STAT3 positively regulates an early step in B-cell development
Open accessAbstract
Transcription factors are critical for instructing the development of B lymphocytes from multipotential progenitor cells in the bone marrow (BM). Here, we show that the absence of STAT3 impaired B-cell development. Mice selectively lacking STAT3 in BM progenitor cells displayed reduced numbers of mature B cells, both in the BM and in the periphery. The reduction in the B-cell compartment included reduced percentages and numbers of pro-B, pre-B, and immature B cells in the absence of STAT3, whereas the number of pre-pro-B cells was increased. We found that pro-B and pre-B-cell populations lacking STAT3 were hyporesponsive to IL-7 because of a decreased number of IL-7-responsive cells rather than decreased expression or signaling of IL-7Ralpha. Moreover, STAT3-deficient mice displayed enhanced apoptosis in the pro-B population when deprived of survival factors, suggesting that at least 2 mechanisms (impaired differentiation and enhanced apoptosis) are involved in the mutant phenotype. Last, BM transplantation confirmed that impaired B lymphopoiesis in the absence of STAT3 was caused by a cell autonomous defect. In sum, these studies defined a specific role for STAT3 in early B-cell development, probably acting at the pre-pro-B transition by contributing to the survival of IL-7-responsive progenitors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
B cell-specific STAT3 knockout reduces B cell compartments and plasma cells.
“Reduced B cell compartments and plasma cells”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Chou et al., 2006
STAT3 is required for developmental transition of pre-pro-B cell progenitors to subsequent precursor populations and their survival.
“STAT3 is required for developmental transition of pre-pro-B cell progenitors to subsequent precursor populations and their survival”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Chou et al., 2006
Cites
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790 · see citing works
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253 · see citing works
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,915 · see citing works
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
von Freeden-Jeffry, U., Vieira, P., Lucian, L., McNeil, T., Burdach, S. E. G., & Murray, R. (1995) · Journal of Experimental Medicine · doi:10.1084/jem.181.4.1519 · Cited by 1,648 · see citing works
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., & Hayakawa, K. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.5.1213 · Cited by 1,604 · see citing works
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
Peschon, J. J., Morrissey, P., Grabstein, K. H., Ramsdell, F. J., Maraskovsky, E., Gliniak, B., Park, L. S., Ziegler, S. F., Williams, D. E., Ware, C. B., et al. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1955 · Cited by 1,553 · see citing works
Hirano, T., Ishihara, K., & Hibi, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203551 · Cited by 1,276 · see citing works
Levy, D., & Lee, C.-K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15650 · Cited by 925 · see citing works
Self-citationDevelopment and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
Opferman, J. T., Letai, A. G., Beard, C., Sorcinelli, M. D., Ong, C. C., & Korsmeyer, S. J. (2003) · Nature · doi:10.1038/nature02067 · Cited by 801 · see citing works
Lin, J.-X., Migone, T.-S., Tseng, M., Friedmann, M., Weatherbee, J. A., Zhou, L., Yamauchi, A., Bloom, E. T., Mietz, J., John, S., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90141-8 · Cited by 752 · see citing works
Levy, D. E., & Lee, C.-K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215650 · Cited by 734 · see citing works
Self-citationB lymphocyte-specific, Cre-mediated mutagenesis in mice
Rickert, R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1317 · Cited by 724 · see citing works
Mackarehtschian, K., Hardin, J. D., Moore, K., Boast, S., Goff, S. P., & Lemischka, I. R. (1995) · Immunity · doi:10.1016/1074-7613(95)90167-1 · Cited by 575 · see citing works
Sano, S., Itami, S., Takeda, K., Tarutani, M., Yamaguchi, Y., Miura, H., Yoshikawa, K., Akira, S., & Takeda, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4657 · Cited by 519 · see citing works
Transcriptional Control of Early B Cell Development
Busslinger, M. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104807 · Cited by 482 · see citing works
Expression and function of the interleukin 7 receptor in murine lymphocytes.
Sudo, T., Nishikawa, S., Ohno, N., Akiyama, N., Tamakoshi, M., Yoshida, H., & Nishikawa, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9125 · Cited by 482 · see citing works
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
Chiarle, R., Simmons, W. J., Cai, H., Dhall, G., Zamò, A., Raz, R., Karras, J. G., Levy, D. E., & Inghirami, G. (2005) · Nature Medicine · doi:10.1038/nm1249 · Cited by 441 · see citing works
Self-citationIwasaki, H., Somoza, C., Shigematsu, H., Duprez, E. A., Iwasaki-Arai, J., Mizuno, S.-I., Arinobu, Y., Geary, K., Zhang, P., Dayaram, T., et al. (2005) · Blood · doi:10.1182/blood-2005-03-0860 · Cited by 433 · see citing works
Hes binding to STAT3 mediates crosstalk between Notch and JAK–STAT signalling
Kamakura, S., Oishi, K., Yoshimatsu, T., Nakafuku, M., Masuyama, N., & Gotoh, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1138 · Cited by 424 · see citing works
Essential role of STAT3 for embryonic stem cell pluripotency
Raz, R., Lee, C., Cannizzaro, L. A., D’Eustachio, P., & Levy, D. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2846 · Cited by 399 · see citing works
Self-citationStat5a/b are essential for normal lymphoid development and differentiation
Yao, Z., Cui, Y., Watford, W. T., Bream, J. H., Yamaoka, K., Hissong, B. D., Li, D., Durum, S. K., Jiang, Q., Bhandoola, A., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507350103 · Cited by 391 · see citing works
Notch signaling controls the generation and differentiation of early T lineage progenitors
Sambandam, A., Maillard, I. P., Zediak, V. P., Xu, L., Gerstein, R. M., Aster, J. C., Pear, W. S., & Bhandoola, A. (2005) · Nature Immunology · doi:10.1038/ni1216 · Cited by 364 · see citing works
STAT3 is required for Flt3L-dependent dendritic cell differentiation
Laouar, Y., Welte, T., Fu, X.-Y., & Flavell, R. A. (2003) · Immunity · doi:10.1016/s1074-7613(03)00332-7 · Cited by 334 · see citing works
Real, P. J., Sierra, A., de Juan, A., Segovia, J. C., Lopez-Vega, J. M., & Fernandez-Luna, J. L. (2002) · Oncogene · doi:10.1038/sj.onc.1206004 · Cited by 321 · see citing works
PU.1 Regulates Expression of the Interleukin-7 Receptor in Lymphoid Progenitors
DeKoter, R. P., Lee, H.-J., & Singh, H. (2002) · Immunity · doi:10.1016/s1074-7613(02)00269-8 · Cited by 319 · see citing works
Sitnicka, E., Bryder, D., Theilgaard‐Mönch, K., Buza-Vidas, N., Adolfsson, J., & Jacobsen, S. E. W. (2002) · Immunity · doi:10.1016/s1074-7613(02)00419-3 · Cited by 290 · see citing works
Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7−/− Mice
Carvalho, T. L., Mota‐Santos, T. A., Cumano, A., Demengeot, J., & Vieira, P. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.8.1141 · Cited by 272 · see citing works
Lee, C.-K., Raz, R., Gimeno, R., Gertner, R., Wistinghausen, B., Takeshita, K., DePinho, R. A., & Levy, D. E. (2002) · Immunity · doi:10.1016/s1074-7613(02)00336-9 · Cited by 242 · see citing works
Self-citationAssembling a Gene Regulatory Network for Specification of the B Cell Fate
Medina, K. L., Pongubala, J. M. R., Reddy, K. L., Lancki, D. W., DeKoter, R. P., Kieslinger, M., Grosschedl, R., & Singh, H. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.006 · Cited by 240 · see citing works
Transcriptional networks in developing and mature B cells
Matthias, P., & Rolink, A. G. (2005) · Nature reviews. Immunology · doi:10.1038/nri1633 · Cited by 238 · see citing works
Sexl, V., Piekorz, R. P., Moriggl, R., Rohrer, J., Brown, M. P., Bunting, K. D., Rothammer, K., Roussel, M. F., & Ihle, J. N. (2000) · Blood · doi:10.1182/blood.v96.6.2277 · Cited by 198 · see citing works
Contingent gene regulatory networks and B cell fate specification
Singh, H., Medina, K. L., & Pongubala, J. M. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500480102 · Cited by 185 · see citing works
Sitnicka, E., Brakebusch, C., Mårtensson, I., Svensson, M., Agace, W. W., Sigvardsson, M., Buza-Vidas, N., Bryder, D., Cilio, C., Ahlenius, H., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20031152 · Cited by 178 · see citing works
Karras, J., Wang, Z.-H., Huo, L., Howard, R., Frank, D., & Rothstein, T. (1997) · Journal of Experimental Medicine · doi:10.1084/jem.185.6.1035 · Cited by 160 · see citing works
Bertolino, E., Reddy, K. L., Medina, K. L., Parganas, E., Ihle, J. N., & Singh, H. (2005) · Nature Immunology · doi:10.1038/ni1226 · Cited by 157 · see citing works
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells
Fornek, J. L., Tygrett, L. T., Waldschmidt, T. J., Poli, V., Rickert, R. C., & Kansas, G. S. (2006) · Blood · doi:10.1182/blood-2005-07-2871 · Cited by 148 · see citing works
Role of STAT3 and PI 3-Kinase/Akt in Mediating the Survival Actions of Cytokines on Sensory Neurons
Alonzi, T., Middleton, G., Wyatt, S. L., Buchman, V. L., Betz, U. A. K., Müller, W., Musiani, P., Poli, V., & Davies, A. M. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1018 · Cited by 147 · see citing works
Lee, C., Smith, E., Gimeno, R., Gertner, R., & Levy, D. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.3.1286 · Cited by 145 · see citing works
Self-citationSTAT5 Activation Underlies IL7 Receptor-Dependent B Cell Development
Goetz, C. A., Harmon, I., O’Neil, J. J., Burchill, M. A., & Farrar, M. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4770 · Cited by 144 · see citing works
Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival
Liu, H., Ma, Y., Cole, S. M., Zander, C., Chen, K.-H., Karras, J., & Pope, R. M. (2003) · Blood · doi:10.1182/blood-2002-11-3396 · Cited by 136 · see citing works
Dallas, M. H., Varnum‐Finney, B., Delaney, C. S., Kato, K., & Bernstein, I. D. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042450 · Cited by 112 · see citing works
Sano, S., Takahama, Y., Sugawara, T., Kosaka, H., Itami, S., Yoshikawa, K., Miyazaki, J., van Ewijk, W., & Takeda, J. (2001) · Immunity · doi:10.1016/s1074-7613(01)00180-7 · Cited by 111 · see citing works
Ye, M., Ermakova, O. V., & Graf, T. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051089 · Cited by 90 · see citing works
CD19 Function in Central and Peripheral B-Cell Development
Nagro, C. J. D., Otero, D. C., Anzelon-Mills, A. N., Omori, S. A., Kolla, R. V., & Rickert, R. C. (2005) · Immunologic Research · doi:10.1385/ir:31:2:119 · Cited by 89 · see citing works
The development of functional B lymphocytes in conditional PU.1 knock-out mice
Polli, M., Dakic, A., Light, A., Wu, L., Tarlinton, D. M., & Nutt, S. L. (2005) · Blood · doi:10.1182/blood-2005-01-0283 · Cited by 89 · see citing works
Lee, C., Gimeno, R., & Levy, D. E. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.10.1451 · Cited by 72 · see citing works
Self-citationMaraskovsky, E. (1998) · International Immunology · doi:10.1093/intimm/10.9.1367 · Cited by 68 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hillmer, E. J., Zhang, H., Li, H. S., & Watowich, S. S. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.05.001 · Cited by 740 · see citing works
Clark, M. R., Mandal, M., Ochiai, K., & Singh, H. (2013) · Nature reviews. Immunology · doi:10.1038/nri3570 · Cited by 337 · see citing works
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works
Corfe, S. A., & Paige, C. J. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.02.001 · Cited by 211 · see citing works
Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein
Debnath, B., Xu, S., & Neamati, N. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300207s · Cited by 205 · see citing works
Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle
Lightman, S. M., Utley, A. T., & Lee, K. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00965 · Cited by 198 · see citing works
Clinical Manifestations, Etiology, and Pathogenesis of the Hyper-IgE Syndromes
Freeman, A. F., & Holland, S. M. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31819dc8c5 · Cited by 193 · see citing works
STAT3 Negatively Regulates Type I IFN-Mediated Antiviral Response
Wang, W., Levy, D. E., & Lee, C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004128 · Cited by 178 · see citing works
Self-citationMechanisms regulating dendritic cell specification and development
Watowich, S. S., & Liu, Y. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00949.x · Cited by 148 · see citing works
Fine-Tuning of Type I Interferon Response by STAT3
Tsai, M.-H., Pai, L., & Lee, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01448 · Cited by 119 · see citing works
Self-citationThe Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy
Wang, C., Kong, L.-Z., Kim, S., Lee, S., Oh, S., Jo, S., Jang, I.-H., & Kim, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810412 · Cited by 112 · see citing works
Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1
Lam, Q. L. K., Wang, S., Ko, O. K. H., Kincade, P. W., & Lu, L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004185107 · Cited by 106 · see citing works
Interleukin-27 directly induces differentiation in hematopoietic stem cells.
Seita, J., Asakawa, M., Ooehara, J., Takayanagi, S.-I., Morita, Y., Watanabe, N., Fujita, K., Kudo, M., Mizuguchi, J., Ema, H., et al. (2008) · Blood · doi:10.1182/blood-2007-06-093328 · Cited by 96 · see citing works
Reduced memory B cells in patients with hyper IgE syndrome
Speckmann, C., Enders, A., Woellner, C., Thiel, D., Rensing‐Ehl, A., Schlesier, M., Rohr, J., Jakob, T., Oswald, E., Kopp, M., et al. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.08.002 · Cited by 81 · see citing works
Reduction of Stat3 Activity Attenuates HIV-Induced Kidney Injury
Feng, X., Lu, T.-C., Chuang, P. Y., Fang, W. Y., Ratnam, K. K., Xiong, H., Ouyang, X., Shen, Y., Levy, D. E., Hyink, D. P., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008080879 · Cited by 79 · see citing works
Self-citationDorritie, K., McCubrey, J. A., & Johnson, D. E. (2014) · Leukemia · doi:10.1038/leu.2013.192 · Cited by 72 · see citing works
Parakh, S., Ernst, M., & Poh, A. R. (2021) · Cancers · doi:10.3390/cancers13246228 · Cited by 76 · see citing works
Featherstone, K., Wood, A. L., Bowen, A. J., & Corcoran, A. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.098251 · Cited by 75 · see citing works
Human hyper-IgE syndrome: singular or plural?
Zhang, Q., Boisson, B., Béziat, V., Puel, A., & Casanova, J.-L. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9767-2 · Cited by 67 · see citing works
Lymphocyte Development: Integration of DNA Damage Response Signaling
Bednarski, J. J., & Sleckman, B. P. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394300-2.00006-5 · Cited by 61 · see citing works
Role of STAT3 in Transformation and Drug Resistance in CML
Nair, R. R., Tolentino, J. H. G., & Hazlehurst, L. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00030 · Cited by 56 · see citing works
The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor
Ecker, A. (2009) · Frontiers in bioscience · doi:10.2741/3425 · Cited by 48 · see citing works
STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia
Mangolini, M., de Boer, J., Walf-Vorderwülbecke, V., Pieters, R., den Boer, M. L., & Williams, O. (2013) · Blood · doi:10.1182/blood-2012-11-465252 · Cited by 47 · see citing works
STAT3 Role in T-Cell Memory Formation
Kaminskiy, Y., & Melenhorst, J. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052878 · Cited by 44 · see citing works
Isoform-specific targeting of ROCK proteins in immune cells
Zanin‐Zhorov, A., Flynn, R. P., Waksal, S. D., & Blazar, B. R. (2016) · Small GTPases · doi:10.1080/21541248.2016.1181698 · Cited by 44 · see citing works
Regulation of hematopoietic cell development and function by Stat3
Pamela, A. H. (2009) · Frontiers in bioscience · doi:10.2741/3597 · Cited by 36 · see citing works
Lee, D.-I., & Roy, S. (2021) · Genome biology · doi:10.1186/s13059-021-02378-z · Cited by 34 · see citing works
STAT transcription factors in normal and cancer stem cells.
Dorritie, K., Redner, R., & Johnson, D. E. (2014) · Advances in Biological Regulation · doi:10.1016/j.jbior.2014.05.004 · Cited by 34 · see citing works
BATF regulates innate lymphoid cell hematopoiesis and homeostasis
Liu, Q., Kim, M. H., Friesen, L., & Kim, C. H. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz8154 · Cited by 31 · see citing works
Premkumar, K., & Shankar, B. S. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02666-w · Cited by 29 · see citing works
Oladipupo, F. O., Yu, C., Olumuyide, E., Jittaysothorn, Y., Choi, J. K., & Egwuagu, C. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-73093-1 · Cited by 28 · see citing works
Macia, L., Viltart, O., Delacre, M., Sachot, C., Héliot, L., Santo, J. P. D., & Wolowczuk, I. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009953 · Cited by 26 · see citing works
Molecular characterization of acute myeloid leukemia and its impact on treatment
Frankfurt, O., Licht, J. D., & Tallman, M. S. (2007) · Current Opinion in Oncology · doi:10.1097/cco.0b013e3282f10e55 · Cited by 26 · see citing works
Combining STAT3-Targeting Agents with Immune Checkpoint Inhibitors in NSCLC
Papavassiliou, K. A., Marinos, G., & Papavassiliou, A. G. (2023) · Cancers · doi:10.3390/cancers15020386 · Cited by 26 · see citing works
Advances in IL-7 Research on Tumour Therapy
Fu, C., Zhang, X., Zhang, X., Wang, D., Han, S., & Ma, Z. (2024) · Pharmaceuticals · doi:10.3390/ph17040415 · Cited by 25 · see citing works
STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response
Chen, L., Wei, P., Liu, T., Kao, C.-H., Pai, L., & Lee, C. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-22 · Cited by 25 · see citing works
Self-citationMoreno, C. M., Bybee, E., Freitas, C. M. T., Pickett, B. E., & Weber, K. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105580 · Cited by 23 · see citing works
Human and mouse early B cell development: So similar but so different
Korzhenevich, J., Janowska, I., van der Burg, M., & Rizzi, M. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.07.004 · Cited by 23 · see citing works
Kasap, N., Çelik, V., Işık, S., Cennetoğlu, P., Kıykım, A. A., Eltan, S. B., Nain, E., Öğülür, İ., Başer, D., Akkelle, E., et al. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108645 · Cited by 22 · see citing works
Sun, J., Daniels, R. R., Balic, A., Andresen, A. M. S., Bjørgen, H., Dobie, R., Henderson, N. C., Koppang, E. O., Martín, S., Fosse, J. H., et al. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109358 · Cited by 21 · see citing works
SOCS3 Deletion in B Cells Alters Cytokine Responses and Germinal Center Output
Jones, S. A., White, C. A., Robb, L. G., Alexander, W. S., & Tarlinton, D. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102057 · Cited by 20 · see citing works
Hu, X. T., Wang, P., Qu, C., Zhang, H., & Li, L. (2021) · Bioengineered · doi:10.1080/21655979.2021.1965697 · Cited by 19 · see citing works
Wang, W., McDonald, M. C. L., Hariprasad, R., Hamilton, T., & Frank, D. A. (2024) · Cancers · doi:10.3390/cancers16071387 · Cited by 19 · see citing works
Ryu, J., Lee, J. J., Kim, E., Seo, H.-B., Park, J., Lee, S.-Y., Moon, Y., Yoo, S., Park, Y.-W., Park, S., et al. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.09.007 · Cited by 19 · see citing works
Signal transducer and activator of transcription 3 regulation by novel binding partners
Matsuda, T. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i4.324 · Cited by 19 · see citing works
Improvement of Sclerodermatous Graft-Versus-Host Disease in Mice by Niclosamide
Morin, F., Kavian, N., Nicco, C., Cerles, O., Chéreau, C., & Batteux, F. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.06.624 · Cited by 19 · see citing works
Lee, S., Moon, S.-J., Park, M.-J., Kim, E., Moon, Y., & Cho, M. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.03.014 · Cited by 18 · see citing works
Yan, D., Jobe, F., Hutchison, R. E., & Mohi, G. (2015) · Leukemia · doi:10.1038/leu.2015.116 · Cited by 17 · see citing works
The research development of STAT3 in hepatic ischemia-reperfusion injury
Yang, H., Zhang, P., Wang, Q., Cheng, K., & Zhao, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1066222 · Cited by 16 · see citing works
A Hematopoietic Perspective on the Promiscuity and Specificity of Gα16 Signaling
Su, Y. L., Ho, M. K. C., & Wong, Y. H. (2009) · Neurosignals · doi:10.1159/000186691 · Cited by 16 · see citing works
Interleukin (IL)-7 Signaling in the Tumor Microenvironment
Bednarz-Misa, I. S., Bromke, M. A., & Krzystek‐Korpacka, M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55617-4_2 · Cited by 15 · see citing works
The Role of the JAK–STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia
Ziętara, K. J., Wróblewska, K., Zajączkowska, M., Taczała, J., & Lejman, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136844 · Cited by 14 · see citing works
Impaired B-Cell Differentiation in a Patient With STAT1 Gain-of-Function Mutation
Nemoto, K., Kawanami, T., Hoshina, T., Ishimura, M., Yamasaki, K., Okada, S., Kanegane, H., Yatera, K., & Kusuhara, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.557521 · Cited by 14 · see citing works
Wang, X., Campbell, M. R., Cho, H., Pittman, G. S., Martos, S. N., & Bell, D. A. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01507-8 · Cited by 14 · see citing works
STAT3 couples with 14-3-3σ to regulate BCR signaling, B-cell differentiation, and IgE production
Du, Z., Chen, A., Huang, L., Dai, X., Chen, Q., Yang, D., Li, L., Miller, H. E., Westerberg, L. S., Ding, Y., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.09.033 · Cited by 13 · see citing works
Blevins, L. K., Zhou, J., Crawford, R. B., & Kaminski, N. E. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109447 · Cited by 13 · see citing works
Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells
Bekiaris, V., Šedý, J. R., & Ware, C. F. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00654 · Cited by 12 · see citing works
Flores-Fernández, R., Aponte-López, A., Suárez-Arriaga, M. C., Gorocica-Rosete, P., Pizaña-Venegas, A., Chávez-Sanchéz, L., Blanco-Favela, F., Fuentes‐Pananá, E. M., & Chávez-Rueda, A. K. (2021) · Cells · doi:10.3390/cells10020316 · Cited by 12 · see citing works
Vašíček, O., Fedr, R., Skoroplyas, S., Chalupa, D., Sklenář, M., Tharra, P. R., Švenda, J., & Kubala, L. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153194 · Cited by 11 · see citing works
Functional involvement of Daxx in gp130‐mediated cell growth and survival in BaF3 cells
Muromoto, R., Kuroda, M., Togi, S., Sekine, Y., Nanbo, A., Shimoda, K., Oritani, K., & Matsuda, T. (2010) · European Journal of Immunology · doi:10.1002/eji.201040688 · Cited by 10 · see citing works
Apigenin ameliorates lupus nephritis by inhibiting SAT3 signaling in CD8 + T cells
Liu, J., Wang, N.-Z., Wu, Z., Gan, Y.-H., Ji, J., Huang, Z., Du, Y., Wen, C., Tian, F.-Y., Fan, Y., et al. (2024) · Food & Function · doi:10.1039/d4fo02773f · Cited by 9 · see citing works
Li, J., Chen, S., Zhen, C., Fan, P., Tang, L., Zhang, Y., Wang, F., & Zhang, C. (2025) · Hepatology International · doi:10.1007/s12072-025-10846-y · Cited by 7 · see citing works
Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases
Ichii, M., Oritani, K., Toda, J., Hosen, N., Matsuda, T., & Kanakura, Y. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.11.002 · Cited by 7 · see citing works
Datta, S., Parajuli, N., Tymoszuk, P., Ottina, E., Parson, W., Sgonc, R., Villunger, A., & Doppler, W. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0113053 · Cited by 6 · see citing works
Molecular mechanisms of versatile biological activity of interleukin-7
Slyvka, A., & Okunev, O. V. (2014) · Biopolymers and Cell · doi:10.7124/bc.0008b1 · Cited by 6 · see citing works
Dichotomy in redundant enhancers points to presence of initiators of gene regulation
Song, W., & Ovcharenko, I. (2018) · BMC Genomics · doi:10.1186/s12864-018-5335-0 · Cited by 6 · see citing works
Enhancer jungles establish robust tissue-specific regulatory control in the human genome
Li, S., & Ovcharenko, I. (2019) · Genomics · doi:10.1016/j.ygeno.2019.12.022 · Cited by 5 · see citing works
Sobah, M. L., Liongue, C., & Ward, A. C. (2024) · Journal of Innate Immunity · doi:10.1159/000538364 · Cited by 5 · see citing works
Haga, Y., Meyer, K., Sung, M. M. H., Reagan, E. K., Weissman, D., & Ray, R. (2023) · Journal of Virology · doi:10.1128/jvi.01809-23 · Cited by 5 · see citing works
Efficient Generation of Plasmacytoid Dendritic Cell from Common Lymphoid Progenitors by Flt3 Ligand
Chen, Y., Chang, S., Chen, T., & Lee, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135217 · Cited by 5 · see citing works
Self-citationParameswaran, R., Morad, V., Laronne, A., Rousso-Noori, L., Shani, N., Amara, S. N.-A., & Zipori, D. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0099 · Cited by 5 · see citing works
Li, S., Zhu, X., Liu, Y.-Y., & Chen, M. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123800 · Cited by 4 · see citing works
Gasparoli, L., Virely, C., Tsakaneli, A., Che, N., Edwards, D., Bartram, J. L., Hubank, M. J. F., Pal, D., Heidenreich, O. T., Martens, J. H. A., et al. (2023) · Haematologica · doi:10.3324/haematol.2023.283613 · Cited by 4 · see citing works
The roles of BST‐2 in murine B cell development and on virus propagation
Urata, S., Yamaguchi, S., Nambu, A., Sudo, K., Nakae, S., & Yasuda, J. (2023) · Microbiology and Immunology · doi:10.1111/1348-0421.13049 · Cited by 4 · see citing works
Xu, Y., Zhou, Q., Wang, X., Zhang, A., Qi, W., Li, Y., Zheng, C., Guan, J., Sun, T., Li, J., et al. (2023) · Haematologica · doi:10.3324/haematol.2023.284041 · Cited by 3 · see citing works
Corfe, S. A., & Paige, C. (2009) · Springer eBooks · doi:10.1007/978-0-387-85816-6_8 · Cited by 8 · see citing works
Expression of biologically active bovine interleukin 7 and evaluating the activity in vitro
Lijo, J., Nagaraj, V. K., Dechamma, H. J., & Reddy, G. R. (2016) · Veterinary World · doi:10.14202/vetworld.2016.160-165 · Cited by 3 · see citing works
Tikoo, S., Rohit, J., Martinez, B., Song, R., Wielscher, M., Márquez-Burgoa, C., Hladik, A., Rizzetto, S., Shaw, L. E., Ghannadan, M., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02686-1 · Cited by 2 · see citing works
Death Domain-associated Protein (DAXX)-mediated Regulation of Transcription and Cell Death
Muromoto, R. (2012) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.132.979 · Cited by 2 · see citing works
Proliferation and Differentiation Programs of Developing B Cells
Werner, M., & Jumaa, H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397933-9.00006-0 · Cited by 2 · see citing works
Tikoo, S., Jain, R., Martinez, B., Song, R., Wielscher, M., Rizzetto, S., Shaw, L. E., Mitchell, A. J., Torres-Pacheco, M. E., Luciani, F., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.24.453629 · Cited by 2 · see citing works
Insights Into the Susceptibility of Fungal Infection and STAT3 Genetic Mutations
Li, F., Liu, X., Li, Y., Wu, J., Dang, N., & Guo, J. (2026) · Mycoses · doi:10.1111/myc.70200 · Cited by 1 · see citing works
New Insights in the Development of Human B Lymphocytes
Blom, B. (2012) · Springer eBooks · doi:10.1007/978-1-4471-4174-7_1 · Cited by 1 · see citing works
Regulación de la linfopoyesis B por la cisteín proteasa catepsina-L
Badano, M. N. (2012) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Corfe, S. A. (2012) · TSpace (University of Toronto)
Martincuks, A., Müller-Newen, G., Lüscher, B., & Zenke, M. (2017) · RWTH Publications (RWTH Aachen) · doi:10.18154/rwth-2017-01944
Defining the Requirement for ShcA IN Murine B Cell Development
Giles, A. J. (2009) · doi:10.18130/v3rz7f
Gibbs, L. C., Oviedo, J. M., Ondigo, B. N., & Fairfax, K. C. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4135720
- Authors
- Chou, W.-C., Levy, D. E., & Lee, C.-K.
- Affiliations
- National Taiwan University (TW)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-11-01
- Volume
- 108
- Issue
- 9
- Pages
- 3005-3011
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC1895520
- OpenAlex
- W2045749875
- Cited by
- 94
- References
- 47
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 8 · 2022: 4 · 2021: 10 · 2020: 8 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 8
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01 AI 28900, R01AI028900)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- STAT3, B cell development, pro-B cells, pre-B cells, IL-7 signaling, IL-7 receptor alpha, apoptosis, bone marrow progenitor cells, transcription factors
- MeSH terms
- Animals, B-Lymphocytes, Genotype, Stem Cells, T-Lymphocytes, Interleukin-7, DNA Primers, Mice, Knockout, STAT3 Transcription Factor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review