Cited by 95T-cell and B-cell ImmunologyCytokine Signaling Pathways and InteractionsHematopoietic Stem Cell Transplantation

STAT3 positively regulates an early step in B-cell development

Open access
Chou, Wei-Chun, Levy, David E., Lee, Chien-Kuo·2006·Blood

Abstract

Transcription factors are critical for instructing the development of B lymphocytes from multipotential progenitor cells in the bone marrow (BM). Here, we show that the absence of STAT3 impaired B-cell development. Mice selectively lacking STAT3 in BM progenitor cells displayed reduced numbers of mature B cells, both in the BM and in the periphery. The reduction in the B-cell compartment included reduced percentages and numbers of pro-B, pre-B, and immature B cells in the absence of STAT3, whereas the number of pre-pro-B cells was increased. We found that pro-B and pre-B-cell populations lacking STAT3 were hyporesponsive to IL-7 because of a decreased number of IL-7-responsive cells rather than decreased expression or signaling of IL-7Ralpha. Moreover, STAT3-deficient mice displayed enhanced apoptosis in the pro-B population when deprived of survival factors, suggesting that at least 2 mechanisms (impaired differentiation and enhanced apoptosis) are involved in the mutant phenotype. Last, BM transplantation confirmed that impaired B lymphopoiesis in the absence of STAT3 was caused by a cell autonomous defect. In sum, these studies defined a specific role for STAT3 in early B-cell development, probably acting at the pre-pro-B transition by contributing to the survival of IL-7-responsive progenitors.

Integrity signals

Registry

Crossref · 10.1182/blood-2006-05-024430

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Chou, W.-C., Levy, D. E., & Lee, C.-K.
Affiliations
National Taiwan University (TW)
Venue
Blood
Published
2006-11-01
Volume
108
Issue
9
Pages
3005-3011
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2045749875
Cited by
94
References
47
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 8 · 2022: 4 · 2021: 10 · 2020: 8 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 8
FWCI
1.52
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R01 AI 28900, R01AI028900)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
STAT3, B cell development, pro-B cells, pre-B cells, IL-7 signaling, IL-7 receptor alpha, apoptosis, bone marrow progenitor cells, transcription factors
MeSH terms
Animals, B-Lymphocytes, Genotype, Stem Cells, T-Lymphocytes, Interleukin-7, DNA Primers, Mice, Knockout, STAT3 Transcription Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review