CoChat
Sign Up
Cited by 286Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsHistorical and Modern Theater Studies

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Psychiatric Symptoms Vary With the Severity of Dementia in Probable Alzheimer's Disease

Lopez, Oscar L., Becker, James T., Sweet, Robert A., Klunk, William, Kaufer, Daniel I., Saxton, Judith, Habeych, Miguel, DeKosky, Steven T.·2003·The Journal of Neuropsychiatry and Clinical Neurosciences
DOI 10.1176/jnp.15.3.346
Open this paper in CoChat — free account

Abstract

This cross-sectional study examines relationships among the constellation of psychiatric syndromes in Alzheimer's disease (AD) as a function of dementia severity in 1155 patients with probable AD. The frequency of major depression decreased in severe stages, while agitation, aggression, and psychosis were more frequent in late stages. Major depression was associated with anhedonia, sleep disorders, depressed mood, low self-esteem, anxiety, and hopelessness in mild/moderate and severe stages. Agitation was associated with aggression and psychosis in mild/moderate stages, and psychosis was associated with aggression in moderate/severe stages. In addition, there was a constellation of psychiatric symptoms (e.g., anxiety, wandering, irritability, inappropriate behavior, uncooperativeness, emotional lability) associated with agitation, aggression, and psychosis, which varied according to the severity of the dementia, suggesting a progressive deterioration of frontal-temporal limbic structures. Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages.

Overview

Integrity signals

Registry

Crossref · 10.1176/jnp.15.3.346

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 45 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Lopez, O. L., Becker, J. T., Sweet, R. A., Klunk, W., Kaufer, D. I., Saxton, J., Habeych, M., & DeKosky, S. T.
Affiliations
  • Received December 11, 2001; revised May 17, 2002; accepted May 24, 2002. From the Alzheimers Disease Research Center and the Departments of Psychiatry, Neurology, and Epidemiology, University of Pittsburgh School of Medicine, Pittsburg, Pennsylvania. Address correspondence to Dr. Oscar L. Lopez, Neuropsychology Research Program, 3501 Forbes Avenue, Suite 830 Pittsburgh, PA 15213; (E-mail).
  • University of Pittsburgh (US)
ORCID
Venue
The Journal of Neuropsychiatry and Clinical Neurosciences
Publisher
American Psychiatric Association Publishing
Published
2003-08
Volume
15
Issue
3
Pages
346-353
ISSN
  • 0895-0172 (ISSN-L)
  • 1545-7222
DOI
10.1176/jnp.15.3.346
OpenAlex
W2163602955
Cited by
286
References
45
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 16 · 2021: 19 · 2020: 8 · 2019: 7 · 2018: 21 · 2017: 12 · 2016: 11 · 2015: 18 · 2014: 10 · 2013: 14 · 2012: 8
FWCI
6.96
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuropsychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01ag003705-04)
  • National Institute on Aging (AG 05-133, P50AG005133, AG 03705)
  • National Institute of Mental Health (K02MH001077, K02-MH-01077)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
Alzheimer's disease, dementia severity, psychiatric symptoms, major depressive disorder, agitation, aggression, psychosis, anhedonia, sleep disorders, anxiety, wandering, emotional lability, race
MeSH terms
Aggression, Alzheimer Disease, Mental Disorders, Cognition Disorders, Dementia, Depression, Female, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychomotor Agitation, Psychotic Disorders, Severity of Illness Index, Comorbidity, Chi-Square Distribution

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review