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Cited by 49Attention Deficit Hyperactivity DisorderObsessive-Compulsive Spectrum DisordersBehavioral and Psychological Studies

Methylphenidate in Children With Oppositional Defiant Disorder and Both Comorbid Chronic Multiple Tic Disorder and ADHD

Gadow, Kenneth D., Nolan, Edith E., Sverd, Jeffrey, Sprafkin, Joyce, Schneider, Jayne·2008·Journal of Child Neurology
DOI 10.1177/0883073808315412
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Abstract

Our primary objective was to determine if immediate-release methylphenidate is an effective treatment for oppositional defiant disorder diagnosed from mother's report in children with both chronic multiple tic disorder and attention-deficit hyperactivity disorder (ADHD). Children (n = 31) aged 6 to 12 years received placebo and 3 doses of methylphenidate twice daily for 2 weeks each under double-blind conditions and were assessed with ratings scales and laboratory measures. Results indicated significant improvement in both oppositional and ADHD behaviors with medication; however, the magnitude of treatment effect varied considerably as a function of disorder (ADHD > Oppositional behaviors), informant (teacher > mother), assessment instrument, and specific oppositional behavior (rebellious > disobeys rules). Drug response was comparable with that in children (n = 26) who did not have diagnosed oppositional defiant disorder, but comorbidity appeared to alter the perceived benefits for ADHD according to mother's report. Methylphenidate is an effective short-term treatment for oppositional behavior in children with comorbid ADHD and chronic multiple tic disorder.

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  • In ADHD comorbid with tic disorders, supratherapeutic doses of dextroamphetamine should be avoided.

    “meta-analyses of stimulants and other ADHD medications in the treatment of ADHD comorbid with tic disorders concluded that supratherapeutic doses of dextroamphetamine should be avoided in this population.”

    From Advances in understanding and treating ADHD (2011) · cites this paper as [52]

  • In ADHD comorbid with tic disorders, methylphenidate gives the best control for ADHD.

    “These studies also indicated that methylphenidate gave the best control for ADHD and that α-2-agonists produced the best improvement in both tics and ADHD [51,52].”

    From Advances in understanding and treating ADHD (2011) · cites this paper as [52]

  • In ADHD comorbid with tic disorders, alpha-2-agonists produce the best improvement in both tics and ADHD.

    “These studies also indicated that methylphenidate gave the best control for ADHD and that α-2-agonists produced the best improvement in both tics and ADHD [51,52].”

    From Advances in understanding and treating ADHD (2011) · cites this paper as [52]

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Authors
Gadow, K. D., Nolan, E. E., Sverd, J., Sprafkin, J., & Schneider, J.
Affiliations
  • Stony Brook University (US)
  • John T. Mather Memorial Hospital (US)
Corresponding author
Gadow, Kenneth D.
Venue
Journal of Child Neurology
Publisher
SAGE Publications
Published
2008-02-20
Volume
23
Issue
9
Pages
981-990
ISSN
  • 0883-0738 (ISSN-L)
  • 1708-8283
DOI
10.1177/0883073808315412
OpenAlex
W2085955598
Cited by
49
References
50
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 2 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 2 · 2012: 6
FWCI
4.20
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Child Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH045358, MH45358)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
Keywords
methylphenidate, oppositional defiant disorder, attention deficit hyperactivity disorder, comorbidities, stimulant medication, oppositional behavior, mothers' reports, teacher reports, informant effects, short-term treatment response, children
MeSH terms
Age Factors, Aggression, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Disability Evaluation, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Methylphenidate, Neuropsychological Tests, Placebos, Sex Factors, Tic Disorders, Comorbidity, Treatment Outcome, Attention Deficit and Disruptive Behavior Disorders

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