Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I
Open accessAbstract
Congenital dyserythropoietic anemia (CDA) is a rare group of red blood cell disorders characterized by ineffective erythropoiesis and increased iron absorption. To determine whether growth differentation factor 15 (GDF15) hyper-expression is associated with the ineffective erythropoiesis and iron-loading complications of CDA type I (CDA I), GDF15 levels and other markers of erythropoiesis and iron overload were studied in blood from 17 CDA I patients. Significantly higher levels of GDF15 were detected among the CDA I patients (10 239 +/- 3049 pg/mL) compared with healthy volunteers (269 +/- 238 pg/mL). In addition, GDF15 correlated significantly with several erythropoietic and iron parameters including Hepcidin-25, Ferritin, and Hepcidin-25/Ferritin ratios. These novel results suggest that CDA I patients express very high levels of serum GDF15, and that GDF15 contributes to the inappropriate suppression of hepcidin with subsequent secondary hemochromatosis.
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Increased GDF15 serum levels associate with syndromes of ineffective erythropoiesis, for example α- and β-thalassemia.
“While increased GDF15 serum levels associate with syndromes of ineffective erythropoiesis, for example α- and β-thalassemia”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [218]
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High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
Tanno, T., Bhanu, N. V., Oneal, P. A., Goh, S.-H., Staker, P., Lee, Y. T., Moroney, J. W., Reed, C. H., Luban, N. L., Wang, R.-H., et al. (2007) · Nature Medicine · doi:10.1038/nm1629 · Cited by 854 · see citing works
Self-citationHepcidin in iron overload disorders
Papanikolaou, G., Tzilianos, M., Christakis, J. I., Bogdanos, D., Tsimirika, K., MacFarlane, J., Goldberg, Y. P., Sakellaropoulos, N., Ganz, T., & Nemeth, E. (2005) · Blood · doi:10.1182/blood-2004-12-4844 · Cited by 445 · see citing works
Hepcidin is decreased in TFR2 hemochromatosis
Nemeth, E., Roetto, A., Garozzo, G., Ganz, T., & Camaschella, C. (2004) · Blood · doi:10.1182/blood-2004-08-3042 · Cited by 396 · see citing works
Liver iron concentrations and urinary hepcidin in -thalassemia
Origa, R., Galanello, R., Ganz, T., Giagu, N., Maccioni, L., Faa, G., & Nemeth, E. (2007) · Haematologica · doi:10.3324/haematol.10842 · Cited by 365 · see citing works
Pinto, J. P., Ribeiro, S., Pontes, H., Thowfeequ, S., Tosh, D., Carvalho, F. D., & Porto, G. (2008) · Blood · doi:10.1182/blood-2007-08-106195 · Cited by 239 · see citing works
Advances in Quantitative Hepcidin Measurements by Time-of-Flight Mass Spectrometry
Swinkels, D. W., Girelli, D., Laarakkers, C. M., Kroot, J. J., Campostrini, N., Kemna, E., & Tjalsma, H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002706 · Cited by 202 · see citing works
Self-citationCongenital dyserythropoietic anemia with karyorrhexis and multinuclearity of erythroblasts.
Heimpel, H., & Wendt, F. L. (1968) · PubMed · Cited by 188 · see citing works
Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1
Dgany, O., Avidan, N., Delaunay, J., Krasnov, T., Shalmon, L., Shalev, H., Eidelitz-Markus, T., Kapelushnik, J., Cattan, D., Pariente, A., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/344781 · Cited by 168 · see citing works
Self-citationHepcidin and iron-loading anemias.
Nemeth, E., & Ganz, T. (2006) · PubMed · Cited by 124 · see citing works
Regulation of hepcidin: Insights from biochemical analyses on human serum samples
Kemna, E., Kartikasari, A. E. R., van Tits, L. J. H., Pickkers, P., Tjalsma, H., & Swinkels, D. W. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.10.002 · Cited by 116 · see citing works
Self-citationHypocholesterolemia in chronic anemias with increased erythropoietic activity
Shalev, H., Kapelushnik, J., Moser, A. M., Knobler, H., & Tamary, H. (2006) · American Journal of Hematology · doi:10.1002/ajh.20804 · Cited by 93 · see citing works
Self-citationDYSERYTHROPOIESIS AND CONGENITAL DYSERYTHROPOIETIC ANAEMIAS
Wickramasinghe, S. N. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.2513065.x · Cited by 83 · see citing works
Tamary, H., Shalev, H., Luria, D., et al. (1996) · Blood · doi:10.1182/blood.v87.5.1763.1763 · Cited by 70 · see citing works
Self-citationClinical and molecular variability in congenital dyserythropoietic anaemia type I
Tamary, H., Dgany, O., Proust, A., et al. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05642.x · Cited by 62 · see citing works
Self-citationCazzola, M., Beguin, Y. P., Bergamaschi, G., Guarnone, R., Cerani, P., Barella, S., Cao, A., & Galanello, R. (1999) · British Journal of Haematology · doi:10.1046/j.1365-2141.1999.01600.x · Cited by 58 · see citing works
Tamary, H., Offret, H., Dgany, O., et al. (2007) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2007.01004.x · Cited by 18 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Ganz, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2013 · Cited by 1,122 · see citing works
Hepcidin and iron regulation, 10 years later
Ganz, T. (2011) · Blood · doi:10.1182/blood-2011-01-258467 · Cited by 962 · see citing works
Regulation of erythropoiesis by hypoxia-inducible factors
Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787 · see citing works
Regulation of iron transport and the role of transferrin
Gkouvatsos, K., Papanikolaou, G., & Pantopoulos, K. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.10.013 · Cited by 518 · see citing works
Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
Liu, Q., Davidoff, O., Niss, K., & Haase, V. H. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63924 · Cited by 328 · see citing works
Hepcidin in Human Iron Disorders: Diagnostic Implications
Kroot, J. J., Tjalsma, H., Fleming, R. E., & Swinkels, D. W. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2009.140053 · Cited by 246 · see citing works
Self-citationBreit, S. N., Johnen, H., Cook, A. D., Tsai, V. W. W., Mohammad, M. G., Kuffner, T., Zhang, H. P., Marquis, C. P., Jiang, L., Lockwood, G., et al. (2011) · Growth Factors · doi:10.3109/08977194.2011.607137 · Cited by 247 · see citing works
Song, S.-N. J., Tomosugi, N., Kawabata, H., Ishikawa, T., Nishikawa, T., & Yoshizaki, K. (2010) · Blood · doi:10.1182/blood-2010-03-271791 · Cited by 228 · see citing works
Ginzburg, Y., & Rivella, S. (2011) · Blood · doi:10.1182/blood-2011-03-283614 · Cited by 201 · see citing works
Ineffective erythropoiesis and regulation of iron status in iron loading anaemias
Camaschella, C., & Nai, A. (2016) · British Journal of Haematology · doi:10.1111/bjh.13820 · Cited by 172 · see citing works
Review article: the iron overload syndromes
Siddique, A., & Kowdley, K. V. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05051.x · Cited by 162 · see citing works
Piperno, A., Galimberti, S., Mariani, R., Pelucchi, S., Ravasi, G., Lombardi, C., Bilo, G., Revera, M., Giuliano, A., Faini, A., et al. (2011) · Blood · doi:10.1182/blood-2010-08-299859 · Cited by 151 · see citing works
Genetics, genetic testing, and management of hemochromatosis: 15 years since hepcidin
Pietrangelo, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.06.045 · Cited by 136 · see citing works
A variant erythroferrone disrupts iron homeostasis in <i>SF3B1</i> -mutated myelodysplastic syndrome
Bondu, S., Alary, A.-S., Lefèvre, C., Houy, A., Jung, G., Lefebvre, T., Rombaut, D., Boussaid, I., Bousta, A., Guillonneau, F., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav5467 · Cited by 85 · see citing works
Diagnosis of iron-deficient states
Archer, N. M., & Brugnara, C. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1038744 · Cited by 82 · see citing works
Theurl, I., Finkenstedt, A., Schroll, A., Nairz, M., Sonnweber, T., Bellmann‐Weiler, R., Theurl, M., Seifert, M., Wroblewski, V. J., Murphy, A. T., et al. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07961.x · Cited by 72 · see citing works
Tanno, T., Rabel, A., Lee, Y. T., Yau, Y. Y., Leitman, S. F., & Miller, J. L. (2010) · Transfusion · doi:10.1111/j.1537-2995.2010.02601.x · Cited by 34 · see citing works
Self-citation
- Authors
- Tamary, H., Shalev, H., Perez-Avraham, G., Zoldan, M., Levi, I., Swinkels, D. W., Tanno, T., & Miller, J. L.
- Affiliations
- Tel Aviv University (IL)
- Ben-Gurion University of the Negev (IL)
- Hematology Soroka Medical Center, Faculty of Medicine, Ben-Gurion University, Beer Sheva, Israel;
- Radboud University Nijmegen (NL)
- National Institutes of Health (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-12-15
- Volume
- 112
- Issue
- 13
- Pages
- 5241-5244
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC2954708
- OpenAlex
- W2090925999
- Cited by
- 135
- References
- 16
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 6 · 2015: 8 · 2014: 4 · 2013: 13 · 2012: 16
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- growth differentiation factor 15, congenital dyserythropoietic anemia type I, ineffective erythropoiesis, iron overload, hepcidin, ferritin, secondary hemochromatosis, serum biomarkers, erythropoiesis
- MeSH terms
- Anemia, Dyserythropoietic, Congenital, Erythropoiesis, Female, Ferritins, Humans, Iron, Israel, Male, Biomarkers, Case-Control Studies, Iron Overload, Antimicrobial Cationic Peptides, Growth Differentiation Factor 15, Hepcidins
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