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Factors Affecting Wound Healing
Open accessAbstract
Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds.
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In the citing paper
“Moreover, tissue repair and wound healing are impaired in old individuals (Guo and Dipietro, 2010)”
From An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA (2014) · cites this paper as Guo and Dipietro, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Monocytes migrate from capillary to ECM where, under the influence of inflammatory mediators, such as TGF- β and products of fibrin and fibronectin degradation coming from the “temporary” wound matrix, they undergo a transformation into macrophages [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
Experimental — accuracy not yet measuredIn the citing paper
“The default mammalian host response following tissue injury is a well-documented series of events that typically result in the deposition of dense fibrous connective tissue (i.e., scar tissue) within the site of injury [85–87].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [87]
In the citing paper
“Wound healing proceeds through four, but overlapping, phases, such as hemostasis, inflammation, proliferation (also known as replication and synthesis stage), and remodeling [3, 36].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“The aggregated platelets, “trapped” in the provisional matrix, release, from α granules, numerous growth factors, such as PDGF, TGF-α, TGF-β, bFGF, IGF-1, and VEGF [3, 35, 36, 43].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“They are formed mainly from nondifferentiated mesenchymal cells, residing in the dermis, which, under the influence of cytokines and growth factors, released from blood platelets, neutrophils, and macrophages, undergoes a transformation into fibroblasts [3, 64, 65].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“After hemostasis and inflammatory phases, which have lasted from 2 to 3 days, the process of rebuilding the damaged tissue is intensified [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“In the late inflammatory phase, lymphocytes also infiltrate the wound environment influencing fibroblast proliferation and collagen biosynthesis [3].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
In the citing paper
“they are the main source of cytokines and growth factors stimulating the proliferation of fibroblasts and collagen biosynthesis [3, 36, 57–59].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [3]
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Citations
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
Cellular and molecular basis of wound healing in diabetes
Brem, H., & Tomic‐Canic, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32169 · Cited by 1,863
The Basic Science of Wound Healing
Broughton, G., Janis, J. E., & Attinger, C. E. (2006) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000225430.42531.c2 · Cited by 1,519 · cited 1×
“wound (chemotaxis) and promote the inflammatory phase, which is characterized by the sequential infiltration of neutrophils, macrophages, and lymphocytes (Gosain and DiPietro, 2004; Broughton et al., 2006; Campos et al., 2008).”
BackgroundGosain, A., & DiPietro, L. A. (2004) · World Journal of Surgery · doi:10.1007/s00268-003-7397-6 · Cited by 1,104
Self-citationSlowing of wound healing by psychological stress
Kiecolt-Glaser, J. K., Marucha, P. T., Mercado, A. M., Malarkey, W. B., & Glaser, R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92899-5 · Cited by 1,104
Edwards, R., & Harding, K. G. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200404000-00004 · Cited by 1,099
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
Sternberg, E. M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1810 · Cited by 1,064
Oxidative Stress in the Pathogenesis of Diabetic Neuropathy
Vincent, A. M., Russell, J. W., Low, P. A., & Feldman, E. L. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0019 · Cited by 1,001
Why chronic wounds will not heal: a novel hypothesis
Bjarnsholt, T., Kirketerp‐Møller, K., Jensen, P. Ø., Madsen, K. G., Phipps, R. K., Krogfelt, K. A., Høiby, N., & Givskov, M. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00283.x · Cited by 886
Jones, M. K., Wang, H., Peskar, B. M., Levin, E. R., Itani, R. M., Sarfeh, I. J., & Tarnawski, A. S. (1999) · Nature Medicine · doi:10.1038/70995 · Cited by 826
Galiano, R. D., Tepper, O. M., Pelo, C. R., Bhatt, K. A., Callaghan, M. J., Bastidas, N., Bunting, S., Steinmetz, H., & Gurtner, G. C. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63754-6 · Cited by 812
Menke, N. B., Ward, K. R., Witten, T. M., Bonchev, D. G., & Diegelmann, R. F. (2007) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2006.12.005 · Cited by 792
Gallagher, K. A., Liu, Z., Xiao, M., Chen, H., Goldstein, L. J., Buerk, D. G., Nedeau, A. E., Thom, S. R., & Velazquez, O. C. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29710 · Cited by 667
Loots, M. A. M., Lamme, E. N., Zeegelaar, J., Mekkes, J. R., Bos, J. D., & Middelkoop, E. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00381.x · Cited by 620
Adipose Tissue: The New Endocrine Organ? A Review Article
Wozniak, S. E., Gee, L. L., Wachtel, M. S., & Frezza, E. E. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0585-3 · Cited by 607
Understanding the role of immune regulation in wound healing
Park, J. E., & Barbul, A. (2004) · The American Journal of Surgery · doi:10.1016/s0002-9610(03)00296-4 · Cited by 590
Oxygen in Wound Healing—More than a Nutrient
Tandara, A. A., & Mustoe, T. A. (2004) · World Journal of Surgery · doi:10.1007/s00268-003-7400-2 · Cited by 562
Abstinence From Smoking Reduces Incisional Wound Infection: A Randomized Controlled Trial
Sorensen, L. T., Karlsmark, T., & Gottrup, F. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000074980.39700.31 · Cited by 551
Scappaticci, F. A., Fehrenbacher, L., Cartwright, T. H., Hainsworth, J. D., Heim, W. J., Berlin, J. D., Kabbinavar, F. F., Novotny, W. F., Sarkar, S., & Hurwitz, H. I. (2005) · Journal of Surgical Oncology · doi:10.1002/jso.20301 · Cited by 535
Cigarette Smoking Decreases Tissue Oxygen
Jensen, J. A. (1991) · Archives of Surgery · doi:10.1001/archsurg.1991.01410330093013 · Cited by 519
Mucosal Wound Healing Is Impaired by Examination Stress
Marucha, P. T., Kiecolt‐Glaser, J. K., & Favagehi, M. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00025 · Cited by 492
Strodtbeck, F. (2001) · Newborn and Infant Nursing Reviews · doi:10.1053/nbin.2001.23176 · Cited by 427
The Role of Oxygen in Wound Healing
RODRIGUEZ, P. G., FELIX, F. N., Woodley, D. T., & SHIM, E. K. (2008) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2008.34254.x · Cited by 408
Age-Related Alterations in the Inflammatory Response to Dermal Injury
Swift, M. E., Burns, A. L., Gray, K. L., & DiPietro, L. A. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01539.x · Cited by 398
Self-citationMicroscopic and physiologic evidence for biofilm-associated wound colonization in vivo
Davis, S. C., Ricotti, C., Cazzaniga, A., Welsh, E., Eaglstein, W. H., & Mertz, P. M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00303.x · Cited by 393
A Recent Perspective on Alcohol, Immunity, and Host Defense
Szabo, G., & Mandrekar, P. (2009) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00842.x · Cited by 387
Stress-Induced Immune Dysregulation: Implications for Wound Healing, Infectious Disease and Cancer
Godbout, J. P., & Glaser, R. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9036-0 · Cited by 385
(1999) · PubMed · Cited by 354
Self-citationAdipose tissue: a regulator of inflammation
Juge-Aubry, C. E., Henrichot, E., & Meier, C. A. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.009 · Cited by 353
Influence of Obesity on Immune Function
Nieman, D. C., Henson, D. A., Nehlsen‐Cannarella, S. L., Ekkens, M. J., Utter, A. C., Butterworth, D. E., & Fagoaga, O. R. (1999) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(99)00077-2 · Cited by 340
Arnold, M. A., & Barbul, A. (2006) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000225432.17501.6c · Cited by 311
The Magnitude of Acute and Chronic Alcohol Abuse in Trauma Patients
Rivara, F. P. (1993) · Archives of Surgery · doi:10.1001/archsurg.1993.01420200081015 · Cited by 301
Nutritional support in wound healing
Casey, G. (2003) · Nursing Standard · doi:10.7748/ns.17.23.55.s57 · Cited by 296
Bone marrow‐derived stem cells in wound healing: a review
Wu, Y., Wang, J., Scott, P. G., & Tredget, E. E. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00221.x · Cited by 288
Hyperoxia, Endothelial Progenitor Cell Mobilization, and Diabetic Wound Healing
Liu, Z., & Velazquez, O. C. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2121 · Cited by 287
Sørensen, L. T., Jørgensen, S., Petersen, L. J., Hemmingsen, U., Bülow, J., Loft, S. H., & Gottrup, F. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.02.066 · Cited by 263
Assessment and nutritional aspects of wound healing
Campos, A. C. L., Groth, A. K., & Branco, A. B. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282fbd35a · Cited by 249
The Obese Surgical Patient: A Susceptible Host for Infection
Anaya, D. A., & Dellinger, E. P. (2006) · Surgical Infections · doi:10.1089/sur.2006.7.473 · Cited by 241
Cigarette Smoking and Flap and Full-Thickness Graft Necrosis
Goldminz, D. (1991) · Archives of Dermatology · doi:10.1001/archderm.1991.01680060086009 · Cited by 232
Obesity: Impediment to Postsurgical Wound Healing
Wilson, J. A., & Clark, J. J. (2004) · Advances in Skin & Wound Care · doi:10.1097/00129334-200410000-00013 · Cited by 230
The hormonal regulation of cutaneous wound healing
Gilliver, S. C., Ashworth, J. J., & Ashcroft, G. S. (2007) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2006.09.012 · Cited by 228
Role of oxygen in wound healing
Bishop, A. (2008) · Journal of Wound Care · doi:10.12968/jowc.2008.17.9.30937 · Cited by 210
Advanced glycation end products and diabetic foot disease
Huijberts, M. S., Schaper, N. C., & Schalkwijk, C. G. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.861 · Cited by 207
The biology of chronic foot ulcers in persons with diabetes
Sibbald, R. G., & Woo, K. Y. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.847 · Cited by 202
Stem cells in cutaneous wound healing
Cha, J., & Falanga, V. (2007) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2006.10.002 · Cited by 198
Cellular and Physiological Effects of Arginine
Tong, B. C., & Barbul, A. (2004) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557043403305 · Cited by 186
Skin γδ T‐cell functions in homeostasis and wound healing
Jameson, J., & Havran, W. L. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00483.x · Cited by 184
Nicotine Accelerates Angiogenesis and Wound Healing in Genetically Diabetic Mice
Jacobi, J., Jang, J. J., Sundram, U. N., Dayoub, H., Fajardo, L. F., & Cooke, J. P. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64161-2 · Cited by 181
Complications in abdominoplasty: A risk factor analysis
Momeni, A., Heier, M., Bannasch, H., & Stark, G. B. (2008) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2008.03.043 · Cited by 173
Optimizing Healing of the Acute Wound by Minimizing Complications
Franz, M., Steed, D. L., & Robson, M. C. (2007) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2007.07.001 · Cited by 167
Omega‐3 fatty acids effect on wound healing
McDaniel, J. C., Belury, M. A., Ahijevych, K., & Blakely, W. P. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00388.x · Cited by 164
Greco, J. A., Castaldo, E. T., Nanney, L. B., Wendel, J. J., Summitt, J. B., Kelly, K. J., Braun, S. A., Hagan, K. F., & Shack, R. B. (2008) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e318166d351 · Cited by 161
Macrophage-Induced Neutrophil Apoptosis
Meszaros, A. J., Reichner, J. S., & Albina, J. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.435 · Cited by 161
Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice
Keylock, K. T., Vieira‐Potter, V. J., Wallig, M. A., DiPietro, L. A., Schrementi, M. E., & Woods, J. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00177.2007 · Cited by 159
Self-citationVileikytė, L. (2007) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2006.09.005 · Cited by 157
Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly
Hardman, M. J., & Ashcroft, G. S. (2008) · Genome Biology · doi:10.1186/gb-2008-9-5-r80 · Cited by 157
Exercise Accelerates Wound Healing Among Healthy Older Adults: A Preliminary Investigation
Emery, C. F., Kiecolt‐Glaser, J. K., Glaser, R., Malarkey, W. B., & Frid, D. J. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.11.1432 · Cited by 155
Role of oxygen in wound healing
Younis, I. (2020) · Journal of Wound Care · doi:10.12968/jowc.2020.29.sup5b.s4 · Cited by 153
The Effect of Cigarette Smoking on Dental Implants and Related Surgery
Levin, L., & Schwartz‐Arad, D. (2005) · Implant Dentistry · doi:10.1097/01.id.0000187956.59276.f8 · Cited by 152
The role of stress in periodontal disease and wound healing
Boyapati, L., & Wang, H. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2007.00211.x · Cited by 142
Quattrini, C., Jeziorska, M., Boulton, A. J. M., & Malik, R. A. (2007) · Diabetes Care · doi:10.2337/dc07-1556 · Cited by 131
Scarless skin repair in immunodeficient mice
Gawrońska‐Kozak, B., Bogacki, M., Rim, J., Monroe, W. T., & Manuel, J. A. (2006) · Wound Repair and Regeneration · doi:10.1111/j.1743-6109.2006.00121.x · Cited by 130
Pieringer, H., Stuby, U., & Biesenbach, G. (2007) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2006.10.003 · Cited by 118
Tobacco smoking and surgical healing of oral tissues: A review
Balaji, S. (2008) · Indian Journal of Dental Research · doi:10.4103/0970-9290.44540 · Cited by 117
Alcohol and Drug Use in Victims of Life-Threatening Trauma
Madan, A. K., Yu, K., & Beech, D. J. (1999) · doi:10.1097/00005373-199909000-00026 · Cited by 116
Smoking and Wound Healing Problems in Reduction Mammaplasty
Chan, L. K. W., Withey, S., & Butler, P. E. M. (2006) · Annals of Plastic Surgery · doi:10.1097/01.sap.0000197635.26473.a2 · Cited by 110
Woo, K. Y., Ayello, E. A., & Sibbald, R. G. (2007) · Advances in Skin & Wound Care · doi:10.1097/00129334-200702000-00009 · Cited by 108
The effect of cigarette smoking on wound healing
Siana, J. E., Rex, S., & Gottrup, F. (1989) · Scandinavian Journal of Plastic and Reconstructive Surgery · doi:10.3109/02844318909075119 · Cited by 103
Obesity, Inflammation, and Vascular Disease
Calabrò, P., & Yeh, E. T. H. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5688-5_3 · Cited by 101
Acute ethanol exposure impairs angiogenesis and the proliferative phase of wound healing
Radek, K. A., Matthies, A. M., Burns, A. L., Heinrich, S. A., Kovacs, E. J., & DiPietro, L. A. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00080.2005 · Cited by 96
Self-citationde Mello, V. D., Kolehmainen, M., Schwab, U., Mager, U., Laaksonen, D. E., Pulkkinen, L., NISKANEN, L. K., Gylling, H., Atalay, M., Rauramaa, R., et al. (2008) · Metabolism · doi:10.1016/j.metabol.2007.08.024 · Cited by 92
Mathieu, D., Linke, J.-C., & Wattel, F. (2006) · Springer eBooks · doi:10.1007/1-4020-4448-8_20 · Cited by 89
The effects of non-steroidal anti-inflammatory drug application on incisional wound healing in rats
Krischak, G. D., Augat, P., Claes, L., Kinzl, L., & Beck, A. (2007) · Journal of Wound Care · doi:10.12968/jowc.2007.16.2.27001 · Cited by 88
Smoking-the Bane of Wound Healing
Ahn, C., Mulligan, P., & Salcido, R. (2008) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000305440.62402.43 · Cited by 87
Nicotine at a Low Concentration Promotes Wound Healing
Morimoto, N., Takemoto, S., Kawazoe, T., & Suzuki, S. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2007.05.031 · Cited by 85
Benefits of an oral nutritional supplement on pressure ulcer healing in long-term care
Heyman, H., Looverbosch, D. V. D., Meijer, E. P., & Schols, J. M. G. A. (2008) · Journal of Wound Care · doi:10.12968/jowc.2008.17.11.31475 · Cited by 81
Dexamethasone impairs hypoxia-inducible factor-1 function
Wagner, A. E., Huck, G., Stiehl, D. P., JELKMANN, W. E. B., & Hellwig‐Bürgel, T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.061 · Cited by 80
Defects in Skin γδ T Cell Function Contribute to Delayed Wound Repair in Rapamycin-Treated Mice
Mills, R. E., Taylor, K. R., Podshivalova, K., McKay, D. B., & Jameson, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3974 · Cited by 79
Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells
Radek, K. A., Kovacs, E. J., Gallo, R. L., & DiPietro, L. A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00699.2007 · Cited by 76
Self-citationNeurogenic Factors in the Impaired Healing of Diabetic Foot Ulcers
Gałkowska, H., Olszewski, W. L., Wojewódzka, U., Rosinski, G., & Karnafel, W. (2006) · Journal of Surgical Research · doi:10.1016/j.jss.2006.02.006 · Cited by 69
Bone marrow-derived cells in the healing burn wound—More than just inflammation
Rea, S. M., Giles, N. L., Webb, S. A. R., Adcroft, K. F., Evill, L. M., Strickland, D. H., Wood, F. M., & Fear, M. W. (2008) · Burns · doi:10.1016/j.burns.2008.07.011 · Cited by 68
EFFECT OF IBUPROFEN ON THE INFLAMMATORY RESPONSE TO SURGICAL WOUNDS
Dong, Y.-L., Fleming, R., Yan, T. Z., Herndon, D. N., & Waymack, J. P. (1993) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199309000-00002 · Cited by 64
ACUTE ETHANOL INTOXICATION INCREASES THE RISK OF INFECTION FOLLOWING PENETRATING ABDOMINAL TRAUMA
Gentilello, L. M., Cobean, R. A., Walker, A. P., Moore, E. E., Wertz, M. J., & Dellinger, E. P. (1993) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199305000-00009 · Cited by 64
Kirchner, L. M., Meerbaum, S. O., Gruber, B. S., Knoll, A. K., Bulgrin, J., Taylor, R. A. J., & Schmidt, S. P. (2003) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2003.11208.x · Cited by 63
Alcohol intoxication and post-burn complications
Mashkoor, A. C. (2006) · Frontiers in bioscience · doi:10.2741/1857 · Cited by 60
Impaired Mononuclear Cell Immune Function in Extreme Obesity Is Corrected by Weight Loss
Fontana, L., Eagon, J. C., Colonna, M., & Klein, S. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.0504 · Cited by 60
Effects of Acute Ethanol Exposure on the Early Inflammatory Response After Excisional Injury
Fitzgerald, D. J., Radek, K. A., Chaar, M., Faunce, D. E., DiPietro, L. A., & Kovacs, E. J. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00307.x · Cited by 56
Self-citationOral glutamine and the healing of colonic anastomoses in rats
da Costa, M., Campos, A. C., Coelho, J., de Barros, A., & Matsumoto, H. (2003) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607103027003182 · Cited by 51
Use of topical corticosteroids on chronic leg ulcers
Hofman, D., Moore, K., Cooper, R., Eagle, M., & Cooper, S. (2007) · Journal of Wound Care · doi:10.12968/jowc.2007.16.5.27047 · Cited by 50
Alcohol-Induced Alterations on Host Defense After Traumatic Injury
Greiffenstein, P. P., & Molina, P. E. (2008) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e318158a4ad · Cited by 49
McMaster, S. K., Paul‐Clark, M. J., Walters, M. J., Fleet, M., Anandarajah, J., Sriskandan, S., & Mitchell, J. A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707595 · Cited by 48
Shingel, K. I., Faure, M., Azoulay, L., Roberge, C., & Deckelbaum, R. J. (2008) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.101 · Cited by 45
Lawrence, W., Tl, T., & Norton, J. A. (1986) · PubMed · Cited by 45
Effect of ibuprofen and diclofenac sodium on experimental would healing.
Dvivedi, S., Tiwari, S. M., & Sharma, A. K. (1997) · PubMed · Cited by 42
Effects of early postoperative chemotherapy on wound healing.
Kolb, B. A., Buller, R. E., Connor, J. P., DiSaia, P. J., & Berman, M. L. (1992) · PubMed · Cited by 41
Transdermal nicotine patch enhances type I collagen synthesis in abstinent smokers
Sørensen, L. T., Jørgensen, L. N., Zillmer, R., Vange, J., Hemmingsen, U., & Gottrup, F. (2006) · Wound Repair and Regeneration · doi:10.1111/j.1743-6109.2006.00118.x · Cited by 38
Nutrition for optimum wound healing.
Shepherd, A. A. (2004) · PubMed · Cited by 32
Why combine a foam dressing with ibuprofen for wound pain and moist wound healing?
Price, P., Fogh, K., Glynn, C. J., Krasner, D. L., Osterbrink, J., & Sibbald, R. G. (2007) · International Wound Journal · doi:10.1111/j.1742-481x.2007.00310.x · Cited by 32
Scott, L. J. (2007) · Drugs · doi:10.2165/00003495-200767120-00009 · Cited by 31
Matrix Proteolytic Activity During Wound Healing: Modulation by Acute Ethanol Exposure
Radek, K. A., Kovacs, E. J., & DiPietro, L. A. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00386.x · Cited by 25
Self-citationManaging patients with metastatic colorectal cancer on bevacizumab
Lemmens, L., Claes, V., & Uzzell, M. (2008) · British Journal of Nursing · doi:10.12968/bjon.2008.17.15.30695 · Cited by 22
Surgical Patient Education Related to Smoking
Lauerman, C. J. (2008) · AORN Journal · doi:10.1016/j.aorn.2007.09.015 · Cited by 15
Burgess, C. (2008) · PubMed · Cited by 15
Vitamin E for treating children's scars. Does it help reduce scarring?
Khoosal, D., & Goldman, R. D. (2006) · PubMed · Cited by 10
Nahabedian, M. Y. (2006) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000194900.08776.59 · Cited by 10
Vitamin E for treating children's scars
Khoosal, D., & Goldman, R. D. (2006) · Cited by 3
Research works printed but not linked: 2
- 10.1097/00042728-200809000-00001 · DOI
- Waldron DR, Zimmerman-Pope N (2003). Superficial skin wounds. In: Textbook of small animal surgery . Slatter DH, editor. NY: Saunders, pp 260–271.
Cited by
Sorted by citations
Pathophysiology of acute wound healing
Li, J., Chen, J., & Kirsner, R. S. (2007) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2006.09.007 · Cited by 4,042
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045
“Moreover, tissue repair and wound healing are impaired in old individuals (Guo and Dipietro, 2010), and the matrix metalloproteinases that comprise the SASP (Coppé et al.”
Immune regulation by glucocorticoids
Cain, D. W., & Cidlowski, J. A. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.1 · Cited by 1,846
Selvaraj, D., Padma, V. V., & Santhini, E. (2015) · Biomedicine · doi:10.7603/s40681-015-0022-9 · Cited by 1,533
Metadata
- Authors
- Guo, S., & DiPietro, L. A.
- Affiliations
- University of Illinois Chicago (US)
- ORCID
- DiPietro, L.A.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2010-02-05
- Volume
- 89
- Issue
- 3
- Pages
- 219-229
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC2903966
- OpenAlex
- W1986308133
- Semantic Scholar
- 47c5693c66389291d022effc62157ccb07c4a29f
- Cited by
- 5,792
- References
- 108
- Citations by year
- 2026: 503 · 2025: 616 · 2024: 609 · 2023: 624 · 2022: 568 · 2021: 510 · 2020: 421 · 2019: 404 · 2018: 354 · 2017: 308 · 2016: 238 · 2015: 216 · 2014: 176 · 2013: 120 · 2012: 75
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p20gm078426-04)
- National Institute of General Medical Sciences (R01-GM-50875, R01GM050875, P20‐GM078426)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- wound healing, delayed wound healing, skin wound healing, hemostasis, inflammation, proliferation, tissue remodeling, oxygenation, wound infection, sex hormones, age, stress, diabetes mellitus, obesity, medication, alcoholism, smoking, nutrition, cellular and molecular mechanisms
- MeSH terms
- Aged, Animals, Body Constitution, Hemostasis, Humans, Inflammation, Middle Aged, Regeneration, Wound Healing, Cell Proliferation
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