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Cited by 100Fatty Acid Research and HealthEdible Oils Quality and AnalysisAquaculture Nutrition and Growth

The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.

Current Clinical Applications of Ω‐6 and Ω‐3 Fatty Acids

Lee, Sang, Gura, Kathleen M., Kim, Sendia, Arsenault, Danielle A., Bistrian, Bruce R., Puder, Mark·2006·Nutrition in Clinical Practice
DOI 10.1177/0115426506021004323
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Abstract

BACKGROUND: Recent years have brought a resurgence of research interest in fatty acids, with studied fields running the gamut of human disease. This movement has run in parallel with an increased interest in using nutrition modalities as therapeutic measures, as opposed to their conventional role as energy sources. The aim of this manuscript is to provide a basic review of current clinical applications of omega-6 and omega-3 fatty acids, with a particular focus on the latter. METHODS: A selective review of the voluminous literature, including randomized controlled trials, meta-analyses, population studies, and case reports, was used to compile data and identify trends in pertinent clinical applications of fatty acid therapy. CONCLUSIONS: There are a myriad of disorders and maladies that seem to benefit from fatty acid supplementation, specifically omega-3 fatty acids. It has clearly been shown that omega-3 fatty acid supplementation provides a protective benefit in heart disease, and in particular sudden cardiac death. Rheumatoid arthritis (RA) is another disease entity that has been proven to benefit from this nutrition intervention, with improvement in symptoms and diminished nonsteroidal antiinflammatory drug (NSAID) usage. In addition, many psychiatric disorders, particularly schizophrenia and major depressive disorder (MDD), have shown positive results when supplementation has been used as an adjunct to standard pharmacotherapy. The remainder of clinical applications for omega-3 fatty acids requires further investigation. Specifically, according to preliminary clinical evidence, parenteral administration of fatty acids warrants further study.

Overview

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Crossref · 10.1177/0115426506021004323

Cites

218 of 218 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 6

  1. American Heart Association, 1992, Heart and Stroke Facts
  2. Begin ME, 1986, Differential killing ofhuman carcinoma cells supplemented with n‐3 and n‐6 polyunsaturated fattyacids, J Natl Cancer Inst., 77, 1053
  3. American Cancer Society, 2004, Breast cancer facts and figures2003– 2004
  4. Simmer K, 2001, Long‐chain polyunsaturated fatty acid supplementation ininfants born at term, Cochrane Database Syst Rev., CD000376
  5. Simmer K, 2004, Long‐chain polyunsaturated fatty acidsupplementation in preterm infants, Cochrane Database Syst Rev., CD000375
  6. Weber PC, 1989, Are We What We Eat? Fatty Acids in Nutritionand in Cell Membranes: Cell Functions and Disorders Induced by Dietary Conditions: Report No. 4, 9

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Metadata

Authors
Lee, S., Gura, K. M., Kim, S., Arsenault, D. A., Bistrian, B. R., & Puder, M.
Affiliations
  • Boston Children's Hospital (US)
  • Beth Israel Deaconess Medical Center (US)
Corresponding author
Puder, Mark
ORCID
Venue
Nutrition in Clinical Practice
Publisher
Wiley
Published
2006-08
Volume
21
Issue
4
Pages
323-341
ISSN
  • 0884-5336 (ISSN-L)
  • 1941-2452
DOI
10.1177/0115426506021004323
OpenAlex
W2345098798
Cited by
100
References
218
Citations by year
2026: 1 · 2024: 3 · 2022: 2 · 2021: 10 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 1 · 2012: 4
FWCI
1.16
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Nutrition in Clinical Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords
omega-3 fatty acids, omega-6 fatty acids, fatty acid supplementation, dietary therapy, cardiovascular disease, sudden cardiac death, rheumatoid arthritis, NSAID use, schizophrenia, major depressive disorder, mental illness
MeSH terms
Animals, Arthritis, Rheumatoid, Mental Disorders, Disease Models, Animal, Heart Diseases, Humans, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Treatment Outcome, Dietary Supplements, Fatty Acids, Omega-6

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