Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia
Open accessAbstract
BACKGROUND: Frontotemporal dementia (FTD) is recognised as a clinically and morphologically heterogeneous group of interrelated neurodegenerative conditions. One of the subtypes within this disease spectrum is the behavioural variant FTD (bvFTD). This is known to be a varied disorder with a mixture of tau-positive and tau-negative underlying pathologies. The other subtypes include semantic dementia (SD), which generally exhibits tau-negative pathology, and progressive non-fluent aphasia (PNFA), which is usually tau-positive. As the clinical presentation of these subtypes may overlap, a specific diagnosis can be difficult to attain and today no specific biomarker can predict the underlying pathology. Neurofilament light chain protein (NFL), a cytoskeletal constituent of intermediate filaments, is thought to reflect neuronal and axonal death when appearing in the cerebrospinal fluid (CSF). NFL has been shown to be elevated in CSF in patients with FTD compared with AD and controls. Our hypothesis was that the levels of NFL also differ between the subtypes of FTD and may indicate the underlying pathological subtype. METHODS: We retrospectively analysed data from previous CSF analyses in 34 FTD cases (23 bvFTD, seven SD, four PNFA), 20 AD cases, and 26 healthy controls. A separate group of 10 neuropathologically verified and subtyped FTD cases (seven tau-negative, three tau-positive) were also analysed. RESULT: NFL levels were significantly higher in FTD compared with both AD (p<0.001) and controls (p<0.001). The NFL levels of SD and bvFTD were significantly higher (p<0.001) compared with AD. The biomarker profiles of PNFA and AD were similar. In the neuropathologically verified FTD cases, NFL was higher in the tau-negative than in the tau-positive cases (exact p=0.017). CONCLUSIONS: The marked NFL elevation in some but not all FTD cases is likely to reflect the different underlying pathologies. The highest NFL values found in the SD group as well as in the neuropathologically verified tau-negative cases may be of subtype diagnostic value, if corroborated in larger patient cohorts. In bvFTD, a mixture of tau-positive and tau-negative underlying pathologies could possibly explain the intermediate NFL values.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NfL is increased in CSF and serum in FTD patients compared to cognitively healthy controls.
“In FTD patients it has been shown to be increased in CSF and serum, compared to cognitively healthy controls [23–26]”
NfL is increased in CSF in FTD patients compared to AD patients.
“and in CSF, compared to AD patients [24, 26, 27].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., et al. (2006) · Science · doi:10.1126/science.1134108 · Cited by 6,576 · see citing works
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Self-citationWeıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,012 · see citing works
O'Brien, J. T., Erkinjuntti, T., Reisberg, ., Román, G. C., Pantoni, L., Bowler, J., Ballard, C., DeCarli, C., Gorelick, P., Rockwood, K., et al. (2014) · International Journal of Stroke · doi:10.1111/ijs.12374_18 · Cited by 1,165 · see citing works
Tibbling, G., Link, H., & Ohman, S. (1977) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365517709091496 · Cited by 863 · see citing works
Tibbling, G., Link, H., & Ohman, S. (1977) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517709091496 · Cited by 813 · see citing works
Blennow, K., Wallin, A., Ågren, H., Spenger, C., Siegfried, J., & Vanmechelen, E. (1995) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815140 · Cited by 789 · see citing works
A new subtype of frontotemporal lobar degeneration with FUS pathology
Neumann, M., Rademakers, R., Roeber, S., Baker, M., Kretzschmar, H. A., & Mackenzie, I. R. A. (2009) · Brain · doi:10.1093/brain/awp214 · Cited by 722 · see citing works
Andreasen, N., Hesse, C., Davidsson, P., Minthon, L., Wallin, A., Winblad, B., Vanderstichele, H., Vanmechelen, E., & Blennow, K. (1999) · Archives of Neurology · doi:10.1001/archneur.56.6.673 · Cited by 660 · see citing works
Rosengren, L. E., Karlsson, J., Karlsson, J., Persson, L. I., & Wikkelsø, C. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67052013.x · Cited by 499 · see citing works
Self-citationVanmechelen, E., Vanderstichele, H., Davidsson, P., Kerschaver, E. V., Perre, B. V. D., Sjögren, M. J. C., Andreasen, N. C., & Blennow, K. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01036-3 · Cited by 487 · see citing works
Neuropathological background of phenotypical variability in frontotemporal dementia
Josephs, K. A., Hodges, J. R., Snowden, J. S., Mackenzie, I. R., Neumann, M., Mann, D. M. A., & Dickson, D. W. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0839-6 · Cited by 453 · see citing works
Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology
Brun, A. E. (1987) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(87)90021-5 · Cited by 396 · see citing works
Elevated neurofilament levels in neurological diseases
Norgren, N., Rosengren, L., & Stigbrand, T. I. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03219-0 · Cited by 351 · see citing works
Self-citationAbundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease
Neumann, M., Roeber, S., Kretzschmar, H. A., Rademakers, R., Baker, M. C., & Mackenzie, I. R. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0581-5 · Cited by 257 · see citing works
FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration
Urwin, H., Josephs, K. A., Rohrer, J. D., Mackenzie, I. R., Neumann, M., Authier, A., Seelaar, H., Swieten, J. C. V., Brown, J. M., Johannsen, P., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0698-6 · Cited by 244 · see citing works
Frontal lobe degeneration of non-Alzheimer type.
Gustafson, L., Brun, A., & Passant, U. (1992) · PubMed · Cited by 241 · see citing works
Self-citationIncreased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis
Kasai, T., Tokuda, T., Ishigami, N., Sasayama, H., Foulds, P., Mitchell, D. J., Mann, D. M. A., Allsop, D., & Nakagawa, M. (2009) · Acta Neuropathologica · doi:10.1007/s00401-008-0456-1 · Cited by 211 · see citing works
Neurofilament protein in cerebrospinal fluid: A marker of white matter changes
Sjögren, M., Blomberg, M., Jonsson, M., Wahlund, L. ‐., Edman, Å., Lind, K., Rosengren, L., Blennow, K., & Wallin, A. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1242 · Cited by 209 · see citing works
Self-citationBiomarkers in Alzheimer's disease drug development
Blennow, K. (2010) · Nature Medicine · doi:10.1038/nm.2221 · Cited by 145 · see citing works
Holmberg, B., Rosengren, L., Karlsson, J., & Johnels, B. (1998) · Movement Disorders · doi:10.1002/mds.870130116 · Cited by 142 · see citing works
Self-citationZetterberg, H., Jacobsson, J., Rosengren, L., Blennow, K., & Andersen, P. M. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01972.x · Cited by 134 · see citing works
Self-citationCSF neurofilament proteins in the differential diagnosis of dementia
de Jong, D., Jansen, R. W. M. M., Pijnenburg, Y. A. L., van Geel, W. J. A., Borm, G. F., Kremer, H. P. H., & Verbeek, M. M. (2007) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp.2006.107326 · Cited by 120 · see citing works
Kersaitis, C., Halliday, G. M., & Kril, J. J. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0917-0 · Cited by 113 · see citing works
A Systematic Review and Meta-Analysis of CSF Neurofilament Protein Levels as Biomarkers in Dementia
Petzold, A., Keir, G., Warren, J. D., Fox, N. C., & Rossor, M. N. (2007) · Neurodegenerative Diseases · doi:10.1159/000101843 · Cited by 112 · see citing works
Erkinjuntti, T., & Rockwood, K. J. (2001) · Psychogeriatrics · doi:10.1111/j.1479-8301.2001.tb00070.x · Cited by 87 · see citing works
Pijnenburg, Y. A. L., Janssen, J. C., Schoonenboom, N. S. M., Petzold, A., Mulder, C., Stigbrand, T. I., Norgren, N., Heijst, H., Hack, C. E., Scheltens, P., et al. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000099473 · Cited by 82 · see citing works
Rostrup, E., Gouw, A. A., Vrenken, H., van Straaten, E. C. W., Ropele, S., Pantoni, L., Inzitari, D., Barkhof, F., & Waldemar, G. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.106 · Cited by 82 · see citing works
Clinicopathological Concordance in Dementia Diagnostics
Brunnström, H., & Englund, E. M. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181a6516e · Cited by 77 · see citing works
Self-citationFrontotemporal Lobar Degeneration: Current Concepts in the Light of Recent Advances
Kumar‐Singh, S., & Broeckhoven, C. V. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00055.x · Cited by 72 · see citing works
Amyloid-related biomarkers and axonal damage proteins in parkinsonian syndromes
Bech, S., Hjermind, L. E., Salvesen, L., Nielsen, J. E., Heegaard, N. H. H., Jørgensen, H. L., Rosengren, L., Blennow, K., Zetterberg, H., & Winge, K. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.08.012 · Cited by 47 · see citing works
Self-citationFialová, L., Švarcová, J., Bartoš, A., Ridzoň, P., Malbohan, I. M., Keller, O., & Rusina, R. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02853.x · Cited by 46 · see citing works
Novel Types of Frontotemporal Lobar Degeneration: Beyond Tau and TDP-43
Mackenzie, I. R., Neumann, M., Cairns, N. J., Muñoz, D. G., & Isaacs, A. M. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9551-1 · Cited by 40 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zetterberg, H., Skillbäck, T., Mattsson, N., Trojanowski, J. Q., Portelius, E., Shaw, L. M., Weiner, M. W., Blennow, K., & Initiative, F. T. A. D. N. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2015.3037 · Cited by 487 · see citing works
Self-citationSerum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
Rohrer, J. D., Woollacott, I., Dick, K. M., Brotherhood, E., Gordón, E., Fellows, A. D., Toombs, J., Druyeh, R., Cardoso, M. J., Sebastien Ourselin, A., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003154 · Cited by 431 · see citing works
Self-citationByrne, L. M., Rodrigues, F. B., Blennow, K., Durr, A., Leavitt, B. R., Roos, R. A. C., Scahill, R. I., Tabrizi, S. J., Zetterberg, H., Langbehn, D., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30124-2 · Cited by 364 · see citing works
Self-citationLewczuk, P., Riederer, P. F., O’Bryant, S. E., Verbeek, M. M., Dubois, B., Visser, P. J., Jellinger, K. A., Engelborghs, S., Ramı́rez, A., Parnetti, L., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1375556 · Cited by 308 · see citing works
Self-citationCerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease
Mattsson, N., Insel, P. S., Palmqvist, S., Portelius, E., Zetterberg, H., Weiner, M. W., Blennow, K., Hansson, O., & Initiative, T. A. D. N. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606540 · Cited by 293 · see citing works
Self-citationNeurofilament light chain: a biomarker for genetic frontotemporal dementia
Meeter, L. H., Dopper, E. G., Jiskoot, L. C., Sanchez‐Valle, R., Graff, C., Benussi, L., Ghidoni, R., Pijnenburg, Y. A., Borroni, B., Galimberti, D., et al. (2016) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.325 · Cited by 263 · see citing works
CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival
Skillbäck, T., Farahmand, B., Bartlett, J. W., Rosén, C., Mattsson, N., Nägga, K., Kilander, L., Religa, D., Wimo, A., Winblad, B., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000001015 · Cited by 263 · see citing works
Self-citationScherling, C. S., Hall, T., Berisha, F., Klepac, K., Karydas, A., Coppola, G., Kramer, J. H., Rabinovici, G., Ahlijanian, M., Miller, B. L., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24052 · Cited by 249 · see citing works
Plasma neurofilament light chain concentration in the inherited peripheral neuropathies
Sandelius, Å., Zetterberg, H., Blennow, K., Adiutori, R., Malaspina, A., Laurá, M., Reilly, M. M., & Rossor, A. M. (2018) · Neurology · doi:10.1212/wnl.0000000000004932 · Cited by 237 · see citing works
Self-citationMolecular biomarkers of Alzheimer's disease: progress and prospects
Lashley, T., Schott, J. M., Weston, P. S. J., Murray, C. E., Wellington, H., Keshavan, A., Foti, S. C., Foiani, M. S., Toombs, J., Rohrer, J. D., et al. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.031781 · Cited by 233 · see citing works
Self-citationImaging and fluid biomarkers in frontotemporal dementia
Meeter, L. H., Kaat, L. D., Rohrer, J. D., & van Swieten, J. C. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.75 · Cited by 210 · see citing works
Gaetani, L., Höglund, K., Parnetti, L., Pujol-Calderón, F., Becker, B., Eusebi, P., Sarchielli, P., Calabresi, P., Filippo, M. D., Zetterberg, H., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0339-1 · Cited by 174 · see citing works
Self-citationBiomarker Evidence of Axonal Injury in Neuroasymptomatic HIV-1 Patients
Jessen Krut, J., Mellberg, T., Price, R. W., Hagberg, L., Fuchs, D., Rosengren, L., Nilsson, S., Zetterberg, H., & Gisslén, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088591 · Cited by 167 · see citing works
Self-citationAn update on semantic dementia: genetics, imaging, and pathology
Landín-Romero, R., Tan, R. H., Hodges, J. R., & Kumfor, F. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0219-5 · Cited by 163 · see citing works
Biomarkers in dementia: clinical utility and new directions
Ahmed, R. M., Paterson, R. W., Warren, J. D., Zetterberg, H., O'Brien, J. T., Fox, N. C., Halliday, G. M., & Schott, J. M. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-307662 · Cited by 155 · see citing works
Self-citationRabinovici, G. D., Carrillo, M. C., Forman, M. S., DeSanti, S., Miller, D. S., Kozauer, N., Petersen, R. C., RANDOLPH, C. C., Knopman, D. S., Smith, E. E., et al. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.09.002 · Cited by 152 · see citing works
Alirezaei, Z., Pourhanifeh, M. H., Borran, S., Nejati, M., Mirzaei, H., & Hamblin, M. R. (2020) · Molecular Neurobiology · doi:10.1007/s12035-019-01698-3 · Cited by 142 · see citing works
CSF neurofilament light chain reflects corticospinal tract degeneration in ALS
Menke, R., Gray, E., Lu, C., Kühle, J., Talbot, K., Malaspina, A., & Turner, M. R. (2015) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.212 · Cited by 141 · see citing works
Mattsson, N., Grinberg, L. T., Boxer, A. L., Ossenkoppele, R., Jonsson, M., Seeley, W., Ehrenberg, A. J., Spina, S., Janelidze, S., Rojas-Martinex, J., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200040 · Cited by 136 · see citing works
Paterson, R. W., Slattery, C. F., Poole, T., Nicholas, J. M., Magdalinou, N. K., Toombs, J., Chapman, M. D., Lunn, M. P., Heslegrave, A., Foiani, M. S., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0361-3 · Cited by 130 · see citing works
Self-citationHampel, H., Toschi, N., Baldacci, F., Zetterberg, H., Blennow, K., Kilimann, I., Teipel, S. J., Cavedo, E., Melo dos Santos, A., Epelbaum, S., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.11.015 · Cited by 129 · see citing works
Self-citationNeurobiological Highlights of Cognitive Impairment in Psychiatric Disorders
Morozova, A. Y., Zorkina, Y., Abramova, O. V., Pavlova, O., Ka, P., Soloveva, K., Volkova, M., Alekseeva, P. A., Andryshchenko, A., Kostyuk, G. P., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031217 · Cited by 126 · see citing works
CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration
Alcolea, D., Vilaplana, E., Suárez-Calvet, M., Illán-Gala, I., Blesa, R., Clarimón, J., Lladó, A., Sánchez-Valle, R., Molinuevo, J. L., García-Ribas, G., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004088 · Cited by 123 · see citing works
Clinical value of neurofilament and phospho-tau/tau ratio in the frontotemporal dementia spectrum
Meeter, L. H. H., Vijverberg, E. G., Del Campo, M., Rozemuller, A. J. M., Donker Kaat, L., de Jong, F. J., van der Flier, W. M., Teunissen, C. E., van Swieten, J. C., & Pijnenburg, Y. A. L. (2018) · Neurology · doi:10.1212/wnl.0000000000005261 · Cited by 122 · see citing works
Serum neurofilament light chain in behavioral variant frontotemporal dementia
Steinacker, P., Anderl-Straub, S., Diehl-Schmid, J., Semler, E., Uttner, I., von Arnim, C. A. F., Barthel, H., Danek, A., Fassbender, K., Fliessbach, K., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000006318 · Cited by 116 · see citing works
Peterson, J. J., Gisslén, M., Zetterberg, H., Fuchs, D., Shacklett, B. L., Hagberg, L., Yiannoutsos, C. T., Spudich, S., & Price, R. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116081 · Cited by 115 · see citing works
Self-citationThe CSF neurofilament light signature in rapidly progressive neurodegenerative dementias
Abu‐Rumeileh, S., Capellari, S., Maserati, M. S., Polischi, B., Martinelli, P., Caroppo, P., Ladogana, A., & Parchi, P. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0331-1 · Cited by 114 · see citing works
Disease modification and Neuroprotection in neurodegenerative disorders
Cummings, J. L. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0096-2 · Cited by 108 · see citing works
Zhao, Y., Xin, Y., Meng, S., He, Z., & Hu, W. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.014 · Cited by 105 · see citing works
Jin, M., Cao, L., & Dai, Y. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00254 · Cited by 105 · see citing works
CSF neurofilament proteins as diagnostic and prognostic biomarkers for amyotrophic lateral sclerosis
Rossi, D., Volanti, P., Brambilla, L., Colletti, T., Spataro, R., & Bella, V. L. (2018) · Journal of Neurology · doi:10.1007/s00415-017-8730-6 · Cited by 101 · see citing works
Wang, S.-Y., Chen, W., Xu, W., Li, J., Hou, X., Ou, Y., Yu, J., & Tan, L. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190615 · Cited by 95 · see citing works
Pijnenburg, Y. A. L., Verwey, N. A., van der Flier, W. M., Scheltens, P., & Teunissen, C. E. (2015) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.11.001 · Cited by 91 · see citing works
Tesco, G., & Lomoio, S. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101628 · Cited by 91 · see citing works
Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias
Steinacker, P., Semler, E., Anderl‐Straub, S., Diehl‐Schmid, J., Schroeter, M. L., Uttner, I., Foerstl, H., Landwehrmeyer, G. B., Arnim, C. A. F. V., Kassubek, J., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000003688 · Cited by 87 · see citing works
Zerr, I., Schmitz, M., Karch, A., Villar‐Piqué, A., Kanata, Ε., Golańska, E., Lucena, D. D., Karsanidou, A., Hermann, P., Knipper, T., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.12.008 · Cited by 87 · see citing works
Self-citationNeurofilaments in disease: what do we know?
Gordon, B. A. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.02.001 · Cited by 82 · see citing works
Antonell, A., Tort‐Merino, A., Ríos, J., Balasa, M., Borrego‐Écija, S., Auge, J. M., Muñoz‐García, C., Bosch, B., Falgàs, N., Rami, L., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.09.001 · Cited by 76 · see citing works
Self-citationSkillbäck, T. B., Mattsson, N., Blennow, K., & Zetterberg, H. (2017) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2017.1281962 · Cited by 74 · see citing works
Self-citationBoxer, A. L., Gold, M., Feldman, H., Boeve, B. F., Dickinson, S. L.-J., Fillit, H., Ho, C., Paul, R., Pearlman, R., Sutherland, M., et al. (2020) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.06.4956 · Cited by 71 · see citing works
Abu‐Rumeileh, S., Mometto, N., Bartoletti‐Stella, A., Polischi, B., Oppi, F., Poda, R., Maserati, M. S., Cortelli, P., Liguori, R., Capellari, S., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180409 · Cited by 69 · see citing works
Brureau, A., Blanchard-Bregeon, V., Pech, C., Hamon, S., Chaillou, P., Guillemot, J.-C., Barneoud, P., Bertrand, P., Pradier, L., Rooney, T., et al. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.04.007 · Cited by 62 · see citing works
Applying fluid biomarkers to Alzheimer's disease
Zetterberg, H. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00007.2017 · Cited by 62 · see citing works
Self-citationLista, S., Toschi, N., Baldacci, F., Zetterberg, H., Blennow, K., Kilimann, I., Teipel, S. J., Cavedo, E., dos Santos, A. M., Epelbaum, S., et al. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.05.010 · Cited by 60 · see citing works
Self-citationIllán‐Gala, I., Montal, V., Borrego‐Écija, S., Vilaplana, E., Pegueroles, J., Alcolea, D. A., Sánchez‐Saudinós, M. B., Clarimón, J., Turón‐Sans, J., Bargalló, N., et al. (2019) · Brain · doi:10.1093/brain/awz031 · Cited by 60 · see citing works
Yang, S., Chiu, M., Chen, T., Lin, C., Jeng, J., Tang, S., Lee, Y.-F., Yang, C., Liu, B.-H., Chen, H.-H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09009-3 · Cited by 58 · see citing works
Biomarkers for diseases with TDP-43 pathology
Steinacker, P., Barschke, P., & Otto, M. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.10.003 · Cited by 57 · see citing works
Goossens, J., Bjerke, M., Mossevelde, S. V., den Bossche, T. V., Goeman, J., Vil, B. B. D., Sieben, A., Martin, J., Cras, P. P., Deyn, P. P. D., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0364-0 · Cited by 56 · see citing works
Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage
Meeker, K. L., Butt, O. H., Gordon, B. A., Fagan, A. M., Schindler, S. E., Morris, J. C., Benzinger, T. L. S., & Ances, B. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105662 · Cited by 54 · see citing works
The role of neurofilament light chain in frontotemporal dementia: a meta-analysis
Karantali, E., Kazis, D. A., Chatzikonstantinou, S., Petridis, F., & Mavroudis, I. A. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01554-8 · Cited by 54 · see citing works
Palermo, G., Mazzucchi, S., Vecchia, A. D., Siciliano, G., Bonuccelli, U., Azuar, C., Ceravolo, R., Lista, S., Hampel, H. J., & Baldacci, F. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02035-9 · Cited by 54 · see citing works
del Campo, M., Zetterberg, H., Gandy, S., Onyike, C. U., Oliveira, F., Udeh‐Momoh, C., Lleó, A., Teunissen, C. E., & Pijnenburg, Y. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12643 · Cited by 52 · see citing works
Self-citationReview: Fluid biomarkers for frontotemporal dementias
Zetterberg, H., van Swieten, J. C., Boxer, A. L., & Rohrer, J. D. (2019) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12530 · Cited by 48 · see citing works
Self-citationSkillbäck, T. B., Zetterberg, H., Blennow, K., & Mattsson, N. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt212 · Cited by 48 · see citing works
Self-citationVijverberg, E. G. B., Dols, A., Krudop, W. A., Del Campo Milan, M., Kerssens, C. J., Gossink, F., Prins, N. D., Stek, M. L., Scheltens, P., Teunissen, C. E., et al. (2017) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.01.009 · Cited by 46 · see citing works
Neuropathogenesis of human immunodeficiency virus infection
Sillman, B., Woldstad, C., McMillan, J., & Gendelman, H. E. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63849-6.00003-7 · Cited by 43 · see citing works
Borroni, B., Benussi, A., Premi, E., Alberici, A., Marcello, E. E., Gardoni, F., Luca, M. D., & Padovani, A. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170584 · Cited by 37 · see citing works
Bolsewig, K., Hok-A-Hin, Y. S., Sepe, F. N., Boonkamp, L., Jacobs, D., Bellomo, G., Paoletti, F. P., Vanmechelen, E., Teunissen, C. E., Parnetti, L., et al. (2022) · Journal of Alzheimer's Disease · doi:10.3233/jad-220318 · Cited by 36 · see citing works
Devenney, E. M., Ahmed, R. M., & Hodges, J. R. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00015-7 · Cited by 33 · see citing works
Spotorno, N., Lindberg, O. E., Nilsson, C., Waldö, M. L., van Westen, D., Nilsson, K., Vestberg, S., Englund, E. M., Zetterberg, H., Blennow, K., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236384 · Cited by 31 · see citing works
Self-citationNeurochemical biomarkers in the diagnosis of frontotemporal lobar degeneration: an update
Oeckl, P., Steinacker, P., Feneberg, E., & Otto, M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13669 · Cited by 30 · see citing works
Neurofilaments Light Chain in Neurodegenerative Dementias: A Review of Imaging Correlates
Gallingani, C., Carbone, C., Tondelli, M., & Zamboni, G. (2024) · Brain Sciences · doi:10.3390/brainsci14030272 · Cited by 29 · see citing works
Biomarkers in Alzheimer’s, Frontotemporal, Lewy Body, and Vascular Dementias
Koenig, A. M., Nobuhara, C. K., Williams, V. J., & Arnold, S. E. (2018) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20170048 · Cited by 28 · see citing works
Neuroinflammatory Pathways in the ALS-FTD Continuum: A Focus on Genetic Variants
Marchi, F. D., Tondo, G., Corrado, L., Menegon, F., Aprile, D., Anselmi, M., D’Alfonso, S., Comi, C., & Mazzini, L. (2023) · Genes · doi:10.3390/genes14081658 · Cited by 28 · see citing works
Serum neurofilament light chain in FTLD: association with C9orf72, clinical phenotype, and prognosis
Cajanus, A., Katisko, K., Kontkanen, A., Jääskeläinen, O., Hartikainen, P. H., Haapasalo, A., Herukka, S., Vanninen, R. L., Solje, E., Hall, A., et al. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51041 · Cited by 27 · see citing works
Oeckl, P., Steinacker, P., Feneberg, E., & Otto, M. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.12.010 · Cited by 27 · see citing works
Duran-Aniotz, C. A., Orellana, P., Rodríguez, T. L., Henríquez, F., Cabello, V., Aguirre-Pinto, M. F., Escobedo, T., Takada, L. T., Piña‐Escudero, S. D., López, O. L., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.663407 · Cited by 26 · see citing works
Recent Advances in Frontotemporal Dementia
Tartaglia, M. C., & Mackenzie, I. R. (2022) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2022.69 · Cited by 24 · see citing works
Endostatin Level in Cerebrospinal Fluid of Patients with Alzheimer's Disease
Salza, R., Oudart, J., Ramont, L., Maquart, F., Bakchine, S., Thoannes, H., & Ricard‐Blum, S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142544 · Cited by 24 · see citing works
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
Meeter, L. H. H., Steketee, R. M. E., Salkovic, D., Vos, M. E., Grossman, M., McMillan, C. T., Irwin, D. J., Boxer, A. L., Rojas, J. C., Olney, N. T., et al. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-319784 · Cited by 23 · see citing works
Brinkmalm, A., Portelius, E., Brinkmalm, G., Pannee, J., Dahlén, R., Gobom, J., Blennow, K., & Zetterberg, H. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14594 · Cited by 21 · see citing works
Self-citationZetterberg, H., Lautner, R., Skillbäck, T. B., Rosén, C., Shahim, P., Mattsson, N., & Blennow, K. (2014) · Advances in clinical chemistry · doi:10.1016/b978-0-12-800141-7.00005-x · Cited by 21 · see citing works
Self-citationThe cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer’s disease
Mäkitalo, S., Mellgren, Å., Borgh, E., Kilander, L., Skillbäck, T. B., Zetterberg, H., & Gisslén, M. (2015) · AIDS Research and Therapy · doi:10.1186/s12981-015-0063-x · Cited by 21 · see citing works
Self-citationNiikado, M., Chrem-Méndez, P., Itzcovich, T., Kennedy, M. B., Calandri, I. L., Martinetto, H., Serra, M., Calvar, J., Campos, J., Russo, M. J., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly179 · Cited by 20 · see citing works
CSF placental growth factor – a novel candidate biomarker of frontotemporal dementia
Hansson, O., Santillo, A. F., Meeter, L. H. H., Nilsson, K. H., Waldö, M. L., Nilsson, C., Blennow, K., Swieten, J. C. V., & Janelidze, S. (2019) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.763 · Cited by 20 · see citing works
Self-citationSomatic complaints in frontotemporal dementia.
Waldö, M. L., Santillo, A. F., Gustafson, L., Englund, E. M., & Passant, U. (2014) · Europe PMC (PubMed Central) · Cited by 19 · see citing works
Self-citationTrautwig, A. N., Fox, E. J., Dammer, E. B., Shantaraman, A., Ping, L., Duong, D. M., Watson, C. M., Wu, F., Asress, S., Guo, Q. J., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00838-9 · Cited by 18 · see citing works
Liu, H.-C., Lin, W., Chiu, M., Lu, C.-H., Lin, C.-Y., & Yang, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234519 · Cited by 18 · see citing works
Neurofilaments in neurologic disorders and beyond
Mak, G. K., Menon, S., & Lu, J. (2022) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120380 · Cited by 18 · see citing works
Waldö, M. L. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.02.001 · Cited by 18 · see citing works
Waldö, M. L., Gustafson, L., Nilsson, K. H., Traynor, B. J., Renton, A. E., Englund, E. M., & Passant, U. (2013) · Europe PMC (PubMed Central) · Cited by 17 · see citing works
Self-citationMiller, A.-M., Rutkowska, A., Bahl, J. M. C., Herukka, S., Simmelink, M. J. A., Kruse, N., Mollenhauer, B., Siloaho, M., Skinningsrud, A., Zetterberg, H., et al. (2016) · Bioanalysis · doi:10.4155/bio-2016-0114 · Cited by 16 · see citing works
Self-citationUpdate on Major Neurocognitive Disorders
Jones, K. C. (2021) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20210004 · Cited by 15 · see citing works
Reyes‐Leiva, D., Dols‐Icardo, O., Sirisi, S., Cortés‐Vicente, E., Turón‐Sans, J., de Luna, N., Blesa, R., Belbin, O., Montal, V., Alcolea, D. A., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.750543 · Cited by 15 · see citing works
López-Gómez, J., Enciso, B. S., Miró, M. A. C., & Pascual, M. R. (2023) · Neurología (English Edition) · doi:10.1016/j.nrleng.2021.01.010 · Cited by 14 · see citing works
Initiative, A. D. N., Niu, L., Xu, W., Li, J., Tan, C., Cao, X., Yu, J., & Tan, L. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.10.66 · Cited by 14 · see citing works
Boehnke, S. E., Robertson, E. L., Armitage‐Brown, B., Wither, R. G., Silva, N. M. L. E., Winterborn, A., Levy, R., Cook, D. J., Felice, F. G. D., & Munoz, D. P. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12069 · Cited by 14 · see citing works
CSF neurofilament light concentration is increased in presymptomatic CHMP2B mutation carriers
Rostgaard, N., Roos, P., Portelius, E., Blennow, K., Zetterberg, H., Simonsen, A. H., & Nielsen, J. E. (2017) · Neurology · doi:10.1212/wnl.0000000000004799 · Cited by 13 · see citing works
Self-citationBrůžová, M., Rusina, R., Stejskalova, Z., & Matěj, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-90366-5 · Cited by 13 · see citing works
Cerebrospinal fluid in the dementias
Zetterberg, H., Rohrer, J. D., & Schott, J. M. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804279-3.00006-x · Cited by 12 · see citing works
Self-citationClement, A., Mitchelmore, C., Andersson, D. R., & Asuni, A. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.030 · Cited by 10 · see citing works
Fluid Biomarkers of Frontotemporal Lobar Degeneration
van der Ende, E. L., & Swieten, J. C. V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_9 · Cited by 10 · see citing works
Jahani, R., Munusamy, S., Zheng, H., Kong, J., Chen, J., Zhou, S., & Guan, X. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00137 · Cited by 9 · see citing works
Serum Neurofilament Light Chain: A Potential Biomarker for Peripheral Neuropathy
Widyadharma, I. P. E., & Tedyanto, E. H. (2022) · Siriraj Medical Journal/San Sirirat · doi:10.33192/smj.2022.84 · Cited by 8 · see citing works
Lucena, D. D., Escaramís, G., Villar‐Piqué, A., Hermann, P., Schmitz, M., Varges, D., Santana, I. J., del Rı́o, J. A., Martı́, E., Ferrer, I., et al. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09870-9 · Cited by 8 · see citing works
Veverová, K., Katonová, A., Horáková, H., Laczó, J., Angelucci, F., Hort, J., Lautrup, S., Fang, E. F., & Vyhnálek, M. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-01954-9 · Cited by 7 · see citing works
Song, Q., Zhang, H., Kong, J., Wong, M. S., & Li, H. (2025) · Microchimica Acta · doi:10.1007/s00604-025-06995-4 · Cited by 6 · see citing works
Olsson, B., Schott, J. M., Blennow, K., & Zetterberg, H. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1341311 · Cited by 6 · see citing works
Self-citationBiomarkers in Frontotemporal Dementia
Rohrer, J. D., & Zetterberg, H. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.30 · Cited by 6 · see citing works
Self-citationLópez-Gómez, J., Enciso, B. S., Caro-Miró, M. A., & Pascual, M. R. (2021) · Neurología · doi:10.1016/j.nrl.2021.01.011 · Cited by 5 · see citing works
- Authors
- Landqvist Waldö, M., Frizell Santillo, A., Passant, U., Zetterberg, H., Rosengren, L., Nilsson, C., & Englund, E.
- Affiliations
- Skåne University Hospital (SE)
- National Hospital for Neurology and Neurosurgery (GB)
- University of Gothenburg (SE)
- Lund University (SE)
- Venue
- BMC Neurology
- Published
- 2013-05-29
- Volume
- 13
- Issue
- 1
- Pages
- 54-54
- ISSN
- 1471-2377 (ISSN-L)
- PMC
- PMC3671150
- OpenAlex
- W2141909536
- Cited by
- 127
- References
- 35
- Citations by year
- 2025: 8 · 2024: 1 · 2023: 3 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 13 · 2018: 22 · 2017: 18 · 2016: 10 · 2015: 12 · 2014: 10 · 2013: 3
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Gothenburg University Publications Electronic Archive (Gothenburg University) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Funders
- Region Skåne
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, neurofilament light chain, cerebrospinal fluid biomarkers, behavioral variant frontotemporal dementia, semantic dementia, progressive nonfluent aphasia, tau pathology, Alzheimer's disease, neuronal cell death
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Humans, Male, Middle Aged, Neurologic Examination, Peptide Fragments, Retrospective Studies, Spinal Puncture, Case-Control Studies, Amyloid beta-Peptides, tau Proteins, Neurofilament Proteins, Statistics, Nonparametric, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
