Analysis of risk factors for the development of thrombotic complications in antiphospholipid antibody positive lupus patients
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The objective of this study was to characterize risk factors for thrombotic events in lupus patients. A total of 272 lupus patients were followed up for five years during which the presence of aPL antibodies [anticardiolipin (aCL), anti-beta2-glycoprotein I (abeta2GPI) and lupus anticoagulant (LAC)] were determined, and all thrombotic incidents and antithrombotic therapy-related data were collected. At baseline, three groups were constituted, an aPL- group with 107 aPL negative patients, an aPL+ group with 81 aPL positive patients without clinical thrombosis and a secondary antiphospholipid syndrome (APS) group with 84 aPL+ patients who met the Sapporo criteria. LAC was more common in the APS than the aPL+ group (32.1% versus 9.9%, P < 0.001). The prevalence of clinical thrombotic events was significantly higher when all three types of aPL were present compared to only aCL positive cases. During follow up, aPL appeared in 7.5% of the aPL- group, and 2.8% of this group had thrombotic complications. In the aPL+ group, thrombotic events reoccurred in 1.9% of those receiving antithrombotic prophylaxis and 6.9% of those without primary prophylaxis. Despite anticoagulant therapy, thrombotic events reoccurred in 8.3% of the APS group. These findings indicate that LAC, constant and cumulative presence of aPL and previous thrombosis are positive predictors for the development of thrombotic complication in lupus patients.
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In systemic lupus erythematosus patients with a low-risk antiphospholipid antibody profile, pooled data from two cohort studies indicate that low-dose aspirin is associated with a lower risk of thrombosis.
“Less evidence is available on the use of LDA in patients with SLE and low-risk aPL profile, but pooled data from two cohort studies indicate that the use of LDA was also associated with a lower risk of thrombosis in this group.16 17”
From EULAR recommendations for the management of antiphospholipid syndrome in adults (2019) · cites this paper as [16]
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- Authors
- Tarr, T., Lakos, G., Bhattoa, H. P., Shoenfeld, Y., Szegedi, G., & Kiss, E.
- Affiliations
- University of Debrecen (HU)
- Tel Aviv University (IL)
- Corresponding author
- Kiss, E
- Venue
- Lupus
- Publisher
- SAGE Publications
- Published
- 2007-01
- Volume
- 16
- Issue
- 1
- Pages
- 39-45
- ISSN
- 0961-2033 (ISSN-L)
- 1477-0962
- OpenAlex
- W1993239392
- Cited by
- 88
- References
- 43
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 10 · 2013: 11 · 2012: 3
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Lupus (publishedVersion)
- PubMed (publishedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- antiphospholipid antibodies, systemic lupus erythematosus, thrombotic complications, lupus anticoagulant, anticardiolipin antibodies, anti-beta2-glycoprotein I antibodies, secondary antiphospholipid syndrome, risk factors, thromboprophylaxis, anticoagulation, recurrent thrombosis
- MeSH terms
- Adult, Antibody Specificity, Anticoagulants, Autoantigens, Female, Fibrinolytic Agents, Follow-Up Studies, Humans, Lupus Erythematosus, Systemic, Male, Middle Aged, Platelet Aggregation Inhibitors, Risk Factors, Thrombosis, Lupus Coagulation Inhibitor, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin, Thrombophilia, Stroke, beta 2-Glycoprotein I
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