Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931 · see citing works

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles

Lötvall, J. O., Hill, A. F., Hochberg, F. H., Buzás, E. I., Vizio, D. D., Gardiner, C., Gho, Y. S., Kurochkin, I. V., Mathivanan, S., Quesenberry, P. J., et al. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.26913 · Cited by 2,710 · see citing works

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

Witwer, K. W., Buzás, E. I., Bemis, L., Bora, A., Lässer, C., Lötvall, J. O., Hoen, E. N. M. N., Piper, M. G., Sivaraman, S., Skog, J., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20360 · Cited by 2,424 · see citing works

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., et al. (2010) · Stem Cell Research · doi:10.1016/j.scr.2009.12.003 · Cited by 2,215 · see citing works

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042 · see citing works

Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009 · see citing works

New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?

Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951 · see citing works

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., & Ochiya, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107821 · Cited by 1,934 · see citing works

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

Schwechheimer, C., & Kuehn, M. J. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3525 · Cited by 1,932 · see citing works

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

Villarroya-Beltri, C., Gutiérrez-Vázquez, C., Sánchez-Cabo, F., Perez-Hernandez, D., Vázquez, J., Martín-Cófreces, N., Martínez-Herrera, D. J., Pascual-Montano, A., Mittelbrunn, M., & Sánchez-Madrid, F. (2013) · Nature Communications · doi:10.1038/ncomms3980 · Cited by 1,907 · see citing works

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,809 · see citing works

Delivery materials for siRNA therapeutics

Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800 · see citing works

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775 · see citing works

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666 · see citing works

Functional delivery of viral miRNAs via exosomes

Pegtel, D. M., Cosmopoulos, K., Thorley‐Lawson, D. A., van Eijndhoven, M. A. J., Hopmans, E. S., Lindenberg, J. L., de Gruijl, T. D., Wurdinger, T. D., & Middeldorp, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914843107 · Cited by 1,648 · see citing works

Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

Ratajczak, J., Miękus, K., Kucia, M., Zhang, J., Reca, R., Dvořák, P., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404132 · Cited by 1,630 · see citing works

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579 · see citing works

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

Kulp, A., & Kuehn, M. J. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.091208.073413 · Cited by 1,540 · see citing works

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Kim, M. S., Haney, M. J., Zhao, Y., Mahajan, V., Le‐Deygen, I. M., Klyachko, N. L., Inskoe, E., Piroyan, A., Sokolsky‐Papkov, M., Okolie, O., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.012 · Cited by 1,498 · see citing works

Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

Heijnen, H. F. G., Schiel, A. E., Fijnheer, R., Geuze, H. J., & Sixma, J. J. (1999) · Blood · doi:10.1182/blood.v94.11.3791 · Cited by 1,488 · see citing works

Detection of microRNA Expression in Human Peripheral Blood Microvesicles

Hunter, M. P., Ismail, N., Zhang, X., Aguda, B. D., Lee, E. J., Yu, L., Xiao, T., Schafer, J., Lee, M. T., Schmittgen, T. D., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003694 · Cited by 1,453 · see citing works

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borràs, F. E., Breakefield, X., Budnik, V., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001450 · Cited by 1,367 · see citing works

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356 · see citing works

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

Rani, S., Ryan, A. E., Griffin, M. D., & Ritter, T. (2015) · Molecular Therapy · doi:10.1038/mt.2015.44 · Cited by 1,233 · see citing works

Using exosomes, naturally-equipped nanocarriers, for drug delivery

Batrakova, E. V., & Kim, M. S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.030 · Cited by 1,122 · see citing works

ExoCarta 2012: database of exosomal proteins, RNA and lipids

Mathivanan, S., Fahner, C. J., Reid, G. E., & Simpson, R. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr828 · Cited by 1,096 · see citing works

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

Jang, S. C., Kim, O. Y., Yoon, C. M., Choi, D., Roh, T., Park, J., Nilsson, J. A., Lötvall, J. O., Kim, Y., & Gho, Y. S. (2013) · ACS Nano · doi:10.1021/nn402232g · Cited by 1,024 · see citing works

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

Yang, T., Martin, P. B., Fogarty, B., Brown, A. H., Schurman, K., Phipps, R. J., Yin, V. P., Lockman, P. R., & Bai, S. (2015) · Pharmaceutical Research · doi:10.1007/s11095-014-1593-y · Cited by 980 · see citing works

Bovine milk-derived exosomes for drug delivery

Munagala, R., Aqil, F., Jeyabalan, J., & Gupta, R. C. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.020 · Cited by 936 · see citing works

Gene Therapy Death Prompts Review of Adenovirus Vector

Marshall, E. (1999) · Science · doi:10.1126/science.286.5448.2244 · Cited by 918 · see citing works

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

Pascucci, L., Coccè, V., Bonomi, A., Ami, D., Ceccarelli, P., Ciusani, E., Viganò, L., Locatelli, A., Sisto, F., Doglia, S. M., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.042 · Cited by 907 · see citing works

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

Ju, S., Mu, J., Dokland, T., Zhuang, X., Wang, Q., Jiang, H., Xiang, X., Deng, Z., Wang, B., Zhang, L., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.64 · Cited by 880 · see citing works

Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells

Savina, A., Furlán, M., Vidal, M., & Colombo, M. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301642200 · Cited by 835 · see citing works

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

Zomer, A., Maynard, C., Verweij, F., Kamermans, A., Schäfer, R., Beerling, E., Schiffelers, R., de Wit, E., Berenguer, J., Ellenbroek, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.042 · Cited by 815 · see citing works

HEK293 cell line: A vehicle for the expression of recombinant proteins

Thomas, P., & Smart, T. G. (2005) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2004.08.014 · Cited by 776 · see citing works

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

Fuhrmann, G., Serio, A., Mazo, M. M., Nair, R., & Stevens, M. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.029 · Cited by 746 · see citing works

Exosomes and other extracellular vesicles in host–pathogen interactions

Schorey, J. S., Cheng, Y., Singh, P., & Smith, V. L. (2014) · EMBO Reports · doi:10.15252/embr.201439363 · Cited by 720 · see citing works

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

Wahlgren, J., Karlson, T. D. L., Brisslert, M., Sani, F. V., Telemo, E., Sunnerhagen, P., & Valadi, H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks463 · Cited by 716 · see citing works

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704 · see citing works

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

Lou, G., Song, X., Yang, F., Wu, S., Wang, J., Chen, Z., & Liu, Y. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0220-7 · Cited by 700 · see citing works

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

Kooijmans, S. A. A., Stremersch, S., Braeckmans, K., de Smedt, S. C., Hendrix, A., Wood, M. J. A., Schiffelers, R. M., Raemdonck, K., & Vader, P. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.014 · Cited by 663 · see citing works

Membrane transport in the endocytic pathway

Gruenberg, J. E., & Maxfield, F. R. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80013-1 · Cited by 645 · see citing works

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module

Yim, N., Ryu, S.-W., Choi, K., Lee, K. R., Lee, S., Choi, H., Kim, J., Shaker, M. R., Sun, W., Park, J.-H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12277 · Cited by 578 · see citing works

Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane

Booth, A. M., Fang, Y., Fallon, J. K., Yang, J.-M., Hildreth, J. E. K., & Gould, S. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508014 · Cited by 562 · see citing works

Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes

Ishida, T., Ichihara, M., Wang, X., Yamamoto, K., Kimura, J., Majima, E., & Kiwada, H. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.01.005 · Cited by 558 · see citing works

Exosomes Secreted by Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Repair Critical-Sized Bone Defects through Enhanced Angiogenesis and Osteogenesis in Osteoporotic Rats

Qi, X., Zhang, J., Yuan, H., Xu, Z., Li, Q., Niu, X., Hu, B., Wang, Y., & Li, X. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.14809 · Cited by 541 · see citing works

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

Munoz, J. L., Bliss, S. A., Greco, S. J., Ramkissoon, S. H., Ligon, K. L., & Rameshwar, P. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.60 · Cited by 520 · see citing works

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

Shtam, T. A., Kovalev, R. A., Varfolomeeva, E. Y., Makarov, E. M., Kil, Y. V., & Filatov, M. V. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-88 · Cited by 499 · see citing works

Electroporation: A general phenomenon for manipulating cells and tissues

Weaver, J. C. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.2400510407 · Cited by 491 · see citing works

Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome

Lai, R. C., Tan, S. S., Teh, B. J., Sze, S. K., Arslan, F., de Kleijn, D. P. V., Choo, A. B. H., & Lim, S. K. (2012) · International Journal of Proteomics · doi:10.1155/2012/971907 · Cited by 485 · see citing works

Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing

Didiot, M.-C., Hall, L. M., Coles, A. H., Haraszti, R. A., Godinho, B. M., Chase, K., Sapp, E., Ly, S., Alterman, J. F., Hassler, M. R., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.126 · Cited by 483 · see citing works

Cell or Cell Membrane-Based Drug Delivery Systems

Tan, S., Wu, T., Zhang, D., & Zhang, Z. (2015) · Theranostics · doi:10.7150/thno.11852 · Cited by 466 · see citing works

Gram-negative and Gram-positive bacterial extracellular vesicles

Kim, J. H., Lee, J., Park, J., & Gho, Y. S. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.006 · Cited by 458 · see citing works

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

Lamichhane, T. N., Raiker, R. S., & Jay, S. M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00364 · Cited by 413 · see citing works

Brain Peroxidase and Catalase in Parkinson Disease

Ambani, L. M., Woert, M. H. V., & Murphy, S. (1975) · Archives of Neurology · doi:10.1001/archneur.1975.00490440064010 · Cited by 404 · see citing works

Microvesicles: Messengers and mediators of tumor progression

Al-Nedawi, K. N. I., Meehan, B., & Rak, J. W. (2009) · Cell Cycle · doi:10.4161/cc.8.13.8988 · Cited by 401 · see citing works

AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness

Bennett, J., Ashtari, M., Wellman, J., Marshall, K. A., Cyckowski, L. L., Chung, D. C., McCague, S., Pierce, E. A., Chen, Y., Bennicelli, J. L., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3002865 · Cited by 395 · see citing works

Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice

Hu, G., Li, Q., Niu, X., Hu, B., Liu, J., Zhou, S.-M., Guo, S., Lang, H., Zhang, C., Wang, Y., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/scrt546 · Cited by 394 · see citing works

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

Wang, B., Yao, K., Huuskes, B. M., Shen, H., Zhuang, J., Godson, C., Brennan, E. P., Wilkinson‐Berka, J. L., Wise, A. F., & Ricardo, S. D. (2016) · Molecular Therapy · doi:10.1038/mt.2016.90 · Cited by 379 · see citing works

A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson’s disease

Muramatsu, S.-I., Fujimoto, K.-I., Kato, S., Mizukami, H., Asari, S., Ikeguchi, K., Kawakami, T., Urabe, M., Kume, A., Sato, T., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.135 · Cited by 344 · see citing works

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O., & Saydam, O. (2013) · Molecular Therapy · doi:10.1038/mt.2012.161 · Cited by 337 · see citing works

Late endosomes derive from early endosomes by maturation

Stoorvogel, W., Strous, G. J., Geuze, H. J., Oorschot, V. M. J., & Schwartzt, A. L. (1991) · Cell · doi:10.1016/0092-8674(91)90459-c · Cited by 331 · see citing works

Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

Jiang, H., Couto, L. B., Patarroyo-White, S., Liu, T., Nagy, D., Vargas, J. A., Zhou, S., Scallan, C. D., Sommer, J., Vijay, S., et al. (2006) · Blood · doi:10.1182/blood-2006-04-017913 · Cited by 330 · see citing works

Long non‐coding RNAs with low expression levels in cells are enriched in secreted exosomes

Deligezer, U., Özgür, E., Çetinkaya, M. B., Işın, M., & Dalay, N. (2014) · Cell Biology International · doi:10.1002/cbin.10301 · Cited by 327 · see citing works

Membrane Vesicles Are Immunogenic Facsimiles of Salmonella typhimurium That Potently Activate Dendritic Cells, Prime B and T Cell Responses, and Stimulate Protective Immunity In Vivo

Alaniz, R. C., Deatherage, B. L., Lara, J. C., & Cookson, B. T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7692 · Cited by 321 · see citing works

Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer

Kogure, T., Yan, I. K., Lin, W.-L., & Patel, T. (2013) · Genes & Cancer · doi:10.1177/1947601913499020 · Cited by 303 · see citing works

Maximizing exosome colloidal stability following electroporation

Hood, J. L., Scott, M. J., & Wickline, S. A. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.12.001 · Cited by 297 · see citing works

miR-1289 and “Zipcode”-like Sequence Enrich mRNAs in Microvesicles

Bolukbasi, M. F., Mizrak, A., Ozdener, G. B., Madlener, S., Ströbel, T., Erkan, E. P., Fan, J., Breakefield, X. O., & Saydam, O. (2012) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2011.2 · Cited by 290 · see citing works

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

Maguire, C. A., Balaj, L., Sivaraman, S., Crommentuijn, M. H., Ericsson, M., Mincheva-Nilsson, L., Baranov, V., Gianni, D., Tannous, B. A., Sena-Esteves, M., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2011.303 · Cited by 283 · see citing works

Permeabilization of Cell Membranes

Jamur, M. C., & Oliver, C. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-324-0_9 · Cited by 280 · see citing works

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

Liu, Y., Li, D., Liu, Z., Zhou, Y., Chu, D., Li, X., Jiang, X., Hou, D., Chen, X., Chen, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep17543 · Cited by 280 · see citing works

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

Giricz, Z., Varga, Z. V., Baranyai, T., Sipos, P., Pálóczi, K., Kittel, Á., Buzás, E. I., & Ferdinándy, P. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.004 · Cited by 273 · see citing works

Role of anti-oncomirs miR-143 and -145 in human colorectal tumors

Akao, Y., Nakagawa, Y., Hirata, I., et al. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2009.88 · Cited by 262 · see citing works

Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

Cai, J., Han, Y., Ren, H., Chen, C., He, D., Zhou, L., Eisner, G. M., Asico, L. D., José, P. A., & Zeng, C. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt011 · Cited by 253 · see citing works

Microvesicle-mediated RNA Molecule Delivery System Using Monocytes/Macrophages

Akao, Y., Iio, A., Itoh, T., Noguchi, S., Itoh, Y., Ohtsuki, Y., & Naoe, T. (2010) · Molecular Therapy · doi:10.1038/mt.2010.254 · Cited by 253 · see citing works

A platform for actively loading cargo RNA to elucidate limiting steps in EV‐mediated delivery

Hung, M. E., & Leonard, J. N. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31027 · Cited by 251 · see citing works

Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment

Ridder, K., Sevko, A., Heide, J., Dams, M., Rupp, A.-K., Macas, J., Starmann, J., Tjwa, M., Plate, K., Sültmann, H., et al. (2015) · Oncoimmunology · doi:10.1080/2162402x.2015.1008371 · Cited by 243 · see citing works

Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration

Shimbo, K., Miyaki, S., Ishitobi, H., Kato, Y., Kubo, T., Shimose, S., & Ochi, M. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.02.007 · Cited by 241 · see citing works

RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer

Lunavat, T. R., Jang, S. C., Nilsson, L. M., Park, H. T., Repiská, G., Lässer, C., Nilsson, J. A., Gho, Y. S., & Lötvall, J. O. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.024 · Cited by 225 · see citing works

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Christiansen, G., Gurevich, L., Moos, T., & Duroux, M. C. (2016) · Cytotechnology · doi:10.1007/s10616-016-9952-7 · Cited by 211 · see citing works

Do Plant Cells Secrete Exosomes Derived from Multivesicular Bodies?

An, Q., van Bel, A. J. E., & Hückelhoven, R. (2007) · Plant Signaling & Behavior · doi:10.4161/psb.2.1.3596 · Cited by 209 · see citing works

FedExosomes: Engineering Therapeutic Biological Nanoparticles that Truly Deliver

Marcus, M., & Leonard, J. N. (2013) · Pharmaceuticals · doi:10.3390/ph6050659 · Cited by 201 · see citing works

Mutational Analysis of a Heterogeneous Nuclear Ribonucleoprotein A2 Response Element for RNA Trafficking

Munro, T. P., Magee, R. J., Kidd, G. J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34389 · Cited by 198 · see citing works

Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

ZHANG, J., LIU, F., & Huang, L. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.004 · Cited by 195 · see citing works

Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems

Su, M.-J., Aldawsari, H. M., & Amiji, M. M. (2016) · Scientific Reports · doi:10.1038/srep30110 · Cited by 194 · see citing works

Therapeutic and diagnostic applications of extracellular vesicles

Stremersch, S., Smedt, S. C. D., & Raemdonck, K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.054 · Cited by 187 · see citing works

Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

Ingato, D., Lee, J. U., Sim, S. J., & Kwon, Y. J. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.09.016 · Cited by 175 · see citing works

Immunization with Escherichia coli Outer Membrane Vesicles Protects Bacteria-Induced Lethality via Th1 and Th17 Cell Responses

Kim, O. Y., Hong, B. S., Park, K., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200742 · Cited by 167 · see citing works

Mining Treasures from 'Junk DNA'

Nowak, R. (1994) · Science · doi:10.1126/science.7508142 · Cited by 161 · see citing works

Immune Responses to Adenovirus and Adeno-Associated Vectors Used for Gene Therapy of Brain Diseases: The Role of Immunological Synapses in Understanding the Cell Biology of Neuroimmune Interactions

Lowenstein, P. R., Mandel, R. J., Xiong, W.-D., Kroeger, K. M., & Castro, M. G. (2007) · Current Gene Therapy · doi:10.2174/156652307782151498 · Cited by 157 · see citing works

Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo

György, B., Fitzpatrick, Z., Crommentuijn, M. H. W., Mu, D., & Maguire, C. A. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.032 · Cited by 153 · see citing works

Membrane cell permeabilisation with saponin and multiparametric analysis by flow cytometry

Jacob, M. C., Favre, M., & Bensa, J. (1991) · Cytometry · doi:10.1002/cyto.990120612 · Cited by 149 · see citing works

Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool

Garcı́a-Castro, J., Trigueros, C., Madrenas, J., Pérez‐Simón, J. A., Rodrı́guez, R., & Menéndez, P. R. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00516.x · Cited by 148 · see citing works

Exosome-associated AAV vector as a robust and convenient neuroscience tool

Hudry, E., Martin, C., Gandhi, S., György, B., Scheffer, D. I., Mu, D., Merkel, S. F., Mingozzi, F., Fitzpatrick, Z., Dimant, H., et al. (2016) · Gene Therapy · doi:10.1038/gt.2016.11 · Cited by 146 · see citing works

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

Stremersch, S., Vandenbroucke, R. E., Wonterghem, E. V., Hendrix, A., Smedt, S. C. D., & Raemdonck, K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.04.005 · Cited by 146 · see citing works

EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance

Jiang, L., Shen, Y., Guo, D., Yang, D., Liu, J., Fei, X., Yang, Y., Zhang, B., Lin, Z., Yang, F., et al. (2016) · Nature Communications · doi:10.1038/ncomms13045 · Cited by 145 · see citing works

DNA in serum extracellular vesicles is stable under different storage conditions

Yang, J., Chen, K., Wang, Z., Wang, Y., Liu, J., Lin, L., Shao, Y., Gao, L., Yin, H., Cui, C., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2783-2 · Cited by 139 · see citing works

A vaccine based on exosomes secreted by a dendritic cell line confers protection against T. gondii infection in syngeneic and allogeneic mice

Beauvillain, C., Ruiz, S., Guiton, R., et al. (2007) · Microbes and Infection · doi:10.1016/j.micinf.2007.07.002 · Cited by 133 · see citing works

A novel long noncoding RNA Lnc‐HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism

Lan, X., Yan, J., Ren, J., et al. (2015) · Hepatology · doi:10.1002/hep.28391 · Cited by 133 · see citing works

Identification and Characterization of 293T Cell-Derived Exosomes by Profiling the Protein, mRNA and MicroRNA Components

Li, J., Chen, X., Yi, J., Liu, Y., Li, D., Wang, J., Hou, D., Jiang, X., Zhang, J., Wang, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163043 · Cited by 130 · see citing works

Cell Penetrating Peptides in the Delivery of Biopharmaceuticals

Munyendo, W. L. L., Lv, H., Benza-Ingoula, H., Baraza, L. D., & Zhou, J. (2012) · Biomolecules · doi:10.3390/biom2020187 · Cited by 124 · see citing works

Exosomes are an effective vaccine against congenital toxoplasmosis in mice

Beauvillain, C., Juste, M., Dion, S., Pierre, J., & Dimier‐Poisson, I. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.01.022 · Cited by 117 · see citing works

Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture

Zhang, X., Abels, E. R., Redzic, J. S., Margulis, J., Finkbeiner, S. M., & Breakefield, X. O. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0350-7 · Cited by 102 · see citing works

Erythrocyte antioxidant enzymes in Parkinson's disease.

Abraham, S., Soundararajan, C. C., Vivekanandhan, S., & Behari, M. (2005) · PubMed · Cited by 101 · see citing works

In vitro evaluation of endothelial exosomes as carriers for small interfering ribonucleic acid delivery

He, J., Banizs, A. B., Huang, T., Dryden, K. A., Berr, S. S., Stone, J. R., Nakamoto, R. K., & Shi, W. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s64267 · Cited by 86 · see citing works

Integration Site Selection by Retroviral Vectors: Molecular Mechanism and Clinical Consequences

Daniel, R., & Smith, J. A. (2008) · Human Gene Therapy · doi:10.1089/hum.2007.148 · Cited by 73 · see citing works

Could Bioengineered Exosome-Mimetic Nanovesicles Be An Efficient Strategy for The Delivery of Chemotherapeutics?

Jang, S. C., & Gho, Y. S. (2014) · Nanomedicine · doi:10.2217/nnm.13.206 · Cited by 42 · see citing works

Electrofusion of cell-size liposomes

Stoicheva, N. G., & Hui, S. W. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90005-1 · Cited by 39 · see citing works

Phase I Study of Paclitaxel (Taxol) and Pegylated Liposomal Doxorubicin (Caelyx) Administered Every 2 Weeks in Patients with Advanced Solid Tumors

Mavroudis, D., Kouroussis, C., Kakolyris, S., et al. (2002) · Oncology · doi:10.1159/000059568 · Cited by 35 · see citing works

Toxicity and inflammatory response in Swiss albino mice after intraperitoneal and oral administration of polyurethane nanoparticles

Silva, A. H., Locatelli, C., Filippin-Monteiro, F. B., Martin, P., Liptrott, N. J., Zanetti-Ramos, B. G., Benetti, L., Nazari, E. M., de Albuquerque, C. A. C., Pasa, A. A., et al. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.01.018 · Cited by 30 · see citing works

Inhibition of porcine reproductive and respiratory syndrome virus infection by recombinant adenovirus- and/or exosome-delivered the artificial microRNAs targeting sialoadhesin and CD163 receptors

Zhu, L., Song, H., Zhang, X., Xia, X., & Sun, H. (2014) · Virology Journal · doi:10.1186/s12985-014-0225-9 · Cited by 29 · see citing works

Solid lipid nanoparticles induced hematological changes and inflammatory response in mice

Silva, A. H., Locatelli, C., Filippin-Monteiro, F. B., Zanetti-Ramos, B. G., Conte, A., & Creczynski‐Pasa, T. B. (2013) · Nanotoxicology · doi:10.3109/17435390.2013.782076 · Cited by 24 · see citing works

In vivo assessment of the aromatic L-amino acid decarboxylase gene expression by positron emission tomography in Parkinson?s disease

Asari, S., Fujimoto, K.-I., Kato, S., et al. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.07.058 · Cited by 6 · see citing works

Exosomes and Ectosomes in Intercellular Communication

Meldolesi, J. (2018) · Current Biology · doi:10.1016/j.cub.2018.01.059 · Cited by 944 · see citing works

Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system

Patel, D. B., Luthers, C. R., Lerman, M. J., Fisher, J. P., & Jay, S. M. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.024 · Cited by 152 · see citing works

The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System

Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

Dar, G. H., Mendes, C. C., Kuan, W.-L., Speciale, A. A., Conceição, M., Görgens, A., Uliyakina, I., Lobo, M. J., Lim, W. F., EL Andaloussi, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27056-3 · Cited by 100 · see citing works

Current advances in non‐viral gene delivery systems: Liposomes versus extracellular vesicles

Belhadj, Z., Qie, Y., Carney, R. P., Li, Y., & Nie, G. (2023) · BMEMat · doi:10.1002/bmm2.12018 · Cited by 79 · see citing works

The launch of Journal of Extracellular Vesicles (JEV), the official journal of the International Society for Extracellular Vesicles – about microvesicles, exosomes, ectosomes and other extracellular vesicles

Lötvall, J. O., Rajendran, L., Gho, Y. S., Théry, C., Wauben, M. H. M., Raposo, G., Sjöstrand, M., Taylor, D. D., Telemo, E., & Breakefield, X. O. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18514 · Cited by 22 · see citing works

Exosomes/EVs: MSC-NTF DERIVED SMALL EXTRACELLULAR VESICLES DISPLAY SUPERIOUR MACROPHAGE IMMUNOMODULATION COMPARED WITH VESICLES DERIVED FROM NAIVE MSC

Dekel, C., Kaspi, H., Kern, R., et al. (2022) · Cytotherapy · doi:10.1016/s1465-3249(22)00264-x

Exosomes and Microvesicles

(2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6728-5 · Cited by 36 · see citing works

Exosomes/EVs: GROWTH MEDIA CONDITIONS INFLUENCE THE SECRETION ROUTE AND RELEASE LEVELS OF ENGINEERED EXTRACELLULAR VESICLES

Bost, J. P., Gupta, D., Andaloussi, S. E., et al. (2022) · Cytotherapy · doi:10.1016/s1465-3249(22)00276-6

Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization

Chiriacò, M. S., Bianco, M., Nigro, A., Primiceri, E., Ferrara, F., Romano, A., Quattrini, A., Furlan, R., Arima, V., & Maruccio, G. (2018) · Sensors · doi:10.3390/s18103175 · Cited by 131 · see citing works