Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial

Farchione, Todd J.; Fairholme, Christopher P.; Ellard, Kristen K.; Boisseau, Christina L.; Thompson-Hollands, Johanna; Carl, Jenna R.; Gallagher, Matthew W.; Barlow, David H.

doi:10.1016/j.beth.2012.01.001

Cited by 746Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and ApplicationsPersonality Disorders and Psychopathology

Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial

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Farchione, Todd J., Fairholme, Christopher P., Ellard, Kristen K., Boisseau, Christina L., Thompson-Hollands, Johanna, Carl, Jenna R., Gallagher, Matthew W., Barlow, David H.·2012·Behavior Therapy

DOI 10.1016/j.beth.2012.01.001PMC PMC3383087

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Abstract

This study further evaluates the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP). A diagnostically heterogeneous clinical sample of 37 patients with a principal anxiety disorder diagnosis was enrolled in a randomized controlled trial (RCT) involving up to 18 sessions of treatment and a 6-month follow-up period. Patients were randomly assigned to receive either immediate treatment with the UP (n=26) or delayed treatment, following a 16-week wait-list control period (WLC; n=11). The UP resulted in significant improvement on measures of clinical severity, general symptoms of depression and anxiety, levels of negative and positive affect, and a measure of symptom interference in daily functioning across diagnoses. In comparison, participants in the WLC condition exhibited little to no change following the 16-week wait-list period. The effects of UP treatment were maintained over the 6-month follow-up period. Results from this RCT provide additional evidence for the efficacy of the UP in the treatment of anxiety and comorbid depressive disorders, and provide additional support for a transdiagnostic approach to the treatment of emotional disorders.

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In that randomized controlled trial, there was a slight increase in residual symptoms at 6-month follow-up.
“Improvements in clinical severity and general symptoms of anxiety and depression were maintained at 3-month follow-up, with a slight increase in residual symptoms at 6-month follow-up [95].”
From Psychotherapeutic treatments for generalized anxiety disorder: cognitive and behavioral therapies, enhancement strategies, and emerging efforts (2022) · cites this paper as [95]
The Discussion (page unavailable) says patients continued to improve six months after treatment, rather than reporting an increase in residual symptoms. The Results section on clinical significance among treatment initiators likewise reports higher rates of subclinical status and treatment response at follow-up than at posttreatment. (LLM, conf=0.78)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
Fifteen percent of audiotapes will be randomly selected for review by an independent evaluator using fidelity scales adapted from a prior large-scale randomized controlled trial.
“Fifteen percent of audiotapes will be randomly selected for review by an independent evaluator using fidelity scales adapted from a prior large-scale randomized controlled trial [32].”
From Unified protocol for the discontinuation of long-term serotonin reuptake inhibitors in obsessive compulsive disorder: Study protocol and methods (2018) · cites this paper as [32]
The Method section (‘Therapists and Treatment Integrity’; page unavailable) says treatment adherence was monitored in weekly supervision but was not systematically assessed. The Discussion (page unavailable) explicitly says treatment fidelity was not evaluated in this trial, contrary to presenting it as the source of fidelity scales for independent audiotape review. (LLM, conf=0.86)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
No posttreatment symptom differences were found between the immediate-treatment and delayed-treatment groups.
“Furthermore, no posttreatment symptom differences were observed between the immediate and delayed treatment groups (see Farchione et al., 2012).”
From Intolerance of Uncertainty: A Common Factor in the Treatment of Emotional Disorders (2013) · cites this paper as Farchione et al., 2012
The Results section (‘Efficacy at Posttreatment’; page unavailable) reports significant differences between the immediate-treatment group and the wait-list/delayed-treatment group in depression and anxiety symptoms, rather than no differences. The Study Design section clarifies that the delayed group received treatment only after its wait-list assessment. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
In that randomized controlled trial, improvements in clinical severity and general anxiety and depression symptoms were maintained at 3-month follow-up.
“Improvements in clinical severity and general symptoms of anxiety and depression were maintained at 3-month follow-up, with a slight increase in residual symptoms at 6-month follow-up [95].”
From Psychotherapeutic treatments for generalized anxiety disorder: cognitive and behavioral therapies, enhancement strategies, and emerging efforts (2022) · cites this paper as [95]
The Results (Efficacy at Posttreatment) report improvements in clinical severity and general anxiety and depression symptoms, and the paper reports that treatment effects were maintained at follow-up. But the Method (Study Design) specifies a 6-month follow-up assessment, not a 3-month one; the claimed follow-up time is unsupported. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Baseline evaluation found no significant differences in type or severity of psychopathology between eligible participants and those excluded from the trial.
“No statistical differences in initial severity or demographic variables were observed between treatment completers and noncompleters, and baseline evaluation indicated that no significant differences in the type or severity of psy-chopathology existed between eligible participants and those excluded from the trial (e.g., refused potential randomization to waitlist/delayed treatment condition; see”
From Intolerance of Uncertainty: A Common Factor in the Treatment of Emotional Disorders (2013) · cites this paper as Farchione et al., 2012
The Method > Participants passage says that, based on the initial diagnostic evaluation, excluded individuals did not appear to have more severe psychopathology than enrolled and randomized patients. It does not report a statistical comparison or establish that the groups did not differ in type of psychopathology. (LLM, conf=0.87)
Experimental — accuracy not yet measured

Results of studies support the efficacy of UP in the treatment of emotional disorders in Iran and other countries.
“The results of studies support the efficacy of UP in the treatment of emotional disorders in Iran and other countries [2, 10, 14, 15, 23, 32].”
From Internet-based UP-A intervention on treatment of stress, anxiety, depression, and psychological flexibility among adolescents with sub-clinical diagnosis of emotional disorders during the COVID-19 pandemic: a clinical trial (2024) · cites this paper as [15]
The Discussion reports that UP improved anxiety-disorder symptoms relative to a wait-list control, supporting the efficacy claim. The Method (Participants) describes recruitment through the Center for Anxiety and Related Disorders, identified in the paper as being at Boston University; our copy provides no evidence about UP's efficacy in Iran. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Some studies have tested the efficacy of transdiagnostic interventions in improving positive affect measures, but these studies do not include a specific component to address positive affect regulation.
“Some studies have tested the efficacy of transdiagnostic interventions in improving PA measures. However, these studies do not include a specific component to address PA regulation [13]”
From Negative and positive affect regulation in a transdiagnostic internet-based protocol for emotional disorders: Randomized controlled trial (2021) · cites this paper as [13]
The Results (Efficacy at Posttreatment) report increased positive affectivity on the PANAS-PA, supporting the claim that a transdiagnostic intervention was tested on a positive-affect measure. But the paper says the version tested placed greater emphasis on positive emotion as a trigger for avoidance and a target for exposure, so it does not support the categorical claim that the intervention lacked a component addressing positive-affect regulation. (LLM, conf=0.86)
Experimental — accuracy not yet measured
These results are comparable with those reported in other transdiagnostic trials in which effect sizes are larger for depression than for anxiety and higher for PANAS-P than for PANAS-N.
“These results are comparable with those reported in other transdiagnostic trials in which effect sizes are larger for depression than for anxiety and higher for PANAS-P than for PANAS-N [13].”
From Negative and positive affect regulation in a transdiagnostic internet-based protocol for emotional disorders: Randomized controlled trial (2021) · cites this paper as [13]
In Results, “Efficacy at Posttreatment,” the positive-affect effect size is larger in magnitude than the negative-affect effect size. Depression exceeds anxiety on the self-report measures (BDI-II versus BAI), but not on the clinician-rated measures (SIGH-D versus SIGH-A), so the unqualified depression-versus-anxiety comparison overstates the findings. (LLM, conf=0.88)
Experimental — accuracy not yet measured
The UP has shown efficacy in treating anxiety, unipolar and bipolar depression, post-traumatic stress disorder, borderline personality disorder, nonsuicidal self-injury, alcohol abuse, and eating disorders.
“The UP has shown efficacy in treating anxiety,31,32 unipolar and bipolar depression,31,33 post-traumatic stress disorder,34 borderline personality disorder,35 nonsuicidal self-injury,36 alcohol abuse,37 and eating disorders.38”
From Improved quality of life and reduced depressive symptoms in medical students after a single-session intervention (2020) · cites this paper as [31]
The Discussion reports efficacy for several anxiety disorders, and the Results report improvement among patients with comorbid mood disorders, while cautiously suggesting the UP may be effective for depression. The Method (Participants) states that current bipolar disorder was an exclusion criterion, so this trial does not support efficacy for bipolar depression. Citation 31 is attached to the anxiety and depression portions of the sentence, not the later conditions. (LLM, conf=0.90)
Experimental — accuracy not yet measured
A few participants in mechanistically transdiagnostic studies had primary or comorbid PTSD, but no study has focused on applying this approach to patients with primary PTSD.
“Whereas a handful of participants in mechanistically transdiagnostic studies [13, 14] have presented with primary or comorbid PTSD; no study to date has focused on applying this approach to patients who present with primary PTSD.”
From Emergence of Transdiagnostic Treatments for PTSD and Posttraumatic Distress (2016) · cites this paper as [14]
In a randomized controlled trial with primary diagnoses of generalized anxiety disorder, social phobia, panic disorder, or obsessive-compulsive disorder, the unified protocol led to greater reductions in primary and comorbid disorder symptom severity than waitlist at posttreatment.
“In an RCT of the UP in a sample with primary diagnoses of GAD, social phobia, panic disorder or obsessive-compulsive disorder, there were greater reductions in primary and comorbid disorder symptom severity relative to waitlist at posttreatment [95].”
From Psychotherapeutic treatments for generalized anxiety disorder: cognitive and behavioral therapies, enhancement strategies, and emerging efforts (2022) · cites this paper as [95]
The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders is an empirically supported cognitive-behavioral treatment.
“The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) [22] is an empirically supported, cognitive-behavioral treatment that has been described extensive elsewhere [32–34].”
From Unified protocol for the discontinuation of long-term serotonin reuptake inhibitors in obsessive compulsive disorder: Study protocol and methods (2018) · cites this paper as [32]
Transdiagnostic treatments for anxiety and other emotional disorders have gained increased attention and empirical study in recent years.
“Transdiagnostic treatments for anxiety and other emotional disorders have gained increased attention and empirical study in recent years (Farchione et al. 2012; Norton and Barrera 2013; Wilamowska et al. 2010).”
From CALM Pregnancy: results of a pilot study of mindfulness-based cognitive therapy for perinatal anxiety (2014) · cites this paper as Farchione et al. 2012
The Unified Protocol is effective in reducing negative affect.
“The UP has been tested and results indicate that it is effective in reducing negative affect (NA) [13]”
From Negative and positive affect regulation in a transdiagnostic internet-based protocol for emotional disorders: Randomized controlled trial (2021) · cites this paper as [13]
The Unified Protocol is more effective than a waitlist control in reducing anxiety and depression.
“is more effective than a wait list control (WLC) in reducing anxiety (controlled between-group ESs: 0.56 on the BAI, and 1.39 on the clinician severity ratings of (co) principal diagnosis), and depression (controlled betweengroup ESs: 1.11 on the BDI-II) (Farchione et al., 2012).”
From Systematic review and meta-analysis of transdiagnostic psychological treatments for anxiety and depressive disorders in adulthood (2015) · cites this paper as Farchione et al., 2012
No statistical differences in initial severity or demographic variables were found between treatment completers and noncompleters.
“No statistical differences in initial severity or demographic variables were observed between treatment completers and noncompleters, and baseline evaluation indicated that no significant differences in the type or severity of psy-chopathology existed between eligible participants and those excluded from the trial (e.g., refused potential randomization to waitlist/delayed treatment condition; see”
From Intolerance of Uncertainty: A Common Factor in the Treatment of Emotional Disorders (2013) · cites this paper as Farchione et al., 2012
The Method (Participants; page unavailable) reports how many patients did not complete treatment, but does not compare their initial severity or demographics with those of completers. I searched for completer–noncompleter baseline and dropout comparisons; the reported demographic comparison is between treatment arms, not between completers and noncompleters. (LLM, conf=0.74)
Experimental — accuracy not yet measured
In a sample of people attending outpatient clinics with a range of clinical diagnoses, all symptoms included in the DSM had a positive predictive value above 75% in differentiating patients with a diagnosis of depression vs. non-depression, with the first two symptoms on the list having the highest values.
“In a sample of people attending outpatient clinics with a range of clinical diagnoses, all symptoms included in the DSM had a positive predictive value above 75%, in differentiating patients with a diagnosis of depression vs. non-depression, with the first two symptoms on the list having the highest values. 49”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [49]
The list of symptoms and signs in Table 1 is based on the best available evidence.
“The list of symptoms and signs in Table 1 - almost identical to that proposed by the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM) since its 3rd edition (DSM-III) 50 -is based on the best available evidence.”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [49]
Transcripts of sessions from randomized controlled trials are rarely available.
“transcripts of sessions from randomized controlled trials are rarely available [13, 25, 26].”
From When ELIZA meets therapists: a Turing test for the heart and mind (2025) · cites this paper as [25]

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Method
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Self-citation
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Background
Efficacy of a cognitive-behavioral treatment for generalized anxiety disorder: Evaluation in a controlled clinical trial
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Method
Reliability of the self-report version of the panic disorder severity scale
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The Hierarchical Taxonomy of Psychopathology (HiTOP): A dimensional alternative to traditional nosologies.
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The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders Compared With Diagnosis-Specific Protocols for Anxiety Disorders: A Randomized Clinical Trial
Barlow, D. H., Farchione, T. J., Bullis, J. R., Gallagher, M. W., Murray-Latin, H., Sauer-Zavala, S., Bentley, K. H., Thompson-Hollands, J., Conklin, L. R., Boswell, J. F., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.2164 · Cited by 853 · see citing works
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Fear of the unknown: One fear to rule them all?
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LGB-affirmative cognitive-behavioral therapy for young adult gay and bisexual men: a randomized controlled trial of a transdiagnostic minority stress approach
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The Lancet Psychiatry Commission on psychological treatments research in tomorrow's science
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“11 on the BDI-II) (Farchione et al., 2012).”
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Intolerance of Uncertainty: A Common Factor in the Treatment of Emotional Disorders
Boswell, J. F., Thompson-Hollands, J., Farchione, T. J., & Barlow, D. H. (2013) · Journal of Clinical Psychology · doi:10.1002/jclp.21965 · Cited by 495 · see citing works
“Method Data for this study were derived from a randomized control trial (RCT; Farchione et al., 2012) investigating the efficacy of the UP compared to a 16-week waitlist/delayed-treatment condition.”
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A hierarchical causal taxonomy of psychopathology across the life span.
Lahey, B. B., Krueger, R. F., Rathouz, P. J., Waldman, I. D., & Zald, D. H. (2017) · Psychological Bulletin · doi:10.1037/bul0000069 · Cited by 443 · see citing works
Maternal psychological distress & mental health service use during the COVID-19 pandemic
Cameron, E. E., Joyce, K. M., Delaquis, C. P., Reynolds, K., Protudjer, J. L. P., & Roos, L. E. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.081 · Cited by 413 · see citing works
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Fusar‐Poli, P., Solmi, M., Brondino, N., Davies, C., Chae, C., Politi, P., Borgwardt, S., Lawrie, S. M., Parnas, J., & McGuire, P. (2019) · World Psychiatry · doi:10.1002/wps.20631 · Cited by 409 · see citing works
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“Some studies have focused on both mood and anxiety disorders (Farchione et al., 2012), but further research is needed in identifying theoretical processes that account for a broader range of disorders.”
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Positive emotion regulation in emotional disorders: A theoretical review
Carl, J. R., Soskin, D. P., Kerns, C., & Barlow, D. H. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.01.003 · Cited by 391 · see citing works
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Current Definitions of “Transdiagnostic” in Treatment Development: A Search for Consensus
Sauer-Zavala, S., Gutner, C. A., Farchione, T. J., Boettcher, H. T., Bullis, J. R., & Barlow, D. H. (2017) · Behavior Therapy · doi:10.1016/j.beth.2016.09.004 · Cited by 371 · see citing works
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Sakiris, N., & Berle, D. (2019) · Clinical Psychology Review · doi:10.1016/j.cpr.2019.101751 · Cited by 369 · see citing works
A transdiagnostic community-based mental health treatment for comorbid disorders: development and outcomes of a randomized controlled trial among Burmese refugees in Thailand
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The Relationship Between Uncertainty and Affect
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Depression, anxiety and their comorbidity in the Swedish general population: point prevalence and the effect on health-related quality of life
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Annual Research Review: Building a science of personalized intervention for youth mental health
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Transdiagnostic versus disorder-specific and clinician-guided versus self-guided internet-delivered treatment for generalized anxiety disorder and comorbid disorders: A randomized controlled trial
Dear, B. F., Staples, L. G., Terides, M. D., Karin, E., Zou, J., Johnston, L., Gandy, M., Fogliati, V. J., Wootton, B. M., McEvoy, P. M., et al. (2015) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2015.09.003 · Cited by 230 · see citing works
The Emotion Regulation Questionnaire: Psychometric properties in general community samples
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Disorder-specific versus transdiagnostic and clinician-guided versus self-guided treatment for major depressive disorder and comorbid anxiety disorders: A randomized controlled trial
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Harvey, A. G., & Gumport, N. B. (2015) · Behaviour Research and Therapy · doi:10.1016/j.brat.2015.02.004 · Cited by 221 · see citing works
“There has been progress in developing transdiagnostic treatments that target transdiagnostic processes across the anxiety disorders and depression in adults (Craske et al., 2011; Farchione et al., 2012; McManus, Shafran, & Cooper, 2010; Norton, 2012), across anxiety, depression, and conduct problems in youth (Bilek &…”
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Anxiety sensitivity and interoceptive exposure: A transdiagnostic construct and change strategy
Boswell, J. F., Farchione, T. J., Sauer-Zavala, S., Murray, H. W., Fortune, M. R., & Barlow, D. H. (2013) · Behavior Therapy · doi:10.1016/j.beth.2013.03.006 · Cited by 232 · see citing works
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Upregulating the positive affect system in anxiety and depression: Outcomes of a positive activity intervention: <scp>Taylor et al.</scp>
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On the efficacy of the unified protocol for transdiagnostic treatment of emotional disorders: a systematic review and meta-analysis
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A transdiagnostic minority stress intervention for gender diverse sexual minority women's depression, anxiety, and unhealthy alcohol use: a randomized controlled trial
Pachankis, J. E., McConocha, E. M., Clark, K. A., Wang, K., Behari, K., Fetzner, B. K., Brisbin, C. D., Scheer, J. R., & Lehavot, K. (2020) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000508 · Cited by 227 · see citing works
Maximizing the Impact of e-Therapy and Serious Gaming: Time for a Paradigm Shift
Fleming, T. M., de Beurs, D., Khazaal, Y., Gaggioli, A., Riva, G., Botella, C., Baños, R. M., Aschieri, F., Bavin, L. M., Kleiboer, A., et al. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00065 · Cited by 212 · see citing works
Uncovering clinical principles and techniques to address minority stress, mental health, and related health risks among gay and bisexual men.
Pachankis, J. E. (2014) · Clinical Psychology: Science and Practice · doi:10.1111/cpsp.12078 · Cited by 217 · see citing works
CALM Pregnancy: results of a pilot study of mindfulness-based cognitive therapy for perinatal anxiety
Goodman, J. H., Guarino, A., Chenausky, K., Klein, L., Prager, J., Petersen, R., Forget, A., & Freeman, M. (2014) · Archives of Women's Mental Health · doi:10.1007/s00737-013-0402-7 · Cited by 198 · see citing works
“Transdiagnostic treatments for anxiety and other emotional disorders have gained increased attention and empirical study in recent years (Farchione et al. 2012; Norton and Barrera 2012; Wilamowska et al. 2010).”
Community-based mental health treatments for survivors of torture and militant attacks in Southern Iraq: a randomized control trial
Weiss, W. M., Murray, L. K., Zangana, G. A. S., Mahmooth, Z., Kaysen, D., Dorsey, S., Lindgren, K., Gross, A., Murray, S. M., Bass, J. K., et al. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0622-7 · Cited by 206 · see citing works
An initial waitlist-controlled trial of the unified protocol for the treatment of emotional disorders in adolescents
Ehrenreich-May, J., Rosenfield, D., Queen, A. H., Kennedy, S. M., Remmes, C. S., & Barlow, D. H. (2017) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2016.10.006 · Cited by 208 · see citing works
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A transdiagnostic minority stress treatment approach for gay and bisexual men's syndemic health conditions
Pachankis, J. E. (2015) · Archives of Sexual Behavior · doi:10.1007/s10508-015-0480-x · Cited by 205 · see citing works
TRANSDIAGNOSTIC TREATMENT FOR ANXIETY AND DEPRESSION: The Cutting Edge: Transdiagnostic Therapy
Craske, M. G. (2012) · Depression and Anxiety · doi:10.1002/da.21992 · Cited by 208 · see citing works
Hierarchical models of psychopathology: empirical support, implications, and remaining issues
Lahey, B. B., Moore, T. M., Kaczkurkin, A. N., & Zald, D. H. (2021) · World Psychiatry · doi:10.1002/wps.20824 · Cited by 188 · see citing works
A minority stress—emotion regulation model of sexual compulsivity among highly sexually active gay and bisexual men.
Pachankis, J. E., Rendina, H. J., Restar, A., Ventuneac, A., Grov, C., & Parsons, J. T. (2015) · Health Psychology · doi:10.1037/hea0000180 · Cited by 185 · see citing works
Toward a unified treatment for emotional disorders: Update on the science and practice
Norton, P. J., & Paulus, D. J. (2016) · Behavior Therapy · doi:10.1016/j.beth.2015.07.002 · Cited by 180 · see citing works
A systematic review of unified protocol applications with adult populations: facilitating widespread dissemination via adaptability
Cassiello-Robbins, C., Southward, M. W., Tirpak, J. W., & Sauer-Zavala, S. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101852 · Cited by 179 · see citing works
Spontaneous Thought and Vulnerability to Mood Disorders: The Dark Side of the Wandering Mind
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Addressing neuroticism in psychological treatment.
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Masculinity, emotion regulation, and psychopathology: A critical review and integrated model
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The role of negative affectivity and negative reactivity to emotions in predicting outcomes in the unified protocol for the transdiagnostic treatment of emotional disorders
Sauer-Zavala, S., Boswell, J. F., Gallagher, M. W., Bentley, K. H., Ametaj, A., & Barlow, D. H. (2012) · Behaviour Research and Therapy · doi:10.1016/j.brat.2012.05.005 · Cited by 163 · see citing works
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Insomnia as a Transdiagnostic Process in Psychiatric Disorders
Dolsen, E. A., Asarnow, L. D., & Harvey, A. G. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0471-y · Cited by 163 · see citing works
Iterative Decision‐making for Evaluation of Adaptations (IDEA): A decision tree for balancing adaptation, fidelity, and intervention impact
Miller, C. J., Wiltsey‐Stirman, S., & Baumann, A. A. (2020) · Journal of Community Psychology · doi:10.1002/jcop.22279 · Cited by 138 · see citing works
Transdiagnostic versus diagnosis specific cognitive behavioural therapies for anxiety: A meta-analysis
Pearl, S. B., & Norton, P. J. (2017) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2016.07.004 · Cited by 156 · see citing works
Efficacy of transdiagnostic cognitive behaviour therapy for anxiety disorders: A systematic review and meta-analysis of published outcome studies
Reinholt, N., & Krogh, J. (2014) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2014.897367 · Cited by 146 · see citing works
An idiographic analysis of change processes in the unified transdiagnostic treatment of depression
Boswell, J. F., Anderson, L. M., & Barlow, D. H. (2014) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0037403 · Cited by 138 · see citing works
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Does the unified protocol really change neuroticism? Results from a randomized trial
Sauer-Zavala, S., Fournier, J. C., Jarvi Steele, S., Woods, B. K., Wang, M., Farchione, T. J., & Barlow, D. H. (2021) · Psychological Medicine · doi:10.1017/s0033291720000975 · Cited by 133 · see citing works
Effectiveness of Transdiagnostic Cognitive Behaviour Therapy for Anxiety and Depression in Adults: A Systematic Review and Meta-analysis
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A preliminary investigation of the long-term outcome of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
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Conceptualizing eating disorder psychopathology using an anxiety disorders framework: Evidence and implications for exposure-based clinical research
Schaumberg, K., Reilly, E. E., Gorrell, S., Levinson, C. A., Farrell, N. R., Brown, T. A., Smith, K. M., Schaefer, L. M., Essayli, J. H., Haynos, A. F., et al. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101952 · Cited by 121 · see citing works
A Randomized Controlled Pilot Trial of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children
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Acceptance and commitment therapy for children: a systematic review of intervention studies
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Evidence-Based Psychological Treatments: An Update and a Way Forward
Barlow, D. H., Bullis, J. R., Comer, J. S., & Ametaj, A. A. (2013) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185629 · Cited by 120 · see citing works
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EFFECT OF TRANSDIAGNOSTIC CBT FOR ANXIETY DISORDERS ON COMORBID DIAGNOSES: Research Article: Transdiagnostic CBT and Comorbidity
Norton, P. J., Barrera, T. L., Mathew, A. R., Chamberlain, L. D., Szafranski, D. D., Reddy, R., & Smith, A. H. (2013) · Depression and Anxiety · doi:10.1002/da.22018 · Cited by 121 · see citing works
CBT for adolescents with anxiety: mature yet still developing
Kendall, P. C., & Peterman, J. S. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14081061 · Cited by 115 · see citing works
Has evidence-based psychosocial treatment for anxiety disorders permeated usual care in community mental health settings?
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Authors: Farchione, T. J., Fairholme, C. P., Ellard, K. K., Boisseau, C. L., Thompson-Hollands, J., Carl, J. R., Gallagher, M. W., & Barlow, D. H.
Affiliations: Boston University (US)
Brown University (US)
Corresponding author: Farchione, Todd J.
ORCID: Farchione, Todd J.
Ellard, Kristen K.
Boisseau, Christina L.
Carl, Jenna R.
Gallagher, Matthew W.
Barlow, David H.
Venue: Behavior Therapy
Publisher: Elsevier BV
Published: 2012-09
Volume: 43
Issue: 3
Pages: 666-678
ISSN: 0005-7894 (ISSN-L)
DOI: 10.1016/j.beth.2012.01.001
PMC: PMC3383087
OpenAlex: W2059796833
Cited by: 746
References: 87
Citations by year: 2026: 23 · 2025: 30 · 2024: 41 · 2023: 42 · 2022: 55 · 2021: 77 · 2020: 61 · 2019: 56 · 2018: 67 · 2017: 74 · 2016: 64 · 2015: 50 · 2014: 53 · 2013: 38 · 2012: 14
FWCI: 66.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavior Therapy (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R01AA013727)
National Institute of Mental Health (R34MH070693, R01MH090053)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords: Unified Protocol for Transdiagnostic Treatment of Emotional Disorders, transdiagnostic treatment, anxiety disorders, depression, comorbid depression, treatment efficacy, waitlist control, symptom maintenance
MeSH terms: Adult, Anxiety Disorders, Depressive Disorder, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Waiting Lists, Cognitive Behavioral Therapy

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Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial

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