Cited by 163Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesChild and Adolescent Psychosocial and Emotional DevelopmentMental Health Research Topics

The role of negative affectivity and negative reactivity to emotions in predicting outcomes in the unified protocol for the transdiagnostic treatment of emotional disorders

Open access
Sauer-Zavala, Shannon, Boswell, James F., Gallagher, Matthew W., Bentley, Kate H., Ametaj, Amantia, Barlow, David H.·2012·Behaviour Research and Therapy

Abstract

The present study aimed to understand the contributions of both the trait tendency to experience negative emotions and how one relates to such experience in predicting symptom change during participation in the Unified Protocol (UP), a transdiagnostic treatment for emotional disorders. Data were derived from a randomized controlled trial comparing the UP to a waitlist control/delayed-treatment condition. First, effect sizes of pre- to post-treatment change for frequency of negative emotions and several variables measuring reactivity to emotional experience (emotional awareness and acceptance, fear of emotions, and anxiety sensitivity) were examined. Second, the relative contributions of change in negative emotions and emotional reactivity in predicting symptom (clinician-rated anxiety, depression, and severity of principal diagnosis) reductions were investigated. Results suggested that decreases in the frequency of negative emotions and reactivity to emotions following participation in the UP were both large in magnitude. Further, two emotional reactivity variables (fear of emotions and anxiety sensitivity) remained significantly related to symptom outcomes when controlling for negative emotions, and accounted for significant incremental variance in their prediction. These findings lend support to the notion that psychological health depends less on the frequency of negative emotions and more on how one relates to these emotions when they occur. © 2012 Elsevier Ltd.

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Crossref · 10.1016/j.brat.2012.05.005

Cites

53 of 54 references verified0 citation errors · 1 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

4 of 42 cited sources checked · 1 supported · 0 flagged · accuracy not yet measured

  • Premisecitation

    The Unified Protocol targets heightened negative reactivity to emotions by identifying maladaptive responses and teaching better management strategies.

    “The UP addresses heightened negative reactivity to emotions by identifying maladaptive responses to emotions and developing more effective strategies to manage these experiences (Ellard et al., 2010).”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites Ellard et al., 2010 source
  • Findingown data

    Following participation in the Unified Protocol, decreases in the frequency of negative emotions were large.

    “Results suggested that decreases in the frequency of negative emotions and reactivity to emotions following participation in the UP were both large in magnitude.”
    Quote in the paperNot a substantial claim
  • Findingown data

    Following participation in the Unified Protocol, decreases in reactivity to emotions were large.

    “Results suggested that decreases in the frequency of negative emotions and reactivity to emotions following participation in the UP were both large in magnitude.”
    Quote in the paperSubstantial claim
  • Findingown data

    Changes in the emotional reactivity variables targeted by the UP all had large effect sizes.

    “Change in the emotional reactivity variables targeted by the UP all represented large effects, as did change in negative affect”
    Quote in the paperNot a substantial claim
  • Findingown data

    In the hierarchical regression predicting change in depression, change in negative affect accounted for 22% of the variance.

    “While change in negative affect accounted for a significant amount of variance in predicting change in depression (22%)”
    Quote in the paperSubstantial claim
  • Classified as probably not a substantial claim. 22
  • May combine two claims. 23
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductcitation

    The Affective Control Scale has acceptable internal consistency and convergent validity.

    “The ACS has demonstrated acceptable internal consistency and convergent validity (Williams et al., 1997).”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites Williams et al., 1997 source

      The passages from “Latent Structure of Emotional Disorders” discuss affective dimensions, and “Preliminary Data” reports treatment outcomes; neither addresses the Affective Control Scale’s psychometric properties. Searches for the scale, internal consistency, convergent validity, and Williams et al. (1997) found no relevant passage in our copy. Page numbers were not available. (LLM, conf=0.72)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    Emotional disorders involve sharp increases in affect in response to environmental triggers and interpreting those experiences as harmful.

    “Emotional disorders are characterized by a tendency to experience steep increases in affect in response to environmental stimuli and, subsequently, interpret these emotional experiences as harmful (Andrews, 1990; Andrews, 1996; Brown & Barlow, 2009).”
    Quote in the paperSubstantial claim1 of 3 sources checked
    • cites Andrews, 1990 source
    • cites Andrews, 1996

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Brown & Barlow, 2009 source

      In “A New Proposal for a Dimensional Classification System” (page unavailable), the paper describes discrete eruptions of emotion, including fear triggered by internal or external cues, and apprehension about anxiety or panic symptoms. These examples support parts of the claim, but the paper does not characterize emotional disorders generally as a sequence of sharp affective increases in response to environmental stimuli followed by interpreting those experiences as harmful. (LLM, conf=0.83)

      Experimental — accuracy not yet measured
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductcitation

    The HAM-A showed good reliability between raters and across time, and it correlated well with comparable clinician-rated and self-report measures of depression.

    “This commonly used measure has demonstrated good levels of interrater and test-retest reliability, as well as convergent validity with similar clinician rated and self-report measures of depression symptoms (Shear et al., 2001).”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites Shear et al., 2001 source

      The Reliability section reports good HAM-A test–retest reliability (ICC 0.86) and interrater reliability (ICC 0.98). The Validity of SIGH-A as a Measure of Hamilton Anxiety Score section reports correlations with the clinician-rated SIGH-A and the self-report Beck Anxiety Inventory, but these measure anxiety, not depression symptoms. (LLM, conf=0.90)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Findingown data

    Anxiety sensitivity remained significantly related to symptom outcomes after controlling for negative emotions and contributed significant incremental variance to their prediction.

    “Further, two emotional reactivity variables (fear of emotions and anxiety sensitivity) remained significantly related to symptom outcomes when controlling for negative emotions, and accounted for significant incremental variance in their prediction.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Fear of emotions remained significantly related to symptom outcomes after controlling for negative emotions and contributed significant incremental variance to their prediction.

    “Further, two emotional reactivity variables (fear of emotions and anxiety sensitivity) remained significantly related to symptom outcomes when controlling for negative emotions, and accounted for significant incremental variance in their prediction.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Increased awareness and acceptance of emotions (ERSQ) was associated with decreases in depression and anxiety scores, but not with clinical severity scores.

    “Increased awareness and acceptance of emotions (ERSQ) was associated with decreases on depression and anxiety scores, but not on clinical severity scores.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Negative emotions and fear of emotions accounted for 10% and 7% of the variance in principal diagnosis severity ratings, respectively, but these predictors were not statistically significant.

    “negative emotions and fear of emotions accounted for 10% and 7% of the variance in principal diagnosis severity rating, respectively, yet these predictors were not statistically significant.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    In that regression, change in fear of emotions and sensitivity to anxiety accounted for significant additional variance (42%) and made negative affect no longer significant.

    “when entered into the model change in fear of emotions and sensitivity to anxiety accounted for significant additional variance (42%) and rendered negative affect no longer significant in the prediction of change in anxiety.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    After controlling for decreases in negative affect, decreases in fear of emotions remained significantly associated with decreases in depression and anxiety, but not with clinical severity.

    “Decreases in fear of emotions remained significantly associated with decreases in depression and anxiety (but not to clinical severity), while decreases in sensitivity to anxiety remained related to depression and clinical severity (but not to anxiety), after controlling for decreases in negative affect.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    In the hierarchical regression predicting clinical severity, change in negative affect predicted 10% of the variance but was not statistically significant.

    “Change in negative affect predicted 10% of the variance in clinical severity ratings but was not a statistically significant predictor.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Premisecitation

    Symptoms of emotional disorders reflect shared underlying factors, especially neuroticism, a stable tendency to experience negative affect.

    “Findings from recent research suggest that the various symptoms of emotional disorders are in fact manifestations of common underlying factors. Such underlying factors include prominently the core temperamental dimension of neuroticism, an enduring tendency to experience negative affect (Brown, Chorpita, & Barlow, 1998; Gershuny & Sher, 1998; Kasch, Rottenberg, Arnow, & Gotlib, 2002; Watson, Clark”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Brown, Chorpita, & Barlow, 1998 source
    • cites Gershuny & Sher, 1998 source
    • cites Kasch, Rottenberg, Arnow, & Gotlib, 2002 source
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductown data

    All medicated participants had been on the same dose for at least three months before enrollment and agreed to keep their medications and doses unchanged during the study.

    “All individuals were stable on the same dose for at least 3 months prior to enrolling in the study as a condition for participation in the study, and all agreed to maintain these dosages and medications for the duration of the study (for a description of medication stability compliance, see Farchione et al., in press).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Farchione et al., in press

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Classified as probably not a substantial claim.

    Premisecitation

    Decreased emotional avoidance is a hypothesized mechanism by which reduced negative reactivity improves psychological functioning.

    “A hypothesized mechanism through which decreased negative reactivity may lead to improvements in psychological functioning is decreased emotional avoidance.”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Bouton, Mineka, & Barlow, 2001 source
    • cites Craske & Barlow, 2007

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Lynch, Chapman, Rosenthal, Kuo & Linehan, 2006 source
  • Classified as probably not a substantial claim.

    Premisecitation

    Accepting and understanding the full range of internal experience without trying to change or reduce it is considered important for symptom reduction.

    “In contrast, acknowledging, understanding, and accepting the full range of internal experience (without attempts to change or reduce it) is thought to be important for symptom reduction (Hayes, Follette, & Linehan, 2004).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Hayes, Follette, & Linehan, 2004

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductcitation

    The Anxiety Sensitivity Index has good internal consistency and convergent validity.

    “The ASI has demonstrated good internal consistency and convergent validity (Peterson & Reiss, 1987; Vujanovic, Arrindell, Bernstein, Norton, & Zvolensky, 2007).”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites Peterson & Reiss, 1987

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Vujanovic, Arrindell, Bernstein, Norton, & Zvolensky, 2007 source
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductcitation

    No differences between groups were found for age or gender.

    “As reported by Farchione et al. (in press), no group differences were observed for age or gender.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Farchione et al. (in press)

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    The Unified Protocol is a cognitive-behavioral treatment created for anxiety, depression, and related emotional disorders.

    “The Unified Protocol (UP) for Transdiagnostic Treatment of Emotional disorders is a cognitive-behavioral intervention recently developed to address anxiety, depression and related disorders (somatoform and dissociative disorders), or “emotional disorders” (Barlow et al., 2011).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Barlow et al., 2011

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductcitation

    The Emotion Regulation Strategies Questionnaire has high internal consistency, adequate test-retest reliability, and construct validity.

    “The ERSQ has demonstrated high internal consistency (α = .90) and adequate test-retest reliability (rtt = .75). Additionally, positive associations with well-being and negative associations with psychopathology and emotion-regulation deficits have provided construct validity for this measure (Berking, Wupperman, Reichard, et al. 2008; Berking & Znoj, 2008).”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites Berking, Wupperman, Reichard, et al. 2008 source
    • cites Berking & Znoj, 2008

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Thought suppression is associated with depression, generalized anxiety disorder, obsessive compulsive disorder, and post-traumatic stress disorder.

    “In fact, thought suppression has been associated with depression, generalized anxiety disorder, obsessive compulsive disorder, and post-traumatic stress disorder (Purdon, 1999).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Purdon, 1999 source
  • Classified as probably not a substantial claim.

    Premisecitation

    Responses to daily mood shifts, rather than the moods themselves, significantly affect the occurrence of depressive symptoms.

    “and that responses to mood shifts in daily life (rather than the moods themselves) have significant impact on the occurrence of depressive symptoms (Segal et al., 2002).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Segal et al., 2002

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductcitation

    The PANAS negative affect scale had high internal consistency and test-retest reliability in its validation sample.

    “In the validation sample, internal consistency and test-retest reliability were high (α = .90; r = .71).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Watson, Clark & Tellegen, 1988 source
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Deliberately hiding emotions from others is linked to poorer adaptive functioning and lower well-being.

    “For example, deliberately trying to conceal emotions from others has been associated with less adaptive functioning and reduced well-being (Gross & John, 2003)”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Gross & John, 2003 source
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductown data

    Sixteen participants were taking psychotropic medications when they enrolled and were randomized.

    “Sixteen individuals were taking psychotropic medications at the time of enrollment and randomization.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductown data

    Thirty-two of 37 patients were treatment completers.

    “Thirty-two out of 37 patients were considered treatment completers (see Procedure section for treatment completer criteria).”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductcitation

    The ADIS-IV-L has excellent to acceptable interrater reliability for anxiety and mood disorders.

    “This measure has demonstrated excellent to acceptable interrater reliability for the anxiety and mood disorders (Brown, Di Nardo, Lehman, & Campbell, 2001).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Brown, Di Nardo, Lehman, & Campbell, 2001 source
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Self-harm, substance abuse, and binge eating have been described as maladaptive reactions to emotions aimed at pushing away emotional experience.

    “Further, behaviors such as self-harm, substance abuse, and binge eating, have also been conceptualized as maladaptive negative reactions to emotions with the goal of pushing away this experience (Hayes, Wilson, Gifford, Follette & Strosahl, 1996).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Hayes, Wilson, Gifford, Follette & Strosahl, 1996 source
  • May combine two claims.

    Study design and conductown data

    Data were collected only at pre- and post-treatment, which limits temporal interpretation.

    “data were only collected at pre- and post-treatment, so temporal interpretation is limited.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    All therapists received extensive training and certification before treating study patients.

    “All therapists underwent extensive training and certification prior to treating study patients”
    Quote in the paperNot a substantial claim
  • Classified as probably not a substantial claim.

    Study design and conductreasoning

    All treatment completers, including immediate treatment and post-waitlist delayed treatment participants, were combined into a single sample.

    “all treatment completers (immediate treatment and post-waitlist delayed treatment participants) were combined into a single sample”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    Treatment adherence was checked in weekly supervision meetings.

    “treatment adherence was monitored during weekly supervision meetings.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationown data

    Decreased levels of negative emotions and decreased reactivity to them both contribute to symptom change.

    “Overall, these results indicate that decreased levels of negative emotions as well as decreased reactivity to them both contribute to symptom change.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Interpretationown data

    Both the frequency of negative emotions and the extent of strong reactions to them changed to a large degree as a function of UP treatment.

    “Overall, these results suggest that both frequency of negative emotions and the extent to which one reacts strongly to them change to a large degree as a function of treatment with the UP.”
    Quote in the paperSubstantial claim
  • Classified as probably not a substantial claim. May combine two claims.

    Study design and conductnone given

    Independent evaluators were trained to a reliability criterion and were unaware of participants' randomized condition.

    “Independent evaluators who were trained to criterion reliability and blind to randomized condition, conducted semi-structured diagnostic clinical interviews and provided clinical ratings.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductcitation

    The Hamilton Depression Rating Scale has good interrater and test-retest reliability and concurrent validity with similar depression measures.

    “This commonly used measure has demonstrated good levels of interrater and test-retest reliability (Williams, 1988), as well as concurrent validity with similar clinician rated and self-report measures of depression symptoms (Bech et al., 1992).”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites Williams, 1988 source
    • cites Bech et al., 1992 source
34 of 34
  • The paper relies on this without support.

    The question of whether symptom reductions depend on the frequency of negative emotions or on how they are managed has not been examined in a treatment outcome study.

    “Despite being a central tenet of cognitive-behavioral therapy, the extent to which reductions in psychological symptoms are a function of the frequency of negative emotions or how they are managed has not been studied in the context of a treatment outcome study.”
  • The paper relies on this without support.

    The Unified Protocol is thought to address neuroticism by reducing reactivity to emotional experience.

    “Given that the UP is posited to address neuroticism, thought to be a stable dimension of personality (Costa & McCrae, 1992), by decreasing reactivity to emotional experience, it is important to clarify what is changing as a function of treatment: the frequency with which patients experience negative emotions, or how they relate to negative emotions when these experiences occur.”
  • The paper relies on this without support.

    Fear of emotions, anxiety sensitivity, and emotional awareness/acceptance are related but distinct indicators of reactivity to emotion.

    “It is important to emphasize that the constructs of fear of emotions, anxiety sensitivity, and emotional awareness/acceptance are related, yet distinct markers of reactivity to emotion.”
  • The paper relies on this without support.

    Trait neuroticism is marked by frequent and intense negative emotions.

    “High frequency and intensity of negative emotions characterize trait neuroticism.”
  • The authors state this as an assumption.

    The tendency to experience negative emotions is a trait construct that temporally precedes learning skills to reduce reactivity.

    “based on the a priori conception that the tendency to experience negative emotions is a trait construct with temporal precedence over learning new skills to decrease reactivity.”
  • The authors state this as an assumption.

    Strong reactions to emotions cause symptoms of depression and anxiety.

    “A priori assumptions that the tendency to experience negative emotions is a trait-level construct and that strong reactions to emotions leads to symptoms of depression and anxiety shaped the formulation of analyses in this study.”
6 of 6

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Authors
Sauer-Zavala, S., Boswell, J. F., Gallagher, M. W., Bentley, K. H., Ametaj, A., & Barlow, D. H.
Affiliations
Boston University (US)
Corresponding author
Sauer-Zavala, Shannon
Venue
Behaviour Research and Therapy
Publisher
Elsevier BV
Published
2012-09
Volume
50
Issue
9
Pages
551-557
ISSN
0005-7967 (ISSN-L)
OpenAlex
W2071566020
Cited by
163
References
61
Citations by year
2026: 8 · 2025: 5 · 2024: 13 · 2023: 16 · 2022: 14 · 2021: 9 · 2020: 21 · 2019: 9 · 2018: 17 · 2017: 11 · 2016: 14 · 2015: 6 · 2014: 8 · 2013: 8
FWCI
6.32
Type
journal article
Language
en
Open access
Locations
  • Behaviour Research and Therapy (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (submittedVersion)
  • PubMed Central (submittedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
negative affectivity, emotional reactivity, Unified Protocol, transdiagnostic treatment, emotional disorders, fear of emotions, anxiety sensitivity, emotional awareness
MeSH terms
Adult, Clinical Protocols, Emotions, Fear, Female, Humans, Male

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