Flanking HS-62.5 and 3′ HS1, and regions upstream of the LCR, are not required for β-globin transcription
Open accessAbstract
The locus control region (LCR) was thought to be necessary and sufficient for establishing and maintaining an open beta-globin locus chromatin domain in the repressive environment of the developing erythrocyte. However, deletion of the LCR from the endogenous locus had no significant effect on chromatin structure and did not silence transcription. Thus, the cis-regulatory elements that confer the open domain remain unidentified. The conserved DNaseI hypersensitivity sites (HSs) HS-62.5 and 3'HS1 that flank the locus, and the region upstream of the LCR have been implicated in globin gene regulation. The flanking HSs bind CCCTC binding factor (CTCF) and are thought to interact with the LCR to form a "chromatin hub" involved in beta-globin gene activation. Hispanic thalassemia, a deletion of the LCR and 27 kb upstream, leads to heterochromatinization and silencing of the locus. Thus, the region upstream of the LCR deleted in Hispanic thalassemia (upstream Hispanic region [UHR]) may be required for expression. To determine the importance of the UHR and flanking HSs for beta-globin expression, we generated and analyzed mice with targeted deletions of these elements. We demonstrate deletion of these regions alone, and in combination, do not affect transcription, bringing into question current models for the regulation of the beta-globin locus.
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The β-globin genes are located in nested neighborhoods.
“the β-globin genes are located in nested neighborhoods, and perturbation of the inside neighborhood anchors has little effect on globin gene expression (Bender et al., 2006)”
From Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control (2016) · cites this paper as Bender et al., 2006
Perturbation of the inside neighborhood anchors has little effect on globin gene expression.
“the β-globin genes are located in nested neighborhoods, and perturbation of the inside neighborhood anchors has little effect on globin gene expression (Bender et al., 2006)”
From Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control (2016) · cites this paper as Bender et al., 2006
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Position-independent, high-level expression of the human β-globin gene in transgenic mice
Grosveld, F. G., van Assendelft, G. B., Greaves, D. R., & Kollias, G. A. (1987) · Cell · doi:10.1016/0092-8674(87)90584-8 · Cited by 1,908 · see citing works
Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus
Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344 · see citing works
HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells
Hooper, M., Hardy, K., Handyside, A. H., Hunter, S., & Monk, M. (1987) · Nature · doi:10.1038/326292a0 · Cited by 1,218 · see citing works
PipMaker—A Web Server for Aligning Two Genomic DNA SequencesPreprint
Schwartz, S., Zhang, Z., Frazer, K. A., Smit, A. F. A., Riemer, C., Bouck, J. B., Gibbs, R. A., Hardison, R. C., & Miller, W. (2000) · Genome Research · doi:10.1101/gr.10.4.577 · Cited by 1,165 · see citing works
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
Bell, A. C., West, A. G., & Felsenfeld, G. (1999) · Cell · doi:10.1016/s0092-8674(00)81967-4 · Cited by 1,101 · see citing works
Chung, J. H., Whiteley, M., & Felsenfeld, G. (1993) · Cell · doi:10.1016/0092-8674(93)80052-g · Cited by 854 · see citing works
The Molecular Basis of Blood Diseases.
(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-6-950_3 · Cited by 640 · see citing works
Insulators: many functions, many mechanismsPreprint
West, A. G., Gaszner, M., & Felsenfeld, G. (2002) · Genes & Development · doi:10.1101/gad.954702 · Cited by 624 · see citing works
The β-globin nuclear compartment in development and erythroid differentiation
Palstra, R.-J., Tolhuis, B., Splinter, E., Nijmeijer, R., Grosveld, F., & de Laat, W. (2003) · Nature Genetics · doi:10.1038/ng1244 · Cited by 559 · see citing works
Hebbes, T. R., Clayton, A. L., Thorne, A. W., & Crane‐Robinson, C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06451.x · Cited by 541 · see citing works
Looping versus linking: toward a model for long-distance gene activationPreprint
Bulger, M., & Groudine, M. T. (1999) · Genes & Development · doi:10.1101/gad.13.19.2465 · Cited by 483 · see citing works
Forrester, W. C., Epner, E. M., Driscoll, M. C., Enver, T., Brice, M. C., Papayannopoulou, T., & Groudine, M. T. (1990) · Genes & Development · doi:10.1101/gad.4.10.1637 · Cited by 464 · see citing works
Pikaart, M. J., Targa, F. R., & Felsenfeld, G. (1998) · Genes & Development · doi:10.1101/gad.12.18.2852 · Cited by 398 · see citing works
Targa, F. R., Pikaart, M. J., Burgess-Beusse, B. L., Bell, A. C., Litt, M. D., West, A. G., Gaszner, M., & Felsenfeld, G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102179399 · Cited by 381 · see citing works
Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci
Litt, M., Simpson, M., Targa, F. R., Prioleau, M., & Felsenfeld, G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2224 · Cited by 361 · see citing works
Kina, T., Ikuta, K., Takayama, E., Wada, K., Sen-Majumdar, A., Weissman, I. L., & Katsura, Y. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02037.x · Cited by 350 · see citing works
Spatial organization of gene expression: the active chromatin hub
de Laat, W. L., & Grosveld, F. G. (2003) · Chromosome Research · doi:10.1023/a:1024922626726 · Cited by 349 · see citing works
Fiering, S., Epner, E. M., Robinson, K. M., Zhuang, Y., Telling, A., Hu, M., Martin, D. I. K., Enver, T., Ley, T. J., & Groudine, M. T. (1995) · Genes & Development · doi:10.1101/gad.9.18.2203 · Cited by 334 · see citing works
Ragoczy, T., Bender, M. A., Telling, A., Byron, R., & Groudine, M. T. (2006) · Genes & Development · doi:10.1101/gad.1419506 · Cited by 326 · see citing works
The insulation of genes from external enhancers and silencing chromatin
Burgess-Beusse, B. L., Farrell, C. M., Gaszner, M., Litt, M. D., Mutskov, V. J., Targa, F. R., Simpson, M., West, A. G., & Felsenfeld, G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162342499 · Cited by 292 · see citing works
Ryan, T. M., Behringer, R. R., Martin, N. C., Townes, T. M., Palmiter, R. D., & Brinster, R. L. (1989) · Genes & Development · doi:10.1101/gad.3.3.314 · Cited by 259 · see citing works
Recruitment of Histone Modifications by USF Proteins at a Vertebrate Barrier Element
West, A. G., Huang, S., Gaszner, M., Litt, M. D., & Felsenfeld, G. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.005 · Cited by 258 · see citing works
Driscoll, M. C., Dobkin, C. S., & Alter, B. P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7470 · Cited by 233 · see citing works
Hardison, R., Slightom, J. L., Gumucio, D. L., Goodman, M., Stojanovic, N., & Miller, W. (1997) · Gene · doi:10.1016/s0378-1119(97)00474-5 · Cited by 230 · see citing works
[49] Derivation of embryonic stem cell lines
Abbondanzo, S. J., Gadi, I. K., & Stewart, C. L. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)25052-4 · Cited by 225 · see citing works
Bender, M. A., Bulger, M., Close, J., & Groudine, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80433-5 · Cited by 224 · see citing works
Self-citationStopped at the border: boundaries and insulators
Bell, A. C., & Felsenfeld, G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80029-x · Cited by 221 · see citing works
Setting the Boundaries of Chromatin Domains and Nuclear Organization
Labrador, M., & Corces, V. G. (2002) · Cell · doi:10.1016/s0092-8674(02)01004-8 · Cited by 221 · see citing works
Participation of the Human β-Globin Locus Control Region in Initiation of DNA Replication
Aladjem, M. I., Groudine, M. T., Brody, L. L., Dieken, E. S., Fournier, R. E. K., Wahl, G. M., & Epner, E. M. (1995) · Science · doi:10.1126/science.270.5237.815 · Cited by 211 · see citing works
Conserved CTCF Insulator Elements Flank the Mouse and Human β-Globin Loci
Farrell, C. M., West, A. G., & Felsenfeld, G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3820-3831.2002 · Cited by 184 · see citing works
Epner, E., Reik, A., Cimbora, D., Telling, A., Bender, M. A., Fiering, S., Enver, T., Martin, D. I. K., Kennedy, M., Keller, G., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80144-6 · Cited by 183 · see citing works
Self-citationMultiple interactions between regulatory regions are required to stabilize an active chromatin hub
Patrinos, G. P., de Krom, M., de Boer, E., Langeveld, A., Imam, A. M. A., Strouboulis, J., de Laat, W., & Grosveld, F. G. (2004) · Genes & Development · doi:10.1101/gad.289704 · Cited by 170 · see citing works
Reik, A., Telling, A., Zitnik, G., Cimbora, D., Epner, E., & Groudine, M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5992 · Cited by 163 · see citing works
Bulger, M., Schübeler, D., Bender, M. A., Hamilton, J., Farrell, C. M., Hardison, R. C., & Groudine, M. T. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5234-5244.2003 · Cited by 157 · see citing works
Structural and functional conservation at the boundaries of the chicken β‐globin domain
Saitoh, N., Bell, A. C., Recillas‐Targa, F., West, A. G., Simpson, M., Pikaart, M., & Felsenfeld, G. (2000) · The EMBO Journal · doi:10.1093/emboj/19.10.2315 · Cited by 149 · see citing works
Mechanisms of developmental control of transcription in the murine α- and β-globin lociPreprint
Trimborn, T., Gribnau, J. H., Grosveld, F. G., & Fraser, P. (1999) · Genes & Development · doi:10.1101/gad.13.1.112 · Cited by 145 · see citing works
Bulger, M., van Doorninck, J. H., Saitoh, N., Telling, A., Farrell, C. M., Bender, M. A., Felsenfeld, G., Axel, R., & Groudine, M. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5129 · Cited by 136 · see citing works
Reitman, M. L., & Felsenfeld, G. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.6.2774-2786.1990 · Cited by 108 · see citing works
Carotta, S., Pilat, S., Mairhofer, A., Schmidt, U., Dolznig, H., Steinlein, P., & Beug, H. (2004) · Blood · doi:10.1182/blood-2004-02-0570 · Cited by 101 · see citing works
Curtin, P. T., Pirastu, M., Kan, Y. W., Gobert-Jones, J. A., Stephens, A. D., & Lehmann, H. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112136 · Cited by 97 · see citing works
γδβ-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human β-globin cluster
Taramelli, R., Kioussis, D., Vanin, E. F., Bartram, K., Groffen, J., Hurst, J., & Grosveld, F. G. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.17.7017 · Cited by 91 · see citing works
ChIPs of the β-globin locus: unraveling gene regulation within an active domain
Bulger, M., Sawado, T., Schübeler, D., & Groudine, M. T. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00283-6 · Cited by 88 · see citing works
Schübeler, D., Groudine, M., & Bender, M. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201394698 · Cited by 87 · see citing works
Bulger, M., Bender, M. A., van Doorninck, J. H., Wertman, B., Farrell, C. M., Felsenfeld, G., Groudine, M. T., & Hardison, R. C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14560 · Cited by 85 · see citing works
Bender, M. A., Reik, A., Close, J., Telling, A., Epner, E. M., Fiering, S., Hardison, R. C., & Groudine, M. T. (1998) · Blood · doi:10.1182/blood.v92.11.4394.423k48_4394_4403 · Cited by 68 · see citing works
Reitman, M. L., & Felsenfeld, G. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.6.2774 · Cited by 68 · see citing works
Erythroid-Specific Nuclease-Hypersensitive Sites Flanking the Human β-Globin Domain
Dhar, V., Nandi, A. K., Schildkraut, C. L., & Skoultchi, A. I. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.8.4324-4333.1990 · Cited by 61 · see citing works
Erythroid-specific nuclease-hypersensitive sites flanking the human beta-globin domain.
Dhar, V., Nandi, A., Schildkraut, C. L., & Skoultchi, A. I. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.8.4324 · Cited by 47 · see citing works
NAKANO, T., Era, T., Takahashi, T., Kodama, H., & Honjo, T. (1997) · PubMed · Cited by 16 · see citing works
Hu, X., Bulger, M., Bender, M. A., Fields, J. L., Groudine, M. T., & Fiering, S. (2005) · Blood · doi:10.1182/blood-2005-06-2308 · Cited by 15 · see citing works
Bacon, E. R., & Sytkowski, A. (1987) · Blood · doi:10.1182/blood.v69.1.103.103 · Cited by 10 · see citing works
Bacon, E. R., & Sytkowski, A. (1987) · Blood · doi:10.1182/blood.v69.1.103.bloodjournal691103 · Cited by 1 · see citing works
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- Ragoczy T, Bender MA, Telling A, Byron R, Grou- dine M. The murine beta-globin LCR positions the globin locus at engaged transcription factories during erythroid maturation. Genes Dev. 2006;20: 1447-1457.
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Nora, E. P., Goloborodko, A., Valton, A.-L., Gibcus, J. H., Uebersohn, A., Abdennur, N., Dekker, J., Mirny, L. A., & Bruneau, B. G. (2017) · Cell · doi:10.1016/j.cell.2017.05.004 · Cited by 1,709 · see citing works
CTCF: Master Weaver of the Genome
Phillips‐Cremins, J. E., & Corces, V. G. (2009) · Cell · doi:10.1016/j.cell.2009.06.001 · Cited by 1,540 · see citing works
Dostie, J., Richmond, T., Arnaout, R., Selzer, R. R., Lee, W. L., Honan, T., Rubio, E. D., Krumm, A., Lamb, J., Nusbaum, C., et al. (2006) · Genome Research · doi:10.1101/gr.5571506 · Cited by 1,182 · see citing works
Topology of mammalian developmental enhancers and their regulatory landscapes
de Laat, W., & Duboule, D. (2013) · Nature · doi:10.1038/nature12753 · Cited by 521 · see citing works
Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control
Hnisz, D., Day, D. S., & Young, R. A. (2016) · Cell · doi:10.1016/j.cell.2016.10.024 · Cited by 420 · see citing works
Long-Range Chromatin Interactions
Dekker, J., & Misteli, T. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019356 · Cited by 255 · see citing works
Cell type specificity of chromatin organization mediated by CTCF and cohesin
Hou, C., Dale, R., & Dean, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912087107 · Cited by 240 · see citing works
CTCF: the protein, the binding partners, the binding sites and their chromatin loops
Holwerda, S. J. B., & de Laat, W. L. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0369 · Cited by 230 · see citing works
Enhancers: The abundance and function of regulatory sequences beyond promoters
Bulger, M., & Groudine, M. T. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.11.035 · Cited by 187 · see citing works
Does CTCF mediate between nuclear organization and gene expression?
OHLSSON, R. I., Lobanenkov, V. V., & Klenova, E. M. (2009) · BioEssays · doi:10.1002/bies.200900118 · Cited by 165 · see citing works
Solovieff, N., Milton, J. N., Hartley, S. W., Sherva, R., Paola Sebastiani, B., Dworkis, D. A., Klings, E. S., Farrer, L. A., Garrett, M. E., Ashley‐Koch, A. E., et al. (2009) · Blood · doi:10.1182/blood-2009-08-239517 · Cited by 141 · see citing works
Palstra, R.-J. T. S., Simonis, M., Klous, P., Brasset, É., Eijkelkamp, B. A., & de Laat, W. L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001661 · Cited by 134 · see citing works
Chapter 4 β‐Globin Regulation and Long‐Range Interactions
Palstra, R., de Laat, W., & Grosveld, F. (2008) · Advances in genetics · doi:10.1016/s0065-2660(07)00004-1 · Cited by 131 · see citing works
β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications
Bian, Q., Khanna, N., Alvikas, J., & Belmont, A. S. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201305027 · Cited by 122 · see citing works
Cohesin Mediates Chromatin Interactions That Regulate Mammalian β-globin Expression
Chien, R., Zeng, W., Kawauchi, S., Bender, M. A., Santos, R., Gregson, H. C., Schmiesing, J. A., Newkirk, D. A., Kong, X., Ball, A. R., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.207365 · Cited by 104 · see citing works
Kim, A., Kiefer, C. M., & Dean, A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01684-06 · Cited by 95 · see citing works
Lower, K. M., Hughes, J. R., De Gobbi, M., Henderson, S., Viprakasit, V., Fisher, C., Goriely, A., Ayyub, H., Sloane-Stanley, J., Vernimmen, D., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909331106 · Cited by 92 · see citing works
Molecular Diagnosis of Thalassemias and Hemoglobinopathies
Sabath, D. E. (2017) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqx047 · Cited by 92 · see citing works
Joining the loops: β‐Globin gene regulation
Noordermeer, D., & de Laat, W. L. (2008) · IUBMB Life · doi:10.1002/iub.129 · Cited by 89 · see citing works
In the loop: long range chromatin interactions and gene regulation
Dean, A. (2011) · Briefings in Functional Genomics · doi:10.1093/bfgp/elq033 · Cited by 83 · see citing works
Chapter 5 Three‐Dimensional Organization of Gene Expression in Erythroid Cells
de Laat, W. L., Klous, P., Kooren, J. A., Noordermeer, D., Palstra, R.-J. T. S., Simonis, M., Splinter, E., & Grosveld, F. G. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)00005-1 · Cited by 83 · see citing works
Epigenetics of β-globin gene regulation
Kiefer, C. M., Hou, C., Little, J. A., & Dean, A. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.07.014 · Cited by 81 · see citing works
Seruggia, D., Fernández, A., Cantero, M., Pelczar, P., & Montoliu, L. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv375 · Cited by 74 · see citing works
Kooren, J. A., Palstra, R.-J. T. S., Klous, P., Splinter, E., Lindern, M. V., Grosveld, F. G., & de Laat, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701159200 · Cited by 72 · see citing works
Chromatin Insulator Elements: Establishing Barriers to Set Heterochromatin Boundaries
Barkess, G., & West, A. G. (2012) · Epigenomics · doi:10.2217/epi.11.112 · Cited by 73 · see citing works
The complex transcription regulatory landscape of our genome: control in three dimensions
Splinter, E., & de Laat, W. L. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.344 · Cited by 64 · see citing works
CCCTC-binding factor: to loop or to bridge
Zlatanova, J. S., & Caiafa, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8647-z · Cited by 58 · see citing works
Bender, M. A., Ragoczy, T., Lee, J., Byron, R., Telling, A., Dean, A., & Groudine, M. (2012) · Blood · doi:10.1182/blood-2011-09-380485 · Cited by 53 · see citing works
Junier, I., Dale, R., Hou, C., Képès, F., & Dean, A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks536 · Cited by 38 · see citing works
Close encounters of the 3C kind: long-range chromatin interactions and transcriptional regulation
Palstra, R.-J. T. S. (2009) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/elp016 · Cited by 36 · see citing works
Dynamic Control of Long-Range Genomic Interactions at the Immunoglobulin κ Light-Chain Locus
de Almeida, C. R., Hendriks, R. W., & Stadhouders, R. (2015) · Advances in immunology · doi:10.1016/bs.ai.2015.07.004 · Cited by 33 · see citing works
Pope, B. D., Chandra, T., Buckley, Q., Hoare, M., Ryba, T., Wiseman, F. K., Kuta, A., Wilson, M. D., Odom, D. T., & Gilbert, D. M. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds232 · Cited by 32 · see citing works
Fang, X., Xiang, P., Yin, W., Stamatoyannopoulos, G., & Li, Q. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.09.072 · Cited by 27 · see citing works
Fromm, G. J., & Bulger, M. (2009) · Biochemistry and Cell Biology · doi:10.1139/o09-048 · Cited by 23 · see citing works
Chapter 3 Epigenetic Control of Complex Loci During Erythropoiesis
Wozniak, R. J., & Bresnick, E. H. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)00003-8 · Cited by 21 · see citing works
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Himadewi, P., Wang, X. Q. D., Feng, F., Gore, H., Liu, Y.-S., Yu, L., Kurita, R., Nakamura, Y., Pfeifer, G., Liu, J., et al. (2021) · bioRxiv · doi:10.7554/elife.70557 · Cited by 16 · see citing works
The Normal Structure and Regulation of Human Globin Gene Clusters
Forget, B. G., & Hardison, R. C. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511596582.007 · Cited by 20 · see citing works
Sun, Y., Dai, H., Chen, S., Xu, M., Wang, X., Zhang, Y., Xu, S., Xu, A., Weng, J., Liu, S., et al. (2018) · Nanotoxicology · doi:10.1080/17435390.2018.1425498 · Cited by 19 · see citing works
Singh, V., & Srivastava, M. P. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00091-08 · Cited by 17 · see citing works
Kang, J. G., Kim, Y. W., Park, S., Kang, Y., & Kim, A. (2021) · The FASEB Journal · doi:10.1096/fj.202100105rr · Cited by 16 · see citing works
Kang, Y., Kim, Y. W., Kang, J., Yun, W. J., & Kim, A. (2017) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2017.01.013 · Cited by 15 · see citing works
Molecular and Cellular Basis of Hemoglobin Switching
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Embryonic Stem Cells as a Platform for Analyzing Neural Gene Transcription
Zhang, X., Horrell, S. A., Delaney, D., & Gottlieb, D. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0902 · Cited by 13 · see citing works
Ferreira, R., Spensberger, D., Silber, Y., Dimond, A., Li, J., Green, A. R., & Göttgens, B. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01525-12 · Cited by 10 · see citing works
Gene insulation. Part II: natural strategies in vertebrates
Amouyal, M. (2010) · Biochemistry and Cell Biology · doi:10.1139/o10-111 · Cited by 10 · see citing works
Wong, H., Winn, P. J., & Mozziconacci, J. (2009) · BioEssays · doi:10.1002/bies.200900062 · Cited by 9 · see citing works
Three Mexican Families with β thalassemia intermedia with different molecular basis
de la Torre, L. D. C. R., Perea, F. J., Cortés, B. I., López, V., Sánchez-López, J. Y., Anzaldo, F. J. S., Magaña‐Torres, M. T., Gonnet, K., Badens, C., & Bonello‐Palot, N. (2019) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2019-0032 · Cited by 8 · see citing works
Reading, N. S., Shooter, C. C., Song, J., Miller, R. E., Agarwal, A. M., Lanikova, L., Clark, B. E., Thein, S. L., Divoký, V., & Prchal, J. T. (2016) · Human Mutation · doi:10.1002/humu.23061 · Cited by 8 · see citing works
Spensberger, D., Kotsopoulou, E., Ferreira, R., Broccardo, C., Scott, L. M., Fourouclas, N., Ottersbach, K., Green, A. R., & Göttgens, B. (2012) · Experimental Hematology · doi:10.1016/j.exphem.2012.02.006 · Cited by 8 · see citing works
Fontela, M. G., Notario, L., Alari‐Pahissa, E., Lorente, E., & Lauzurica, P. (2019) · Genes · doi:10.3390/genes10090651 · Cited by 4 · see citing works
Insulators in vertebrates: regulatory mechanisms and chromatin structure
Ulianov, S. V., Markova, E. N., Gavrilov, A. A., & Razin, S. V. (2012) · Biopolymers and Cell · doi:10.7124/bc.000057 · Cited by 3 · see citing works
Itaya, K., Chayahara, K., Hirai, T., Minbuta, T., Uchikawa, T., Tanaka, T., Masaki, S., Kuroda, K., & Ono, M. (2011) · Genes to Cells · doi:10.1111/j.1365-2443.2011.01486.x · Cited by 2 · see citing works
THE MOLECULAR, CELLULAR, AND GENETIC BASIS OF HEMOGLOBIN DISORDERS
Steinberg, M. H., Forget, B. G., Higgs, D. R., & Weatherall, D. J. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511596582.004 · Cited by 1 · see citing works
Three‐Dimensional Architecture of Genomes
Dekker, J. (2011) · doi:10.1002/9783527639991.ch9
Molekularbiologische Analysen zur Regulation des T-Zell-Rezeptor-β-Lokus
München, L.-M.-U. (2007)
Garrick, D., Gobbi, M., Gibbons, R. J., & Higgs, D. R. (2009) · Epigenomics · doi:10.2217/epi.09.36
The molecular mechanism of the aberrant expression of the B-cell specific PAX5 gene in t(8;21) AML
Ray, D. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)
Epigenetic Gene Regulation—Lessons from Globin
Dean, A., & Fiering, S. (2008) · Springer eBooks · doi:10.1007/978-1-4020-9187-2_16
- Authors
- Bender, M. A., Byron, R., Ragoczy, T., Telling, A., Bulger, M., & Groudine, M.
- Affiliations
- University of Washington (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-08-15
- Volume
- 108
- Issue
- 4
- Pages
- 1395-1401
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC1895883
- OpenAlex
- W2084095051
- Cited by
- 59
- References
- 52
- Citations by year
- 2021: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2013: 5 · 2012: 7
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- Fred Hutchinson Cancer Research Center
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 44746)
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- locus control region, CTCF, globin gene regulation, cis-regulatory elements, erythroid gene expression
- MeSH terms
- Animals, Base Sequence, Chromatin, Gene Expression Regulation, Globins, Models, Genetic, Thalassemia, Transcription, Genetic, Transcriptional Activation, Sequence Deletion, Mice, Knockout, Locus Control Region, 5' Flanking Region, Quantitative Trait Loci, Mice
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