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Cited by 108Multiple Sclerosis Research StudiesCancer survivorship and careAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Prediction of anxiety and distress following diagnosis of multiple sclerosis: a two-year longitudinal study

Janssens, A CJW, Buljevac, D, van Doorn, P A, van der Meché, F GA, Polman, C H, Passchier, J, Hintzen, R Q·2006·Multiple Sclerosis Journal
DOI 10.1177/1352458506070935
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Abstract

Objective: To investigate the course of anxiety, depression and disease-related distress of patients with multiple sclerosis (MS) and their partners in the first years after diagnosis. Methods: The Hospital Anxiety and Depression Scale (HADS) and Impact of Event Scale (IES) were completed at baseline, six-month, one-and two-year follow-up in 101 recently diagnosed patients and 78 partners. The Expanded Disability Status Scale (EDSS) was assessed annually. Results: Mean time since diagnosis at baseline was 7.8 (SD 6.5) months. Mean anxiety scores of patients and partners did not change during the two years of follow-up and remained higher than that observed in the general population at all assessments (P <0.05). The high levels of disease-related distress at baseline were lower at follow-up. Of the patients and partners with high anxiety scores at baseline (HADS anxiety ≥8), 69% also had high scores at any time during follow-up, compared to 26% in those with low baseline anxiety scores. For severe distress at follow-up, these percentages were 41 and 14%. The sensitivity and specificity of baseline anxiety screening for the prediction of high anxiety or distress scores at follow-up were 55 and 85%. Conclusion: MS patients and their partners continued to have high levels of anxiety and distress in the first years after diagnosis. Screening for anxiety after diagnosis can be used to predict levels of anxiety and distress during two-year follow-up.

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Metadata

Authors
Janssens, A. C., Buljevac, D., van Doorn, P. A., van der Meché, F. G., Polman, C. H., Passchier, J., & Hintzen, R. Q.
Affiliations
  • Department of Public Health, PO Box 2040, 3000 CA, Department of Neurology, Department of Medical Psychology and Psychotherapy, Erasmus MC, Rotterdam, the Netherlands,
  • Erasmus MC (NL)
  • Department of Neurology, Erasmus MC, Rotterdam, the Netherlands
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
ORCID
Venue
Multiple Sclerosis Journal
Publisher
SAGE Publications
Published
2006-11
Volume
12
Issue
6
Pages
794-801
ISSN
  • 1352-4585 (ISSN-L)
  • 1477-0970
DOI
10.1177/1352458506070935
OpenAlex
W2162191903
Cited by
107
References
30
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 8
FWCI
3.28
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Multiple Sclerosis Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vrije Universiteit Amsterdam
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
multiple sclerosis, anxiety, depression, partners of patients, anxiety screening, longitudinal course, disability progression, psychosocial impact
MeSH terms
Adaptation, Psychological, Adolescent, Adult, Affective Symptoms, Anxiety, Depression, Disability Evaluation, Family Health, Female, Follow-Up Studies, Health Status, Humans, Longitudinal Studies, Male, Middle Aged, Multiple Sclerosis, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity, Comorbidity, Spouses

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