disorders, Tacrolimus Binding Proteins, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Epigenesis, Genetic, Young Adult

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Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal Neurobehavior

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