Cited by 100Fatty Acid Research and HealthEdible Oils Quality and AnalysisAquaculture Nutrition and Growth

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Current Clinical Applications of Ω‐6 and Ω‐3 Fatty Acids

Lee, Sang, Gura, Kathleen M., Kim, Sendia, Arsenault, Danielle A., Bistrian, Bruce R., Puder, Mark·2006·Nutrition in Clinical Practice

DOI 10.1177/0115426506021004323

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Abstract

BACKGROUND: Recent years have brought a resurgence of research interest in fatty acids, with studied fields running the gamut of human disease. This movement has run in parallel with an increased interest in using nutrition modalities as therapeutic measures, as opposed to their conventional role as energy sources. The aim of this manuscript is to provide a basic review of current clinical applications of omega-6 and omega-3 fatty acids, with a particular focus on the latter. METHODS: A selective review of the voluminous literature, including randomized controlled trials, meta-analyses, population studies, and case reports, was used to compile data and identify trends in pertinent clinical applications of fatty acid therapy. CONCLUSIONS: There are a myriad of disorders and maladies that seem to benefit from fatty acid supplementation, specifically omega-3 fatty acids. It has clearly been shown that omega-3 fatty acid supplementation provides a protective benefit in heart disease, and in particular sudden cardiac death. Rheumatoid arthritis (RA) is another disease entity that has been proven to benefit from this nutrition intervention, with improvement in symptoms and diminished nonsteroidal antiinflammatory drug (NSAID) usage. In addition, many psychiatric disorders, particularly schizophrenia and major depressive disorder (MDD), have shown positive results when supplementation has been used as an adjunct to standard pharmacotherapy. The remainder of clinical applications for omega-3 fatty acids requires further investigation. Specifically, according to preliminary clinical evidence, parenteral administration of fatty acids warrants further study.

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Authors: Lee, S., Gura, K. M., Kim, S., Arsenault, D. A., Bistrian, B. R., & Puder, M.
Affiliations: Boston Children's Hospital (US)
Beth Israel Deaconess Medical Center (US)
Corresponding author: Puder, Mark
ORCID: Gura, Kathleen M.
Bistrian, Bruce R.
Puder, Mark
Venue: Nutrition in Clinical Practice
Publisher: Wiley
Published: 2006-08
Volume: 21
Issue: 4
Pages: 323-341
ISSN: 0884-5336 (ISSN-L)
1941-2452
DOI: 10.1177/0115426506021004323
OpenAlex: W2345098798
Cited by: 100
References: 218
Citations by year: 2026: 1 · 2024: 3 · 2022: 2 · 2021: 10 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 1 · 2012: 4
FWCI: 1.16
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Nutrition in Clinical Practice (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords: omega-3 fatty acids, omega-6 fatty acids, fatty acid supplementation, dietary therapy, cardiovascular disease, sudden cardiac death, rheumatoid arthritis, NSAID use, schizophrenia, major depressive disorder, mental illness
MeSH terms: Animals, Arthritis, Rheumatoid, Mental Disorders, Disease Models, Animal, Heart Diseases, Humans, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Treatment Outcome, Dietary Supplements, Fatty Acids, Omega-6

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Current Clinical Applications of Ω‐6 and Ω‐3 Fatty Acids

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