Biodiversity-Based Identification and Functional Characterization of the Mannose-Specific Adhesin of Lactobacillus plantarum
Open accessAbstract
Lactobacillus plantarum is a frequently encountered inhabitant of the human intestinal tract, and some strains are marketed as probiotics. Their ability to adhere to mannose residues is a potentially interesting characteristic with regard to proposed probiotic features such as colonization of the intestinal surface and competitive exclusion of pathogens. In this study, the variable capacity of 14 L. plantarum strains to agglutinate Saccharomyces cerevisiae in a mannose-specific manner was determined and subsequently correlated with an L. plantarum WCFS1-based genome-wide genotype database. This led to the identification of four candidate mannose adhesin-encoding genes. Two genes primarily predicted to code for sortase-dependent cell surface proteins displayed a complete gene-trait match. Their involvement in mannose adhesion was corroborated by the finding that a sortase (srtA) mutant of L. plantarum WCFS1 lost the capacity to agglutinate S. cerevisiae. The postulated role of these two candidate genes was investigated by gene-specific deletion and overexpression in L. plantarum WCFS1. Subsequent evaluation of the mannose adhesion capacity of the resulting mutant strains showed that inactivation of one candidate gene (lp_0373) did not affect mannose adhesion properties. In contrast, deletion of the other gene (lp_1229) resulted in a complete loss of yeast agglutination ability, while its overexpression quantitatively enhanced this phenotype. Therefore, this gene was designated to encode the mannose-specific adhesin (Msa; gene name,msa) of L. plantarum. Domain homology analysis of the predicted 1,000-residue Msa protein identified known carbohydrate-binding domains, further supporting its role as a mannose adhesin that is likely to be involved in the interaction of L. plantarum with its host in the intestinal tract.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Molecular Cloning. A Laboratory Manual
Wood, E. (1983) · Biochemical Education · doi:10.1016/0307-4412(83)90068-7 · Cited by 29,534 · see citing works
Yanisch-Perron, C., Vieira, J., & Messing, J. W. (1985) · Gene · doi:10.1016/0378-1119(85)90120-9 · Cited by 14,868 · see citing works
Complete genome sequence of <i>Lactobacillus plantarum</i> WCFS1
Kleerebezem, M., Boekhorst, J., van Kranenburg, R., Molenaar, D., Kuipers, O. P., Leer, R., Tarchini, R., Peters, S. A., Sandbrink, H. M., Fiers, M. W. E. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337704100 · Cited by 1,472 · see citing works
Self-citationNavarre, W. W., & Schneewind, O. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.1.174-229.1999 · Cited by 1,391 · see citing works
Horinouchi, S., & Weisblum, B. (1982) · Journal of Bacteriology · doi:10.1128/jb.150.2.815-825.1982 · Cited by 738 · see citing works
Mack, D. R., Ahrné, S., Hyde, L., Wei, S. H., & Hollingsworth, M. A. (2003) · Gut · doi:10.1136/gut.52.6.827 · Cited by 666 · see citing works
Ton-That, H., Liu, G., Mazmanian, S. K., Faull, K. F., & Schneewind, O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12424 · Cited by 567 · see citing works
The nucleotide sequence of pACYC177
Rose, R. E. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.1.356 · Cited by 489 · see citing works
Use of Lactobacillus to prevent infection by pathogenic bacteria
Reid, G., & Burton, J. P. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01544-7 · Cited by 445 · see citing works
The normal Lactobacillus flora of healthy human rectal and oral mucosa
Ahrné, Nobaek, Jeppsson, Adlerberth, Wold, A. E., & Molin (1998) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.1998.00480.x · Cited by 439 · see citing works
Predicting function: from genes to genomes and back 1 1Edited by P. E. Wright
Peer Bork, B., Dandekar, T., Diaz-Lazcoz, Y., Eisenhaber, F., Huynen, M. A., & Yuan, Y. P. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2144 · Cited by 422 · see citing works
Johansson, M. L., Molin, G., Jeppsson, B. W., Nobaek, S., Ahrné, S., & Bengmark, S. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.1.15-20.1993 · Cited by 417 · see citing works
The Scientific Basis for Probiotic Strains ofLactobacillus
Reid, G. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.9.3763-3766.1999 · Cited by 399 · see citing works
Roos, S., & Jonsson, H. (2002) · Microbiology · doi:10.1099/00221287-148-2-433 · Cited by 376 · see citing works
Krogfelt, K. A., Bergmans, H. E. N., & Klemm, P. (1990) · Infection and Immunity · doi:10.1128/iai.58.6.1995-1998.1990 · Cited by 375 · see citing works
Functional analysis of promoters in the nisin gene cluster of Lactococcus lactis
de Ruyter, P. G. G. A., Kuipers, O. P., Beerthuyzen, M. M., van Alen-Boerrigter, I., & de Vos, W. M. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.12.3434-3439.1996 · Cited by 331 · see citing works
Imberty, A., Wimmerová, M., Mitchell, E. P., & Gilboa-Garber, N. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2003.10.016 · Cited by 314 · see citing works
Adlerberth, I., Ahrne, S., Johansson, M. L., Molin, G., Hanson, L. A., & Wold, A. E. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.7.2244-2251.1996 · Cited by 293 · see citing works
Isolation and characterization of Streptococcus cremoris Wg2-specific promoters
van der Vossen, J. M., van der Lelie, D., & Venema, G. (1987) · Applied and Environmental Microbiology · doi:10.1128/aem.53.10.2452-2457.1987 · Cited by 293 · see citing works
van Kranenburg, R., Marugg, J. D., van Swam, I. I., Willem, N. J., & de Vos, W. M. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.3521720.x · Cited by 262 · see citing works
Molin, G. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.380s · Cited by 261 · see citing works
ExploringLactobacillus plantarumGenome Diversity by Using Microarrays
Molenaar, D., Bringel, F., Schuren, F. H. J., de Vos, W. M., Siezen, R. J., & Kleerebezem, M. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.17.6119-6127.2005 · Cited by 252 · see citing works
Self-citationEvolution of Staphylococcus aureus by Large Chromosomal Replacements
Robinson, D. A., & Enright, M. C. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.4.1060-1064.2004 · Cited by 241 · see citing works
Identification ofLactobacillus plantarumGenes That Are Induced in the Gastrointestinal Tract of Mice
Bron, P. A., Grangette, C., Mercenier, A., de Vos, W. M., & Kleerebezem, M. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.17.5721-5729.2004 · Cited by 239 · see citing works
Self-citationRoche, F. M., Massey, R. C., Peacock, S. J., Day, N., Visai, L., Speziale, P., Lam, A., Pallen, M. J., & Foster, T. J. (2003) · Microbiology · doi:10.1099/mic.0.25996-0 · Cited by 212 · see citing works
Vesa, Pochart, & Marteau (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00763.x · Cited by 200 · see citing works
Molin, G., Jeppsson, B. W., Johansson, M. ‐., Ahrné, S., Nobaek, S., Ståhl, M., & Bengmark, S. (1993) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1993.tb03031.x · Cited by 189 · see citing works
Johansson, M.-L., Nobaek, S., Berggren, A., Nyman, M., Björck, I., Ahrné, S., Jeppsson, B., & Molin, G. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00055-5 · Cited by 187 · see citing works
Platteeuw, C., Simons, G., & de Vos, W. M. (1994) · Applied and Environmental Microbiology · doi:10.1128/aem.60.2.587-593.1994 · Cited by 186 · see citing works
Vaughan, E. E., de Vries, M. C., Zoetendal, E. G., Amor, K. B., Akkermans, A. D. L., & de Vos, W. M. (2002) · PubMed · Cited by 175 · see citing works
Neeser, J., Granato, D., Rouvet, M., Servin, A. L., Teneberg, S., & Karlsson, K. ‐. (2000) · Glycobiology · doi:10.1093/glycob/10.11.1193 · Cited by 165 · see citing works
Lactic acid bacteria and the human gastrointestinal tract
Hove, H., Nørgaard, H., & Mortensen, P. B. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600773 · Cited by 159 · see citing works
Characterization of a gram-positive broad-host-range plasmid isolated from Lactobacillus hilgardii
Josson, K., Scheirlinck, T., Michiels, F., Platteeuw, C., Stanssens, P. E., Joos, H., D’Haese, P. C., Zabeau, M., & Mahillon, J. (1989) · Plasmid · doi:10.1016/0147-619x(89)90082-6 · Cited by 143 · see citing works
Vaughan, E. E., de Vries, M. C., Zoetendal, E. G., Amor, K. B., Akkermans, A. D. L., & de Vos, W. M. (2002) · Antonie van Leeuwenhoek · doi:10.1023/a:1020672724450 · Cited by 136 · see citing works
Lee, Y.-K., & Puong, K.-Y. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002635 · Cited by 130 · see citing works
Wold, A. E., Thorssén, M., Hull, S., & Edén, C. S. (1988) · Infection and Immunity · doi:10.1128/iai.56.10.2531-2537.1988 · Cited by 119 · see citing works
Screening of bacterial isolates for mannose-specific lectin activity by agglutination of yeasts
Mirelman, D., Altmann, G., & Eshdat, Y. (1980) · Journal of Clinical Microbiology · doi:10.1128/jcm.11.4.328-331.1980 · Cited by 119 · see citing works
Comparative Whole-Genome Hybridization Reveals Genomic Islands inBrucellaSpecies
Rajashekara, G., Glasner, J. D., Glover, D. A., & Splitter, G. A. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.15.5040-5051.2004 · Cited by 117 · see citing works
Wedekind, J. E., Trame, C. B., Dorywalska, M., Koehl, P., Raschke, T. M., McKee, M. L., FitzGerald, D. J., Collier, R. J., & McKay, D. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5195 · Cited by 115 · see citing works
Lactobacillus plantarum ldhL gene: overexpression and deletion
Ferain, T., Garmyn, D., Bernard, N., Pascal Hols, A., & Delcour, J. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.3.596-601.1994 · Cited by 108 · see citing works
Goossens, D. A. M., Jonkers, D. M. A. E., Rüssel, M. G., Stobberingh, E. E., van den Bogaard, A. E. J. M., & Stockbrügger, R. W. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01708.x · Cited by 99 · see citing works
Functional Flexibility of the FimH Adhesin: Insights from a Random Mutant Library
Schembri, M. A., Sokurenko, E. V., & Klemm, P. (2000) · Infection and Immunity · doi:10.1128/iai.68.5.2638-2646.2000 · Cited by 99 · see citing works
Velloso, L. M., Svensson, K., Schneider, G., Pettersson, R. F., & Lindqvist, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112098200 · Cited by 84 · see citing works
Bernard, N., Ferain, T., Garmyn, D., Pascal Hols, A., & Delcour, J. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81226-x · Cited by 81 · see citing works
Hahn, M. G., Pons, J., Planas, A., Querol, E., & Heinemann, U. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01111-q · Cited by 78 · see citing works
Dalle, F., Jouault, T., Trinel, P. A., Esnault, J., Mallet, J., d’Athis, P., Poulain, D., & Bonnin, A. (2003) · Infection and Immunity · doi:10.1128/iai.71.12.7061-7068.2003 · Cited by 76 · see citing works
COMPARATIVE GENOMICS ANALYSES OF CITRUS-ASSOCIATED BACTERIA
Moreira, L. M., de Souza, R. F., Almeida, N. F., Setúbal, J. C., de Oliveira, J. C. F., Furlan, L. R., Ferro, J. A., & da Silva, A. C. R. (2004) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.42.040803.140310 · Cited by 75 · see citing works
The Functional ccpA Gene Is Required for Carbon Catabolite Repression in Lactobacillus plantarum
Muscariello, L., Marasco, R., Felice, M. D., & Sacco, M. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.7.2903-2907.2001 · Cited by 75 · see citing works
Post-genomics of lactic acid bacteria and other food-grade bacteria to discover gut functionality
de Vos, W. M., Bron, P. A., & Kleerebezem, M. (2004) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2004.02.006 · Cited by 62 · see citing works
Self-citationDerzelle, S., Hallet, B., Francis, K. P., Ferain, T., Delcour, J., & Pascal Hols, A. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.18.5105-5113.2000 · Cited by 62 · see citing works
Ivleva, N. B., Сидорук, К. В., Pakrasi, H. B., & Shestakov, S. V. (2002) · Microbiology · doi:10.1023/a:1019845610873 · Cited by 57 · see citing works
A Cross-Genomic Approach for Systematic Mapping of Phenotypic Traits to GenesPreprint
Jim, K., Parmar, K. M., Singh, M., & Tavazoie, S. (2004) · Genome Research · doi:10.1101/gr.1586704 · Cited by 55 · see citing works
Diarrhoea caused byEscherichia coli
Hart, C. A., Batt, R. M., & Saunders, J. R. (1993) · Annals of Tropical Paediatrics · doi:10.1080/02724936.1993.11747636 · Cited by 53 · see citing works
Bringel, F., Quénée, P., & Tailliez, P. (2001) · Systematic and Applied Microbiology · doi:10.1078/0723-2020-00061 · Cited by 50 · see citing works
Cloning and characterization of cspL and cspP, two cold-inducible genes from Lactobacillus plantarum
Mayo, B., Derzelle, S., Fernández, M., Leonard, C. A., Ferain, T., Pascal Hols, A., Suárez, J. E., & Delcour, J. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.9.3039-3042.1997 · Cited by 47 · see citing works
Turner, M. S., Hafner, L. M., Walsh, T., & Giffard, P. M. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.10.5855-5863.2003 · Cited by 41 · see citing works
Mannose-sensitive Haemagglutinins in Adherence of Vibrio cholerae eltor to Intestine
BHATTACHARJEE, J. W., & SRIVASTAVA, B. S. (1978) · Journal of General Microbiology · doi:10.1099/00221287-107-2-407 · Cited by 41 · see citing works
Levesque, M. P., Shasha, D. E., Kim, W., Surette, M. G., & Benfey, P. N. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00009-5 · Cited by 38 · see citing works
Aslanzadeh, J., & Paulissen, L. J. (1992) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1992.tb02034.x · Cited by 35 · see citing works
The molecular response of Lactobacillus plantarum to intestinal passage and conditions
Bron, P. A. (2004) · doi:10.18174/121556 · Cited by 19 · see citing works
Self-citationClerck, E. D., Gevers, D., Sergeant, K., Rodríguez‐Díaz, M., Herman, L., Logan, N. A., BEEUMEN, J. V., & Vos, P. D. (2004) · Research in Microbiology · doi:10.1016/j.resmic.2004.02.007 · Cited by 12 · see citing works
[Nucleic base composition of bacteria of the Lactobacillus genus].
Gasser, F., & Sebald, M. (1966) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2297 · Cited by 1,062 · see citing works
Genes and Molecules of Lactobacilli Supporting Probiotic Action
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00017-08 · Cited by 1,013 · see citing works
Stress Physiology of Lactic Acid Bacteria.
Papadimitriou, K., Alegría, Á., Bron, P. A., de Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., et al. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00076-15 · Cited by 914 · see citing works
Self-citationEmerging molecular insights into the interaction between probiotics and the host intestinal mucosa
Bron, P. A., van Baarlen, P., & Kleerebezem, M. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2690 · Cited by 690 · see citing works
Self-citationFate, activity, and impact of ingested bacteria within the human gut microbiota
Derrien, M., & van Hylckama Vlieg, J. E. T. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.03.002 · Cited by 605 · see citing works
Can probiotics modulate human disease by impacting intestinal barrier function?
Bron, P. A., Kleerebezem, M., Brummer, R.-J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L., & Wells, J. M. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004037 · Cited by 499 · see citing works
Self-citationGenome-scale analyses of health-promoting bacteria: probiogenomics
Ventura, M., O'Flaherty, S., Claesson, M. J., Turroni, F., Klaenhammer, T. R., van Sinderen, D., & O'Toole, P. W. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2047 · Cited by 471 · see citing works
Immunomodulatory mechanisms of lactobacilli
Wells, J. M. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-s1-s17 · Cited by 431 · see citing works
The extracellular biology of the lactobacilli
Kleerebezem, M., Pascal Hols, A., Bernard, E., Rolain, T., Zhou, M., Siezen, R. J., & Bron, P. A. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2009.00208.x · Cited by 381 · see citing works
Self-citationTowards understanding molecular modes of probiotic action
Marco, M. L., Pavan, S., & Kleerebezem, M. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.02.005 · Cited by 343 · see citing works
Self-citationvan Zyl, W. F., Deane, S. M., & Dicks, L. M. T. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1831339 · Cited by 348 · see citing works
Lactobacillus Adhesion to Mucus
Tassell, M. L. V., & Miller, M. J. (2011) · Nutrients · doi:10.3390/nu3050613 · Cited by 335 · see citing works
Kleerebezem, M., & Vaughan, E. E. (2009) · Annual Review of Microbiology · doi:10.1146/annurev.micro.091208.073341 · Cited by 315 · see citing works
Self-citationMicrobial adhesins to gastrointestinal mucus
Juge, N. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.10.001 · Cited by 304 · see citing works
Characterization and probiotic potential of Lactobacillus plantarum strains isolated from cheeses
Zago, M., Fornasari, M. E., Carminati, D., Burns, P., Suárez, V., Vinderola, G., Reinheimer, J. A., & Giraffa, G. (2011) · Food Microbiology · doi:10.1016/j.fm.2011.02.009 · Cited by 298 · see citing works
Functional and Probiotic Attributes of an Indigenous Isolate of Lactobacillus plantarum
Kaushik, J. K., Kumar, A., Duary, R. K., Mohanty, A. K., Grover, S., & Batish, V. K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008099 · Cited by 295 · see citing works
Sengupta, R., Altermann, E., Anderson, R. C., McNabb, W. C., Moughan, P. J., & Roy, N. C. (2013) · Mediators of Inflammation · doi:10.1155/2013/237921 · Cited by 287 · see citing works
Genomic features of lactic acid bacteria effecting bioprocessing and health
Klaenhammer, T. R., Barrangou, R., Buck, B. L., Azcárate-Peril, M. A., & Altermann, E. (2005) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2005.04.007 · Cited by 282 · see citing works
Johnson-Henry, K. C., Hagen, K. E., Gordonpour, M., Tompkins, T. A., & Sherman, P. M. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00791.x · Cited by 274 · see citing works
The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept
den Abbeele, P. V., de Wiele, T. V., Verstraete, W., & Possemiers, S. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00270.x · Cited by 263 · see citing works
ExploringLactobacillus plantarumGenome Diversity by Using Microarrays
Molenaar, D., Bringel, F., Schuren, F. H. J., de Vos, W. M., Siezen, R. J., & Kleerebezem, M. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.17.6119-6127.2005 · Cited by 252 · see citing works
Self-citationLactobacillus and intestinal diseases: Mechanisms of action and clinical applications
Huang, R., Wu, F. L., Zhou, Q., Wei, W., Juan, Y., Xiao, B., & Luo, Z. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127019 · Cited by 258 · see citing works
Duary, R. K., Rajput, Y. S., Batish, V. K., & Grover, S. (2011) · Indian Journal of Medical Research · doi:10.4103/0971-5916.90992 · Cited by 242 · see citing works
Ruas‐Madiedo, P., Gueimonde, M., Margollés, A., Reyes‐Gavilán, C. G. D. L., & Salminen, S. (2006) · Journal of Food Protection · doi:10.4315/0362-028x-69.8.2011 · Cited by 241 · see citing works
Glycobiome: Bacteria and mucus at the epithelial interface
Ouwerkerk, J. P., de Vos, W. M., & Belzer, C. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.001 · Cited by 228 · see citing works
von Ossowski, I., Reunanen, J., Satokari, R. M., Vesterlund, S., Kankainen, M., Huhtinen, H., Tynkkynen, S., Salminen, S., de Vos, W. M., & Palva, A. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.01958-09 · Cited by 216 · see citing works
d ‐Mannose: Properties, Production, and Applications: An Overview
Hu, X., Shi, Y., Zhang, P., Miao, M., Zhang, T., & Jiang, B. (2016) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12211 · Cited by 211 · see citing works
Adherence factors ofLactobacillusin the human gastrointestinal tract
Vélez, M. P., Keersmaecker, S. C. J. D., & Vanderleyden, J. (2007) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2007.00908.x · Cited by 207 · see citing works
Meijerink, M., van Hemert, S., Taverne, N., Wels, M., de Vos, P., Bron, P. A., Savelkoul, H. F. J., van Bilsen, J. H. M., Kleerebezem, M., & Wells, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010632 · Cited by 206 · see citing works
Self-citationIn vitro testing of commercial and potential probiotic lactic acid bacteria
Jensen, H., Grimmer, S., Naterstad, K., & Axelsson, L. T. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.11.020 · Cited by 205 · see citing works
Probiotic Lactic Acid Bacteria: A Review
Quinto, E. J., Jiménez, P., Caro, I., Tejero, J., Mateo, J., & Girbés, T. (2014) · Food and Nutrition Sciences · doi:10.4236/fns.2014.518190 · Cited by 210 · see citing works
MacKenzie, D. A., Jeffers, F., Parker, M. L., Vibert-Vallet, A., Bongaerts, R. J., Roos, S., Walter, J., & Juge, N. (2010) · Microbiology · doi:10.1099/mic.0.043265-0 · Cited by 202 · see citing works
van Hemert, S., Meijerink, M., Molenaar, D., Bron, P. A., de Vos, P., Kleerebezem, M., Wells, J. M., & Marco, M. L. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-293 · Cited by 195 · see citing works
Self-citationBoekhorst, J., Helmer, Q., Kleerebezem, M., & Siezen, R. J. (2005) · Microbiology · doi:10.1099/mic.0.28415-0 · Cited by 191 · see citing works
Self-citationThe genomics of lactic acid bacteria
Pfeiler, E. A., & Klaenhammer, T. R. (2007) · Trends in Microbiology · doi:10.1016/j.tim.2007.09.010 · Cited by 192 · see citing works
Impact of mycotoxins on the intestine: are mucus and microbiota new targets?
Robert, H., Payros, D., Pinton, P., Théodorou, V., Mercier‐Bonin, M., & Oswald, I. P. (2017) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2017.1326071 · Cited by 184 · see citing works
Denou, E., Pridmore, R. D., Berger, B. W., Panoff, J.-M., Arigoni, F., & Brüssow, H. (2008) · Journal of Bacteriology · doi:10.1128/jb.01637-07 · Cited by 179 · see citing works
Vaginal microbiota and its role in HIV transmission and infection
Petrova, M., van den Broek, M., Balzarini, J. M., Vanderleyden, J., & Lebeer, S. (2013) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12029 · Cited by 178 · see citing works
Experimental models to study intestinal microbes–mucus interactions in health and disease
Etienne‐Mesmin, L., Chassaing, B., Desvaux, M., Paepe, K. D., Gresse, R., Sauvaitre, T., Forano, É., de Wiele, T. V., Schüller, S., Juge, N., et al. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz013 · Cited by 178 · see citing works
Adhesion Properties of Lactic Acid Bacteria on Intestinal Mucin
Nishiyama, K., Sugiyama, M., & Mukai, T. (2016) · Microorganisms · doi:10.3390/microorganisms4030034 · Cited by 170 · see citing works
Surface displaced alfa-enolase of Lactobacillus plantarum is a fibronectin binding protein
Castaldo, C., Vastano, V., Siciliano, R. A., Candela, M., Vici, M., Muscariello, L., Marasco, R., & Sacco, M. (2009) · Microbial Cell Factories · doi:10.1186/1475-2859-8-14 · Cited by 146 · see citing works
Thy, H. T. T., Tri, N. N., Quy, O. M., Fotedar, R. K., Kannika, K., Unajak, S., & Areechon, N. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.11.016 · Cited by 146 · see citing works
Sánchez, B., Bressollier, P., & Urdaci, M. C. (2008) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2008.00454.x · Cited by 141 · see citing works
van Pijkeren, J., Canchaya, C. A., Ryan, K. A., Li, Y., Claesson, M. J., Sheil, B., Steidler, L., O’Mahony, L., Fitzgerald, G. F., van Sinderen, D., et al. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03023-05 · Cited by 141 · see citing works
Lactobacillus plantarum WCFS 1 and its host interaction: a dozen years after the genome
van den Nieuwboer, M., van Hemert, S., Claassen, E., & de Vos, W. M. (2016) · Microbial Biotechnology · doi:10.1111/1751-7915.12368 · Cited by 136 · see citing works
Tallon, R., Arias, S., Bressollier, P., & Urdaci, M. C. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.03086.x · Cited by 138 · see citing works
Lactobacillus: Host–Microbe Relationships
O’Callaghan, J., & O’Toole, P. W. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_187 · Cited by 135 · see citing works
Systems Solutions by Lactic Acid Bacteria: From Paradigms to Practice
de Vos, W. M. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-s1-s2 · Cited by 134 · see citing works
Gueimonde, M., Jalonen, L., He, F., Hiramatsu, M., & Salminen, S. (2005) · Food Research International · doi:10.1016/j.foodres.2005.10.003 · Cited by 135 · see citing works
Complete Resequencing and Reannotation of the Lactobacillus plantarum WCFS1 Genome
Siezen, R. J., Francke, C., Renckens, B. A. M., Boekhorst, J., Wels, M., Kleerebezem, M., & van Hijum, S. A. F. T. (2011) · Journal of Bacteriology · doi:10.1128/jb.06275-11 · Cited by 130 · see citing works
Self-citationMechanisms of Action of Probiotics in Intestinal Diseases
O’Hara, A. M., & Shanahan, F. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.26 · Cited by 129 · see citing works
Ladero, V., Ramos, A., Wiersma, A., Goffin, P., Schanck, A., Kleerebezem, M., Hugenholtz, J., Smid, E. J., & Hols, P. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02304-06 · Cited by 127 · see citing works
Self-citationLiu, Y., Liu, B., Li, D., Hu, Y., Zhao, L., Zhang, M., Ge, S., Pang, J., Li, Y., Wang, R., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202001157 · Cited by 125 · see citing works
Host‐microbe interaction in the gastrointestinal tract
Parker, A., Lawson, M. A., Vaux, L., & Pin, C. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13926 · Cited by 123 · see citing works
Lactobacillaceae and Cell Adhesion: Genomic and Functional Screening
Turpin, W., Humblot, C., Noordine, M.-L., Thomas, M., & Guyot, J.-P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038034 · Cited by 118 · see citing works
Marco, M. L., Bongers, R. S., de Vos, W. M., & Kleerebezem, M. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01475-06 · Cited by 117 · see citing works
Self-citationHoppe, M., Önning, G., Berggren, A., & Hulthén, L. (2015) · British Journal Of Nutrition · doi:10.1017/s000711451500241x · Cited by 114 · see citing works
Boekhorst, J., Wels, M., Kleerebezem, M., & Siezen, R. J. (2006) · Microbiology · doi:10.1099/mic.0.29217-0 · Cited by 114 · see citing works
Self-citationStructural basis for adaptation of lactobacilli to gastrointestinal mucus
Etzold, S., Coleman, O. I., MacKenzie, D. A., Tailford, L. E., Gunning, A. P., Walshaw, J., Hemmings, A. M., & Juge, N. (2013) · Environmental Microbiology · doi:10.1111/1462-2920.12377 · Cited by 111 · see citing works
Molecular approaches: advantages and artifacts in assessing bacterial diversity
Pontes, D. S., Lima-Bittencourt, C. I., Chartone‐Souza, E., & Nascimento, A. M. A. (2007) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-007-0219-3 · Cited by 111 · see citing works
Buron-Moles, G., Chailyan, A., Dolejš, I., Förster, J., & Mikš‐Krajnik, M. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09701-6 · Cited by 110 · see citing works
Muñoz-Provencio, D., Llopis, M., Antolı́n, M., de Torres, I. M., Guarner, F., Pérez‐Martínez, G., & Monedero, V. (2008) · Archives of Microbiology · doi:10.1007/s00203-008-0436-9 · Cited by 109 · see citing works
The quest for probiotic effector molecules—Unraveling strain specificity at the molecular level
Lee, I.-C., Tomita, S., Kleerebezem, M., & Bron, P. A. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.010 · Cited by 109 · see citing works
Self-citationProbiotic bacteria affect the composition of salivary pellicle and streptococcal adhesion in vitro
Haukioja, A. L., Loimaranta, V., & Tenovuo, J. O. (2008) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2008.00435.x · Cited by 109 · see citing works
von Ossowski, I., Satokari, R. M., Reunanen, J., Lebeer, S., Keersmaecker, S. C. J. D., Vanderleyden, J., de Vos, W. M., & Palva, A. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.02497-10 · Cited by 107 · see citing works
Bove, P., Russo, P., Capozzi, V., Gallone, A., Spano, G., & Fiocco, D. (2013) · Microbiological Research · doi:10.1016/j.micres.2013.01.004 · Cited by 105 · see citing works
Muscariello, L., Siena, B. D., & Marasco, R. (2020) · Current Microbiology · doi:10.1007/s00284-020-02243-5 · Cited by 106 · see citing works
Probiotic Properties of Lactobacillus Salivarius and Closely Related Lactobacillus Species
Neville, B., & O’Toole, P. W. (2010) · Future Microbiology · doi:10.2217/fmb.10.35 · Cited by 104 · see citing works
Chicken intestinal microbiota function with a special emphasis on the role of probiotic bacteria
Cisek, A. A., & Binek, M. (2014) · Polish Journal of Veterinary Sciences · doi:10.2478/pjvs-2014-0057 · Cited by 102 · see citing works
Petrova, M., Imholz, N. C. E., Verhoeven, T. L. A., Balzarini, J. M., Damme, E. J. M. V., Schols, D., Vanderleyden, J., & Lebeer, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161337 · Cited by 102 · see citing works
Jensen, H., Roos, S., Jonsson, H., Rud, I., Grimmer, S., van Pijkeren, J., Britton, R. A., & Axelsson, L. T. (2014) · Microbiology · doi:10.1099/mic.0.073551-0 · Cited by 97 · see citing works
Lactiplantibacillus plantarum 299v (LP299V®): three decades of research
Nordström, E. A., Teixeira, C., Montelius, C., Jeppsson, B. W., & Larsson, N. (2021) · Beneficial Microbes · doi:10.3920/bm2020.0191 · Cited by 95 · see citing works
Mucus: An Underestimated Gut Target for Environmental Pollutants and Food Additives
Gillois, K., Lévêque, M., Théodorou, V., Robert, H., & Mercier‐Bonin, M. (2018) · Microorganisms · doi:10.3390/microorganisms6020053 · Cited by 93 · see citing works
Siragusa, S., Angelis, M. D., Calasso, M. P., Campanella, D., Minervini, F., Cagno, R. D., & Gobbetti, M. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.11.003 · Cited by 91 · see citing works
Sommer, F., & Bäckhed, F. (2016) · BioEssays · doi:10.1002/bies.201500151 · Cited by 90 · see citing works
Deo, D., Davray, D., & Kulkarni, R. (2019) · Microorganisms · doi:10.3390/microorganisms7100444 · Cited by 90 · see citing works
Proteomics of the bacterial cross-talk by quorum sensing
Cagno, R. D., Angelis, M. D., Calasso, M. P., & Gobbetti, M. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.09.003 · Cited by 90 · see citing works
Kensche, P. R., van Noort, V., Dutilh, B. E., & Huynen, M. A. (2007) · Journal of The Royal Society Interface · doi:10.1098/rsif.2007.1047 · Cited by 89 · see citing works
Functional Genomics for Food Fermentation Processes
Smid, E. J., & Hugenholtz, J. (2010) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.102308.124143 · Cited by 89 · see citing works
MacKenzie, D. A., Tailford, L. E., Hemmings, A. M., & Juge, N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040907 · Cited by 88 · see citing works
Turchi, B., Mancini, S., Fratini, F., Pedonese, F., Nuvoloni, R., Bertelloni, F., Ebani, V. V., & Cerri, D. (2013) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-013-1356-7 · Cited by 90 · see citing works
Modulating gastrointestinal microbiota to alleviate diarrhea in calves
Du, W., Wang, X., Hu, M., Hou, J., Du, Y., Si, W., Yang, L., Xu, L., & Xu, Q. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1181545 · Cited by 87 · see citing works
Effect of Flavan-3-ols on the Adhesion of Potential Probiotic Lactobacilli to Intestinal Cells
Bustos, I., García‐Cayuela, T., Hernández‐Ledesma, B., Peláez, C., Requena, T., & Martínez‐Cuesta, M. C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301133g · Cited by 87 · see citing works
Functional properties of Lactobacillus plantarum strains: A multivariate screening study
Guidone, A., Zotta, T., Ross, R. P., Stanton, C., Rea, M. C., Parente, E., & Ricciardi, A. (2013) · LWT · doi:10.1016/j.lwt.2013.10.036 · Cited by 85 · see citing works
Arena, M. P., Capozzi, V., Spano, G., & Fiocco, D. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-017-8182-z · Cited by 86 · see citing works
Ardita, C., Mercante, J. W., Kwon, Y. M., Luo, L., Houser, M. C., Powell, D. N., Jones, R. M., & Neish, A. S. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.01039-14 · Cited by 82 · see citing works
Glenting, J., Beck, H. C., Vrang, A., Riemann, H., Ravn, P., Hansen, A. M., Antonsson, M., Ahrné, S., Israelsen, H., & Madsen, S. M. (2013) · Microbiological Research · doi:10.1016/j.micres.2013.01.003 · Cited by 80 · see citing works
Multifunctional properties of Lactobacillus plantarum strains isolated from fermented cereal foods
Oguntoyinbo, F. A., & Narbad, A. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.022 · Cited by 79 · see citing works
Functional Properties of Lactobacillus mucosae Strains Isolated from Brazilian Goat Milk
de Moraes, G. M. D., de Abreu, L. R., do Egito, A. S., Salles, H. O., da Silva, L. M. F., Nero, L. A., Todorov, S. D., & dos Santos, K. M. O. (2016) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-016-9244-8 · Cited by 76 · see citing works
Gutierrez‐Merino, J., Isla, B., Combes, T., Martínez, F. O., & de Motes, C. M. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1707015 · Cited by 76 · see citing works
Interactomics in the Human Intestine
Boesten, R. J., & de Vos, W. M. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31817dbd62 · Cited by 74 · see citing works
de Carvalho-Netto, O. V., Carazzolle, M. F., Mofatto, L. S., Teixeira, P. J. P. L., Noronha, M. F., Calderón, L. A. L., Mieczkowski, P. A., Argueso, J. L., & Pereira, G. A. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0196-6 · Cited by 72 · see citing works
Factors involved in binding of Lactobacillus plantarum Lp6 to rat small intestinal mucus
Sun, J., Le, G.-W., Shi, Y.-H., & Su, G.-W. (2007) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2006.02031.x · Cited by 70 · see citing works
The Starting Lineup: Key Microbial Players in Intestinal Immunity and Homeostasis
Reading, N. C., & Kasper, D. L. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00148 · Cited by 69 · see citing works
Significance of microbial symbiotic coexistence in traditional fermentation
Furukawa, S., Watanabe, T., Toyama, H., & Morinaga, Y. (2013) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2013.05.017 · Cited by 68 · see citing works
Wang, L., Yu, X., Xu, H., Aguilar, Z. P., & Wei, H. (2015) · LWT · doi:10.1016/j.lwt.2015.12.001 · Cited by 67 · see citing works
Explaining microbial phenotypes on a genomic scale: GWAS for microbes
Dutilh, B. E., Backus, L., Edwards, R. A., Wels, M., Bayjanov, J. R., & van Hijum, S. A. F. T. (2013) · Briefings in Functional Genomics · doi:10.1093/bfgp/elt008 · Cited by 65 · see citing works
Golowczyc, M. A., Mobili, P., Garrote, G. L., Serradell, M. D. L. Á., Abraham, A. G., & Antoni, G. L. D. (2009) · Journal of Dairy Research · doi:10.1017/s0022029908003749 · Cited by 64 · see citing works
Arellano, K., Bucheli, J. E. V., Park, H., Lim, J.-H., Ji, Y., Kang, H., Cho, D., Jeong, H. W., & Holzapfel, W. H. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09620-y · Cited by 64 · see citing works
Engineering lactic acid bacteria for increased industrial functionality
Bron, P. A., & Kleerebezem, M. (2011) · Bioengineered Bugs · doi:10.4161/bbug.2.2.13910 · Cited by 63 · see citing works
Self-citation
- Authors
- Pretzer, G., Snel, J., Molenaar, D., Wiersma, A., Bron, P. A., Lambert, J., de Vos, W. M., van der Meer, R., Smits, M. A., & Kleerebezem, M.
- Affiliations
- Nederlands Instituut Voor Zuivel Oonderzoek (NL)
- NIZO Food Research, P.O. Box 20, 6710 BA Ede, The Netherlands
- Wageningen Centre for Food Sciences, P.O. Box 557, 6700 AN Wageningen, The Netherlands
- Wageningen University & Research (NL)
- Corresponding author
- Kleerebezem, Michiel
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2005-09
- Volume
- 187
- Issue
- 17
- Pages
- 6128-6136
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC1196140
- OpenAlex
- W2109055419
- Cited by
- 316
- References
- 63
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 11 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 16 · 2019: 13 · 2018: 9 · 2017: 15 · 2016: 19 · 2015: 16 · 2014: 17 · 2013: 24 · 2012: 20
- FWCI
- 25.73
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Bacteriology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- VU Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Lactobacillus plantarum, carbohydrate-binding domain, probiotic colonization, host-bacteria interactions
- MeSH terms
- Agglutination, Base Sequence, Mannose, Phenotype, Plasmids, Saccharomyces cerevisiae, Genetic Variation, DNA Primers, Adhesins, Bacterial, Lactobacillus plantarum, Lactiplantibacillus plantarum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review