Sex differences between APPswePS1dE9 mice in A-beta accumulation and pancreatic islet function during the development of Alzheimer’s disease
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The pathogenesis of Alzheimer’s disease (AD), a type of neurodegenerative disease characterized by learning and memory impairment, is often associated with pathological features, such as amyloid-beta (Aβ) accumulation and insulin resistance. The transgenic mouse, APPswePS1dE9 (APP/PS1), is one of the most commonly used animal models in pathogenesis studies of AD. The purpose of this study is to investigate the sex differences between APP/PS1 mice in the pathogenesis of AD. The impairment of glucose and insulin tolerance was found to develop earlier in male APP/PS1 mice than in females. Plasma insulin levels were significantly decreased in male APP/PS1 mice, while total cholesterol levels in male APP/PS1 mice were higher than those in females. Triglyceride levels in male mice in both the wild-type (WT) and APP/PS1 groups were higher than in their female littermates. Soluble and insoluble Aβ levels in female APP/PS1 mouse brains were higher than those in males. And the learning and memorizing abilities of female APP/PS1 mice were poorer than those of males. Our results concluded that there were sex differences in Aβ formation, pancreatic islet function and insulin sensitivity between male and female APP/PS1 mice during the pathogenesis of AD.
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The APP/PS1 female mice used in this study presented more pronounced β-amyloid-related pathology and greater learning and memory impairments than their male counterparts did.
“In general, the APP/PS1 female mice used in this study presented more pronounced β-amyloid-related pathology and greater learning and memory impairments than their male counterparts did [40].”
From The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions (2025) · cites this paper as [40]
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- Authors
- Li, X., Feng, Y., Wu, W., Zhao, J., Fu, C., Li, Y., Ding, Y., Wu, B., Gong, Y., Yang, G., & Zhou, X.
- Affiliations
- Sichuan University (CN)
- West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
- Corresponding author
- Zhou, Xue
- Venue
- Laboratory Animals
- Publisher
- SAGE Publications
- Published
- 2016-07-10
- Volume
- 50
- Issue
- 4
- Pages
- 275-285
- ISSN
- 0023-6772 (ISSN-L)
- 1758-1117
- OpenAlex
- W2285805868
- Cited by
- 59
- References
- 37
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 14 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 3 · 2019: 2 · 2018: 3
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Laboratory Animals (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of South Australia
- Sichuan University
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, sex differences, amyloid-beta deposition, islet function, insulin resistance, glucose tolerance, insulin sensitivity, plasma insulin, cholesterol, triglycerides, learning and memory, transgenic mouse model
- MeSH terms
- Alzheimer Disease, Animals, Body Weight, Brain, Disease Models, Animal, Female, Glucose Tolerance Test, Humans, Insulin, Islets of Langerhans, Lipids, Male, Memory, Mice, Transgenic, Sex Characteristics, Amyloid beta-Peptides, Mice, Spatial Learning
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