Cited by 59Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Sex differences between APPswePS1dE9 mice in A-beta accumulation and pancreatic islet function during the development of Alzheimer’s disease

Open access
Li, Xin, Feng, Ying, Wu, Wei, Zhao, Jia, Fu, Chunmei, Li, Yang, Ding, Yangnan, Wu, Binghuo +3 more·2016·Laboratory Animals

Abstract

The pathogenesis of Alzheimer’s disease (AD), a type of neurodegenerative disease characterized by learning and memory impairment, is often associated with pathological features, such as amyloid-beta (Aβ) accumulation and insulin resistance. The transgenic mouse, APPswePS1dE9 (APP/PS1), is one of the most commonly used animal models in pathogenesis studies of AD. The purpose of this study is to investigate the sex differences between APP/PS1 mice in the pathogenesis of AD. The impairment of glucose and insulin tolerance was found to develop earlier in male APP/PS1 mice than in females. Plasma insulin levels were significantly decreased in male APP/PS1 mice, while total cholesterol levels in male APP/PS1 mice were higher than those in females. Triglyceride levels in male mice in both the wild-type (WT) and APP/PS1 groups were higher than in their female littermates. Soluble and insoluble Aβ levels in female APP/PS1 mouse brains were higher than those in males. And the learning and memorizing abilities of female APP/PS1 mice were poorer than those of males. Our results concluded that there were sex differences in Aβ formation, pancreatic islet function and insulin sensitivity between male and female APP/PS1 mice during the pathogenesis of AD.

Integrity signals

Registry

Crossref · 10.1177/0023677215615269

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Li, X., Feng, Y., Wu, W., Zhao, J., Fu, C., Li, Y., Ding, Y., Wu, B., Gong, Y., Yang, G., & Zhou, X.
Affiliations
  • Sichuan University (CN)
  • West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
Corresponding author
Zhou, Xue
Venue
Laboratory Animals
Published
2016-07-10
Volume
50
Issue
4
Pages
275-285
ISSN
  • 0023-6772 (ISSN-L)
  • 1758-1117
OpenAlex
W2285805868
Cited by
59
References
37
Citations by year
2026: 4 · 2025: 10 · 2024: 14 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 3 · 2019: 2 · 2018: 3
FWCI
0.74
Type
journal article
Language
en
Open access
Locations
  • Laboratory Animals (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of South Australia
  • Sichuan University
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, sex differences, amyloid-beta deposition, islet function, insulin resistance, glucose tolerance, insulin sensitivity, plasma insulin, cholesterol, triglycerides, learning and memory, transgenic mouse model
MeSH terms
Alzheimer Disease, Animals, Body Weight, Brain, Disease Models, Animal, Female, Glucose Tolerance Test, Humans, Insulin, Islets of Langerhans, Lipids, Male, Memory, Mice, Transgenic, Sex Characteristics, Amyloid beta-Peptides, Mice, Spatial Learning

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review