Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens
Open accessAbstract
BACKGROUND: Health-promoting polyunsaturated fatty acids (PUFA) are abundant in forages grazed by ruminants and in vegetable and fish oils used as dietary supplements, but only a small proportion of PUFA finds its way into meat and milk, because of biohydrogenation in the rumen. Butyrivibrio fibrisolvens plays a major role in this activity. The aim of this study was to investigate the mechanisms by which PUFA affect the growth of B. fibrisolvens, how PUFA are metabolized and the metabolic response to growth in the presence of PUFA. RESULTS: Linoleic acid (LA; cis-9, cis-12-18:2) and alpha-linolenic acid (LNA; cis-9, cis-12, cis-15-18:3) increased the lag phase of B. fibrisolvens JW11, LNA having the greater effect. Growth was initiated only when the PUFA had been converted to vaccenic acid (VA; trans-11-18:1). The major fish oil fatty acids, eicosapentaenoic acid (EPA; 20:5(n-3)) and docosahexaenoic acid (DHA; 22:6(n-3)), were not metabolized and prevented growth. Cellular integrity, as determined fluorimetrically by propidium iodide (PI) ingression, was affected as much by 18:1 fatty acids, including VA, as 18:2 fatty acids. The methyl esters of LNA, LA, EPA and DHA had no effect on growth or other measurements. The ATP pool decreased by 2/3 when LA was added to growing bacteria, whereas most acyl CoA pools decreased by >96%. CONCLUSIONS: It was concluded that biohydrogenation occurs to enable B. fibrisolvens to survive the bacteriostatic effects of PUFA, and that the toxicity of PUFA is probably mediated via a metabolic effect rather than disruption of membrane integrity.
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Rumen microbiota can detoxify unsaturated FA through the biohydrogenation process to reduce/eliminate the adverse effects on rumen fermentation.
“However, rumen microbiota can detoxify unsaturated FA through the biohydrogenation process to reduce/eliminate the adverse effects on rumen fermentation (121, 124).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [124]
The Discussion (page unavailable) describes biohydrogenation as a detoxification mechanism, and the Abstract says it enables Butyrivibrio fibrisolvens to survive the bacteriostatic effects of some polyunsaturated fatty acids. The claim extends this finding to rumen microbiota and adverse effects on rumen fermentation generally. The Abstract also reports that EPA and DHA were not metabolized and prevented growth, so the paper does not support detoxification of unsaturated fatty acids without qualification. (LLM, conf=0.88)
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Cites
Nicholson, J. K., Lindon, J. C., & Holmes, E. C. (1999) · Xenobiotica · doi:10.1080/004982599238047 · Cited by 3,903 · see citing works
Hobson, P. N., & Stewart, C. S. (1997) · Springer eBooks · doi:10.1007/978-94-009-1453-7 · Cited by 2,146 · see citing works
Owens, F. N., Secrist, D. S., Hill, W. J., & Gill, D. R. (1998) · Journal of Animal Science · doi:10.2527/1998.761275x · Cited by 1,385 · see citing works
Stewart, C. S., Flint, H. J., & Bryant, M. P. (1997) · The Rumen Microbial Ecosystem · doi:10.1007/978-94-009-1453-7_2 · Cited by 772 · see citing works
Keilin's Respiratory Chain Concept and Its Chemiosmotic Consequences
Mitchell, P. (1979) · Science · doi:10.1126/science.388618 · Cited by 738 · see citing works
Harfoot, C. G. (1978) · Progress in Lipid Research · doi:10.1016/0079-6832(78)90004-6 · Cited by 710 · see citing works
Intermediates and Products of the Biohydrogenation of Linoleic Acid by Butyrivibrio fibrisolvens
Kepler, C. R., Hirons, K. P., McNeill, J. J., & Tove, S. B. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96781-5 · Cited by 693 · see citing works
Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen
Maia, M. R. G., Chaudhary, L. C., Figueres, L., & Wallace, R. J. (2006) · Antonie van Leeuwenhoek · doi:10.1007/s10482-006-9118-2 · Cited by 530 · see citing works
Self-citationManipulating the fatty acid composition of muscle and adipose tissue in beef cattle
Scollan, N. D., Choi, N., Kurt, E., Fisher, A. V., Enser, M., & Wood, J. D. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2000223 · Cited by 473 · see citing works
Effect of dietary fish oil on biohydrogenation of fatty acids and milk fatty acid content in cows
Shingfield, K. J., Ahvenjärvi, S. A., Toivonen, V., Ärölä, A., Nurmela, K., Huhtanen, P. J., & Griinari, J. M. (2003) · Animal Science · doi:10.1017/s1357729800053765 · Cited by 409 · see citing works
Menotti, A., Kromhout, D., BLACKBURN, H. W., Fidanza, F., Buzina, R., & Nissinen, A. M. (1999) · European Journal of Epidemiology · doi:10.1023/a:1007529206050 · Cited by 373 · see citing works
Galbraith, H., Miller, T. B., Paton, A., & Thompson, J. K. (1971) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1971.tb01019.x · Cited by 339 · see citing works
Harfoot, C. G., & Hazlewood, G. P. (1997) · The Rumen Microbial Ecosystem · doi:10.1007/978-94-009-1453-7_9 · Cited by 322 · see citing works
Conjugated linoleic acid: implications for human health
Whigham, L. D., Cook, M. E., & Atkinson, R. L. (2000) · Pharmacological Research · doi:10.1006/phrs.2000.0735 · Cited by 283 · see citing works
The effects of fatty acids on pure cultures of rumen bacteria
Henderson, C. (1973) · The Journal of Agricultural Science · doi:10.1017/s0021859600058378 · Cited by 283 · see citing works
Bioenergetics: An introduction to the chemiosmotic theory
Nicholls, D. G. (1982) · Medical Entomology and Zoology · Cited by 259 · see citing works
BIOHYDROGENATION OF UNSATURATED FATTY ACIDS BY RUMEN BACTERIA
Polan, C. E., McNeill, J. J., & Tove, S. B. (1964) · Journal of Bacteriology · doi:10.1128/jb.88.4.1056-1064.1964 · Cited by 251 · see citing works
Biohydrogenation of Unsaturated Fatty Acids
Rosenfeld, I. S., & Tove, S. B. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61964-7 · Cited by 248 · see citing works
Ishizaki, K., Larson, T. R., Schauer, N., Fernie, A. R., Graham, I. A., & Leaver, C. J. (2005) · The Plant Cell · doi:10.1105/tpc.105.035162 · Cited by 244 · see citing works
Self-citationTrans unsaturated fatty acids in bacteria
Keweloh, H., & Heipieper, H. J. (1996) · Lipids · doi:10.1007/bf02522611 · Cited by 240 · see citing works
Antimutagenic and some other effects of conjugated linoleic acid
Kritchevsky, D. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000581 · Cited by 218 · see citing works
A novel technique for the sensitive quantification of acyl CoA esters from plant tissues
Larson, T. R., & Graham, I. A. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.00929.x · Cited by 210 · see citing works
Self-citationBioenergetics — an Introduction to the Chemiosmotic Theory
Harris, D. (1982) · Biochemical Education · doi:10.1016/0307-4412(82)90097-8 · Cited by 192 · see citing works
Kim, Y. J., Liu, R. H., Bond, D. R., & Russell, J. B. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.12.5226-5230.2000 · Cited by 181 · see citing works
Paillard, D., McKain, N., Chaudhary, L. C., Walker, N. D., Pizette, F., Koppova, I., McEwan, N. R., Kopečný, J., Vercoe, P. E., Louis, P., et al. (2006) · Antonie van Leeuwenhoek · doi:10.1007/s10482-006-9121-7 · Cited by 164 · see citing works
Self-citationKemp, P., White, R. W., & Lander, D. J. (1975) · Journal of General Microbiology · doi:10.1099/00221287-90-1-100 · Cited by 158 · see citing works
Clostridium proteoclasticum: a ruminal bacterium that forms stearic acid from linoleic acid
Wallace, R. J., Chaudhary, L. C., McKain, N., McEwan, N. R., Richardson, A. J., Vercoe, P. E., Walker, N. D., & Paillard, D. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00487.x · Cited by 139 · see citing works
Self-citationInfluence of fish oil on ruminal biohydrogenation of C18 unsaturated fatty acids
Wąsowska, I., Maia, M. R. G., Niedźwiedzka, K., Czauderna, M., Ribeiro, J. M. C. R., Devillard, E., Shingfield, K. J., & Wallace, R. J. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061783 · Cited by 129 · see citing works
Self-citationThe Role of Different Species of Bacteria in the Hydrolysis of Protein in the Rumen
Wallace, R. J., & Brammall, M. L. (1985) · Microbiology · doi:10.1099/00221287-131-4-821 · Cited by 128 · see citing works
Self-citationEffect of the Rumen on Dietary Fat
Shorland, F. B., Weenink, R. O., & Johns, A. T. (1955) · Nature · doi:10.1038/1751129a0 · Cited by 125 · see citing works
Metabolism of Long-Chain Fatty Acids in the Rumen
VIVIANI, R. (1970) · Advances in lipid research · doi:10.1016/b978-0-12-024908-4.50013-1 · Cited by 121 · see citing works
Fatty acid uncoupling of oxidative phosphorylation in rat liver mitochondria.
Rottenberg, H., & Hashimoto, K. (1986) · Biochemistry · doi:10.1021/bi00355a045 · Cited by 120 · see citing works
Kemp, P., & Lander, D. J. (1984) · Microbiology · doi:10.1099/00221287-130-3-527 · Cited by 120 · see citing works
Lipid Metabolism in the Bacteria
Lennarz, W. J. (1966) · Advances in lipid research · doi:10.1016/b978-1-4831-9940-5.50012-0 · Cited by 112 · see citing works
Moon, C. D., Pacheco, D. M., Kelly, W. J., Leahy, S. C., Li, D., Kopečný, J., & Attwood, G. T. (2008) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.65845-0 · Cited by 97 · see citing works
Hughes, P. E., Hunter, W. J., & Tove, S. B. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34828-2 · Cited by 91 · see citing works
Ultrastructure of Butyrivibrio fibrisolvens: a gram-positive bacterium
Cheng, K.-J., & Costerton, J. W. (1977) · Journal of Bacteriology · doi:10.1128/jb.129.3.1506-1512.1977 · Cited by 82 · see citing works
Regulation of Lipid Metabolism in the Rumen
Jenkins, T. C. (1994) · Journal of Nutrition · doi:10.1093/jn/124.suppl_8.1372s · Cited by 79 · see citing works
The glyceride structure of beef tallows
Banks, A., & Hilditch, T. P. (1931) · Biochemical Journal · doi:10.1042/bj0251168 · Cited by 76 · see citing works
Boynton, Z. L., Bennett, G. N., & Rudolph, F. B. (1994) · Applied and Environmental Microbiology · doi:10.1128/aem.60.1.39-44.1994 · Cited by 68 · see citing works
Offer, N. W., Marsden, M. A., & Phipps, R. H. (2001) · Animal Science · doi:10.1017/s1357729800058501 · Cited by 55 · see citing works
The hydrogenation of somecis- andtrans-octadecenoic acids to stearic acid by a rumenFusocillussp.
Kemp, P., Lander, D. J., & Gunstone, F. D. (1984) · British Journal Of Nutrition · doi:10.1079/bjn19840083 · Cited by 51 · see citing works
Fukuda, S., Furuya, H., Suzuki, Y., Asanuma, N., & Hino, T. (2005) · The Journal of General and Applied Microbiology · doi:10.2323/jgam.51.105 · Cited by 47 · see citing works
Hazlewood, G. P., Kemp, P., Lander, D. J., & DAWSON, R. M. C. (1976) · British Journal Of Nutrition · doi:10.1079/bjn19760034 · Cited by 42 · see citing works
Rottenberg, H., & Steiner‐Mordoch, S. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80708-6 · Cited by 36 · see citing works
Effect of caprylic, capric and oleic acid on growth of rumen and rabbit caecal bacteria
Marounek, M., Skřivanová, V., & Savka, O. G. (2002) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/67904/2002 · Cited by 35 · see citing works
Hazlewood, G. P., Orpin, C. G., Greenwood, Y., & Black, M. E. (1983) · Applied and Environmental Microbiology · doi:10.1128/aem.45.6.1780-1784.1983 · Cited by 35 · see citing works
ROCHE, C., ALBERTYN, H., Gylswyk, N. O. V., & Kistner, A. (1973) · Journal of General Microbiology · doi:10.1099/00221287-78-2-253 · Cited by 29 · see citing works
White, R. W., Kemp, P., & DAWSON, R. M. C. (1970) · Biochemical Journal · doi:10.1042/bj1160767 · Cited by 23 · see citing works
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Hungate RE Norris JR, Ribbons DW A roll tube method for cultivation of strict anaerobes Methods in Microbiology 1969 3B London: Academic Press 117 132 full_text
- Hobson PN Norris JR, Ribbons DW Rumen bacteria Methods in Microbiology 1969 3B London: Academic Press 133 139 full_text
- Herbert D Phipps PJ Strange RE Norris JR, Ribbons DW Chemical analysis of microbial cells Methods in Microbiology 1971 5B London: Academic Press 209 344 full_text
Cited by
Sorted by citations
The role of microbes in rumen lipolysis and biohydrogenation and their manipulation
Lourenço, M., Ramos-Morales, E., & Wallace, R. J. (2010) · animal · doi:10.1017/s175173111000042x · Cited by 401 · see citing works
Self-citationden Hartigh, L. (2019) · Nutrients · doi:10.3390/nu11020370 · Cited by 371 · see citing works
Zened, A., Combes, S., Cauquil, L., Mariette, J., Klopp, C., Bouchez, O., Meynadier, A., & Enjalbert, F. (2012) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12011 · Cited by 271 · see citing works
Nutritional enhancement of sheep meat fatty acid profile for human health and wellbeing
Chikwanha, O. C., Vahmani, P., Muchenje, V., Dugan, M. E. R., & Mapiye, C. (2017) · Food Research International · doi:10.1016/j.foodres.2017.05.005 · Cited by 220 · see citing works
Huws, S., Kim, E. J., Lee, M. R. F., Scott, M. B., Tweed, J. K. S., Pinloche, E., Wallace, R. J., & Scollan, N. D. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02452.x · Cited by 204 · see citing works
Self-citationMaximizing efficiency of rumen microbial protein production
Hackmann, T. J., & Firkins, J. L. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00465 · Cited by 187 · see citing works
Ferlay, A., Bernard, L., Meynadier, A., & Malpuech‐Brugère, C. (2017) · Biochimie · doi:10.1016/j.biochi.2017.08.006 · Cited by 185 · see citing works
Rumen microorganisms and fermentation
Castillo-González, A., Burrola-Barraza, E., Domínguez-Viveros, J., & Chávez‐Martínez, A. (2014) · Archivos de medicina veterinaria · doi:10.4067/s0301-732x2014000300003 · Cited by 184 · see citing works
Bessa, R. J. B., Alves, S. P., & Santos‐Silva, J. (2015) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201400468 · Cited by 176 · see citing works
Dewanckele, L., Toral, P. G., Vlaeminck, B., & Fievez, V. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-17662 · Cited by 164 · see citing works
Hassan, F.-U., Arshad, M. A., Ebeid, H. M., Rehman, M. S.-U., Khan, M. S., Shahid, S., & Yang, C. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.575801 · Cited by 160 · see citing works
Rumen microbiota and dietary fat: a mutual shaping
Enjalbert, F., Combes, S., Zened, A., & Meynadier, A. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13501 · Cited by 142 · see citing works
Kamboh, A. A., & Zhu, W. (2013) · Poultry Science · doi:10.3382/ps.2012-02584 · Cited by 141 · see citing works
Boerman, J. P., Firkins, J. L., St-Pierre, N. R., & Lock, A. L. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9592 · Cited by 116 · see citing works
Weld, K. A., & Armentano, L. E. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-11500 · Cited by 116 · see citing works
Vargas, J. E., Andrés, S., López-Ferreras, L., Snelling, T. J., Yáñez-Ruíz, D. R., García-Estrada, C., & López, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-58401-z · Cited by 113 · see citing works
Firkins, J. L., & Yu, Z. (2015) · Journal of Animal Science · doi:10.2527/jas.2014-8754 · Cited by 113 · see citing works
Salsinha, A. S., Pimentel, L. L., Fontes, A. L., Gomes, A., & Rodríguez-Alcalá, L. M. (2018) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00019-18 · Cited by 107 · see citing works
Modulation of the Gut Microbiota by Nutrients with Prebiotic and Probiotic Properties
Druart, C., Alligier, M., Salazar, N., Neyrinck, A. M., & Delzenne, N. M. (2014) · Advances in Nutrition · doi:10.3945/an.114.005835 · Cited by 103 · see citing works
In vitro evaluation of macroalgae as unconventional ingredients in ruminant animal feeds
Maia, M. R. G., Fonseca, A. J. M., Cortez, P. P., & Cabrita, A. R. J. (2019) · Algal Research · doi:10.1016/j.algal.2019.101481 · Cited by 98 · see citing works
Self-citationBoerman, J. P., Potts, S. B., VandeHaar, M. J., & Lock, A. L. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9467 · Cited by 94 · see citing works
Liu, T., Hougen, H. Y., Vollmer, A. C., & Hiebert, S. M. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2012.02.004 · Cited by 93 · see citing works
Alves, S. P., Santos‐Silva, J., Cabrita, A. R. J., Fonseca, A. J. M., & Bessa, R. J. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058386 · Cited by 91 · see citing works
Bacterial Production of Conjugated Linoleic and Linolenic Acid in Foods: A Technological Challenge
Gorissen, L., Leroy, F., Vuyst, L. D., SMET, S. D., & Raes, K. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.706243 · Cited by 88 · see citing works
Yang, B. K., Chen, H., Gu, Z., Tian, F., Ross, R. P., Stanton, C., Chen, Y. Q., Chen, W., & Zhang, H. (2014) · Journal of Applied Microbiology · doi:10.1111/jam.12524 · Cited by 80 · see citing works
Ladeira, M. M., Santarosa, L. D. C., Chizzotti, M. L., Ramos, E. M., Neto, O. R. M., de Oliveira, D. M., de Carvalho, J. R. R., Lopes, L. S., & Ribeiro, J. S. (2013) · Meat Science · doi:10.1016/j.meatsci.2013.04.062 · Cited by 80 · see citing works
Invited review: Sphingolipid biology in the dairy cow: The emerging role of ceramide
McFadden, J. W., & Rico, J. E. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-16095 · Cited by 80 · see citing works
Castro-Carrera, T., Toral, P. G., Frutos, P., McEwan, N. R., Hervás, G., Abecia, L., Pinloche, E., Girdwood, S. E., & Belenguer, Á. (2014) · Journal of Dairy Science · doi:10.3168/jds.2013-7243 · Cited by 77 · see citing works
Hackmann, T. J., & Firkins, J. L. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00622 · Cited by 76 · see citing works
Vargas, J. E., Andrés, S., Snelling, T. J., López‐Ferreras, L., Yáñez-Ruíz, D. R., García‐Estrada, C., & López, S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01124 · Cited by 75 · see citing works
Knieper, M., Viehhauser, A., & Dietz, K. (2023) · Antioxidants · doi:10.3390/antiox12040814 · Cited by 74 · see citing works
Pitta, D. W., Indugu, N., Vecchiarelli, B., Rico, D. E., & Harvatine, K. J. (2018) · Journal of Dairy Science · doi:10.3168/jds.2016-12514 · Cited by 73 · see citing works
Ishlak, A., Günal, M., & AbuGhazaleh, A. A. (2015) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2015.05.023 · Cited by 64 · see citing works
Zened, A., Enjalbert, F., Nicot, M.-C., & Meynadier, A. (2012) · Journal of Dairy Science · doi:10.3168/jds.2012-5690 · Cited by 62 · see citing works
Correddu, F., Nudda, A., Battacone, G., Boe, R., Francesconi, A. H. D., & Pulina, G. (2014) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2014.11.002 · Cited by 59 · see citing works
Correddu, F., Gaspa, G., Pulina, G., & Nudda, A. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-10108 · Cited by 59 · see citing works
Zanferari, F., Vendramini, T. H. A., Rentas, M. F., Gardinal, R., Calomeni, G. D., Mesquita, L. G., Takiya, C. S., & Rennó, F. P. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-14675 · Cited by 59 · see citing works
Pretorius, C. J., Zeiss, D. R., & Dubery, I. A. (2021) · Plant Signaling & Behavior · doi:10.1080/15592324.2021.1989215 · Cited by 58 · see citing works
Fiorentini, G., de Carvalho, I. P. C., Messana, J. D., Castagnino, P. D. S., Berndt, A., Canesin, R. C., Frighetto, R. T. S., & Berchielli, T. T. (2014) · Journal of Animal Science · doi:10.2527/jas.2013-6868 · Cited by 58 · see citing works
Production of conjugated fatty acids: A review of recent advances
Gong, M., Hu, Y., Wei, W., Jin, Q., & Wang, X. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.107454 · Cited by 55 · see citing works
Rico, D. E., Preston, S. H., Risser, J. M., & Harvatine, K. J. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515001865 · Cited by 55 · see citing works
Mavrommatis, A., Tsiplakou, E., Zerva, A., Pantiora, P. D., Georgakis, N., Tsintzou, G. P., Madesis, P. B., & Labrou, N. E. (2023) · Antioxidants · doi:10.3390/antiox12101882 · Cited by 54 · see citing works
Meignan, T., Lechartier, C., Chesneau, G., & Bareille, N. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-11850 · Cited by 50 · see citing works
Kairenius, P. K., Toivonen, V., & Shingfield, K. J. (2011) · Lipids · doi:10.1007/s11745-011-3561-1 · Cited by 49 · see citing works
Sun, X., Wang, Y., Ma, X., Li, S., & Wang, W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.955846 · Cited by 48 · see citing works
Rico, J. E., Mathews, A. T., Lovett, J., Haughey, N. J., & McFadden, J. W. (2016) · Journal of Dairy Science · doi:10.3168/jds.2016-11296 · Cited by 48 · see citing works
Manipulating Ruminal Biohydrogenation by the Use of Plants Bioactive Compounds
Vasta, V., & Bessa, R. J. B. (2012) · Springer eBooks · doi:10.1007/978-94-007-3926-0_9 · Cited by 46 · see citing works
Firkins, J. L. (2010) · Revista Brasileira de Zootecnia · doi:10.1590/s1516-35982010001300049 · Cited by 45 · see citing works
Garlic skin induces shifts in the rumen microbiome and metabolome of fattening lambs
Zhu, W., Su, Z., Xu, W., Sun, H., Gao, J. F., Tu, D., Ren, C. H., Zhang, Z. J., & Cao, H. G. (2021) · animal · doi:10.1016/j.animal.2021.100216 · Cited by 45 · see citing works
Potu, R. B., AbuGhazaleh, A. A., Hastings, D., Jones, K. L., & Ibrahim, S. A. (2011) · The Journal of Microbiology · doi:10.1007/s12275-011-0365-1 · Cited by 45 · see citing works
Wang, Y., Nan, X., Zhao, Y., Wang, Y., Jiang, L., & Xiong, B. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.01908-20 · Cited by 44 · see citing works
Iorizzo, M., Martino, C. D., Letizia, F., Crawford, T. W., & Paventi, G. (2024) · Foods · doi:10.3390/foods13070975 · Cited by 43 · see citing works
Senizza, A., Rocchetti, G., Callegari, M. L., Lucini, L., & Morelli, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-62897-w · Cited by 43 · see citing works
Biology, strategies, and fresh meat consequences of manipulating the fatty acid composition of meat
Burnett, D. D., Legako, J. F., Phelps, K. J., & Gonzalez, J. M. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa033 · Cited by 42 · see citing works
Campione, A., Natalello, A., Valenti, B., Luciano, G., Rufino‐Moya, P. J., Avondo, M., Morbidini, L., Pomente, C., Król, B., Wilk, M., et al. (2020) · Animals · doi:10.3390/ani10040588 · Cited by 42 · see citing works
Martínez-Álvaro, M., Mattock, J., Auffret, M. D., Weng, Z., Duthie, C.-A., Dewhurst, R. J., Cleveland, M. A., Watson, M., & Roehe, R. (2022) · Microbiome · doi:10.1186/s40168-022-01352-6 · Cited by 41 · see citing works
Vargas‐Bello‐Pérez, E., Cancino‐Padilla, N., Romero, J., & Garnsworthy, P. C. (2016) · animal · doi:10.1017/s1751731116000756 · Cited by 40 · see citing works
Druart, C., Neyrinck, A. M., Dewulf, E. M., Backer, F. C. D., Possemiers, S., de Wiele, T. V., Moens, F., Vuyst, L. D., Cani, P. D., Larondelle, Y., et al. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513000123 · Cited by 40 · see citing works
Fontes, A. L., Pimentel, L. L., Rodríguez-Alcalá, L. M., & Gomes, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-33970-2 · Cited by 39 · see citing works
Effects of feeding whole linseed on ruminal fatty acid composition and microbial population in goats
Abuelfatah, K., Zuki, A. B. Z., Goh, Y. M., Sazili, A. Q., & Mohammed, A. A. (2016) · Animal nutrition · doi:10.1016/j.aninu.2016.10.004 · Cited by 38 · see citing works
Pi, Y., Ma, L., Pierce, K. M., Wang, H., Xu, J. C., & Bu, D. (2019) · animal · doi:10.1017/s175173111900137x · Cited by 38 · see citing works
Carreño, D., Toral, P. G., Pinloche, E., Belenguer, Á., Yáñez-Ruíz, D. R., Hervás, G., McEwan, N. R., Newbold, C. J., & Frutos, P. (2019) · Scientific Reports · doi:10.1038/s41598-019-48294-y · Cited by 38 · see citing works
DHA content in milk and biohydrogenation pathway in rumen: a review
Huang, G., Zhang, Y., Xu, Q., Zheng, N., Zhao, S., Liu, K., Qu, X., Yu, J., & Wang, J. (2020) · PeerJ · doi:10.7717/peerj.10230 · Cited by 38 · see citing works
Ramírez, H., Castillo‐Lopez, E., Jenkins, C. J. R., Aluthge, N. D., Anderson, C. L., Fernando, S. C., Harvatine, K. J., & Kononoff, P. J. (2016) · Journal of Dairy Science · doi:10.3168/jds.2015-9712 · Cited by 36 · see citing works
Research progress on conjugated linoleic acid bio-conversion in Bifidobacterium
Mei, Y., Chen, H., Yang, B. K., Zhao, J., Zhang, H., & Chen, W. (2022) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2022.109593 · Cited by 35 · see citing works
Vlaeminck, B., Braeckman, T., & Fievez, V. (2014) · Lipids · doi:10.1007/s11745-014-3905-8 · Cited by 35 · see citing works
Towards an understanding of oleate hydratases and their application in industrial processes
Prem, S., Helmer, C. P. O., Dimos, N., Himpich, S., Brück, T., Garbe, D., & Loll, B. (2022) · Microbial Cell Factories · doi:10.1186/s12934-022-01777-6 · Cited by 34 · see citing works
Mavrommatis, A., Skliros, D., Flemetakis, E., & Tsiplakou, E. (2021) · Microorganisms · doi:10.3390/microorganisms9071528 · Cited by 33 · see citing works
Lopes, J. C., Harper, M. T., Giallongo, F., Oh, J., Smith, L., Ortega-Perez, A. M., Harper, S., Audino Melgar, M., Kniffen, D. M., Fabin, R. A., et al. (2016) · Journal of Dairy Science · doi:10.3168/jds.2016-11911 · Cited by 33 · see citing works
Li, Y., Gao, J., Lv, J., Lambo, M. T., Wang, Y., Wang, L., & Zhang, Y. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-22503 · Cited by 32 · see citing works
Biohydrogenation of C20 polyunsaturated fatty acids by anaerobic bacteria
Sakurama, H., Kishino, S., Mihara, K., Ando, A., Kita, K., Takahashi, S., Shimizu, S., & Ogawa, J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m045450 · Cited by 31 · see citing works
Energy conservation involving 2 respiratory circuits
Schoelmerich, M. C., Katsyv, A., Dönig, J., Hackmann, T. J., & Müller, V. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914939117 · Cited by 31 · see citing works
Zhu, Z., Mao, S., & Zhu, W. (2012) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2011.11442 · Cited by 30 · see citing works
Biohydrogenation of 22:6n-3 by Butyrivibrio proteoclasticus P18
Jeyanathan, J., Escobar, M., Wallace, R. J., Fievez, V., & Vlaeminck, B. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0720-9 · Cited by 30 · see citing works
Self-citationMangrum, K. S., Tuttle, G., Duckett, S. K., Sell, G. S., Krehbiel, C. R., & Long, N. (2016) · Journal of Animal Science · doi:10.2527/jas.2015-9809 · Cited by 30 · see citing works
Mitchell, K. E., Kienzle, S., Lee, C. H., Socha, M. T., Kleinschmit, D. H., & Firkins, J. L. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-23192 · Cited by 29 · see citing works
Li, X. Z., Park, B. K., Shin, J. S., Choi, S. H., Smith, S. B., & Yan, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126473 · Cited by 29 · see citing works
Rodríguez, L. G. R., Bleckwedel, J., Ortiz, M. E., Pescuma, M., & Mozzi, F. (2016) · Industrial Biotechnology · doi:10.1002/9783527807796.ch11 · Cited by 29 · see citing works
Mohammed, A. A., Alimon, A. R., Yaakub, H., Abdullah, N., & Ivan, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095713 · Cited by 28 · see citing works
Vargas, J. E., Andrés, S., López‐Ferreras, L., & López, S. (2019) · Anaerobe · doi:10.1016/j.anaerobe.2019.102143 · Cited by 28 · see citing works
Panahiha, P., Alamouti, H. M., Kazemi‐Bonchenari, M., & Aschenbach, J. R. (2022) · Journal of Dairy Science · doi:10.3168/jds.2022-22165 · Cited by 28 · see citing works
Edwards, H. D., Shelver, W. L., Choi, S. H., Nisbet, D. J., Krueger, N. A., Anderson, R. C., & Smith, S. B. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.09.052 · Cited by 26 · see citing works
Herdmann, A., Martin, J., Nuernberg, G., Dannenberger, D., & Nuernberg, K. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf101145y · Cited by 26 · see citing works
Pitta, D., Indugu, N., Vecchiarelli, B., Hennessy, M. L., Baldin, M., & Harvatine, K. J. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-17389 · Cited by 26 · see citing works
Khamis, W. M., Behiry, S. I., Marey, S. A., Al-Askar, A. A., Amer, G. M., Heflish, A. A., Su, Y., Abdelkhalek, A. A., & Gaber, M. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-43749-9 · Cited by 25 · see citing works
Diet containing glycerine and soybean oil can reduce ruminal biohydrogenation in Nellore steers
Granja-Salcedo, Y. T., de Souza, V. C., Dias, A. V. L., Insuasti, A. S. G., Messana, J. D., & Berchielli, T. T. (2017) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2017.01.021 · Cited by 25 · see citing works
Kadkhoday, A., Riasi, A., Alikhani, M., Dehghan-Banadaky, M., & Kowsar, R. (2017) · Livestock Science · doi:10.1016/j.livsci.2017.08.012 · Cited by 25 · see citing works
Barragán-Hernández, W. A., Aalhus, J. L., Penner, G. B., Dugan, M. E. R., Juarez, M. M., López-Campos, Ó., Vahmani, P., Segura, J., Angulo-Arizala, J., & Prieto, N. (2020) · Meat Science · doi:10.1016/j.meatsci.2020.108342 · Cited by 24 · see citing works
Morales, E. R., Mata-Espinosa, M. Á., McKain, N., & Wallace, R. J. (2012) · Journal of Animal Science · doi:10.2527/jas.2011-4670 · Cited by 24 · see citing works
Self-citationGuerreiro, O., Alves, S. P., Costa, M. M., Duarte, M. F., Jerónimo, E., & Bessa, R. J. B. (2021) · Animals · doi:10.3390/ani11030761 · Cited by 23 · see citing works
Campione, A., Pauselli, M., Natalello, A., Valenti, B., Pomente, C., Avondo, M., Luciano, G., Caccamo, M., & Morbidini, L. (2021) · animal · doi:10.1016/j.animal.2021.100243 · Cited by 23 · see citing works
de Oliveira, D. E., da Gama, M. A. S., Fernandes, D., Tedeschi, L. O., & Bauman, D. E. (2012) · Journal of Dairy Science · doi:10.3168/jds.2011-4618 · Cited by 23 · see citing works
Maeda, K., Nguyen, V. T., Suzuki, T., Yamada, K., Kudo, K., Hikita, C., Le, V. P., Nguyen, M. C., & Yoshida, N. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13702 · Cited by 23 · see citing works
Prom, C., & Lock, A. L. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19985 · Cited by 23 · see citing works
Zened, A., Enjalbert, F., Nicot, M.-C., & Meynadier, A. (2011) · animal · doi:10.1017/s1751731111001777 · Cited by 22 · see citing works
The first complete genomic structure of Butyrivibrio fibrisolvens and its chromid
Rodriguez-Hernaez, J., Cerón‐Cucchi, M. E., Cravero, S., Martinez, M. C., González, S., Puebla, A., Dopazo, J., Farber, M. D., Paniego, N. B., & Rivarola, M. (2018) · Microbial Genomics · doi:10.1099/mgen.0.000216 · Cited by 21 · see citing works
Valldecabres, A., Gilmore, S. P., Embree, J., Zhelev, I. Z., Gaffney, J., Marotz, C. A., Yang, F., Izzo, A. S., Embree, M. M., & Lago, A. (2022) · Journal of Animal Science · doi:10.1093/jas/skac275 · Cited by 21 · see citing works
Vargas, J. E., López‐Ferreras, L., Andrés, S., Mateos, I., Horst, E. H., & López, S. (2023) · Fermentation · doi:10.3390/fermentation9040320 · Cited by 21 · see citing works
Alfalfa hay substitution for wheat straw improves beef quality via rumen microflora alteration
Gao, Z., Liu, B., La, S., Li, D., Zhu, X., Sun, H., Ma, S., Cui, Y., & Shi, Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20803 · Cited by 21 · see citing works
Mavrommatis, A., Skliros, D., Simoni, M., Righi, F., Flemetakis, E., & Tsiplakou, E. (2021) · Sustainability · doi:10.3390/su13020607 · Cited by 21 · see citing works
- Authors
- Maia, M. R., Chaudhary, L. C., Bestwick, C. S., Richardson, A. J., McKain, N., Larson, T. R., Graham, I. A., & Wallace, R. J.
- Affiliations
- University of Aberdeen (GB)
- University of York (GB)
- Corresponding author
- Wallace, Robert J
- Venue
- BMC Microbiology
- Published
- 2010-02-18
- Volume
- 10
- Issue
- 1
- Pages
- 52-52
- ISSN
- 1471-2180 (ISSN-L)
- PMC
- PMC2836310
- OpenAlex
- W2162688963
- Cited by
- 298
- References
- 50
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 16 · 2023: 25 · 2022: 21 · 2021: 25 · 2020: 22 · 2019: 21 · 2018: 20 · 2017: 18 · 2016: 21 · 2015: 20 · 2014: 22 · 2013: 11 · 2012: 13
- FWCI
- 23.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Scottish Government
- Fundação para a Ciência e a Tecnologia
- Topics
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Keywords
- polyunsaturated fatty acids, Butyrivibrio fibrisolvens, biohydrogenation, rumen bacteria, linoleic acid, alpha-linolenic acid, vaccenic acid, eicosapentaenoic acid, docosahexaenoic acid, fish oil, bacterial growth inhibition, membrane integrity, ATP depletion, fatty acid metabolism
- MeSH terms
- Acyl Coenzyme A, Adenosine Triphosphate, Animals, Cell Membrane, Culture Media, Fatty Acids, Unsaturated, Flow Cytometry, Hydrogenation, Sheep, Sodium Lactate, Linoleic Acid, Butyrivibrio, Lipid Metabolism
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