Bioindicators in the MIDUS National Study: Protocol, Measures, Sample, and Comparative Context
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Objectives: Midlife in the United States (MIDUS) is a national study of health and aging among individuals aged 25 to 74 at baseline (1995-1996). Longitudinal survey assessments (2004-2005), were followed by biological assessments on a subsample (aged 35-85).To facilitate public use, we describe the protocol, measures, and sample. Method: Respondents traveled to clinics for a 2-day data-collection protocol that included fasting blood specimens, 12-hr urine specimen, medical history, physical exam, bone densitometry, and a laboratory challenge (heart rate variability, blood pressure, respiration, salivary cortisol). Results: Response rates for the biological protocol ( N = 1,255) were 39.3% or 43.1% (adjusting for those who could not be located or contacted). Reasons for nonparticipation were travel, family obligations, and being too busy. Respondents were comparable to the recruitment pool on most demographic characteristics and health assessments. Discussion: Strengths of the protocol vis-à-vis similar studies include opportunities to link biological factors with diverse content from other MIDUS projects.
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- Authors
- Dienberg Love, G., Seeman, T. E., Weinstein, M., & Ryff, C. D.
- Affiliations
- University of Wisconsin, Madison,
- University of California, Los Angeles (US)
- Georgetown University (US)
- University of Wisconsin–Madison (US)
- Venue
- Journal of Aging and Health
- Publisher
- SAGE Publications
- Published
- 2010-09-27
- Volume
- 22
- Issue
- 8
- Pages
- 1059-1080
- ISSN
- 0898-2643 (ISSN-L)
- 1552-6887
- PMC
- PMC2972372
- OpenAlex
- W1967392886
- Cited by
- 333
- References
- 18
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 20 · 2023: 26 · 2022: 21 · 2021: 25 · 2020: 21 · 2019: 24 · 2018: 23 · 2017: 19 · 2016: 22 · 2015: 22 · 2014: 24 · 2013: 17 · 2012: 12
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Aging and Health (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Georgetown University
- National Institute on Aging (P01AG020166)
- National Center for Research Resources ((M01 RR00865), M01RR023942, UL1RR025011, M01RR000865)
- NIH Clinical Center
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Social Sciences › Sociology and Political Science › Survey Methodology and Nonresponse
- Keywords
- bioindicators, MIDUS, midlife health, aging, biological evaluation, urine collection, bone densitometry, heart rate variability, blood pressure, salivary cortisol, respiration, response rate, non-participation, health and aging
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Blood Pressure, Clinical Protocols, Data Collection, Fasting, Female, Health Status, Health Surveys, Heart Rate, Humans, Longitudinal Studies, Male, Middle Aged, Patient Participation, Surveys and Questionnaires, Saliva, United States, Program Evaluation, Biomarkers, Bone Density
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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