Cited by 259Suicide and Self-Harm StudiesPersonality Disorders and PsychopathologySubstance Abuse Treatment and Outcomes

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Treating Nonsuicidal Self-Injury: A Systematic Review of Psychological and Pharmacological Interventions

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Turner, Brianna J, Austin, Sara B, Chapman, Alexander L·2014·The Canadian Journal of Psychiatry

DOI 10.1177/070674371405901103PMC PMC4244876

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Abstract

Objective: Nonsuicidal self-injury (NSSI), the deliberate, self-inflicted damage of bodily tissue without the intent to die, is associated with various negative outcomes. Although basic and epidemiologic research on NSSI has increased during the last 2 decades, literature on effective interventions targeting NSSI is still emerging. Here, we present a comprehensive, systematic review of existing psychological and pharmacological treatments designed specifically for NSSI, or including outcome assessments examining change in NSSI. Method: We conducted a systematic search of PsycINFO, MEDLINE, and ERIC databases to retrieve relevant articles that met inclusion criteria; specifically, uncontrolled and controlled trials that 1) presented quantitative outcome data on NSSI, and 2) clearly differentiated NSSI from suicidal self-injury (SSI). Consistent with the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, definition of NSSI, we excluded studies examining populations with developmental or intellectual disabilities, or with psychotic disorders. Results: Several interventions appear to hold promise for reducing NSSI, including dialectical behaviour therapy, emotion regulation group therapy, manual-assisted cognitive therapy, dynamic deconstructive psychotherapy, atypical antipsychotics (aripiprazole), naltrexone, and selective serotonin reuptake inhibitors (with or without cognitive-behavioural therapy). Nevertheless, there remains a paucity of well-controlled studies investigating treatment efficacy for NSSI. Conclusions: Structured psychotherapeutic approaches focusing on collaborative therapeutic relationships, motivation for change, and directly addressing NSSI behaviours seem to be most effective in reducing NSSI. Medications targeting the serotonergic, dopaminergic and opioid systems also have demonstrated some benefits. Future studies employing controlled designs as well as a clear delineation of NSSI and SSI will improve knowledge regarding treatment effects.

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Authors: Turner, B. J., Austin, S. B., & Chapman, A. L.
Affiliations: Simon Fraser University (CA)
Corresponding author: Turner, Brianna J
ORCID: Turner, Brianna J
Chapman, Alexander L
Venue: The Canadian Journal of Psychiatry
Publisher: SAGE Publications
Published: 2014-11
Volume: 59
Issue: 11
Pages: 576-585
ISSN: 0706-7437 (ISSN-L)
1497-0015
DOI: 10.1177/070674371405901103
PMC: PMC4244876
OpenAlex: W2226199416
Cited by: 259
References: 109
Citations by year: 2026: 17 · 2025: 30 · 2024: 31 · 2023: 36 · 2022: 23 · 2021: 37 · 2020: 19 · 2019: 13 · 2018: 15 · 2017: 15 · 2016: 17 · 2015: 3 · 2014: 1
FWCI: 1.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: The Canadian Journal of Psychiatry (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Psychological Association
Michael Smith Health Research BC
Health Canada
Canadian Institutes of Health Research
Topics: Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: non-suicidal self-injury, suicidal self-injury, psychological intervention, pharmacotherapy, dialectical behavior therapy, atypical antipsychotics, aripiprazole, naltrexone, selective serotonin reuptake inhibitors, cognitive behavioral therapy, treatment efficacy
MeSH terms: Adolescent, Adult, Borderline Personality Disorder, Combined Modality Therapy, Humans, Psychotherapy, Psychotherapy, Group, Psychotropic Drugs, Suicide, Attempted, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Self-Injurious Behavior, Outcome Assessment, Health Care, Young Adult, Theory of Mind

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Treating Nonsuicidal Self-Injury: A Systematic Review of Psychological and Pharmacological Interventions

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