The DOI matches its Crossref record; 107 of the 108 references it cites were found in a registry or an index.
Factors Affecting Wound Healing
Open accessAbstract
Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds.
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In the citing paper
“Moreover, tissue repair and wound healing are impaired in old individuals (Guo and Dipietro, 2010)”
From An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA (2014) · cites this paper as Guo and Dipietro, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Monocytes migrate from capillary to ECM where, under the influence of inflammatory mediators, such as TGF- β and products of fibrin and fibronectin degradation coming from the “temporary” wound matrix, they undergo a transformation into macrophages [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
Experimental — accuracy not yet measuredIn the citing paper
“The default mammalian host response following tissue injury is a well-documented series of events that typically result in the deposition of dense fibrous connective tissue (i.e., scar tissue) within the site of injury [85–87].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [87]
In the citing paper
“Wound healing proceeds through four, but overlapping, phases, such as hemostasis, inflammation, proliferation (also known as replication and synthesis stage), and remodeling [3, 36].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“The aggregated platelets, “trapped” in the provisional matrix, release, from α granules, numerous growth factors, such as PDGF, TGF-α, TGF-β, bFGF, IGF-1, and VEGF [3, 35, 36, 43].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“They are formed mainly from nondifferentiated mesenchymal cells, residing in the dermis, which, under the influence of cytokines and growth factors, released from blood platelets, neutrophils, and macrophages, undergoes a transformation into fibroblasts [3, 64, 65].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“After hemostasis and inflammatory phases, which have lasted from 2 to 3 days, the process of rebuilding the damaged tissue is intensified [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“In the late inflammatory phase, lymphocytes also infiltrate the wound environment influencing fibroblast proliferation and collagen biosynthesis [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“they are the main source of cytokines and growth factors stimulating the proliferation of fibroblasts and collagen biosynthesis [3, 36, 57–59].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
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Citations
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
Cellular and molecular basis of wound healing in diabetes
Brem, H., & Tomic‐Canic, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32169 · Cited by 1,863
The Basic Science of Wound Healing
Broughton, G., Janis, J. E., & Attinger, C. E. (2006) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000225430.42531.c2 · Cited by 1,519 · cited 1×
“wound (chemotaxis) and promote the inflammatory phase, which is characterized by the sequential infiltration of neutrophils, macrophages, and lymphocytes (Gosain and DiPietro, 2004; Broughton et al., 2006; Campos et al., 2008).”
BackgroundGosain, A., & DiPietro, L. A. (2004) · World Journal of Surgery · doi:10.1007/s00268-003-7397-6 · Cited by 1,104
Self-citationSlowing of wound healing by psychological stress
Kiecolt-Glaser, J. K., Marucha, P. T., Mercado, A. M., Malarkey, W. B., & Glaser, R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92899-5 · Cited by 1,104
Edwards, R., & Harding, K. G. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200404000-00004 · Cited by 1,099
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
Sternberg, E. M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1810 · Cited by 1,064
Oxidative Stress in the Pathogenesis of Diabetic Neuropathy
Vincent, A. M., Russell, J. W., Low, P. A., & Feldman, E. L. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0019 · Cited by 1,001
Why chronic wounds will not heal: a novel hypothesis
Bjarnsholt, T., Kirketerp‐Møller, K., Jensen, P. Ø., Madsen, K. G., Phipps, R. K., Krogfelt, K. A., Høiby, N., & Givskov, M. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00283.x · Cited by 886
Research works printed but not linked: 2
- 10.1097/00042728-200809000-00001 · DOI
- Waldron DR, Zimmerman-Pope N (2003). Superficial skin wounds. In: Textbook of small animal surgery . Slatter DH, editor. NY: Saunders, pp 260–271.
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The effects of social isolation on wound healing mechanisms in female mice
Pyter, L. M., Yang, L., da Rocha, J. M., & Engeland, C. G. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.01.008 · Cited by 28
Clinical outcomes following surgical management of deep infiltrating endometriosis
Leborne, P., Huberlant, S., Masia, F., de Tayrac, R., Letouzey, V., & Allegre, L. (2022) · Scientific Reports · doi:10.1038/s41598-022-25751-9 · Cited by 26
Ayoub, N., Badr, N., Al-Ghamdi, S. S., Alsanosi, S., Alzahrani, A. R., Abdel-Naim, A. B., Nematallah, K. A., & Swilam, N. (2021) · Nutrients · doi:10.3390/nu14010028 · Cited by 19
Diabetic Foot Ulcers: Evaluation and Management
Maderal, A. D., Vivas, A. C., Zwick, T. G., & Kirsner, R. S. (2012) · Hospital Practice · doi:10.3810/hp.2012.08.994 · Cited by 15
Ai, X., Luo, R., Wang, H., Yan, B., Li, K., Yu, X., Dong, W., Tan, Y., Liu, M., Chen, Y., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100776 · Cited by 14
Bassam, S. M., Ali, D. E., Awwad, Z. M., Mahmoud, S. A., & Abou-Taleb, B. A. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105543 · Cited by 12
Tang, Q., Tan, Y., Leng, S., Liu, Q., Zhu, L., & Wang, C. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101087 · Cited by 11
Metadata
- Authors
- Guo, S., & DiPietro, L. A.
- Affiliations
- University of Illinois Chicago (US)
- ORCID
- DiPietro, L.A.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2010-02-05
- Volume
- 89
- Issue
- 3
- Pages
- 219-229
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC2903966
- OpenAlex
- W1986308133
- Semantic Scholar
- 47c5693c66389291d022effc62157ccb07c4a29f
- Cited by
- 5,792
- References
- 108
- Citations by year
- 2026: 503 · 2025: 616 · 2024: 609 · 2023: 624 · 2022: 568 · 2021: 510 · 2020: 421 · 2019: 404 · 2018: 354 · 2017: 308 · 2016: 238 · 2015: 216 · 2014: 176 · 2013: 120 · 2012: 75
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p20gm078426-04)
- National Institute of General Medical Sciences (R01-GM-50875, R01GM050875, P20‐GM078426)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- wound healing, delayed wound healing, skin wound healing, hemostasis, inflammation, proliferation, tissue remodeling, oxygenation, wound infection, sex hormones, age, stress, diabetes mellitus, obesity, medication, alcoholism, smoking, nutrition, cellular and molecular mechanisms
- MeSH terms
- Aged, Animals, Body Constitution, Hemostasis, Humans, Inflammation, Middle Aged, Regeneration, Wound Healing, Cell Proliferation
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