The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6
Abstract
Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking. Objective: To investigate the contribution of cytokines/chemokines in the pathogenesis of NMO. Methods: We measured 27 cytokines/chemokines and Th17 cell-associated cytokines in the cerebrospinal fluid (CSF) of 31 NMO, 29 MS and 18 other non-inflammatory neurological disorders patients. The serum levels of some cytokines/ chemokines were also measured. The correlations between clinical characteristics/laboratory findings and levels of cytokines/chemokines in NMO were examined. Results: The CSF levels of interleukin (IL)-1 receptor antagonist, IL-6, IL-8, IL-13 and granulocyte colony-stimulating factor were significantly increased in NMO, while IL-9, fibroblast growth factor-basic, granulocyte macrophage colony-stimulating factor, macrophage inflammatory protein-1-beta and tumor necrosis factor-alpha were increased in MS. IL-10 and interferon-gamma-inducible protein-10 were elevated in NMO and MS. In serum analyses, only the IL-6 level showed significant elevation in NMO. The CSF IL-6 level had a significant correlation with the CSF glial fibrillary acidic protein level and CSF cells, and a weak correlation with anti-aquaporin-4 antibody titers. Conclusions: Different immunological status and pathophysiologies exist between NMO and MS, and IL-6 may play important roles in the pathogenesis of NMO.
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Cites
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,630
Revised diagnostic criteria for neuromyelitis optica
Wingerchuk, D. M., Lennon, V. A., Pittock, S. J., Lucchinetti, C. F., & Weinshenker, B. G. (2006) · Neurology · doi:10.1212/01.wnl.0000216139.44259.74 · Cited by 2,574
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
Lennon, V. A., Kryzer, T. J., Pittock, S. J., Verkman, A. S., & Hinson, S. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050304 · Cited by 2,288
The spectrum of neuromyelitis optica
Wingerchuk, D. M., Lennon, V. A., Lucchinetti, C. F., Pittock, S. J., & Weinshenker, B. G. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70216-8 · Cited by 2,179
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
The clinical course of neuromyelitis optica (Devic’s syndrome)
Wingerchuk, D. M., Hogancamp, W. F., O’Brien, P. C., & Weinshenker, B. G. (1999) · Neurology · doi:10.1212/wnl.53.5.1107 · Cited by 1,822
Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E., Garren, H., Langer-Gould, A., Strober, S., Cannella, B., Allard, J., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,669
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 2×
“Th17 cells are responsible for organ-specific autoimmune diseases,(28) differentiating upon exposure to combinations of IL-1, IL-6, and TGF-b(29) and inducing various downstream cytokines and chemokines, such as IL-6,(30,31) IL-8 and G-CSF.(32) We could not detect IL-17, IL-23, and TGF-b in patients with NMO, although…”
ResultA role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica
Lucchinetti, C. F. (2002) · Brain · doi:10.1093/brain/awf151 · Cited by 1,210
Cited by
Neuromyelitis Optica Study Group (NEMOS), Trebst, C., Jarius, S., Berthele, A., Paul, F., Schippling, S., Wildemann, B., Borisow, N., Kleiter, I., Aktas, O., et al. (2014) · Journal of Neurology · doi:10.1007/s00415-013-7169-7 · Cited by 595
Traboulsee, A., Greenberg, B. M., Bennett, J. L., Szczechowski, L., Fox, E., Shkrobot, S., Yamamura, T., Terada, Y., Kawata, Y., Wright, P., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30078-8 · Cited by 513
The Pathology of an Autoimmune Astrocytopathy: Lessons Learned from Neuromyelitis Optica
Lucchinetti, C. F., Guo, Y., Popescu, B. F. G., Fujihara, K., Itoyama, Y., & Misu, T. (2014) · Brain Pathology · doi:10.1111/bpa.12099 · Cited by 414
Varrin‐Doyer, M., Spencer, C. M., Schulze‐Topphoff, U., Nelson, P. A., Stroud, R. M., C. Cree, B. A., & Zamvil, S. S. (2012) · Annals of Neurology · doi:10.1002/ana.23651 · Cited by 341
Failure of Natalizumab to Prevent Relapses in Neuromyelitis Optica
Kleiter, I. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.216 · Cited by 294
Metadata
- Authors
- Uzawa, A., Mori, M., Arai, K., Sato, Y., Hayakawa, S., Masuda, S., Taniguchi, J., & Kuwabara, S.
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2010-08-25
- Volume
- 16
- Issue
- 12
- Pages
- 1443-1452
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2096069651
- Cited by
- 323
- References
- 40
- FWCI
- 10.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Uzawa, A., Mori, M., Arai, K., Sato, Y., Hayakawa, S., Masuda, S., Taniguchi, J., & Kuwabara, S. (2010). Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6. Multiple Sclerosis Journal. https://doi.org/10.1177/1352458510379247
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