Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α
Abstract
Recently, it was shown that interferon consensus sequence binding protein (ICSBP), a member of the interferon regulatory factor (IRF) family, has a potential role in chronic myeloid leukemia (CML). Deletion of ICSBP gene in mice leads to a CML-like syndrome and samples from CML patients exhibited impaired ICSBP expression. The present study found that ICSBP expression correlated with risk features determined by Sokal score in untreated CML (P = .007 for high versus low risk). In addition, analyzing ICSBP expression during interferon-α (IFN-α) therapy in “good” (n = 27) versus “poor” (n = 15) cytogenetic responders, high ICSBP levels were only observed in “good” responders (P = .0002). Together, these data suggest that ICSBP levels are related to initial presentation of CML and the therapeutic response of CML to IFN-α, indicating an important role of ICSBP in CML.
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IFN-α, the effective cytokine for therapy of CML, induced ICSBP expression in vivo, and ICSBP expression correlated with pretreatment risk features and cytogenetic response to IFN-α in CML.
“IFNa , the effective cytokine for therapy of CML, induced ICSBP expression in vivo , and the ICSBP expression correlated with pretreatment risk features and cytogenetic response to IFNa in CML. (51)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [51]
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Talpaz, M., Mercer, J., & Hehlmann, R. (2021) · Hematologic malignancies · doi:10.1007/978-3-030-71913-5_13
Self-citationMolekulare Grundlagen der malignen Transformation
Neubauer, A. (2015) · Springer eBooks · doi:10.1007/978-3-642-54676-1_186-1
Self-citation
- Authors
- Schmidt, M., Hochhaus, A., Nitsche, A., Hehlmann, R., & Neubauer, A.
- Affiliations
- Philipps University of Marburg (DE)
- From the Klinikum der Philipps-Universität Marburg, Zentrum Innere Medizin, Abteilung Hämatologie/Onkologie/Immunologie, Marburg, Germany; III. Medizinische Universitätsklinik, Klinikum Mannheim der Universität Heidelberg, Germany; and Klinik für Innere Medizin m.S. Hamatologie und Onkologie, Charité-Campus Virchow Klinikum, Humboldt Universität, Berlin, Germany.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2001-06-01
- Volume
- 97
- Issue
- 11
- Pages
- 3648-3650
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2050268640
- Cited by
- 77
- References
- 22
- Citations by year
- 2022: 1 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 3
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Keywords
- IRF8, chronic myeloid leukemia, interferon regulatory factors, interferon-alpha therapy, cytogenetic response, Sokal score, risk stratification, prognostic factors, gene expression
- MeSH terms
- Interferon Regulatory Factor-8, Humans, Repressor Proteins, Retrospective Studies, Risk Factors, RNA, Messenger, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Gene Expression, Interferon-alpha, Cytogenetic Analysis, Interferon Regulatory Factors
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