Effects of Aging on the Common Lymphoid Progenitor to Pro-B Cell Transition
Abstract
The number of common lymphoid progenitors (CLP) and their pre-pro-B and pro-B cell progeny is reduced in old mice, but the age-related changes responsible for these declines have not been fully elucidated. The aim of this study was to provide additional insights into the impact of senescence on early B cell development by analyzing the CLP and pro-B cell compartments under steady-state conditions and after cytoablation with 5-fluorouracil. 5-Fluorouracil subjects the hemopoietic system to acute stress and has the advantage of revealing defects in progenitors that may otherwise be subtle. The data demonstrate significant, age-related defects in the proliferative potential of early B cell precursors and suggest that the ability of CLP to differentiate into pre-pro-B cells is also compromised by senescence. These age-related changes in early B lymphopoiesis do not result from a general defect in HSC or the bone marrow microenvironment that impairs development in all hemopoietic lineages. Instead, data demonstrating that myeloid progenitor number and developmental potential do not decline with age indicate that B lymphopoiesis is particularly sensitive to defects that accumulate during senescence.
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Common lymphoid progenitors, pre-pro-B cells, and pro-B cells from old mice proliferate less and undergo apoptosis more than young cells.
“For example, common lymphoid progenitors, pre-pro-B cells, and pro-B cells from old mice do not proliferate as extensively as do young cells, and they exhibit significantly higher rates of apoptosis.”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [29]
The poor quality of lymphoid progenitors produced in aged animals worsens the decline in lymphopoiesis.
“In addition, the poor quality of the lymphoid progenitors that are generated in the aged further exacerbates the decline in lymphopoiesis (29,32,34).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [29]
Cites
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617 · see citing works
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253 · see citing works
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., & Hayakawa, K. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.5.1213 · Cited by 1,604 · see citing works
Hardy, R. R., & Hayakawa, K. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.595 · Cited by 1,236 · see citing works
Cell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · cited 2× · see citing works
“intrinsic defects in early B-lymphoid progenitors exists is consistent with data demonstrating that hemopoietic stem cells from old mice do not efficiently repopulate lymphoid cells in young recipients (25) and down-regulate genes necessary for lymphoid specification (26).”
BackgroundResultSchlüter, C., Duchrow, M., Wohlenberg, C., Becker, M., Key, G., Flad, H. ‐., & Gerdes, J. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.3.513 · Cited by 766 · see citing works
Age-Associated Characteristics of Murine Hematopoietic Stem Cells
Sudo, K., Ema, H., Morita, Y., & Nakauchi, H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1273 · Cited by 722 · see citing works
Thymopoiesis independent of common lymphoid progenitors.
Allman, D., Sambandam, A., Kim, S., Miller, J. P., Pagan, A., Well, D., Meraz, A., & Bhandoola, A. (2003) · Nature Immunology · doi:10.1038/ni878 · Cited by 544 · see citing works
HODGSON, G. S., & Bradley, T. R. (1979) · Nature · doi:10.1038/281381a0 · Cited by 509 · see citing works
Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow
Igarashi, H., Gregory, S. C., Yokota, T., Sakaguchi, N., & Kincade, P. W. (2002) · Immunity · doi:10.1016/s1074-7613(02)00366-7 · Cited by 452 · see citing works
Identification of the Earliest B Lineage Stage in Mouse Bone Marrow
Li, Y. S., Wasserman, R., Hayakawa, K., & Hardy, R. R. (1996) · Immunity · doi:10.1016/s1074-7613(00)80268-x · Cited by 376 · see citing works
The Decline in B Lymphopoiesis in Aged Mice Reflects Loss of Very Early B-Lineage Precursors
Miller, J. P., & Allman, D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2326 · Cited by 255 · see citing works
Miller, J. P., Izon, D., DeMuth, W., Gerstein, R., Bhandoola, A., & Allman, D. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020784 · Cited by 198 · see citing works
Impaired Ability of Bone Marrow Stromal Cells to Support B-Lymphopoiesis With Age
Stephan, R. P., Reilly, C. R., & Witte, P. L. (1998) · Blood · doi:10.1182/blood.v91.1.75 · Cited by 197 · see citing works
Kline, G. H., Hayden, T. A., & Klinman, N. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3342 · Cited by 170 · see citing works
Lymphocyte Development from Stem Cells
Ikuta, K., Uchida, N., Friedman, J. S., & Weissman, I. L. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.003551 · Cited by 164 · see citing works
Labrie, J. E., Sah, A. P., Allman, D. M., Cancro, M. P., & Gerstein, R. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040845 · Cited by 145 · see citing works
Aging and developmental transitions in the B cell lineage
Johnson, K. M. (2002) · International Immunology · doi:10.1093/intimm/dxf092 · Cited by 128 · see citing works
Stage-specific alterations in murine B lymphopoiesis with age
Stephan, R. P., Sanders, V. M., & Witte, P. L. (1996) · International Immunology · doi:10.1093/intimm/8.4.509 · Cited by 126 · see citing works
Tudor, K.-S. R. S., Payne, K. J., Yamashita, Y., & Kincade, P. W. (2000) · Immunity · doi:10.1016/s1074-7613(00)80186-7 · Cited by 123 · see citing works
Early T Lineage Progenitors: New Insights, but Old Questions Remain
Bhandoola, A., Sambandam, A., Allman, D., Meraz, A., & Schwarz, B. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.5653 · Cited by 81 · see citing works
der Put, E. V., Frasca, D., King, A. M., Blomberg, B. B., & Riley, R. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.818 · Cited by 76 · see citing works
Bruce, W. R., & Meeker, B. E. (1967) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/38.3.401 · Cited by 76 · see citing works
Increased apoptosis of bone marrow pre-B cells in old mice associated with their low number
Kirman, I. (1998) · International Immunology · doi:10.1093/intimm/10.9.1385 · Cited by 50 · see citing works
Effects of 5-fluorouracil on B lymphocyte lineage cells.
Větvička, V., Kincade, P. W., & Witte, P. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.8.2405 · Cited by 38 · see citing works
Dorshkind, K. A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.12.4204 · Cited by 37 · see citing works
Self-citationPost-irradiation regeneration of early B-lymphocyte precursor cells in mouse bone marrow.
Park, Y. H., & Osmond, D. G. (1989) · PubMed · Cited by 28 · see citing works
Impaired Ability of Bone Marrow Stromal Cells to Support B-Lymphopoiesis With Age
Stephan, R. P., Reilly, C. R., & Witte, P. L. (1998) · Blood · doi:10.1182/blood.v91.1.75.75_75_88 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works
“Further, the proliferative potency of lymphoid progenitor is also impaired by ageing, while that of myeloid progenitor does not changes.(74) Different from mice, as individuals age, there is a decline in the proportion and absolute number of B cells in the peripheral blood.”
BackgroundImmunosenescence: emerging challenges for an ageing population
Aw, D., Silva, A. B., & Palmer, D. B. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02555.x · Cited by 880 · see citing works
Gruver, A., Hudson, L., & Sempowski, G. (2007) · The Journal of Pathology · doi:10.1002/path.2104 · Cited by 834 · see citing works
Causes, consequences, and reversal of immune system aging
Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works
Self-citationBeerman, I., Bhattacharya, D., Zandi, S., Sigvardsson, M., Weissman, I. L., Bryder, D., & Rossi, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000834107 · Cited by 711 · see citing works
The ageing immune system: is it ever too old to become young again?
Dorshkind, K., Montecino-Rodriguez, E., & Signer, R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2471 · Cited by 445 · see citing works
Self-citationCellular senescence in renal ageing and disease
Sturmlechner, I., Durik, M., Sieben, C. J., Baker, D. J., & van Deursen, J. M. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.183 · Cited by 345 · see citing works
Changes in primary lymphoid organs with aging
Chinn, I. K., Blackburn, C. C., Manley, N. R., & Sempowski, G. D. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.005 · Cited by 282 · see citing works
Ju, Z., Jiang, H., Jaworski, M., Rathinam, C., Gompf, A., Klein, C., Trumpp, A., & Rudolph, K. L. (2007) · Nature Medicine · doi:10.1038/nm1578 · Cited by 284 · see citing works
IBD across the age spectrum—is it the same disease?
Ruel, J., Ruane, D., Mehandru, S., Gower‐Rousseau, C., & Colombel, J. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.240 · Cited by 237 · see citing works
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity
Ross, J., Myers, L. M., Noh, J. J., Collins, M. M., Carmody, A., Messer, R. J., Dhuey, E., Hasenkrug, K. J., & Weissman, I. L. (2024) · Nature · doi:10.1038/s41586-024-07238-x · Cited by 239 · see citing works
Sellami, M., Gasmi, M., Denham, J., Hayes, L. D., Stratton, D., Padulo, J., & Bragazzi, N. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02187 · Cited by 224 · see citing works
Immunosenescence: deficits in adaptive immunity in the elderly
Hakim, F. T., & Gress, R. E. (2007) · Tissue Antigens · doi:10.1111/j.1399-0039.2007.00891.x · Cited by 215 · see citing works
Immunosenescence, aging and successful aging
Wang, Y., Chen, D., Han, Y., Gu, Z., & Sun, C. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.942796 · Cited by 215 · see citing works
Effects of aging on B cell function
Frasca, D., & Blomberg, B. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.06.001 · Cited by 161 · see citing works
The role of nutrition in enhancing immunity in aging.
Pae, M., Meydani, S. N., & Wu, D. (2012) · Europe PMC (PubMed Central) · Cited by 173 · see citing works
Hematopoietic Stem Cell Heterogeneity Takes Center Stage
Copley, M. R., Beer, P. A., & Eaves, C. J. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.006 · Cited by 174 · see citing works
Le, O. N. L., Rodier, F., Fontaine, F., Coppe, J., Campisi, J., DeGregori, J., Laverdière, C., Kokta, V., Haddad, E., & Beauséjour, C. M. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00567.x · Cited by 168 · see citing works
Age-related decline in immunity: implications for vaccine responsiveness
Kumar, R., & Burns, E. A. (2008) · Expert Review of Vaccines · doi:10.1586/14760584.7.4.467 · Cited by 156 · see citing works
The ageing B cell population: Composition and function
Ademokun, A., Wu, Y.-C. B., & Dunn‐Walters, D. K. (2009) · Biogerontology · doi:10.1007/s10522-009-9256-9 · Cited by 146 · see citing works
The role of sex steroids and gonadectomy in the control of thymic involution
Hince, M. N., Sakkal, S., Vlahos, K., Dudakov, J. A., Boyd, R. L., & Chidgey, A. P. (2008) · Cellular Immunology · doi:10.1016/j.cellimm.2007.10.007 · Cited by 138 · see citing works
Plasma cells are obligate effectors of enhanced myelopoiesis in aging bone marrow
Pioli, P. D., Casero, D., Montecino-Rodriguez, E., Morrison, S. L., & Dorshkind, K. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.006 · Cited by 131 · see citing works
Self-citationBecker-Merok, A., Nikolaisen, C., & Nossent, J. C. (2006) · Lupus · doi:10.1177/0961203306071871 · Cited by 127 · see citing works
Fate Decisions Regulating Bone Marrow and Peripheral B Lymphocyte Development
Monroe, J. G., & Dorshkind, K. A. (2007) · Advances in immunology · doi:10.1016/s0065-2776(07)95001-4 · Cited by 121 · see citing works
Self-citationSun, X., Cao, B., Naval-Sánchez, M., Pham, T. A., Sun, Y., Williams, B., Heazlewood, S. Y., Deshpande, N., Li, J., Kraus, F., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22863-0 · Cited by 118 · see citing works
Immunoaging induced by hematopoietic stem cell aging
Wang, J., Geiger, H., & Rudolph, K. L. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.05.004 · Cited by 107 · see citing works
Impact of niche aging on thymic regeneration and immune reconstitution
Chidgey, A. P., Dudakov, J. A., Seach, N., & Boyd, R. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.006 · Cited by 105 · see citing works
The inflammatory status of the elderly: The intestinal contribution
Schiffrin, E. J., Morley, J. E., Donnet‐Hughes, A., & Guigoz, Y. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.07.011 · Cited by 103 · see citing works
Young, K. A., Borikar, S., Bell, R. K., Kuffler, L., Philip, V. M., & Trowbridge, J. J. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160168 · Cited by 102 · see citing works
Signer, R. A. J., Montecino-Rodriguez, E., Witte, O. N., & Dorshkind, K. (2008) · Genes & Development · doi:10.1101/gad.1715808 · Cited by 102 · see citing works
Self-citationThe role of immunity in elderly cancer
Malaguarnera, L., Cristaldi, E., & Malaguarnera, M. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.06.002 · Cited by 101 · see citing works
B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging
Keren, Z., Naor, S., Nussbaum, S., Golan, K., Itkin, T., Sasaki, Y., Schmidt-Supprian, M., Lapidot, T., & Melamed, D. (2011) · Blood · doi:10.1182/blood-2010-09-307983 · Cited by 100 · see citing works
Aging in the lympho-hematopoietic stem cell compartment
Geiger, H., & Rudolph, K. L. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.010 · Cited by 97 · see citing works
Do haematopoietic stem cells age?
Dorshkind, K. A., Höfer, T., Montecino‐Rodriguez, E., Pioli, P. D., & Rodewald, H.-R. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0236-2 · Cited by 93 · see citing works
Self-citationImmunosenescence of Polymorphonuclear Neutrophils
Weßels, I., Jansen, J., Rink, L., & Uciechowski, P. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.14 · Cited by 89 · see citing works
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
Tizazu, A. M., Mengist, H. M., & Demeke, G. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00309-5 · Cited by 91 · see citing works
Liu, Y., Gibson, G. R., & Walton, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162604 · Cited by 88 · see citing works
Montecino‐Rodriguez, E., Fice, M. P., Casero, D., Berent-Maoz, B., Barber, C. L., & Dorshkind, K. A. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.012 · Cited by 86 · see citing works
Self-citationAging-Associated Changes in Hematopoiesis and Leukemogenesis: What's the Connection?
Henry, C. J., Marusyk, A., & DeGregori, J. V. (2011) · Aging · doi:10.18632/aging.100351 · Cited by 83 · see citing works
Hematopoietic Stem Cells and the Aging Hematopoietic System
Gazit, R., Weissman, I. L., & Rossi, D. J. (2008) · Seminars in Hematology · doi:10.1053/j.seminhematol.2008.07.010 · Cited by 84 · see citing works
Montecino‐Rodriguez, E., Kong, Y., Casero, D., Rouault, A., Dorshkind, K. A., & Pioli, P. D. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.01.016 · Cited by 79 · see citing works
Self-citationAge-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia
Signer, R. A. J., Montecino-Rodriguez, E., Witte, O. N., McLaughlin, J., & Dorshkind, K. (2007) · Blood · doi:10.1182/blood-2007-01-069401 · Cited by 77 · see citing works
Self-citationLNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors
Cheng, Y. H., Chikwava, K. R., Wu, C., Zhang, H., Bhagat, A., Pei, D., Choi, J. K., & Tong, W. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81468 · Cited by 74 · see citing works
Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated
Ertl, R. P., Chen, J., Astle, C. M., Duffy, T. M., & Harrison, D. E. (2007) · Blood · doi:10.1182/blood-2007-01-069807 · Cited by 71 · see citing works
Kumar, R., Fossati, V., Israel, M. A., & Snoeck, H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.11.7507 · Cited by 70 · see citing works
Reduced EBF expression underlies loss of B‐cell potential of hematopoietic progenitors with age
Lescale, C., Dias, S., Maës, J., Cumano, A., Szabo, P., Charron, D. J., Weksler, M. E., Dosquet, C., Vieira, P., & Goodhardt, M. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00566.x · Cited by 60 · see citing works
Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?
Woolthuis, C. M., de Haan, G., & Huls, G. A. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.05.006 · Cited by 59 · see citing works
Dudakov, J. A., Goldberg, G. L., Reiseger, J. J., Vlahos, K., Chidgey, A. P., & Boyd, R. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900196 · Cited by 60 · see citing works
van Beek, A. A., Sovran, B., Hugenholtz, F., Meijer, B., Hoogerland, J. A., Mihailova, V., van der Ploeg, C., Belzer, C., Boekschoten, M. V., Hoeijmakers, J. H. J., et al. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00408 · Cited by 59 · see citing works
Age-associated B cells (ABC) inhibit B lymphopoiesis and alter antibody repertoires in old age
Riley, R. L., Khomtchouk, K. M., & Blomberg, B. B. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.04.008 · Cited by 56 · see citing works
B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice
Weitzmann, M. N., Li, Y., Terauchi, M., Vikulina, T., & Roser‐Page, S. (2015) · The Open Bone Journal · doi:10.2174/1876525401406010008 · Cited by 55 · see citing works
Adipocyte-Derived Soluble Factor(s) Inhibits Early Stages of B Lymphopoiesis
Bilwani, F., & Knight, K. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201176 · Cited by 53 · see citing works
Inflammation and Aging of Hematopoietic Stem Cells in Their Niche
Yang, D., & de Haan, G. (2021) · Cells · doi:10.3390/cells10081849 · Cited by 46 · see citing works
Brown, B. N., Haschak, M. J., Lopresti, S. T., & Stahl, E. C. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.05.001 · Cited by 55 · see citing works
Krishnarajah, S., Ingelfinger, F., Friebel, E., Cansever, D., Amorim, A., Andreadou, M., Bamert, D., Litscher, G., Lutz, M., Mayoux, M., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00148-x · Cited by 52 · see citing works
Chronic Inflammation Potentiates Kidney Aging
Mei, C., & Zheng, F. (2009) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2009.07.002 · Cited by 50 · see citing works
Dudakov, J. A., Goldberg, G. L., Reiseger, J. J., Chidgey, A. P., & Boyd, R. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802446 · Cited by 44 · see citing works
Kraus, H., Kaiser, S., Aumann, K., Bönelt, P., Salzer, U., Vestweber, D., Erlacher, M., Kunze, M., Burger, M., Pieper, K., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301815 · Cited by 44 · see citing works
Konturek-Cieśla, A., Dhapola, P., Zhang, Q., Säwén, P., Wan, H., Karlsson, G., & Bryder, D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112304 · Cited by 41 · see citing works
Khong, D., Dudakov, J. A., Hammett, M. V., Jurblum, M. I., Khong, S. M. L., Goldberg, G. L., Ueno, T., Spyroglou, L., Young, L. F., van den Brink, M. R. M., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.01.018 · Cited by 39 · see citing works
van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O., Vermeij, W. P., Brandt, R. M. C., Barnhoorn, S., Hoeijmakers, J. H. J., de Vos, P., et al. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1hi0216-062rr · Cited by 36 · see citing works
Updates on Old and Weary Haematopoiesis
Konieczny, J., & Arranz, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092567 · Cited by 33 · see citing works
Considering Cause and Effect of Immune Cell Aging on Cardiac Repair after Myocardial Infarction
Tobin, S. W., Alibhai, F. J., Weisel, R. D., & Li, R. (2020) · Cells · doi:10.3390/cells9081894 · Cited by 30 · see citing works
Buza-Vidas, N., Cheng, M., Duarte, S., Charoudeh, H. N., Jacobsen, S. E. W., & Sitnicka, E. (2007) · Blood · doi:10.1182/blood-2006-09-047480 · Cited by 29 · see citing works
Hematopoietic stem cell aging and chronic lymphocytic leukemia pathogenesis
Kikushige, Y., & Miyamoto, T. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1651-6 · Cited by 28 · see citing works
Cho, J. S., Kook, S. H., Robinson, A. R., Niedernhofer, L. J., & Lee, B.-C. (2013) · Stem Cells · doi:10.1002/stem.1261 · Cited by 27 · see citing works
Mehr, R., & Melamed, D. (2011) · Aging · doi:10.18632/aging.100313 · Cited by 27 · see citing works
Chidgey, A. P., Seach, N., Dudakov, J. A., Hammett, M. V., & Boyd, R. L. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0140-5 · Cited by 26 · see citing works
Evolving Patterns of Lymphopoiesis from Embryogenesis through Senescence
Montecino‐Rodriguez, E., & Dorshkind, K. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.001 · Cited by 25 · see citing works
Self-citationShaping up a lineage—lessons from B lymphopoesis
Bryder, D., & Sigvardsson, M. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.02.001 · Cited by 24 · see citing works
Tsuboi, I., Harada, T., Hirabayashi, Y., Kanno, J., Inoue, T., & Aizawa, S. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012158 · Cited by 23 · see citing works
Immunology of Gut-Bone Signaling
Collins, F. L., Schepper, J. D., Rios‐Arce, N. D., Steury, M. D., Kang, H. J., Mallin, H., Schoenherr, D. T., Camfield, G., Chishti, S., McCabe, L. R., et al. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-66653-2_5 · Cited by 21 · see citing works
Chronic B Cell Deficiency from Birth Prevents Age-Related Alterations in the B Lineage
Zohar, K., Averbuch, D., Shahaf, G. L., Zisman‐Rozen, S., Golan, K., Itkin, T., Lapidot, T., Mehr, R., & Melamed, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100999 · Cited by 21 · see citing works
Ekman, A., Ilves, M., & Iivanainen, A. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.12.009 · Cited by 20 · see citing works
Aging, B lymphopoiesis, and patterns of leukemogenesis
Signer, R. A. J., Montecino‐Rodriguez, E., & Dorshkind, K. A. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.11.010 · Cited by 20 · see citing works
Self-citationSuppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits
Kalis, S. L., Zhai, S. K., Yam, P.-C., Witte, P. L., & Knight, K. L. (2007) · International Immunology · doi:10.1093/intimm/dxm048 · Cited by 19 · see citing works
Aging and neoteny in the B lineage
Melamed, D., & Scott, D. W. (2012) · Blood · doi:10.1182/blood-2012-07-444711 · Cited by 19 · see citing works
Effect of aged bone marrow microenvironment on mesenchymal stem cell migration
Yang, Y., Li, P., Cui, D., Dang, R., Zhang, L., Wen, N., & Jiang, X. (2015) · AGE · doi:10.1007/s11357-014-9743-z · Cited by 18 · see citing works
Agrafiotis, A., Neumeier, D., Hong, K., Chowdhury, T., Ehling, R. A., Kuhn, R., Sandu, I., Kreiner, V., Cotet, T., Shlesinger, D., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106055 · Cited by 15 · see citing works
Updates of the role of B-cells in ischemic stroke
Wu, S., Tabassum, S., Payne, C. T., Hu, H., Gusdon, A. M., Choi, H. A., & Ren, X. S. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1340756 · Cited by 18 · see citing works
Montecino-Rodriguez, E., Casero, D., Fice, M., Le, J., & Dorshkind, K. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701336 · Cited by 17 · see citing works
Self-citationResearch progress on immune aging and its mechanisms affecting geriatric diseases
Yu, Y., & Zheng, S. (2019) · Aging Medicine · doi:10.1002/agm2.12089 · Cited by 14 · see citing works
Tsuboi, I., Hirabayashi, Y., Harada, T., Koshinaga, M., Kawamata, T., Kanno, J., Inoue, T., & Aizawa, S. (2008) · Journal of Applied Toxicology · doi:10.1002/jat.1341 · Cited by 15 · see citing works
The Adaptor Protein Shc Plays a Key Role during Early B Cell Development
Giles, A. J., Bender, T. P., & Ravichandran, K. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902344 · Cited by 12 · see citing works
Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42
Geiger, H., & Zheng, Y. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.001 · Cited by 12 · see citing works
Microbiota Signals Suppress B Lymphopoiesis With Aging in Mice
Krambs, J. R., Monlish, D. A., Gao, F., Schuettpelz, L. G., & Link, D. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767267 · Cited by 11 · see citing works
Unwinding the Role of the CMG Helicase in Inborn Errors of Immunity
Guilz, N. C., Ahn, Y., Seo, S., & Mace, E. M. (2023) · Journal of Clinical Immunology · doi:10.1007/s10875-023-01437-3 · Cited by 9 · see citing works
Mechanisms of Stem Cell Ageing
Waterstrat, A., Oakley, E. J., Miller, A. R., Swiderski, C. F., Liang, Y., & Zant, G. E. V. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_6 · Cited by 8 · see citing works
Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunity
Montecino‐Rodriguez, E., Estrada, O. I., & Dorshkind, K. A. (2024) · Life Science Alliance · doi:10.26508/lsa.202402629 · Cited by 7 · see citing works
Self-citationLiu, Y., Gibson, G. R., & Walton, G. (2015) · Nutrition and Aging · doi:10.3233/nua-150058 · Cited by 7 · see citing works
Intra‐bone marrow bone marrow transplantation rejuvenates the B‐cell lineage in aged mice
Hida, D., Ishiguro, N., Haneda, M., Ishida, Y., Suzuki, H., & Isobe, K. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.69 · Cited by 6 · see citing works
Riley, R. L., Khomtchouk, K. M., & Blomberg, B. B. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.023 · Cited by 6 · see citing works
Nauman, G., Danzl, N. M., Lee, J., Borsotti, C., Madley, R., Fu, J., Hölzl, M. A., Dahmani, A., Dorronsoro, A., Chavez, É., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100966 · Cited by 5 · see citing works
Enhancing T Lineage Production in Aged Mice: A Novel Function of Foxn1 in the Bone Marrow Niche
Zook, E. C., Zhang, S., Gerstein, R. M., Witte, P. L., & Le, P. T. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202278 · Cited by 4 · see citing works
Bone marrow niches in myelodysplastic syndromes
Tosato, G., Feng, J., Ohnuki, H., & Sim, M. (2021) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2021.120 · Cited by 4 · see citing works
Cellular senescence, a novel therapeutic target for mesenchymal stem cells in acute kidney injury
Zhao, L., Hu, C., Han, F., Chen, D., Ma, Y., Wang, J., & Chen, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16163 · Cited by 4 · see citing works
Alteration of long- and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesisPreprint
Nishi, K., Sakamaki, T., Nagasaka, A., Kao, K. S., Sadaoka, K., Asano, M., Yamamoto, N., Takaori‐Kondo, A., & Miyanishi, M. (2024) · eLife · doi:10.7554/elife.95880 · Cited by 4 · see citing works
Bone Loss and TLR4 Signals Contribute Independently to B Lineage Aging
Baker, E., Montecino-Rodriguez, E., Xu, S., Tetradis, S., Rouault, A., Estrada, O. I., & Dorshkind, K. (2025) · Aging Cell · doi:10.1111/acel.70267 · Cited by 3 · see citing works
Self-citationAge-related functional changes in hematopoietic microenvironment
Tsuboi, I., Harada, T., & Aizawa, S. (2016) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.5.167 · Cited by 2 · see citing works
Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesisPreprint
Nishi, K., Sakamaki, T., Nagasaka, A., Kao, K. S., Sadaoka, K., Asano, M., Yamamoto, N., Takaori‐Kondo, A., & Miyanishi, M. (2024) · eLife · doi:10.7554/elife.95880.2 · Cited by 2 · see citing works
- Authors
- Min, H., Montecino-Rodriguez, E., & Dorshkind, K.
- Affiliations
- University of California, Los Angeles (US)
- Department of Pathology and Laboratory Medicine and Hemopoietic Malignancies Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California , Los Angeles, CA 90095
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-01
- Volume
- 176
- Issue
- 2
- Pages
- 1007-1012
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1575237114
- Cited by
- 126
- References
- 27
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 10
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-21450, R01AG021450)
- National Cancer Institute (CAS106042)
- National Institute of Allergy and Infectious Diseases (AI21256)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- aging, common lymphoid progenitors, pro-B cells, B cell development, senescence, 5-fluorouracil, hematopoietic stem cells, myeloid progenitor cells, bone marrow microenvironment
- MeSH terms
- Aging, Animals, B-Lymphocytes, Hematopoietic Stem Cells, Mice, Inbred C57BL, Lymphocyte Count, Lymphopoiesis, Myelopoiesis, Cell Proliferation, Mice
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