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Cited by 288

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Diabetes Enhances Periodontal Bone Loss through Enhanced Resorption and Diminished Bone Formation

Open access
Liu, R., Bal, H.S., Desta, T., Krothapalli, N., Alyassi, M., Luan, Q., Graves, D.T.·2006·Journal of Dental Research
DOI 10.1177/154405910608500606
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Abstract

Using a ligature-induced model in type-2 Zucker diabetic fatty (ZDF) rat and normoglycemic littermates, we investigated whether diabetes primarily affects periodontitis by enhancing bone loss or by limiting osseous repair. Diabetes increased the intensity and duration of the inflammatory infiltrate (P < 0.05). The formation of osteoclasts and percent eroded bone after 7 days of ligature placement was similar, while four days after removal of ligatures, the type 2 diabetic group had significantly higher osteoclast numbers and activity (P < 0.05). The amount of new bone formation following resorption was 2.4- to 2.9-fold higher in normoglycemic vs. diabetic rats (P < 0.05). Diabetes also increased apoptosis and decreased the number of bone-lining cells, osteoblasts, and periodontal ligament fibroblasts (P < 0.05). Thus, diabetes caused a more persistent inflammatory response, greater loss of attachment and more alveolar bone resorption, and impaired new bone formation. The latter may be affected by increased apoptosis of bone-lining and PDL cells.

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Metadata

Authors
Liu, R., Bal, H. S., Desta, T., Krothapalli, N., Alyassi, M., Luan, Q., & Graves, D. T.
Venue
Journal of Dental Research
Publisher
SAGE Publications
Published
2006-06
Volume
85
Issue
6
Pages
510-514
ISSN
  • 0022-0345 (ISSN-L)
  • 1544-0591
DOI
10.1177/154405910608500606
OpenAlex
W2134937110
Cited by
288
References
24
FWCI
11.14
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Diabetes Enhances Periodontal Bone Loss through Enhanced Resorption and Diminished Bone Formation. https://app.cochat.ai/papers/10.1177/154405910608500606
The paper
Liu, R., Bal, H. S., Desta, T., Krothapalli, N., Alyassi, M., Luan, Q., & Graves, D. T. (2006). Diabetes Enhances Periodontal Bone Loss through Enhanced Resorption and Diminished Bone Formation. Journal of Dental Research. https://doi.org/10.1177/154405910608500606

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.