Depression and anxiety in patients with COPD
Open accessAbstract
Under-recognised and untreated depression and anxiety symptoms have deleterious effects on physical functioning and social interaction increasing fatigue and healthcare utilisation in patients with chronic obstructive pulmonary disease (COPD). Depression and anxiety are challenging to identify and treat because their symptoms often overlap with those of COPD. The cause(s) of depression and anxiety symptoms are multifactorial and include behavioural, social and biological factors. Less than one-third of COPD patients with comorbid depression or anxiety symptoms are receiving appropriate treatment. Factors that contribute to the lack of provision of treatment are varied, they include patient perceived barriers, for example lack of knowledge and reluctance to receive antidepressant drug therapy; poor treatment compliance and lack of a standardised diagnostic approach; and scarcity of adequate resources for mental health treatment. The evidence for the efficacy of antidepressant drug therapy in patients with COPD with comorbid depression and anxiety is inconclusive. There are some promising findings regarding pulmonary rehabilitation, psychological therapy and the collaborative care model in reducing depression and anxiety symptoms in patients with COPD, but these findings are limited by short-term follow-up periods. Further work is required to examine the efficacy of these interventions in randomised controlled trials with larger samples and long-term follow-up.
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Only a few studies have paid attention to adherence to NIV in COPD people, and most focused only on early NIV failure or quantification of adherence.
“Nevertheless, only a few studies have paid attention to adherence to NIV in COPD people, and most of them have focused only on early NIV failure (33,34) or on the quantification of adherence (35).”
From Promoting Acceptance and Adherence to Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial. (2022) · cites this paper as [35]
The Introduction discusses reduced treatment adherence in COPD, and ‘What are the treatment options?’ discusses adherence to antidepressants. Neither passage addresses adherence to noninvasive ventilation (NIV), early NIV failure, or studies quantifying NIV adherence; searches for those terms found no such passage in our copy. (LLM, conf=0.77)
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- Authors
- Yohannes, A. M., & Alexopoulos, G. S.
- Affiliations
- Manchester Metropolitan University (GB)
- Corresponding author
- Yohannes, Abebaw M.
- Venue
- European Respiratory Review
- Publisher
- European Respiratory Society (ERS)
- Published
- 2014-08-31
- Volume
- 23
- Issue
- 133
- Pages
- 345-349
- ISSN
- 0905-9180 (ISSN-L)
- 1600-0617
- PMC
- PMC4523084
- OpenAlex
- W2122570705
- Cited by
- 463
- References
- 24
- Citations by year
- 2026: 36 · 2025: 55 · 2024: 53 · 2023: 54 · 2022: 52 · 2021: 51 · 2020: 46 · 2019: 36 · 2018: 32 · 2017: 23 · 2016: 15 · 2015: 9 · 2014: 1
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- European Respiratory Review (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Mental Health (R01MH076829, P30MH085943)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- chronic obstructive pulmonary disease, depression, anxiety, comorbidities, antidepressant treatment, barriers to treatment, medication adherence, pulmonary rehabilitation, psychotherapy, collaborative care, mental health services
- MeSH terms
- Anxiety, Depression, Humans, Pulmonary Disease, Chronic Obstructive
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