Customizing Treatment of Chronic Fatigue Syndrome and Fibromyalgia: The Role of Perpetuating Factors
Abstract
Background Syndromes characterized by chronic, medically unexplained fatigue, effort- and stress-intolerance, and widespread pain are highly prevalent in medicine.Results In chronic fatigue syndrome (CFS) and fibromyalgia (FM), various perpetuating factors may impair patients' quality of life and functioning and impede recovery. Although cognitive-behavioral and graded-exercise therapy are evidence-based treatments, the effectiveness and acceptability of therapeutic interventions in CFS/FM may largely depend on a customized approach taking the heterogeneity of perpetuating factors into account.Conclusion Further research should clarify the aim and outcome of different treatment strategies in CFS/FM, as well as the underlying mechanisms of change, including those facilitating neurobiological recovery.
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Symptom avoidance seems to be a general problem leading to disability and lower quality of life in patients with FSS.
“Symptom avoidance seems to be a general problem leading to disability and lower quality of life in patients with FSS.49”
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- Authors
- Houdenhove, B. V., & Luyten, P.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Corresponding author
- Houdenhove, Boudewijn van
- ORCID
- Luyten, Patrick
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 49
- Issue
- 6
- Pages
- 470-477
- ISSN
- 0033-3182 (ISSN-L)
- OpenAlex
- W2008875691
- Cited by
- 122
- References
- 85
- Citations by year
- 2026: 2 · 2024: 4 · 2022: 2 · 2021: 4 · 2020: 9 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 8 · 2013: 12 · 2012: 11
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- chronic fatigue syndrome, fibromyalgia, perpetuating factors, personalized treatment, cognitive behavioral therapy, graded exercise therapy, widespread pain, treatment acceptability, mechanisms of change
- MeSH terms
- Adaptation, Psychological, Exercise Therapy, Fibromyalgia, Humans, Fatigue Syndrome, Chronic, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Disease Management
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