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Factors Affecting Wound Healing
Open accessAbstract
Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds.
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In the citing paper
“Moreover, tissue repair and wound healing are impaired in old individuals (Guo and Dipietro, 2010)”
From An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA (2014) · cites this paper as Guo and Dipietro, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Monocytes migrate from capillary to ECM where, under the influence of inflammatory mediators, such as TGF- β and products of fibrin and fibronectin degradation coming from the “temporary” wound matrix, they undergo a transformation into macrophages [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
Experimental — accuracy not yet measuredIn the citing paper
“The default mammalian host response following tissue injury is a well-documented series of events that typically result in the deposition of dense fibrous connective tissue (i.e., scar tissue) within the site of injury [85–87].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [87]
In the citing paper
“Wound healing proceeds through four, but overlapping, phases, such as hemostasis, inflammation, proliferation (also known as replication and synthesis stage), and remodeling [3, 36].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“The aggregated platelets, “trapped” in the provisional matrix, release, from α granules, numerous growth factors, such as PDGF, TGF-α, TGF-β, bFGF, IGF-1, and VEGF [3, 35, 36, 43].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“They are formed mainly from nondifferentiated mesenchymal cells, residing in the dermis, which, under the influence of cytokines and growth factors, released from blood platelets, neutrophils, and macrophages, undergoes a transformation into fibroblasts [3, 64, 65].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“After hemostasis and inflammatory phases, which have lasted from 2 to 3 days, the process of rebuilding the damaged tissue is intensified [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“In the late inflammatory phase, lymphocytes also infiltrate the wound environment influencing fibroblast proliferation and collagen biosynthesis [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“they are the main source of cytokines and growth factors stimulating the proliferation of fibroblasts and collagen biosynthesis [3, 36, 57–59].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
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Citations
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
Cellular and molecular basis of wound healing in diabetes
Brem, H., & Tomic‐Canic, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32169 · Cited by 1,863
The Basic Science of Wound Healing
Broughton, G., Janis, J. E., & Attinger, C. E. (2006) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000225430.42531.c2 · Cited by 1,519 · cited 1×
“wound (chemotaxis) and promote the inflammatory phase, which is characterized by the sequential infiltration of neutrophils, macrophages, and lymphocytes (Gosain and DiPietro, 2004; Broughton et al., 2006; Campos et al., 2008).”
BackgroundGosain, A., & DiPietro, L. A. (2004) · World Journal of Surgery · doi:10.1007/s00268-003-7397-6 · Cited by 1,104
Self-citationSlowing of wound healing by psychological stress
Kiecolt-Glaser, J. K., Marucha, P. T., Mercado, A. M., Malarkey, W. B., & Glaser, R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92899-5 · Cited by 1,104
Edwards, R., & Harding, K. G. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200404000-00004 · Cited by 1,099
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
Sternberg, E. M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1810 · Cited by 1,064
Oxidative Stress in the Pathogenesis of Diabetic Neuropathy
Vincent, A. M., Russell, J. W., Low, P. A., & Feldman, E. L. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0019 · Cited by 1,001
Why chronic wounds will not heal: a novel hypothesis
Bjarnsholt, T., Kirketerp‐Møller, K., Jensen, P. Ø., Madsen, K. G., Phipps, R. K., Krogfelt, K. A., Høiby, N., & Givskov, M. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00283.x · Cited by 886
Research works printed but not linked: 2
- 10.1097/00042728-200809000-00001 · DOI
- Waldron DR, Zimmerman-Pope N (2003). Superficial skin wounds. In: Textbook of small animal surgery . Slatter DH, editor. NY: Saunders, pp 260–271.
Cited by
Sorted by citations
Pathophysiology of acute wound healing
Li, J., Chen, J., & Kirsner, R. S. (2007) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2006.09.007 · Cited by 4,042
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045
“Moreover, tissue repair and wound healing are impaired in old individuals (Guo and Dipietro, 2010), and the matrix metalloproteinases that comprise the SASP (Coppé et al.”
Immune regulation by glucocorticoids
Cain, D. W., & Cidlowski, J. A. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.1 · Cited by 1,846
Selvaraj, D., Padma, V. V., & Santhini, E. (2015) · Biomedicine · doi:10.7603/s40681-015-0022-9 · Cited by 1,533
Dunnill, C., Patton, T., Brennan, J. J., Barrett, J., Dryden, M., Cooke, J., Leaper, D. J., & Georgopoulos, N. T. (2015) · International Wound Journal · doi:10.1111/iwj.12557 · Cited by 1,392
Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration
Tottoli, E. M., Dorati, R., Genta, I., Chiesa, E., Pisani, S., & Conti, B. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080735 · Cited by 1,436
Human Wounds and Its Burden: An Updated Compendium of Estimates
Sen, C. K. (2019) · Advances in Wound Care · doi:10.1089/wound.2019.0946 · Cited by 1,204
Diabetes and Wound Angiogenesis
Okonkwo, U. A., & DiPietro, L. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071419 · Cited by 1,071
Self-citationMathew‐Steiner, S. S., Roy, S., & Sen, C. K. (2021) · Bioengineering · doi:10.3390/bioengineering8050063 · Cited by 1,080
Advanced Therapeutic Dressings for Effective Wound Healing—A Review
Boateng, J. S., & Catanzano, O. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24610 · Cited by 983
Diabetic Wound-Healing Science
Burgess, J. L., Wyant, W. A., Abujamra, B. A., Kirsner, R. S., & Jozic, I. (2021) · Medicina · doi:10.3390/medicina57101072 · Cited by 1,024
Brown, B. N., Ratner, B. D., Goodman, S. B., Amar, S., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.034 · Cited by 926
Recent advances on antimicrobial wound dressing: A review
Simões, D., Miguel, S. P., Ribeiro, M. P., Coutinho, P., Mendonça, A., & Correia, I. J. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.02.022 · Cited by 963
Liu, H., Wang, C., Li, C., Qin, Y., Wang, Z., Yang, F., Li, Z., & Wang, J. (2018) · RSC Advances · doi:10.1039/c7ra13510f · Cited by 947
Wang, C., Wang, M., Xu, T., Zhang, X., Lin, C., Gao, W., Xu, H., Lei, B., & Mao, C. (2018) · Theranostics · doi:10.7150/thno.29766 · Cited by 925
The wound microbiota: microbial mechanisms of impaired wound healing and infection
Uberoi, A., McCready-Vangi, A. R., & Grice, E. A. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01035-z · Cited by 963
Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering
Yu, R., Zhang, H., & Guo, B. (2021) · Nano-Micro Letters · doi:10.1007/s40820-021-00751-y · Cited by 911
Aderibigbe, B. A., & Buyana, B. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10020042 · Cited by 855
Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
Hesketh, M., Sahin, K. B., West, Z. E., & Murray, R. Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071545 · Cited by 852
Drug delivery systems and materials for wound healing applications
Saghazadeh, S., Rinoldi, C., Schot, M., Kashaf, S. S., Sharifi, F., Jalilian, E., Nuutila, K., Giatsidis, G., Mostafalu, P., Derakhshandeh, H., et al. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.008 · Cited by 888
Shafey, A. M. E. (2020) · Green Processing and Synthesis · doi:10.1515/gps-2020-0031 · Cited by 869
Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review
Moura, L. I. F., Dias, A. M. A., Carvalho, E., & de Sousa, H. C. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.03.033 · Cited by 801
Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review
Hamedi, H., Moradi, S., Hudson, S. M., & Tonelli, A. E. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.06.114 · Cited by 772
Treatment Strategies for Infected Wounds
Neguț, I., Grumezescu, V., & Grumezescu, A. M. (2018) · Molecules · doi:10.3390/molecules23092392 · Cited by 763
Hypertrophic scarring: the greatest unmet challenge after burn injury
Finnerty, C. C., Jeschke, M. G., Branski, L. K., Barret, J. P., Dziewulski, P. G., & Herndon, D. N. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31406-4 · Cited by 732
Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies
Rousselle, P., Braye, F., & Dayan, G. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.019 · Cited by 679
Advanced drug delivery systems and artificial skin grafts for skin wound healing
Kim, H. S., Sun, X., Lee, J., Kim, H., Fu, X., & Leong, K. W. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.014 · Cited by 639
Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing
Pakyari, M., Farrokhi, A., Maharlooei, M. K., & Ghahary, A. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0406 · Cited by 615
Sanchez, M. C. C., Lancel, S., Boulanger, É., & Nevière, R. (2018) · Antioxidants · doi:10.3390/antiox7080098 · Cited by 584
Kular, J. K., Basu, S., & Sharma, R. I. (2014) · Journal of Tissue Engineering · doi:10.1177/2041731414557112 · Cited by 585
Jahromi, M. A. M., Zangabad, P. S., Basri, S. M. M., Zangabad, K. S., Ghamarypour, A., Aref, A. R., Karimi, M., & Hamblin, M. R. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.08.001 · Cited by 566
Wang, M., Wang, C., Chen, M., Xi, Y., Cheng, W., Mao, C., Xu, T., Zhang, X., Lin, C., Gao, W., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b03656 · Cited by 556
Experimental models and methods for cutaneous wound healing assessment
Masson‐Meyers, D. S., de Andrade, T. A. M., Caetano, G. F., Guimarães, F. R., Leite, M. N., Leite, S. N., & Frade, M. A. C. (2020) · International Journal of Experimental Pathology · doi:10.1111/iep.12346 · Cited by 560
Traditional Therapies for Skin Wound Healing
Pereira, R. F., & Bártolo, P. (2014) · Advances in Wound Care · doi:10.1089/wound.2013.0506 · Cited by 557
Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
Dehkordi, A. N., Mirahmadi, F., Chehelgerdi, M., & Dehkordi, S. R. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1212-2 · Cited by 561
Synthetic polymeric biomaterials for wound healing: a review
Mir, M., Ali, M. N., Barakullah, A., Gulzar, A., Arshad, M., Fatima, S., & Asad, M. (2018) · Progress in Biomaterials · doi:10.1007/s40204-018-0083-4 · Cited by 527
Selection of Appropriate Wound Dressing for Various Wounds
Shi, C., Wang, C., Liu, H., Li, Q., Li, R., Zhang, Y., Liu, Y., Shao, Y., & Wang, J. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00182 · Cited by 522
Platelet-Rich Fibrin and Soft Tissue Wound Healing: A Systematic Review
Miron, R. J., Fujioka‐Kobayashi, M., Bishara, M., Zhang, Y., Hernandez, M., & Choukroun, J. (2016) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0233 · Cited by 520
Nitric Oxide Therapy for Diabetic Wound Healing
Malone‐Povolny, M. J., Maloney, S. E., & Schoenfisch, M. H. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801210 · Cited by 515
The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review
Diller, R. B., & Tabor, A. J. (2022) · Biomimetics · doi:10.3390/biomimetics7030087 · Cited by 550
Cutaneous wound healing: recruiting developmental pathways for regeneration
Bielefeld, K. A., Amini‐Nik, S., & Alman, B. A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1152-9 · Cited by 491
Vasvani, S., Kulkarni, P., & Rawtani, D. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.066 · Cited by 492
Exosomes from adipose‐derived stem cells and application to skin wound healing
An, Y., Lin, S., Tan, X.-J., Zhu, S., Nie, F., Zhen, Y., Gu, L., Zhang, C., Wang, B., Wei, W., et al. (2021) · Cell Proliferation · doi:10.1111/cpr.12993 · Cited by 477
Regulation of Collagen I and Collagen III in Tissue Injury and Regeneration
Singh, D., Rai, V., & Agrawal, D. K. (2023) · Cardiology and Cardiovascular Medicine · doi:10.26502/fccm.92920302 · Cited by 519
Biomedical materials for wound dressing: recent advances and applications
Nguyen, H. M., Le, T. T. N., Nguyen, A. T., Le, N. T. H., & Pham, T. T. (2023) · RSC Advances · doi:10.1039/d2ra07673j · Cited by 501
Development of novel alginate based hydrogel films for wound healing applications
Pereira, R. F., Carvalho, A., Vaz, D. C., Gil, M. H., Mendes, A., & Bártolo, P. (2012) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2012.09.031 · Cited by 453
Zhang, T., Wang, X., Wang, Z., Lou, D., Fang, Q., Hu, Y., Zhao, W.-Y., Zhang, L., Wu, L., & Tan, W. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110287 · Cited by 463
Tu, Z., Chen, M., Wang, M., Shao, Z., Jiang, X., Wang, K., Yao, Z., Yang, S., Zhang, X., Gao, W., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100924 · Cited by 430
Hydrogel-based commercial products for biomedical applications: A review
Cascone, S., & Lamberti, G. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118803 · Cited by 422
Vijayakumar, V., Samal, S. K., Mohanty, S., & NAYAK, S. K. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.10.120 · Cited by 422
Oxygen and Air Nanobubble Water Solution Promote the Growth of Plants, Fishes, and Mice
Ebina, K., Shi, K., Hirao, M., Hashimoto, J., Kawato, Y., Kaneshiro, S., Morimoto, T., Koizumi, K., & Yoshikawa, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065339 · Cited by 409
Design Challenges in Polymeric Scaffolds for Tissue Engineering
Echeverria Molina, M. I., Malollari, K. G., & Komvopoulos, K. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.617141 · Cited by 397
The role of the extracellular matrix components in cutaneous wound healing
Olczyk, P., Mencner, Ł., & Komosinska-Vassev, K. (2014) · BioMed Research International · doi:10.1155/2014/747584 · Cited by 387
The plasma jet kINPen – A powerful tool for wound healing
Bekeschus, S., Schmidt, A., Weltmann, K., & von Woedtke, T. (2016) · Clinical Plasma Medicine · doi:10.1016/j.cpme.2016.01.001 · Cited by 395
Mogana, R., Adhikari, A., Tzar, M. N., Ramli, R., & Wiart, C. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-2837-5 · Cited by 391
A review on nanoparticle based treatment for wound healing
Rajendran, N. K., Kumar, S. S. D., Houreld, N. N., & Abrahamse, H. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.01.009 · Cited by 409
Zhu, J., Li, F., Wang, X., Yu, J., & Wu, D. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18927 · Cited by 376
Matrix remodeling by MMPs during wound repair
Rohani, M. G., & Parks, W. C. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.03.002 · Cited by 407
Biopolymers: Applications in wound healing and skin tissue engineering
Sahana, T. G., & Rekha, P. D. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4296-3 · Cited by 384
Role of adipose‐derived stem cells in wound healing
Hassan, W., Greiser, U., & Wang, W.-X. (2014) · Wound Repair and Regeneration · doi:10.1111/wrr.12173 · Cited by 354
Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism
Shyh‐Chang, N., Zhu, H., de Soysa, Y., Shinoda, G., Seligson, M. T., Tsanov, K. M., Nguyen, L. H., Asara, J. M., Cantley, L. C., & Daley, G. Q. (2013) · Cell · doi:10.1016/j.cell.2013.09.059 · Cited by 368
Regeneration of Dental-Pulp-like Tissue by Chemotaxis-Induced Cell Homing
Kim, J. Y., Xin, X., Moioli, E. K., Chung, J., Lee, C., Chen, M., Fu, S. Y., Koch, P. D., & Mao, J. J. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0181 · Cited by 363
Penna, M., Hompes, R., Arnold, S., Wynn, G., Austin, R. C. T., Warusavitarne, J. H., Moran, B. J., Hanna, G. B., Mortensen, N., & Tekkis, P. P. (2018) · Annals of Surgery · doi:10.1097/sla.0000000000002653 · Cited by 358
Wound dressings functionalized with silver nanoparticles: promises and pitfalls
Kalantari, K., Mostafavi, E., Afifi, A. M., Izadiyan, Z., Jahangirian, H., Rafiee-Moghaddam, R., & Webster, T. J. (2019) · Nanoscale · doi:10.1039/c9nr08234d · Cited by 356
Bioprinting: From Tissue and Organ Development to in Vitro Models
Mota, C., Camarero‐Espinosa, S., Baker, M. B., Wieringa, P. A., & Moroni, L. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00789 · Cited by 359
Ayuk, S. M., Abrahamse, H., & Houreld, N. N. (2016) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2016.05.027 · Cited by 346
Ansari, M. J., Rajendran, R. R., Mohanto, S., Agarwal, U., Panda, K., Dhotre, K., Manne, R., Deepak, A., Zafar, A., Yasir, M., et al. (2022) · Gels · doi:10.3390/gels8070454 · Cited by 368
Diabetes as a potential risk for periodontitis: association studies
Genco, R. J., & Borgnakke, W. S. (2020) · Periodontology 2000 · doi:10.1111/prd.12270 · Cited by 345
Xu, X., Zhang, D., Oswald, B. E., Carrim, N., Wang, X., Hou, Y., Zhang, Q., Lavalle, C., McKeown, T., Marshall, A. H., et al. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2016.1200008 · Cited by 355
Advanced Biofabrication Strategies for Skin Regeneration and Repair
Pereira, R. F., Barrias, C. C., Granja, P. L., & Bártolo, P. (2013) · Nanomedicine · doi:10.2217/nnm.13.50 · Cited by 336
The production and application of hydrogels for wound management: A review
Gupta, A., Kowalczuk, M. M., Heaselgrave, W., Britland, S. T., Martin, C., & Radecka, I. (2018) · European Polymer Journal · doi:10.1016/j.eurpolymj.2018.12.019 · Cited by 349
Smart Bandages: The Future of Wound Care
Derakhshandeh, H., Kashaf, S. S., Aghabaglou, F., Ghanavati, I., & Tamayol, A. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.07.007 · Cited by 320
Liu, J., Chen, Z., Wang, J., Li, R., Li, T., Chang, M., Yan, F., & Wang, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b03868 · Cited by 310
Phillip, J. M., Aifuwa, I., Walston, J. D., & Wirtz, D. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071114-040829 · Cited by 304
The Exosome ‐ A Naturally Secreted Nanoparticle and its Application to Wound Healing
Rani, S., & Ritter, T. (2015) · Advanced Materials · doi:10.1002/adma.201504009 · Cited by 295
Recent advances in molecular mechanisms of skin wound healing and its treatments
Mamun, A. A., Shao, C., Geng, P., Wang, S., & Xiao, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1395479 · Cited by 338
Kocher, T., König, J., Borgnakke, W. S., Pink, C., & Meisel, P. (2018) · Periodontology 2000 · doi:10.1111/prd.12235 · Cited by 310
Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies
Gushiken, L. F. S., Beserra, F. P., Bastos, J. K., Jackson, C. J., & Pellizzon, C. H. (2021) · Life · doi:10.3390/life11070665 · Cited by 332
Microbiome in healthy skin, update for dermatologists
Dréno, B., Araviiskaia, E., Berardesca, E., Gontijo, G., Sanchez Viera, M., Xiang, L. F., Martin, R., & Bieber, T. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13965 · Cited by 292
Biopolymer-based biomaterials for accelerated diabetic wound healing: A critical review
Shah, S. A., Sohail, M. F., Khan, S., Minhas, M. U., de Matas, M., Sikstone, V., Hussain, Z., Abbasi, M., & Kousar, M. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.08.007 · Cited by 301
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Gholipourmalekabadi, M., Sapru, S., Samadikuchaksaraei, A., Reis, R. L., Kaplan, D. L., & Kundu, S. C. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.09.003 · Cited by 292
Huang, H., Feng, W., & Chen, Y. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01138j · Cited by 289
Avishai, E., Yeghiazaryan, K., & Golubnitschaja, O. (2017) · The EPMA Journal · doi:10.1007/s13167-017-0081-y · Cited by 298
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Sundaramurthi, D., Krishnan, U. M., & Sethuraman, S. (2014) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2014.881374 · Cited by 282
Baltazar, T., Merola, J., Catarino, C. M., Xie, C. B., Kirkiles-Smith, N. C., Lee, V., Hotta, S. Y. K., Dai, G., Xu, X., Ferreira, F. C., et al. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2019.0201 · Cited by 299
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Zulkefli, N., Zahari, C. N. M. C., Sayuti, N. H., Kamarudin, A. A., Saad, N., Hamezah, H. S., Bunawan, H., Baharum, S. N., Mediani, A., Ahmed, Q. U., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054607 · Cited by 334
Hattori, Y., Falgout, L., Lee, W., Jung, S., Poon, E., Lee, J. W., Na, I., Geisler, A., Sadhwani, D., Zhang, Y., et al. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400073 · Cited by 279
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López, R., Smith, P. C., Göstemeyer, G., & Schwendicke, F. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12683 · Cited by 291
Maleki, A., Ghomi, M., Nikfarjam, N., Akbari, M., Sharifi, E., Shahbazi, M., Kermanian, M., Seyedhamzeh, M., Zare, E. N., Mehrali, M., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202203430 · Cited by 267
Brown, B. N., & Badylak, S. F. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.10.025 · Cited by 269
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Ahmad, A., & Nawaz, M. I. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30344 · Cited by 274
Khatami, M., Varma, R. S., Zafarnia, N., Yaghoobi, H., Sarani, M., & Kumar, V. (2018) · Sustainable Chemistry and Pharmacy · doi:10.1016/j.scp.2018.08.001 · Cited by 261
Delgado, L. M., Bayon, Y., Pandit, A., & Zeugolis, D. I. (2015) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2014.0290 · Cited by 272
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Sicari, B. M., Dziki, J. L., Siu, B. F., Medberry, C. J., Dearth, C. L., & Badylak, S. F. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.060 · Cited by 255
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Mostafalu, P., Kiaee, G., Giatsidis, G., Khalilpour, A., Nabavinia, M., Dokmeci, M. R., Sonkusale, S., Orgill, D. P., Tamayol, A., & Khademhosseini, A. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201702399 · Cited by 258
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Metadata
- Authors
- Guo, S., & DiPietro, L. A.
- Affiliations
- University of Illinois Chicago (US)
- ORCID
- DiPietro, L.A.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2010-02-05
- Volume
- 89
- Issue
- 3
- Pages
- 219-229
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC2903966
- OpenAlex
- W1986308133
- Semantic Scholar
- 47c5693c66389291d022effc62157ccb07c4a29f
- Cited by
- 5,792
- References
- 108
- Citations by year
- 2026: 503 · 2025: 616 · 2024: 609 · 2023: 624 · 2022: 568 · 2021: 510 · 2020: 421 · 2019: 404 · 2018: 354 · 2017: 308 · 2016: 238 · 2015: 216 · 2014: 176 · 2013: 120 · 2012: 75
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p20gm078426-04)
- National Institute of General Medical Sciences (R01-GM-50875, R01GM050875, P20‐GM078426)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- wound healing, delayed wound healing, skin wound healing, hemostasis, inflammation, proliferation, tissue remodeling, oxygenation, wound infection, sex hormones, age, stress, diabetes mellitus, obesity, medication, alcoholism, smoking, nutrition, cellular and molecular mechanisms
- MeSH terms
- Aged, Animals, Body Constitution, Hemostasis, Humans, Inflammation, Middle Aged, Regeneration, Wound Healing, Cell Proliferation
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