Cited by 77Chronic Myeloid Leukemia TreatmentsProtein Tyrosine PhosphatasesChronic Lymphocytic Leukemia Research

Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α

Schmidt, Manuel, Hochhaus, Andreas, Nitsche, Andreas, Hehlmann, Rüdiger, Neubauer, Andreas·2001·Blood

Abstract

Recently, it was shown that interferon consensus sequence binding protein (ICSBP), a member of the interferon regulatory factor (IRF) family, has a potential role in chronic myeloid leukemia (CML). Deletion of ICSBP gene in mice leads to a CML-like syndrome and samples from CML patients exhibited impaired ICSBP expression. The present study found that ICSBP expression correlated with risk features determined by Sokal score in untreated CML (P = .007 for high versus low risk). In addition, analyzing ICSBP expression during interferon-α (IFN-α) therapy in “good” (n = 27) versus “poor” (n = 15) cytogenetic responders, high ICSBP levels were only observed in “good” responders (P = .0002). Together, these data suggest that ICSBP levels are related to initial presentation of CML and the therapeutic response of CML to IFN-α, indicating an important role of ICSBP in CML.

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Crossref · 10.1182/blood.v97.11.3648

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  • IFN-α, the effective cytokine for therapy of CML, induced ICSBP expression in vivo, and ICSBP expression correlated with pretreatment risk features and cytogenetic response to IFN-α in CML.

    “IFNa , the effective cytokine for therapy of CML, induced ICSBP expression in vivo , and the ICSBP expression correlated with pretreatment risk features and cytogenetic response to IFNa in CML. (51)”

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Authors
Schmidt, M., Hochhaus, A., Nitsche, A., Hehlmann, R., & Neubauer, A.
Affiliations
  • Philipps University of Marburg (DE)
  • From the Klinikum der Philipps-Universität Marburg, Zentrum Innere Medizin, Abteilung Hämatologie/Onkologie/Immunologie, Marburg, Germany; III. Medizinische Universitätsklinik, Klinikum Mannheim der Universität Heidelberg, Germany; and Klinik für Innere Medizin m.S. Hamatologie und Onkologie, Charité-Campus Virchow Klinikum, Humboldt Universität, Berlin, Germany.
Venue
Blood
Published
2001-06-01
Volume
97
Issue
11
Pages
3648-3650
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2050268640
Cited by
77
References
22
Citations by year
2022: 1 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 3
FWCI
2.58
Type
journal article
Language
en
Open access
closed
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
Keywords
IRF8, chronic myeloid leukemia, interferon regulatory factors, interferon-alpha therapy, cytogenetic response, Sokal score, risk stratification, prognostic factors, gene expression
MeSH terms
Interferon Regulatory Factor-8, Humans, Repressor Proteins, Retrospective Studies, Risk Factors, RNA, Messenger, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Gene Expression, Interferon-alpha, Cytogenetic Analysis, Interferon Regulatory Factors

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