The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
Psychiatric Symptoms Vary With the Severity of Dementia in Probable Alzheimer's Disease
Abstract
This cross-sectional study examines relationships among the constellation of psychiatric syndromes in Alzheimer's disease (AD) as a function of dementia severity in 1155 patients with probable AD. The frequency of major depression decreased in severe stages, while agitation, aggression, and psychosis were more frequent in late stages. Major depression was associated with anhedonia, sleep disorders, depressed mood, low self-esteem, anxiety, and hopelessness in mild/moderate and severe stages. Agitation was associated with aggression and psychosis in mild/moderate stages, and psychosis was associated with aggression in moderate/severe stages. In addition, there was a constellation of psychiatric symptoms (e.g., anxiety, wandering, irritability, inappropriate behavior, uncooperativeness, emotional lability) associated with agitation, aggression, and psychosis, which varied according to the severity of the dementia, suggesting a progressive deterioration of frontal-temporal limbic structures. Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages.
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“Interpretation of many MDD/AD risk studies, however, are complicated in that incipient or early AD can present clinically as apparent late-life depression in some cases (42).”
From Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans (2011) · cites this paper as [42]
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Behavioral and psychological symptoms of dementia
Cerejeira, J., Lagarto, L., & Mukaetova-Ladinska, E. B. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00073 · Cited by 1,425
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Predictors of progression from mild cognitive impairment to Alzheimer disease
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Metadata
- Authors
- Lopez, O. L., Becker, J. T., Sweet, R. A., Klunk, W., Kaufer, D. I., Saxton, J., Habeych, M., & DeKosky, S. T.
- Affiliations
- Received December 11, 2001; revised May 17, 2002; accepted May 24, 2002. From the Alzheimers Disease Research Center and the Departments of Psychiatry, Neurology, and Epidemiology, University of Pittsburgh School of Medicine, Pittsburg, Pennsylvania. Address correspondence to Dr. Oscar L. Lopez, Neuropsychology Research Program, 3501 Forbes Avenue, Suite 830 Pittsburgh, PA 15213; (E-mail).
- University of Pittsburgh (US)
- ORCID
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2003-08
- Volume
- 15
- Issue
- 3
- Pages
- 346-353
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W2163602955
- Cited by
- 286
- References
- 45
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 16 · 2021: 19 · 2020: 8 · 2019: 7 · 2018: 21 · 2017: 12 · 2016: 11 · 2015: 18 · 2014: 10 · 2013: 14 · 2012: 8
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ag003705-04)
- National Institute on Aging (AG 05-133, P50AG005133, AG 03705)
- National Institute of Mental Health (K02MH001077, K02-MH-01077)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- Alzheimer's disease, dementia severity, psychiatric symptoms, major depressive disorder, agitation, aggression, psychosis, anhedonia, sleep disorders, anxiety, wandering, emotional lability, race
- MeSH terms
- Aggression, Alzheimer Disease, Mental Disorders, Cognition Disorders, Dementia, Depression, Female, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychomotor Agitation, Psychotic Disorders, Severity of Illness Index, Comorbidity, Chi-Square Distribution
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