Cited by 108T-cell and B-cell ImmunologyImmune Response and InflammationGenetics, Aging, and Longevity in Model Organisms

Impact of age on T cell signaling: A general defect or specific alterations?

Larbi, Anis, Pawelec, Graham, Wong, Siew Cheng, Goldeck, David, Tai, June Jing-Yi, Fulop, Tamas·2011·Ageing Research Reviews

Abstract

Decreased immune responsiveness associated with aging is generally termed "immunosenescence". Several theories have been proposed to explain age-related declines in immune responses. Here, we will focus on and describe potential defects in T cell signal transduction from the membrane to the nucleus, leading to changes in the type, intensity and duration of the response as a major factor contributing to immunosenescence. We will first detail T cell signaling through the T cell receptor (TCR), CD28 and IL-2 receptor (IL-2R) and then discuss the observed age-related alterations to these signaling pathways. The role of membrane rafts in T cell signaling and T cell aging will be described. These factors will be considered in the context of the notion that age-related changes to T cell signaling may be attributed to changes in the functionality of the T cells due to shifts in T cell subpopulations with age. For this reason, we conclude by highlighting the application of multiparametric signaling analysis in leukocyte subsets using flow cytometry as a means to obtain a clearer picture with respect to age-related changes to immune signaling.

Integrity signals

Registry

Crossref · 10.1016/j.arr.2010.09.008

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • CD4+ T cells show reduced T cell receptor signaling intensity and altered cytokine production after antigen binding.

    “CD4 + T cells exhibit reduced T cell receptor signaling intensity and altered production of various cytokines following antigen binding (70,71).”

    From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [71]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Larbi, A., Pawelec, G., Wong, S. C., Goldeck, D., Tai, J. J.-Y., & Fulop, T.
Affiliations
  • Agency for Science, Technology and Research (SG)
  • University of Tübingen (DE)
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2011-07
Volume
10
Issue
3
Pages
370-378
ISSN
1568-1637 (ISSN-L)
OpenAlex
W2054650629
Cited by
108
References
100
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 1 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 11 · 2014: 12 · 2013: 10 · 2012: 10
FWCI
0.64
Type
journal article
Language
en
Open access
closed
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Canadian Institutes of Health Research (63149)
  • Biomedical Research Council
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
immunosenescence, T cell signaling, aging, T cell receptor signaling, CD28, interleukin-2 receptor, lipid rafts, T cell senescence, T cell subsets, age-related immune decline
MeSH terms
Aged, Aged, 80 and over, Aging, Homeostasis, Humans, T-Lymphocytes, Signal Transduction, Cellular Senescence, Membrane Microdomains

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review