Effectiveness of the unified protocol for transdiagnostic treatment of emotional disorders among veterans with posttraumatic stress disorder: a pilot study
Abstract
Effective treatment options are needed for veterans who do not participate in trauma-focused psychotherapy. Research has yet to examine the effectiveness of transdiagnostic psychotherapy in veterans with posttraumatic stress disorder (PTSD) and co-occurring psychological disorders. This pilot study examined the effectiveness of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) delivered in a 16-week group format. We examined treatment outcomes in male and female veterans ( n = 52) in an outpatient specialty PTSD clinic at a large Veterans Affairs (VA) medical center. We hypothesized significant decreases in emotion regulation difficulty (Difficulties in Emotion Regulation Scale), PTSD symptom severity (PTSD Checklist for DSM-5), and depressive symptom severity (Patient Health Questionnaire-9). In addition, we hypothesized that reductions in emotion regulation difficulty across treatment would negatively predict PTSD and depressive symptoms at posttreatment. PTSD symptoms, depressive symptoms, and emotion regulation difficulty all evidenced significant improvements at the end of treatment relative to baseline ( ps < .001). In addition, reductions in emotion regulation across treatment were associated with lower PTSD and depressive symptoms at posttreatment ( ps < .001). This pilot study provides preliminary evidence supporting use of UP among veterans with PTSD and co-occurring disorders. Well-designed clinical trials evaluating efficacy of UP among veterans are needed.
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A growing evidence base supports the utility of the UP for improving emotional and emotion-adjacent symptoms, including anxiety, depression, anger, substance misuse, self-injury, somatization, obsessive-compulsive symptoms, and trauma-related symptoms.
“A growing evidence base supports the utility of the UP for improving emotional and emotion-adjacent symptoms, including anxiety, depression, anger, substance misuse, self-injury, somatization, obsessive-compulsive symptoms, and trauma-related symptoms (26, 31–37).”
From Pilot outcomes and exploration of treatment mechanisms using a culturally adapted version of the unified protocol for transdiagnostic treatment of emotional disorders to improve mental health symptoms, alcohol misuse, functional outcomes, and sleep quality in emergency responders (2025) · cites this paper as [37]
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Apuntes sobre el Protocolo Unificado Transdiagnóstico
Arrigoni, F. S., Consejero, E. M., & Guzmán, J. I. N. (2023) · Acción Psicológica · doi:10.5944/ap.19.1.36971 · Cited by 2 · see citing works
Psychopathy and Mood Disorders
Dargis, M. A. (2022) · Dangerous behavior in clinical and forensic psychology · doi:10.1007/978-3-030-83156-1_8 · Cited by 2 · see citing works
A Trauma-Informed Approach to the Unified Protocol for Children with Exposure to Child Maltreatment
Gruen, R. L., Lindenbach, D., Arnold, P. D., Ehrenreich, J. T., & Dimitropoulos, G. (2023) · Child maltreatment solutions network · doi:10.1007/978-3-031-33739-0_10 · Cited by 1 · see citing works
Rolerson, C., Robinson, M., & Sims, O. T. (2026) · Cogent Psychology · doi:10.1080/23311908.2026.2635760 · Cited by 1 · see citing works
Veteran resilience, meaning-making and posttraumatic growth: A cross-sectional network analysis
McMurtrie, B. L., Ponder, W. N., Schuman, D. L., Ahmadi, A., & Carbajal, J. (2026) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2026.100686 · Cited by 1 · see citing works
Fostering engagement in early sessions of transdiagnostic cognitive-behavioral therapy.
Curreri, A. J., Farchione, T. J., & Wang, M. (2019) · Psychotherapy · doi:10.1037/pst0000207 · Cited by 1 · see citing works
Transdiagnostic Cognitive Behavioral Psychotherapy: Unified Protocol as an Example
Batmaz, S. (2023) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.1064590 · Cited by 1 · see citing works
SEVER, M., & Allahverdi, F. Z. (2023) · Dokuz Eylül Üniversitesi Sosyal Bilimler Enstitüsü Dergisi · doi:10.16953/deusosbil.1282604 · Cited by 1 · see citing works
Ferreres-Galán, V., Péris-Baquero, Ó., Moreno-Pérez, J. D., & Osma, J. (2024) · Current Psychology · doi:10.1007/s12144-024-06159-2 · Cited by 1 · see citing works
Meyer, E. C., Farchione, T. J., Kimbrel, N. A., Kwok, O., Pennington, M. L., Rostockyj, J. A., & Gulliver, S. B. (2025) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2025.101537 · Cited by 1 · see citing works
Unified Protocol for Treatment of Depression
Bentley, K. H., Conklin, L. R., Boswell, J. F., Shapero, B. G., & Olesnycky, O. S. (2018) · Springer eBooks · doi:10.1007/978-3-319-97241-1_12
TRANSDİYAGNOSTİK BİLİŞSEL DAVRANIŞÇI TERAPİ: BİR ÖRNEK OLARAK BÜTÜNLEŞİK PROTOKOLPreprint
Batmaz, S. (2020) · doi:10.31234/osf.io/fvy83
La luce dell'anima. Savonarola e la profezia
Garfagnini, G. C. (2019) · I Castelli di Yale online · doi:10.15160/2282-5460/2044
Ward‐Ciesielski, E. F., Curreri, A. J., Woods, B. K., & Barlow, D. H. (2022) · Springer eBooks · doi:10.1007/978-3-031-14332-8_10
Evaluation of a unified protocol transdiagnostic group for treatment of anxiety and depression
McPhail, L., & Ferguson, M. (2022) · Clinical Psychology Forum · doi:10.53841/bpscpf.2022.1.352.9
Kajiwara, M., Kato, N., Nishiuchi, M., Fujisato, H., Kaneko, K., Kuga, H., & Ito, M. (2025) · Behavioral Sciences · doi:10.3390/bs15030389
Rolerson, C., Robinson, M. V., & Sims, O. T. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5257910
The emotional resources group: an extended real-world evaluation
Ford, E., Bacon, T., Gemmell, R., Rae, S., Wiffen, B. D. R., & Watson, P. (2026) · Mental Health Review Journal · doi:10.1108/mhrj-07-2025-0053
Piri, N., Parvizifard, A., Jaberghaderi, N., & Davarinejad, O. (2026) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_1303_24
Coe, E., Torres, V. A., Beattie, E. H., Thomas, K. L., Rostockyj, J. A., Pennington, M. L., Cardenas, M. N., Strack, J. E., Dupree, J., Lewis, J. E., et al. (2026) · Journal of Military Veteran and Family Health · doi:10.3138/jmvfh-2024-0025
Gamoran, J., Bushnell, A., Fragkos, E., Darbro, R., Guéyé, A., & Snow‐Hill, N. L. (2026) · Community Mental Health Journal · doi:10.1007/s10597-026-01734-2
- Authors
- Varkovitzky, R. L., Sherrill, A. M., & Reger, G. M.
- Affiliations
- University of Washington (US)
- Emory University (US)
- Corresponding author
- Varkovitzky, Ruth L.
- Venue
- Behavior Modification
- Publisher
- SAGE Publications
- Published
- 2017-08-27
- Volume
- 42
- Issue
- 2
- Pages
- 210-230
- ISSN
- 0145-4455 (ISSN-L)
- 1552-4167
- OpenAlex
- W2748476071
- Cited by
- 55
- References
- 60
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 9 · 2021: 7 · 2020: 2 · 2019: 5 · 2018: 4
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavior Modification (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- Unified Protocol for Transdiagnostic Treatment of Emotional Disorders, transdiagnostic psychotherapy, post-traumatic stress disorder, veterans, emotion regulation, depression, PTSD symptom severity, group therapy
- MeSH terms
- Adult, Depression, Emotions, Female, Humans, Male, Pilot Projects, Psychotherapy, Severity of Illness Index, Stress Disorders, Post-Traumatic, Veterans, Treatment Outcome
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