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Cited by 486Death Anxiety and Social ExclusionPain Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

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Acetaminophen Reduces Social Pain: Behavioral and Neural Evidence

DeWall, C. Nathan, MacDonald, Geoff, Webster, Gregory D., Masten, Carrie L., Baumeister, Roy F., Powell, Caitlin, Combs, David, Schurtz, David R., Stillman, Tyler F., Tice, Dianne M., Eisenberger, Naomi I.·2010·Psychological Science
DOI 10.1177/0956797610374741
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Abstract

Pain, whether caused by physical injury or social rejection, is an inevitable part of life. These two types of pain-physical and social-may rely on some of the same behavioral and neural mechanisms that register pain-related affect. To the extent that these pain processes overlap, acetaminophen, a physical pain suppressant that acts through central (rather than peripheral) neural mechanisms, may also reduce behavioral and neural responses to social rejection. In two experiments, participants took acetaminophen or placebo daily for 3 weeks. Doses of acetaminophen reduced reports of social pain on a daily basis (Experiment 1). We used functional magnetic resonance imaging to measure participants' brain activity (Experiment 2), and found that acetaminophen reduced neural responses to social rejection in brain regions previously associated with distress caused by social pain and the affective component of physical pain (dorsal anterior cingulate cortex, anterior insula). Thus, acetaminophen reduces behavioral and neural responses associated with the pain of social rejection, demonstrating substantial overlap between social and physical pain.

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Research works printed but not linked: 21

  1. 10.1016/j.ejpain.2004.11.001 · DOI · Paper page
  2. 10.1002/ana.410240109 · DOI · Paper page
  3. 10.1162/jocn.2009.21051 · DOI
  4. 10.1037/0022-3514.91.1.1 · DOI · Paper page
  5. 10.1037/a0013196 · DOI · Paper page
  6. 10.3171/jns.1962.19.2.0089 · DOI · Paper page
  7. 10.1016/S0028-3932(02)00325-1 · DOI · Paper page
  8. Hebben N., 1985, Evaluation and treatment of chronic pain, 451
  9. 10.1093/scan/nsp052 · DOI · Paper page
  10. 10.1017/CBO9780511596544.034 · DOI
  11. 10.1016/0006-8993(88)91550-8 · DOI · Paper page
  12. 10.1037/0022-3514.55.1.102 · DOI
  13. 10.1016/j.neuroimage.2008.04.256 · DOI · Paper page
  14. 10.1093/oso/9780195096736.001.0001 · DOI · Paper page
  15. Pappas A.A., 1991, Laboratory medicine: Test selection and interpretation, 382
  16. 10.1016/S0987-7053(00)00227-6 · DOI · Paper page
  17. 10.1016/0031-9384(67)90050-9 · DOI
  18. 10.36076/ppj.2009/12/269 · DOI
  19. 10.1016/j.jesp.2005.03.005 · DOI
  20. 10.1073/pnas.0812612106 · DOI · Paper page
  21. Williams K.D., 2001, Ostracism: The power of silence

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Metadata

Authors
DeWall, C. N., MacDonald, G., Webster, G. D., Masten, C. L., Baumeister, R. F., Powell, C., Combs, D., Schurtz, D. R., Stillman, T. F., Tice, D. M., & Eisenberger, N. I.
Affiliations
  • University of Kentucky (US)
  • University of Toronto (CA)
  • University of Florida (US)
  • University of California, Los Angeles (US)
  • Florida State University (US)
  • Georgia College & State University (US)
ORCID
Venue
Psychological Science
Publisher
SAGE Publications
Published
2010-06-14
Volume
21
Issue
7
Pages
931-937
ISSN
  • 0956-7976 (ISSN-L)
  • 1467-9280
DOI
10.1177/0956797610374741
OpenAlex
W2114477072
Cited by
486
References
0
Citations by year
2026: 13 · 2025: 18 · 2024: 29 · 2023: 27 · 2022: 20 · 2021: 34 · 2020: 34 · 2019: 30 · 2018: 51 · 2017: 32 · 2016: 34 · 2015: 36 · 2014: 46 · 2013: 25 · 2012: 27
FWCI
35.85
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Psychological Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH-65999)
Topics
  • Social Sciences › Psychology › Social Psychology › Death Anxiety and Social Exclusion
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
paracetamol, social pain, social rejection, bodily pain, analgesia, dorsal anterior cingulate cortex, anterior insula, placebo, affective pain
MeSH terms
Acetaminophen, Brain, Brain Mapping, Female, Humans, Interpersonal Relations, Magnetic Resonance Imaging, Male, Pain, Reference Values, Rejection, Psychology, Social Behavior, Social Desirability, Stress, Psychological, Students, Analgesics, Non-Narcotic

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