Cited by 590Immunotherapy and Immune ResponsesImmune cells in cancerT-cell and B-cell Immunology

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Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor

Menetrier-Caux, C., Montmain, G., Dieu, M.C., Bain, C., Favrot, M.C., Caux, C., Blay, J.Y.·1998·Blood

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Abstract

The escape of malignant cells from the immune response against the tumor may result from a defective differentiation or function of professional antigen-presenting cells (APC), ie, dendritic cells (DC). To test this hypothesis, the effect of human renal cell carcinoma cell lines (RCC) on the development of DC from CD34(+) progenitors was investigated in vitro. RCC cell lines were found to release soluble factors that inhibit the differentiation of CD34(+) cells into DC and trigger their commitment towards monocytic cells (CD14(+)CD64(+)CD1a-CD86(-)CD80(-)HLA-D Rlow) with a potent phagocytic capacity but lacking APC function. RCC CM were found to act on the two distinct subpopulations emerging in the culture at day 6 ([CD14(+)CD1a-] and [CD14(-)CD1a+]) by inhibiting the differentiation into DC of [CD14(+)CD1a-] precursors and blocking the acquisition of APC function of the [CD14(-)CD1a+] derived DC. Interleukin-6 (IL-6) and macrophage colony-stimulating factor (M-CSF) were found to be responsible for this phenomenon: antibodies against IL-6 and M-CSF abrogated the inhibitory effects of RCC CM; and recombinant IL-6 and/or M-CSF inhibited the differentiation of DC similarly to RCC CM. The inhibition of DC differentiation by RCC CM was preceeded by an induction of M-CSF receptor (M-CSFR; CD115) and a loss of granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR; CD116) expression at the surface of CD34(+) cells, two phenomenon reversed by anti-IL-6/IL-6R and anti-M-C…

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The Dendritic Cell System and its Role in Immunogenicity
Steinman, R. M. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001415 · Cited by 4,659
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
Gabrilovich, D. I., Chen, H. L., Girgis, K. R., Cunningham, H. T., Meny, G. M., Nadaf, S., Kavanaugh, D., & Carbone, D. P. (1996) · Nature Medicine · doi:10.1038/nm1096-1096 · Cited by 1,977
Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells
Hsu, F. J., Benike, C., Fagnoni, F., Liles, T. M., Czerwinski, D., Taidi, B., Engleman, E. G., & Levy, R. (1996) · Nature Medicine · doi:10.1038/nm0196-52 · Cited by 1,804
GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells
Caux, C., Dezutter‐Dambuyant, C., Schmitt, D., & Banchereau, J. (1992) · Nature · doi:10.1038/360258a0 · Cited by 1,551
Self-citation
Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.
Schwartz, R. H. (1992) · Cell · doi:10.1016/s0092-8674(05)80055-8 · Cited by 1,293
Induction of tolerance by IL-10-treated dendritic cells
Steinbrink, K., Wölfl, M., Jonuleit, H., Knop, J., & Enk, A. H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.10.4772 · Cited by 1,245
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.
Caux, C., Vanbervliet, B., Massacrier, C., Dezutter‐Dambuyant, C., de Saint-Vis, B., Jacquet, C., Yoneda, K., Imamura, S., Schmitt, D., & Banchereau, J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.695 · Cited by 920
Self-citation
Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.
Zitvogel, L., Mayordomo, J. I., Tjandrawan, T., DeLeo, A. B., Clarke, M. R., Lotze, M. T., & Storkus, W. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.1.87 · Cited by 824
Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.
Zhou, L., & Tedder, T. F. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.8.3821 · Cited by 751
Molecular Cloning of a Complementary DNA Encoding Human Macrophage-Specific Colony-Stimulating Factor (CSF-1)
Kawasaki, E. S., Ladner, M. B., Wang, A. M., Arsdell, J. V., Warren, M. K., Coyne, M. Y., Schweickart, V. L., Lee, M.-T., Wilson, K. J., Boosman, A., et al. (1985) · Science · doi:10.1126/science.2996129 · Cited by 523

Show all 48 references

Research works printed but not linked: 1

Négrier, 1996, The FNCLCC CRECY trial: Interleukin 2 (IL2) + interferon (IFN)-α is the optimal treatment to induce responses in metastatic renal cell carcinoma (MRCC)., Proc Am Soc Clin Oncol, 15, 248

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Authors: Menetrier-Caux, C., Montmain, G., Dieu, M. C., Bain, C., Favrot, M. C., Caux, C., & Blay, J. Y.
Affiliations: From Unité Cytokine et Cancer, Unité INSERM 453, Centre Léon Bérard, Lyon, France; and Schering Plough, Dardilly, France.
Inserm (FR)
ORCID: Caux, C.
Blay, J.Y.
Venue: Blood
Publisher: American Society of Hematology
Published: 1998-12-15
Volume: 92
Issue: 12
Pages: 4778-4791
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v92.12.4778
OpenAlex: W193748226
Cited by: 590
References: 48
Citations by year: 2026: 3 · 2025: 4 · 2024: 10 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 20 · 2019: 16 · 2018: 13 · 2017: 9 · 2016: 25 · 2015: 26 · 2014: 19 · 2013: 30 · 2012: 25
FWCI: 6.33
Type: journal article
Language: en
Open access: closed
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: dendritic cell differentiation, CD34+ progenitors, renal cell carcinoma, tumor immune evasion, interleukin-6, macrophage colony-stimulating factor, M-CSF receptor, GM-CSF receptor, antigen-presenting cells, monocyte differentiation, CD1a, CD14, soluble factors
MeSH terms: Antibodies, Carcinoma, Renal Cell, Cell Differentiation, Cell Division, Dendritic Cells, Dose-Response Relationship, Drug, Gene Expression Regulation, Humans, Lymphokines, Tumor Cells, Cultured, Interleukin-6, Immunophenotyping, Macrophage Colony-Stimulating Factor, Receptor, Macrophage Colony-Stimulating Factor, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Endothelial Growth Factors, Culture Media, Conditioned, Antigens, CD34, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Cell Size

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Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor

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