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Factors Affecting Wound Healing
Open accessAbstract
Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds.
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In the citing paper
“Moreover, tissue repair and wound healing are impaired in old individuals (Guo and Dipietro, 2010)”
From An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA (2014) · cites this paper as Guo and Dipietro, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Monocytes migrate from capillary to ECM where, under the influence of inflammatory mediators, such as TGF- β and products of fibrin and fibronectin degradation coming from the “temporary” wound matrix, they undergo a transformation into macrophages [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
Experimental — accuracy not yet measuredIn the citing paper
“The default mammalian host response following tissue injury is a well-documented series of events that typically result in the deposition of dense fibrous connective tissue (i.e., scar tissue) within the site of injury [85–87].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [87]
In the citing paper
“Wound healing proceeds through four, but overlapping, phases, such as hemostasis, inflammation, proliferation (also known as replication and synthesis stage), and remodeling [3, 36].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“The aggregated platelets, “trapped” in the provisional matrix, release, from α granules, numerous growth factors, such as PDGF, TGF-α, TGF-β, bFGF, IGF-1, and VEGF [3, 35, 36, 43].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“They are formed mainly from nondifferentiated mesenchymal cells, residing in the dermis, which, under the influence of cytokines and growth factors, released from blood platelets, neutrophils, and macrophages, undergoes a transformation into fibroblasts [3, 64, 65].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“After hemostasis and inflammatory phases, which have lasted from 2 to 3 days, the process of rebuilding the damaged tissue is intensified [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“In the late inflammatory phase, lymphocytes also infiltrate the wound environment influencing fibroblast proliferation and collagen biosynthesis [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“they are the main source of cytokines and growth factors stimulating the proliferation of fibroblasts and collagen biosynthesis [3, 36, 57–59].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
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Metadata
- Authors
- Guo, S., & DiPietro, L. A.
- Affiliations
- University of Illinois Chicago (US)
- ORCID
- DiPietro, L.A.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2010-02-05
- Volume
- 89
- Issue
- 3
- Pages
- 219-229
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC2903966
- OpenAlex
- W1986308133
- Semantic Scholar
- 47c5693c66389291d022effc62157ccb07c4a29f
- Cited by
- 5,792
- References
- 108
- Citations by year
- 2026: 503 · 2025: 616 · 2024: 609 · 2023: 624 · 2022: 568 · 2021: 510 · 2020: 421 · 2019: 404 · 2018: 354 · 2017: 308 · 2016: 238 · 2015: 216 · 2014: 176 · 2013: 120 · 2012: 75
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p20gm078426-04)
- National Institute of General Medical Sciences (R01-GM-50875, R01GM050875, P20‐GM078426)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- wound healing, delayed wound healing, skin wound healing, hemostasis, inflammation, proliferation, tissue remodeling, oxygenation, wound infection, sex hormones, age, stress, diabetes mellitus, obesity, medication, alcoholism, smoking, nutrition, cellular and molecular mechanisms
- MeSH terms
- Aged, Animals, Body Constitution, Hemostasis, Humans, Inflammation, Middle Aged, Regeneration, Wound Healing, Cell Proliferation
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