Cited by 134Probiotics and Fermented FoodsMicrobial Metabolic Engineering and BioproductionBacterial Genetics and Biotechnology

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Systems solutions by lactic acid bacteria: from paradigms to practice

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de Vos, Willem M·2011·Microbial Cell Factories

DOI 10.1186/1475-2859-10-s1-s2PMC PMC3231926

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Abstract

Lactic acid bacteria are among the powerhouses of the food industry, colonize the surfaces of plants and animals, and contribute to our health and well-being. The genomic characterization of LAB has rocketed and presently over 100 complete or nearly complete genomes are available, many of which serve as scientific paradigms. Moreover, functional and comparative metagenomic studies are taking off and provide a wealth of insight in the activity of lactic acid bacteria used in a variety of applications, ranging from starters in complex fermentations to their marketing as probiotics. In this new era of high throughput analysis, biology has become big science. Hence, there is a need to systematically store the generated information, apply this in an intelligent way, and provide modalities for constructing self-learning systems that can be used for future improvements. This review addresses these systems solutions with a state of the art overview of the present paradigms that relate to the use of lactic acid bacteria in industrial applications. Moreover, an outlook is presented of the future developments that include the transition into practice as well as the use of lactic acid bacteria in synthetic biology and other next generation applications.

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Figure 1 Development of genome sequencing in the last two decades. The number of entries in the NCBI database were scored and summed for the plasmids and bacteriophages [phages] as well as the genomes from Lactobacillus or Lactococcus and Streptrococcus spp. that are considered as LAB.CC BY · PubMed Central

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See all 134

Authors: de Vos, W. M.
Venue: Microbial Cell Factories
Publisher: Springer Science and Business Media LLC
Published: 2011
Volume: 10
Issue: Suppl 1
Pages: S2
ISSN: 1475-2859 (ISSN-L)
DOI: 10.1186/1475-2859-10-s1-s2
PMC: PMC3231926
OpenAlex: W2097603527
Cited by: 134
References: 131
Citations by year: 2026: 4 · 2025: 10 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 5 · 2020: 8 · 2019: 9 · 2018: 12 · 2017: 7 · 2016: 8 · 2015: 12 · 2014: 18 · 2013: 12 · 2012: 9
Type: conference abstract
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Microbial Cell Factories (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Academy of Finland
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: lactic acid bacteria, probiotics, starter cultures, metagenomics, comparative genomics, synthetic biology, industrial applications, self-learning systems
MeSH terms: Animals, Bifidobacterium, Biotechnology, Fermentation, Food-Processing Industry, Humans, Lactic Acid, Probiotics, Lactobacillales

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Systems solutions by lactic acid bacteria: from paradigms to practice

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