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Cited by 406

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Social networking of human neutrophils within the immune system

Scapini, Patrizia, Cassatella, Marco A.·2014·Blood

Abstract

It is now widely recognized that neutrophils are highly versatile and sophisticated cells that display de novo synthetic capacity and may greatly extend their lifespan. In addition, concepts such as “neutrophil heterogeneity” and “neutrophil plasticity” have started to emerge, implying that, under pathological conditions, neutrophils may differentiate into discrete subsets defined by distinct phenotypic and functional profiles. A number of studies have shown that neutrophils act as effectors in both innate and adaptive immunoregulatory networks. In fact, once recruited into inflamed tissues, neutrophils engage into complex bidirectional interactions with macrophages, natural killer, dendritic and mesenchymal stem cells, B and T lymphocytes, or platelets. As a result of this cross-talk, mediated either by contact-dependent mechanisms or cell-derived soluble factors, neutrophils and target cells reciprocally modulate their survival and activation status. Altogether, these novel aspects of neutrophil biology have shed new light not only on the potential complex roles that neutrophils play during inflammation and immune responses, but also in the pathogenesis of several inflammatory disorders including infection, autoimmunity, and cancer.

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Registry

Crossref · 10.1182/blood-2014-03-453217

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Metadata

Authors
Scapini, P., & Cassatella, M. A.
Venue
Blood
Published
2014-07-31
Volume
124
Issue
5
Pages
710-719
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2036965973
Cited by
406
References
9
FWCI
16.08
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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