Anterior Cingulate Volumetric Alterations in Treatment-Naïve Adults With ADHD: A Pilot Study
Open accessAbstract
Objective: We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naïve adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD. Method: Segmentation and parcellation of the ACC was performed on controls ( n = 22), treated ( n = 13) and treatment-naïve adults with ADHD ( n = 13). Results: There was a 21% volume reduction in the left ACC of the treatment-naïve group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group. Conclusion: These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment. (J. of Att. Dis. 2010; 13(4) 407-413)
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Structural characteristics of the anterior cingulate have been found to be related to self-regulation in a number of neurodevelopmental conditions.
“its structural characteristics have been found to be related to self-regulation in a number of neurodevelopmental conditions (9–13, 32, 50, 51).”
From Multimodal imaging of the self-regulating developing brain (2012) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565 · see citing works
Structured Clinical Interview for DSM-IV Axis I Disorders
Spitzer, R. L., First, M. B., & Gibbon, M. (1997) · Medical Entomology and Zoology · Cited by 3,582 · see citing works
Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J. P., Greenstein, D., Clasen, L., Evans, A., Giedd, J., & Rapoport, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707741104 · Cited by 1,819 · see citing works
Primate anterior cingulate cortex: Where motor control, drive and cognition interface
Paus, T. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077500 · Cited by 1,722 · see citing works
Castellanos, F. X. (2002) · JAMA · doi:10.1001/jama.288.14.1740 · Cited by 1,646 · see citing works
Rubia, K., Overmeyer, S., Taylor, E., Brammer, M., Williams, S. C. R., Simmons, A., & Bullmore, E. T. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.891 · Cited by 1,010 · see citing works
Cerebral Glucose Metabolism in Adults with Hyperactivity of Childhood Onset
Zametkin, A. J., NORDAHL, T. E., Gross, M., King, A. C., Semple, W. E., Rumsey, J. M., Hamburger, S., & Cohen, R. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011153232001 · Cited by 962 · see citing works
Bush, G., Frazier, J. A., Rauch, S. L., Seidman, L. J., Whalen, P. J., Jenike, M. A., Rosen, B. R., & Biederman, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00083-9 · Cited by 866 · see citing works
Self-citationThe National Comorbidity Survey Replication (NCS‐R): background and aims
Kessler, R. C., & Merikangas, K. R. (2004) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.166 · Cited by 718 · see citing works
Bush, G., Valera, E. M., & Seidman, L. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.034 · Cited by 714 · see citing works
Self-citationShaw, P., Lerch, J., Greenstein, D., Sharp, W., Clasen, L., Evans, A., Giedd, J., Castellanos, F. X., & Rapoport, J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.5.540 · Cited by 703 · see citing works
The Young Adult Human Brain: An MRI-based Morphometric Analysis
Filipek, P. A., Richelme, C., Kennedy, D. N., & Caviness, V. S. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.4.344 · Cited by 643 · see citing works
Self-citationDifferential patterns of striatal activation in young children with and without ADHD
Durston, S., Tottenham, N. T., Thomas, K. M., Davidson, M. C., Eigsti, I.-M., Yang, Y., Ulug, A. M., & Casey, B. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01904-2 · Cited by 619 · see citing works
Biederman, J., Faraone, S. V., Spencer, T. J., Mick, E., Monuteaux, M. C., & Aleardi, M. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0403 · Cited by 565 · see citing works
Self-citationMakris, N., Biederman, J., Valera, E. M., Bush, G., Kaiser, J., Kennedy, D. N., Caviness, V. S., Faraone, S. V., & Seidman, L. J. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl047 · Cited by 450 · see citing works
Self-citationAnterior cingulate and prefrontal cortex: who's in control?
Cohen, J. D., Botvinick, M., & Carter, C. S. (2000) · Nature Neuroscience · doi:10.1038/74783 · Cited by 436 · see citing works
Seidman, L. J., Valera, E. M., Makris, N., Monuteaux, M. C., Boriel, D., Kelkar, K., Kennedy, D. N., Caviness, V. S., Bush, G., Aleardi, M., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.031 · Cited by 378 · see citing works
Self-citationKonrad, K., Neufang, S., Hanisch, C., Fink, G. R., & Herpertz-Dahlmann, B. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.013 · Cited by 335 · see citing works
Caviness, V. S., Meyer, J. W., Makris, N., & Kennedy, D. N. (1996) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1996.8.6.566 · Cited by 298 · see citing works
Self-citationPliszka, S. R., Glahn, D. C., Semrud-Clikeman, M., Franklin, C., Perez III, R., Xiong, J., & Liotti (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.1052 · Cited by 278 · see citing works
The psychometric tradition: Developing the wechsler adult intelligence scale
Wechsler, D. (1981) · Contemporary Educational Psychology · doi:10.1016/0361-476x(81)90035-7 · Cited by 274 · see citing works
TAMM, L., MENON, V., RINGEL, J., & REISS, A. L. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000140452.51205.8d · Cited by 272 · see citing works
Neural substrates of decision making in adults with attention deficit hyperactivity disorder
Ernst, M., Kimes, A. S., London, E. D., Matochik, J. A., Eldreth, D., Tata, S., Contoreggi, C., Leff, M., & Bolla, K. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1061 · Cited by 254 · see citing works
Makris, N., Buka, S. L., Biederman, J., Papadimitriou, G. M., Hodge, S. M., Valera, E. M., Brown, A. B., Bush, G., Monuteaux, M. C., Caviness, V. S., et al. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm156 · Cited by 239 · see citing works
Self-citationBush, G., Spencer, T. J., Holmes, J., Shin, L. M., Valera, E. M., Seidman, L. J., Makris, N., Surman, C., Aleardi, M., Mick, E., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.16 · Cited by 201 · see citing works
Self-citationBiederman, J., Makris, N., Valera, E. M., Monuteaux, M. C., Goldstein, J. M., Buka, S. L., Boriel, D., Bandyopadhyay, S., Kennedy, D. N., Caviness, V. S., et al. (2007) · Psychological Medicine · doi:10.1017/s0033291707001791 · Cited by 95 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Filipek PA Kennedy DN Caviness VS Jr 1988 A method of morphometric analysis of the human brain based upon magnetic resonance imaging Annals of Neurology 24 356
Cited by
Sorted by citations
Updated European Consensus Statement on diagnosis and treatment of adult ADHD
Kooij, J. J. S., Bijlenga, D., Salerno, L., Jaeschke, R., Bitter, I., Balázs, J., Thome, J., Dom, G., Kasper, S., Nunes Filipe, C., et al. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2018.11.001 · Cited by 686 · see citing works
Frodl, T., & Skokauskas, N. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01786.x · Cited by 530 · see citing works
Cubillo, A., Halari, R., Smith, A., Taylor, E., & Rubia, K. (2012) · Cortex · doi:10.1016/j.cortex.2011.04.007 · Cited by 505 · see citing works
Cingulate, Frontal, and Parietal Cortical Dysfunction in Attention-Deficit/Hyperactivity Disorder
Bush, G. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.022 · Cited by 304 · see citing works
Self-citationMultimodal imaging of the self-regulating developing brain
Fjell, A. M., Walhovd, K. B., Brown, T. T., Kuperman, J. M., Chung, Y., Hagler, D. J., Venkatraman, V., Roddey, J. C., Erhart, M., McCabe, C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208243109 · Cited by 212 · see citing works
Self-citationProal, E. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.117 · Cited by 207 · see citing works
Bond, D. J., Hadjipavlou, G., Lam, R. W., McIntyre, R. S., Beaulieu, S., Schaffer, A., & Weiss, M. (2012) · Annals of Clinical Psychiatry · doi:10.1177/104012371202400104 · Cited by 133 · see citing works
Zhu, J., Zhang, X., Xu, Y., Spencer, T. J., Biederman, J., & Bhide, P. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1041-12.2012 · Cited by 125 · see citing works
Self-citationCortese, S., Imperati, D., Zhou, J., Proal, E., Klein, R. G., Mannuzza, S., Ramos-Olazagasti, M. A., Milham, M. P., Kelly, C., & Castellanos, F. X. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.025 · Cited by 127 · see citing works
Amico, F., Stauber, J., Koutsouleris, N., & Frodl, T. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.08.011 · Cited by 98 · see citing works
Substance exposure in utero and developmental consequences in adolescence: A systematic review
Irner, T. B. (2012) · Child Neuropsychology · doi:10.1080/09297049.2011.628309 · Cited by 78 · see citing works
Duarte, N. A., Woods, S. P., Rooney, A., Atkinson, J. H., & Grant, I. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.01.006 · Cited by 56 · see citing works
Kim, S., Baek, J. H., Kwon, Y. J., Lee, H. Y., Yoo, J. H., Shim, S.-H., & Kim, J. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01604-3 · Cited by 38 · see citing works
- Authors
- Makris, N., Seidman, L. J., Valera, E. M., Biederman, J., Monuteaux, M. C., Kennedy, D. N., Caviness, V. S., Bush, G., Crum, K., Brown, A. B., & Faraone, S. V.
- Affiliations
- Boston University (US)
- Harvard University (US)
- SUNY Upstate Medical University (US)
- ORCID
- Venue
- Journal of Attention Disorders
- Publisher
- SAGE Publications
- Published
- 2009-12-14
- Volume
- 13
- Issue
- 4
- Pages
- 407-413
- ISSN
- 1087-0547 (ISSN-L)
- 1557-1246
- PMC
- PMC3746768
- OpenAlex
- W2088296351
- Cited by
- 60
- References
- 27
- Citations by year
- 2026: 1 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Attention Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Massachusetts General Hospital
- National Institutes of Health (1f32mh065040-01a1)
- National Institute of Mental Health (F32 MH065040-01A1, MH 16259, F32 MH065040, MH-62152, R01MH062152, T32MH016259)
- National Institute on Drug Abuse (R01DA027804)
- National Center for Research Resources (P41-RR-14075, P41RR014075)
- National Center for Complementary and Integrative Health (P01AT002048)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- adult ADHD, anterior cingulate cortex, brain atrophy, treatment-naive adults, neuroanatomical changes, impulsivity, hyperactivity, inattention, cognitive control, attention allocation
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Brain Mapping, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Pilot Projects, Patient Selection, Imaging, Three-Dimensional, Diagnostic and Statistical Manual of Mental Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
